Dietary iodine and risk of breast, endometrial, and ovarian cancer

B V Stadel, Stadel BV
Lancet (London, England) · 1976 · vol. 1(7965) , pp. 890–1 · doi:10.1016/s0140-6736(76)92102-4 · PMID:58152
Other OA: closed public-domain-us
View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-09-12 ⓘ

Researchers propose that low dietary iodine may increase breast, endometrial, and ovarian cancer risk by inducing a hyperoestrogenic state via increased gonadotrophin stimulation, suggesting higher iodine intake could reduce these risks.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Geographic differences in the rates of breast, endometrial, and ovarian cancer appear to be inversely correlated with dietary iodine intake. Endocrinological considerations suggest that a low dietary iodine intake may produce a state of increased effective gonadotrophin stimulation, which in turn may produce a hyperoestrogenic state characterised by relatively high production of oestrone and oestradiol and a relatively low oestriol to oestrone plus oestradiol ratio. This altered endocrine state may increase the risk of breast, endometrial, and ovarian cancer. Increasing dietary iodine intake may reduce the risk of these cancers.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Breast Neoplasms Diet Diet Endometriosis Iodine Iodine Iodine Ovarian Neoplasms Uterine Neoplasms Breast Neoplasms Breast Neoplasms Breast Neoplasms Endometriosis Endometriosis Endometriosis Estrogens Estrogens Estrogens Female Female

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

europepmc
last seen: 2026-10-18T09:30:06.152893+00:00
pubmed
last seen: 2026-10-08T21:57:54.098323+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine