Clinical Observation of Stage I～II Endometriosis Infertility after Laparoscopic Surgery

Objective To look for the most appropriate assisted reproduction protocol for infertility patients with stage Ⅰ to Ⅱ pelvic endometriosis after laparoscopic surgery.Methods 437cases of infertility patients with endometriosis who have taken laparoscopic surgery are collected in our hospital from March 2009 to March 2011.Among them,298patients enrolled in this study.They were divided into primary infertility group and secondary infertility group.According to the different attempts to pregnancy,they were then divided into three groups of natural cycle,ovulation induction and insemination.We compared the clinic outcome of the three groups respectively.The cumulative pregnancy rates of 1 year after surgery between two types of endometriosis infertility patients were also compared.Results The clinical pregnancy rate per cycle by using the three different therapeutic attempts was statistically significant different both in primary and secondary infertility patients after laparoscopic surgery(P=0.032andP=0.034).The clinical pregnancy rate in IUI group was higher than the natural cycle and induction groups.There were no statistically significant difference in pregnancy rate per cycle,miscarriage rate,ectopic pregnancy rate and twin pregnancy rate between the three treatment groups(P0.05).But the cycle pregnancy rate of artificial insemination had a significant increasing trend.There were significant difference in the cumulative pregnancy rate per cycle(64%vs.81.2%) and cumulative clinical pregnancy rates(53.8%vs.69.3%) between the two groups(P 0.05).The early abortion rate,ectopic pregnancy rate and twin pregnancy rate had no statistical difference(P0.05).Conclusions The pregnancy outcome of stage Ⅰ～Ⅱ endometriosis patients seemed good after laparoscopy surgery.We can get higher clinical pregnancy rate by using artificial insemination technique with ovulation induction protocol.