Minimally invasive abdominal catheter placement in ventriculoperitoneal shunt patients is associated with lower abdominal catheter complications: A single center experience

Minimally invasive abdominal catheter placement in ventriculoperitoneal shunt patients is associated with lower abdominal catheter complications: A single center experience | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Minimally invasive abdominal catheter placement in ventriculoperitoneal shunt patients is associated with lower abdominal catheter complications: A single center experience Obada T. Alhalabi, Nour Ghreib, Mohammed Issa, Ahmed Eldamaty, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7368277/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 23 Jan, 2026 Read the published version in Langenbeck's Archives of Surgery → Version 1 posted 13 You are reading this latest preprint version Abstract Purpose Ventriculoperitoneal (VP) shunt placement represents one of the modalities for hydrocephalus (HC) requiring cerebrospinal fluid (CSF) flow diversion and is a complication-abundant procedure. Reducing VP-shunt placement procedure time and optimizing abdominal catheter placement could help surgical VP-shunt complication rates. Methods A 7-year, single-center retrospective analysis was performed on adult patients who underwent minimally invasive (MI) trocar-guided direct peritoneocentesis for abdominal catheter insertion during VP-shunt implantation. This was compared with a reference cohort undergoing standard insertion in 2018 pertaining to surgical procedure time and method related complication rates (abdominal catheter migration and surgical site or wound infection), with matched-pair analysis used to confirm the observations made. Results Between 2015 and 2022, 25 adult patients (average age: 57 years) underwent VP-shunt insertion with MI abdominal catheter placement and showed a significantly shorter average procedure time (35.1 minutes ± 16.3) compared to 59.2 ± 16.2 minutes in the reference cohort (n = 103) undergoing standard insertion (p < 0.001). The rate of abdominal catheter migration or shunt infections in the MI group was 0%, while the standard insertion cohort showed rates of 16% and 8% respectively (p < 0.001). No cases of bowel injury were reported in any of the cohorts. After a cohort-matched analysis of n = 25 MI and n = 25 standard method patients, significant differences in surgical procedure time were confirmed (35.1 vs 75.1 minutes, p < 0.001). In addition, a higher rate of abdominal catheter migration (0% vs 8%, p < 0.001) and infection rate (0% vs 8%, p < 0.001) in the standard reference cohort was observed. Conclusion Using a direct MI trocar-based peritoneocentesis approach was associated with a decreased surgical duration time and subsequently reduced abdominal catheter migration and shunt infection rate compared to a standard insertion cohort. These findings highlight an alternative approach that could help reduce VP-shunt complications in adult patients. ventriculoperitoneal shunt abdominal catheter complication hydrocephalus Introduction Ventriculoperitoneal shunt (VP-shunt) implantation is indicated for a variety of conditions requiring cerebrospinal fluid (CSF) diversion [ 1 ], including hydrocephalus (HC) of various etiologies [ 2 ]. In 1995, 33000 shunt insertion procedures per year were documented in the United States and in 2012, the VP-shunt implantation rate for any indication was six per 100000 patients per year in Germany [ 3 , 4 ], thus representing a relevant neurosurgical procedure. Although usually perceived as a novice procedure, VP-shunt insertion shows a high rate of complications of about 21 per 100 patients per year [ 5 , 6 ]. Complications requiring revision of VP-shunts show an overall rate that ranges from 17–32% according to the literature [ 7 , 8 ]. These generally involve the ventricular catheter, valve hardware, or the abdominal (distal) catheter. Abdominal shunt catheter complications include pseudocysts, kinking, wound healing disorders, abdominal shunt migration and wound healing disorders [ 9 – 11 ]. VP-shunt complications can even lead to VP-shunt explanation in the case of infection[ 12 ], occurring at a rate of about 10 to 20% per patient and 6% per procedure and incurring an increased burden of disease for affected patients[ 13 , 14 ] and additional expenses for health care systems [ 15 ]. Previous strategies intended to reduce VP-shunt infections comprised the use of standardized surgical insertion protocols, antibiotic-coated material and topical antibiotics, in addition to reducing operative time [ 16 – 19 ]. Further efforts focused on reducing abdominal catheter migration rate through laparoscopic or trocar-based insertion techniques [ 20 – 22 ]. In addition, fixing the abdominal catheter through suturing was also reported to be associated with lower abdominal catheter complication rates [ 23 ]. Trocar-based abdominal catheter insertion methods can involve either an open dissection of the outer abdominal fascia with subsequent puncture of the inner fascia and the peritoneum or direct invasive peritoneocentesis through a small skin incision. Theoretically, this minimally invasive swift technique may reduce surgical time, minimize tissue trauma to the abdominal wall, and eliminate the need for a preparation cavity. These advantages, in turn, may reduce the rates of shunt infections, wound infections, wound healing disorders (surgical site infections: SSI), and catheter migration[ 24 ]. In this study, we evaluated a minimally invasive (MI) trocar-based direct peritoneocentesis insertion technique of the shunt abdominal catheter in reducing surgical duration, with subsequent reduction of abdominal catheter migration and shunt infection rates. Methods In this retrospective study, we analyzed clinical and follow-up data of adult (age > 18 years) patients undergoing primary VP-shunt implantation with minimally invasive (MI) trocar-guided abdominal catheter insertion (direct peritoneocentesis through the outer and inner fascia and the peritoneum) between 2015 and 2022. The duration of the implantation procedure and the rate and nature of surgical complications in this cohort were compared to a reference group that included patients undergoing VP-shunt implantation with placement of the abdominal catheter using the usual small incision trocar-based placement through puncturing of the inner fascia after having dissected the outer abdominal fascia in 2018. Patients with previous abdominal surgery were excluded. To verify our findings, an additional matched cohort analysis (matching according to age and shunt indication) was performed. In line with this, patients undergoing revision surgery were not included in this study. Statistical analysis Patient characteristics were analyzed using descriptive statistics. Continuous variables are reported as mean ± standard deviation or median (and interquartile range (IQR)), while ordinal and nominal variables are presented as numbers and frequencies. Missing data are designated as such. Comparison of nominal variables between groups was performed using Chi-square or Fischer’s exact test, depending on sample size. Significance was set at p < 0.05 and all statistical analyses were performed using Graphpad PRISM or SPSS of IBM. Results Non-matched cohort analysis of surgical time and complications for VP-shunt surgery in the open and minimally invasive insertion groups. In this time period, 25 patients (20%) underwent VP-shunt implantation with mini-incision MI trocar-guided abdominal catheter insertion (MI cohort) and 103 (80%) patients with the usual, small incision, open inner fascia trocar-guided method (‘standard’ method) who underwent VP-shunt placement were included in the analysis as a reference cohort. In total, 128 patients undergoing VP-shunt placement were included. In a primary analysis of an unmatched cohort, the mean age at surgery of all patients included in the study was 58.8 years (standard deviation – SD of 15.3 years). There were no significant differences in the age of patients who underwent MI insertion of the abdominal catheter (57.1 years versus 59.2 years in the ‘open’ method, p = 0.528, two-sided t-test). Indications for VP-shunt placement in the MI cohort (n = 25) included normal pressure hydrocephalus (NPH) and leptomeningeal carcinomatosis (LMC) in four cases each. Further indications comprised communicating malabsorptive hydrocephalus (HC - after trauma or subarachnoid hemorrhage) in two (8%) cases and occlusive hydrocephalus in 6 (24%) cases. VP-shunting after meningioma or glioma surgery was performed in 9 patients (36%). These indications showed slightly different proportions in the ‘open’ method cohort, however, these differences were not significant (p = 0.363, Chi-square test). Of note, no significant differences in past medical history aspects related to previous traumatic brain injury (TBI), intracranial hemorrhage, tumor or meningitis were found (Chi-square test, Table 1 ). The implanted valves included ProGAV 1.0/2.0 valves in 18 cases (72%) and Codman Certas Plus valves in 7 cases (28%). These distributions were not substantially different to the standard group (see Table 1 ). Using the MI method for abdominal shunt placement significantly reduced procedure time to about a half, with a mean incision to closure time of 35.1 minutes in the MI cohort (SD +/-16.3 minutes) versus 59.2 minutes (SD+/-16.2 minutes) in the reference cohort (p < 0.001, two-tailed student’s t-test, Table 2 ). The difference in the general complication rate in both groups, albeit lower in the MI group, was not statistically significant (24% in the MI group vs 33% in the standard group, p = 0.480, Chi-square test). While no abdominal catheter migration or shunt infections/wound healing disorders were documented in MI insertion cohort, complications in the standard insertion group included abdominal catheter migration in 14 cases (14%), shunt infections in 6 cases (6%, leading to shunt explanation) and wound healing disorders in 5 cases (5%). Therefore, the rate of surgical complications related to the insertion method was 0% in the MI group, compared to 25% in the reference group (26/103, p = 0.004, Fisher's exact test). Further complications included valve failure, documented in 5 cases in the MI group (all PROGAV valves) compared to 3 cases (3%) in the standard method cohort (p = 0.001, Fisher's exact test). In addition, an additional ventricular catheter was placed in one patient of the MI group (4%). In the standard insertion group, overdrainage-induced subdural hematoma (SDH) was observed in 5 cases each (5%). Of note, no cases of bowel injury were reported in any of the cohorts. (see Table 2 ). Matched cohort analysis of surgical procedure time and method-related complications. We generated matched cases from the standard insertion cohort to cases in the MI placement cohort based on age and shunt indication (Table 3 ). As expected, no significant differences between the matched cohort and the MI cohort were noted with regards to age, shunt indications or relevant past medical history (Fisher’s exact test, Table 3 ). The duration of surgery was also confirmed to be shorter under the MI cohort (mean of 35.1 ± 16.3 minutes compared to 75.1 ± 25.1 minutes in the matched standard cohort, p < 0.001, two-tailed student’s t-test, Table 3 ). In this matched cohort analysis, the overall surgical complication rate was 28% (n = 7) compared to 24% (n = 6) in the MI cohort. Shunt infections were observed in 2 (8%) cases of the standard cohort compared to 0 (%) cases in the MI cohort and abdominal catheter migration was reported in also 2 (8%) cases of the standard cohort compared to 0 (%) cases in the MI cohort (p = 0.177, Fisher’s exact test). Hence, the MI group was associated with a lower method-related (infections and abdominal catheter migration) complication rate than the standard open insertion method (16% vs 0%). However, this overrepresentation was not significant (p = 0.110, Fisher’s exact test, p = 0.04 using the Chi-square test, Table 3 ), possibly due to small sample size. Valve failure rates were 20% (n = 5) in the MI cohort and 12% (n = 3) in the standard open cohort (p = 0.177, Fisher’s exact test). Discussion VP-shunt patients are known to show high complication rates. This study aimed to establish an association between the reduction of several VP-shunt complications related to the abdominal shunt catheter and the general shunt infection rate with a minimally invasive insertion technique of the abdominal catheter, using a one-off trocar-based direct peritoneocentesis technique. In this current study, complications related to the method of VPS abdominal catheter insertion were non-existent in the MI cohort, compared to a significantly higher rate of 24% in the standard insertion group. This aspect is similar to what has been reported in previous studies that did manage to reduce distal catheter failure rates without reducing the overall complication rates of affected patients, with complication rates including primarily abdominal catheter migration and shunt or surgical site infections of 18% [ 25 ]. Arguably, the lower complication rate observed in the MI could be potentially attributed to the shorter surgical time in the MI group (without the need of open dissection of the abdominal wall layers) that could reduce the duration of open skin and hardware exposure, leading to a reduced infection rate of the surgical site or shunt infection [ 24 , 26 , 27 ]. Almost all complications in the MI group were valve failures (5 of the 6 complications), which cannot be linked to the abdominal catheter insertion method. Indeed, after matching for age and underlying disease, patients with the standard method still showed a cumulative method-related complication rate of 16%, compared to, once again, 0% in the matched MI cohort, with the matched cohort analysis confirming the significantly shorter mean surgical time (to a half) in the MI cohort. Previous reports on abdominal catheter migration in the context of VPS have shown similar complication rates of 7–10%[ 20 , 25 ], which are virtually eliminated in the MI cohort treated by the method we present. The novelty and advantage of the rationale of this study compared to the previously known concept of using minimally invasive approaches to reduce abdominal catheter complications is its non-dependency on laparoscopic techniques that might otherwise require the participation of an abdominal surgeon and the very limited skin exposure, speculatively reducing surgical site related complications [ 20 , 21 , 23 , 25 ]. While the idea that a less-invasive insertion of the abdominal catheter is more likely to preserve the integrity of the abdominal wall and hence reduce the risk of abdominal catheter migration seems more obvious than linking the reduction of surgical duration to a reduced risk of SSI or hardware infection, data from non-neurosurgical trials have underlined the importance of minimizing surgical times to reduce adverse outcomes related to SSI or implanted hardware [ 24 , 27 , 28 ]. However, proving a direct link between both aspects might seem troublesome, especially with specific evidence either suggesting no association between surgical time and infection rates in shunt surgery [ 29 ] or showing surgeries that last longer than 60 minutes to be at a higher risk of infection in pediatric patients [ 28 ] or 80 minutes in a mixed patient cohort[ 30 ]. Beside its single-center retrospective nature, there are many limitations to this study. Firstly, data on patients’ BMI or other variables that might affect their physical constituency or influence their intraabdominal pressure and hence increase their risk of abdominal catheter dislocation. Secondly, history of comorbidities such as additional metabolic disease that might put patients at a higher risk for SSI and shunt infections, would have given more reliability to the data presented. The small sample size of the study must also be noted. In addition, the time lapsing between the VP-shunt placement and the complications was not included in this current study. The matched analysis accounted for differences in cranial pathologies that might correct for potential bias concerning the risk for shunt infections, however, since no data is available on previous abdominal surgery, this potential risk factor for abdominal catheter migration (due to adhesions) might not be accounted for. On the other hand, evidence that previous abdominal surgery increases the inherit risk of abdominal catheter complications after VP-shunting is scarce. In summary, the findings of this study demonstrate how a direct MI trocar-based peritoneocentesis approach was associated with reduced abdominal catheter migration rates after VP-shunt implantation, possibly through eliciting the lowest tissue damage to the fasciae possible, eliminate the need for a preparation cavity and hence maintaining the integrity of the abdominal wall under a possible reduction of shunt and surgical site infection owing to a short operative duration compared to a standard insertion cohort. Hence, the MI method for abdominal catheter insertion could be worth evaluating for further prospective controlled studies on abdominal catheter insertion. Declarations CONFLICTS OF INTEREST: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. FUNDING: No external funding was used for this study. ETHICS APPROVAL: The local standing committee of ethnical practice approved the protocol of this retrospective analysis which has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments and for which patient consent was not required. DATA AVAILABILITY: Data is available upon reasonable request. References Soler, G.J., et al., A Review of Cerebral Shunts, Current Technologies, and Future Endeavors. Yale J Biol Med, 2018. 91 (3): p. 313-321. Lutz, B.R., P. Venkataraman, and S.R. Browd, New and improved ways to treat hydrocephalus: Pursuit of a smart shunt. Surg Neurol Int, 2013. 4 (Suppl 1): p. S38-50. Bondurant, C.P. and D.F. Jimenez, Epidemiology of cerebrospinal fluid shunting. Pediatr Neurosurg, 1995. 23 (5): p. 254-8; discussion 259. Lemcke, J., et al., Nationwide Incidence of Normal Pressure Hydrocephalus (NPH) Assessed by Insurance Claim Data in Germany. Open Neurol J, 2016. 10 : p. 15-24. Merkler, A.E., et al., The Rate of Complications after Ventriculoperitoneal Shunt Surgery. World Neurosurg, 2017. 98 : p. 654-658. Paff, M., et al., Ventriculoperitoneal shunt complications: A review. Interdisciplinary Neurosurgery, 2018. 13 : p. 66-70. Korinek, A.M., et al., Morbidity of ventricular cerebrospinal fluid shunt surgery in adults: an 8-year study. Neurosurgery, 2011. 68 (4): p. 985-94; discussion 994-5. Reddy, G.K., et al., Management of adult hydrocephalus with ventriculoperitoneal shunts: long-term single-institution experience. Neurosurgery, 2011. 69 (4): p. 774-80; discussion 780-1. Desai, V.R., et al., Ventriculoperitoneal shunt complications in an adult population: A comparison of various shunt designs to prevent overdrainage. Surg Neurol Int, 2020. 11 : p. 269. Abou-Al-Shaar, H., et al., Ventriculoperitoneal Shunt Failure Due to Distal Peritoneal Catheter Kinking. Am J Case Rep, 2022. 23 : p. e935077. Ferreira Furtado, L.M., et al., Abdominal Complications Related to Ventriculoperitoneal Shunt Placement: A Comprehensive Review of Literature. Cureus, 2021. 13 (2): p. e13230. Simon, T.D., et al., Cerebrospinal Fluid Shunt Infection: Emerging Paradigms in Pathogenesis that Affect Prevention and Treatment. J Pediatr, 2019. 206 : p. 13-19. Mansoor, N., et al., Revision and complication rates in adult shunt surgery: a single-institution study. Acta Neurochirurgica, 2021. 163 (2): p. 447-454. Mitchell, K.-A.S., et al., The Impact of Hydrocephalus Shunt Devices on Quality of Life. Journal of Craniofacial Surgery, 2021. 32 (5): p. 1746-1750. Shannon, C.N., et al., The economic impact of ventriculoperitoneal shunt failure. J Neurosurg Pediatr, 2011. 8 (6): p. 593-9. van Lindert, E.J., et al., Topical vancomycin reduces the cerebrospinal fluid shunt infection rate: A retrospective cohort study. PLoS One, 2018. 13 (1): p. e0190249. Kestle, J.R., et al., A standardized protocol to reduce cerebrospinal fluid shunt infection: the Hydrocephalus Clinical Research Network Quality Improvement Initiative. J Neurosurg Pediatr, 2011. 8 (1): p. 22-9. Muram, S., et al., A standardized infection prevention bundle for reduction of CSF shunt infections in adult ventriculoperitoneal shunt surgery performed without antibiotic-impregnated catheters. Journal of Neurosurgery, 2023. 138 (2): p. 494-502. Choksey, M.S. and I.A. Malik, Zero tolerance to shunt infections: can it be achieved? Journal of Neurology, Neurosurgery & Psychiatry, 2004. 75 (1): p. 87-91. He, M., et al., Laparoscopy versus mini-laparotomy peritoneal catheter insertion of ventriculoperitoneal shunts: a systematic review and meta-analysis. Neurosurg Focus, 2016. 41 (3): p. E7. Naftel, R.P., et al., Laparoscopic versus open insertion of the peritoneal catheter in ventriculoperitoneal shunt placement: review of 810 consecutive cases. J Neurosurg, 2011. 115 (1): p. 151-8. Osman, M., A. Diraz, and A. Wild, Trocar assisted distal shunt tube insertion with intra-operative X-Ray confirmation. Br J Neurosurg, 2019. 33 (4): p. 394-397. Wu, J.N., et al., Two-point fixation enhanced the outcome of laparoscopy-assisted ventriculoperitoneal shunt in adult patients with hydrocephalus: a retrospective study. Front Surg, 2023. 10 : p. 1135818. Cheng, H., et al., Prolonged Operative Duration Increases Risk of Surgical Site Infections: A Systematic Review. Surg Infect (Larchmt), 2017. 18 (6): p. 722-735. Schucht, P., et al., Laparoscopically assisted ventriculoperitoneal shunt placement: a prospective randomized controlled trial. J Neurosurg, 2015. 122 (5): p. 1058-67. Karhade, A.V., et al., Neurosurgical Infection Rates and Risk Factors: A National Surgical Quality Improvement Program Analysis of 132,000 Patients, 2006-2014. World Neurosurg, 2017. 97 : p. 205-212. Patel, S., et al., Risk factors for surgical site infections in neurosurgery. Ann R Coll Surg Engl, 2019. 101 (3): p. 220-225. Paudel, P., et al., Ventriculoperitoneal Shunt Complication in Pediatric Hydrocephalus: Risk Factor Analysis from a Single Institution in Nepal. Asian J Neurosurg, 2020. 15 (1): p. 83-87. Mansoor, N., et al., Revision and complication rates in adult shunt surgery: a single-institution study. Acta Neurochir (Wien), 2021. 163 (2): p. 447-454. Abuhadi, M., et al., Predictors and Outcome of Ventriculoperitoneal Shunt Infection: A Retrospective Single-Center Study. Cureus, 2022. 14 (7): p. e27494. Tables Table 1: Comparison of baseline. patient characteristics between the MI (minimally invasive) placement cohort (n=25) and the standard placement cohort (n=103). SD= Standard deviation. IQR= Interquartile range. NPH= Normal Pressure Hydrocephalus. HC= Hydrocephalus. LMC= Leptomeningeal Carcinomatosis. a Two-tailed student’s t-test, b Mann Whitney test, c Chi-square test, d Fisher's exact test. Table 3 is available in the Supplementary Files section. Additional Declarations No competing interests reported. Supplementary Files Table3.docx Cite Share Download PDF Status: Published Journal Publication published 23 Jan, 2026 Read the published version in Langenbeck's Archives of Surgery → Version 1 posted Editorial decision: Revision requested 05 Sep, 2025 Reviews received at journal 30 Aug, 2025 Reviews received at journal 23 Aug, 2025 Reviewers agreed at journal 20 Aug, 2025 Reviewers agreed at journal 18 Aug, 2025 Reviewers agreed at journal 17 Aug, 2025 Reviewers agreed at journal 15 Aug, 2025 Reviewers agreed at journal 15 Aug, 2025 Reviewers agreed at journal 15 Aug, 2025 Reviewers invited by journal 15 Aug, 2025 Editor assigned by journal 14 Aug, 2025 Submission checks completed at journal 14 Aug, 2025 First submitted to journal 13 Aug, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7368277","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":503089494,"identity":"c782aad0-a6d9-4558-ad1e-ac7525e6adac","order_by":0,"name":"Obada T. 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In 1995, 33000 shunt insertion procedures per year were documented in the United States and in 2012, the VP-shunt implantation rate for any indication was six per 100000 patients per year in Germany [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e], thus representing a relevant neurosurgical procedure. Although usually perceived as a novice procedure, VP-shunt insertion shows a high rate of complications of about 21 per 100 patients per year [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eComplications requiring revision of VP-shunts show an overall rate that ranges from 17\u0026ndash;32% according to the literature [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e, \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. These generally involve the ventricular catheter, valve hardware, or the abdominal (distal) catheter. Abdominal shunt catheter complications include pseudocysts, kinking, wound healing disorders, abdominal shunt migration and wound healing disorders [\u003cspan additionalcitationids=\"CR10\" citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. VP-shunt complications can even lead to VP-shunt explanation in the case of infection[\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e], occurring at a rate of about 10 to 20% per patient and 6% per procedure and incurring an increased burden of disease for affected patients[\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e] and additional expenses for health care systems [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e].\u003c/p\u003e\u003cp\u003ePrevious strategies intended to reduce VP-shunt infections comprised the use of standardized surgical insertion protocols, antibiotic-coated material and topical antibiotics, in addition to reducing operative time [\u003cspan additionalcitationids=\"CR17 CR18\" citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]. Further efforts focused on reducing abdominal catheter migration rate through laparoscopic or trocar-based insertion techniques [\u003cspan additionalcitationids=\"CR21\" citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. In addition, fixing the abdominal catheter through suturing was also reported to be associated with lower abdominal catheter complication rates [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eTrocar-based abdominal catheter insertion methods can involve either an open dissection of the outer abdominal fascia with subsequent puncture of the inner fascia and the peritoneum or direct invasive peritoneocentesis through a small skin incision. Theoretically, this minimally invasive swift technique may reduce surgical time, minimize tissue trauma to the abdominal wall, and eliminate the need for a preparation cavity. These advantages, in turn, may reduce the rates of shunt infections, wound infections, wound healing disorders (surgical site infections: SSI), and catheter migration[\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eIn this study, we evaluated a minimally invasive (MI) trocar-based direct peritoneocentesis insertion technique of the shunt abdominal catheter in reducing surgical duration, with subsequent reduction of abdominal catheter migration and shunt infection rates.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003eIn this retrospective study, we analyzed clinical and follow-up data of adult (age\u0026thinsp;\u0026gt;\u0026thinsp;18 years) patients undergoing primary VP-shunt implantation with minimally invasive (MI) trocar-guided abdominal catheter insertion (direct peritoneocentesis through the outer and inner fascia and the peritoneum) between 2015 and 2022. The duration of the implantation procedure and the rate and nature of surgical complications in this cohort were compared to a reference group that included patients undergoing VP-shunt implantation with placement of the abdominal catheter using the usual small incision trocar-based placement through puncturing of the inner fascia after having dissected the outer abdominal fascia in 2018. Patients with previous abdominal surgery were excluded. To verify our findings, an additional matched cohort analysis (matching according to age and shunt indication) was performed. In line with this, patients undergoing revision surgery were not included in this study.\u003c/p\u003e\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e\u003ch2\u003eStatistical analysis\u003c/h2\u003e\u003cp\u003ePatient characteristics were analyzed using descriptive statistics. Continuous variables are reported as mean\u0026thinsp;\u0026plusmn;\u0026thinsp;standard deviation or median (and interquartile range (IQR)), while ordinal and nominal variables are presented as numbers and frequencies. Missing data are designated as such. Comparison of nominal variables between groups was performed using Chi-square or Fischer\u0026rsquo;s exact test, depending on sample size. Significance was set at p\u0026thinsp;\u0026lt;\u0026thinsp;0.05 and all statistical analyses were performed using Graphpad PRISM or SPSS of IBM.\u003c/p\u003e\u003c/div\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eNon-matched cohort analysis of surgical time and complications for VP-shunt surgery in the open and minimally invasive insertion groups.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn this time period, 25 patients (20%) underwent VP-shunt implantation with mini-incision MI trocar-guided abdominal catheter insertion (MI cohort) and 103 (80%) patients with the usual, small incision, open inner fascia trocar-guided method (\u0026lsquo;standard\u0026rsquo; method) who underwent VP-shunt placement were included in the analysis as a reference cohort. In total, 128 patients undergoing VP-shunt placement were included. In a primary analysis of an unmatched cohort, the mean age at surgery of all patients included in the study was 58.8 years (standard deviation \u0026ndash; SD of 15.3 years). There were no significant differences in the age of patients who underwent MI insertion of the abdominal catheter (57.1 years versus 59.2 years in the \u0026lsquo;open\u0026rsquo; method, p\u0026thinsp;=\u0026thinsp;0.528, two-sided t-test). Indications for VP-shunt placement in the MI cohort (n\u0026thinsp;=\u0026thinsp;25) included normal pressure hydrocephalus (NPH) and leptomeningeal carcinomatosis (LMC) in four cases each. Further indications comprised communicating malabsorptive hydrocephalus (HC - after trauma or subarachnoid hemorrhage) in two (8%) cases and occlusive hydrocephalus in 6 (24%) cases. VP-shunting after meningioma or glioma surgery was performed in 9 patients (36%). These indications showed slightly different proportions in the \u0026lsquo;open\u0026rsquo; method cohort, however, these differences were not significant (p\u0026thinsp;=\u0026thinsp;0.363, Chi-square test). Of note, no significant differences in past medical history aspects related to previous traumatic brain injury (TBI), intracranial hemorrhage, tumor or meningitis were found (Chi-square test, Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e). The implanted valves included ProGAV 1.0/2.0 valves in 18 cases (72%) and Codman Certas Plus valves in 7 cases (28%). These distributions were not substantially different to the standard group (see Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e).\u003c/p\u003e\n\u003cp\u003eUsing the MI method for abdominal shunt placement significantly reduced procedure time to about a half, with a mean incision to closure time of 35.1 minutes in the MI cohort (SD +/-16.3 minutes) versus 59.2 minutes (SD+/-16.2 minutes) in the reference cohort (p\u0026thinsp;\u0026lt;\u0026thinsp;0.001, two-tailed student\u0026rsquo;s t-test, Table \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e). The difference in the general complication rate in both groups, albeit lower in the MI group, was not statistically significant (24% in the MI group vs 33% in the standard group, p\u0026thinsp;=\u0026thinsp;0.480, Chi-square test). While no abdominal catheter migration or shunt infections/wound healing disorders were documented in MI insertion cohort, complications in the standard insertion group included abdominal catheter migration in 14 cases (14%), shunt infections in 6 cases (6%, leading to shunt explanation) and wound healing disorders in 5 cases (5%). Therefore, the rate of surgical complications related to the insertion method was 0% in the MI group, compared to 25% in the reference group (26/103, p\u0026thinsp;=\u0026thinsp;0.004, Fisher\u0026apos;s exact test). Further complications included valve failure, documented in 5 cases in the MI group (all PROGAV valves) compared to 3 cases (3%) in the standard method cohort (p\u0026thinsp;=\u0026thinsp;0.001, Fisher\u0026apos;s exact test). In addition, an additional ventricular catheter was placed in one patient of the MI group (4%). In the standard insertion group, overdrainage-induced subdural hematoma (SDH) was observed in 5 cases each (5%). Of note, no cases of bowel injury were reported in any of the cohorts. (see Table \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMatched cohort analysis of surgical procedure time and method-related complications.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe generated matched cases from the standard insertion cohort to cases in the MI placement cohort based on age and shunt indication (Table \u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e). As expected, no significant differences between the matched cohort and the MI cohort were noted with regards to age, shunt indications or relevant past medical history (Fisher\u0026rsquo;s exact test, Table \u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e). The duration of surgery was also confirmed to be shorter under the MI cohort (mean of 35.1\u0026thinsp;\u0026plusmn;\u0026thinsp;16.3 minutes compared to 75.1\u0026thinsp;\u0026plusmn;\u0026thinsp;25.1 minutes in the matched standard cohort, p\u0026thinsp;\u0026lt;\u0026thinsp;0.001, two-tailed student\u0026rsquo;s t-test, Table \u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e). In this matched cohort analysis, the overall surgical complication rate was 28% (n\u0026thinsp;=\u0026thinsp;7) compared to 24% (n\u0026thinsp;=\u0026thinsp;6) in the MI cohort. Shunt infections were observed in 2 (8%) cases of the standard cohort compared to 0 (%) cases in the MI cohort and abdominal catheter migration was reported in also 2 (8%) cases of the standard cohort compared to 0 (%) cases in the MI cohort (p\u0026thinsp;=\u0026thinsp;0.177, Fisher\u0026rsquo;s exact test). Hence, the MI group was associated with a lower method-related (infections and abdominal catheter migration) complication rate than the standard open insertion method (16% vs 0%). However, this overrepresentation was not significant (p\u0026thinsp;=\u0026thinsp;0.110, Fisher\u0026rsquo;s exact test, p\u0026thinsp;=\u0026thinsp;0.04 using the Chi-square test, Table \u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e), possibly due to small sample size. Valve failure rates were 20% (n\u0026thinsp;=\u0026thinsp;5) in the MI cohort and 12% (n\u0026thinsp;=\u0026thinsp;3) in the standard open cohort (p\u0026thinsp;=\u0026thinsp;0.177, Fisher\u0026rsquo;s exact test).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eVP-shunt patients are known to show high complication rates. This study aimed to establish an association between the reduction of several VP-shunt complications related to the abdominal shunt catheter and the general shunt infection rate with a minimally invasive insertion technique of the abdominal catheter, using a one-off trocar-based direct peritoneocentesis technique.\u003c/p\u003e\u003cp\u003eIn this current study, complications related to the method of VPS abdominal catheter insertion were non-existent in the MI cohort, compared to a significantly higher rate of 24% in the standard insertion group. This aspect is similar to what has been reported in previous studies that did manage to reduce distal catheter failure rates without reducing the overall complication rates of affected patients, with complication rates including primarily abdominal catheter migration and shunt or surgical site infections of 18% [\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]. Arguably, the lower complication rate observed in the MI could be potentially attributed to the shorter surgical time in the MI group (without the need of open dissection of the abdominal wall layers) that could reduce the duration of open skin and hardware exposure, leading to a reduced infection rate of the surgical site or shunt infection [\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e, \u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e, \u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]. Almost all complications in the MI group were valve failures (5 of the 6 complications), which cannot be linked to the abdominal catheter insertion method.\u003c/p\u003e\u003cp\u003eIndeed, after matching for age and underlying disease, patients with the standard method still showed a cumulative method-related complication rate of 16%, compared to, once again, 0% in the matched MI cohort, with the matched cohort analysis confirming the significantly shorter mean surgical time (to a half) in the MI cohort.\u003c/p\u003e\u003cp\u003ePrevious reports on abdominal catheter migration in the context of VPS have shown similar complication rates of 7\u0026ndash;10%[\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e, \u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e], which are virtually eliminated in the MI cohort treated by the method we present. The novelty and advantage of the rationale of this study compared to the previously known concept of using minimally invasive approaches to reduce abdominal catheter complications is its non-dependency on laparoscopic techniques that might otherwise require the participation of an abdominal surgeon and the very limited skin exposure, speculatively reducing surgical site related complications [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e, \u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e, \u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eWhile the idea that a less-invasive insertion of the abdominal catheter is more likely to preserve the integrity of the abdominal wall and hence reduce the risk of abdominal catheter migration seems more obvious than linking the reduction of surgical duration to a reduced risk of SSI or hardware infection, data from non-neurosurgical trials have underlined the importance of minimizing surgical times to reduce adverse outcomes related to SSI or implanted hardware [\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e, \u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e, \u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e]. However, proving a direct link between both aspects might seem troublesome, especially with specific evidence either suggesting no association between surgical time and infection rates in shunt surgery [\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e] or showing surgeries that last longer than 60 minutes to be at a higher risk of infection in pediatric patients [\u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e] or 80 minutes in a mixed patient cohort[\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eBeside its single-center retrospective nature, there are many limitations to this study. Firstly, data on patients\u0026rsquo; BMI or other variables that might affect their physical constituency or influence their intraabdominal pressure and hence increase their risk of abdominal catheter dislocation. Secondly, history of comorbidities such as additional metabolic disease that might put patients at a higher risk for SSI and shunt infections, would have given more reliability to the data presented. The small sample size of the study must also be noted. In addition, the time lapsing between the VP-shunt placement and the complications was not included in this current study. The matched analysis accounted for differences in cranial pathologies that might correct for potential bias concerning the risk for shunt infections, however, since no data is available on previous abdominal surgery, this potential risk factor for abdominal catheter migration (due to adhesions) might not be accounted for. On the other hand, evidence that previous abdominal surgery increases the inherit risk of abdominal catheter complications after VP-shunting is scarce.\u003c/p\u003e\u003cp\u003eIn summary, the findings of this study demonstrate how a direct MI trocar-based peritoneocentesis approach was associated with reduced abdominal catheter migration rates after VP-shunt implantation, possibly through eliciting the lowest tissue damage to the fasciae possible, eliminate the need for a preparation cavity and hence maintaining the integrity of the abdominal wall under a possible reduction of shunt and surgical site infection owing to a short operative duration compared to a standard insertion cohort. Hence, the MI method for abdominal catheter insertion could be worth evaluating for further prospective controlled studies on abdominal catheter insertion.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eCONFLICTS OF INTEREST:\u0026nbsp;\u003c/strong\u003eThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cstrong\u003eFUNDING:\u0026nbsp;\u003c/strong\u003eNo external funding was used for this study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cstrong\u003eETHICS APPROVAL:\u0026nbsp;\u003c/strong\u003eThe local standing committee of ethnical practice approved the protocol of this retrospective analysis which has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments and for which patient consent was not required.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cstrong\u003eDATA AVAILABILITY:\u0026nbsp;\u003c/strong\u003eData is available upon reasonable request.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eSoler, G.J., et al., \u003cem\u003eA Review of Cerebral Shunts, Current Technologies, and Future Endeavors.\u003c/em\u003e Yale J Biol Med, 2018. \u003cstrong\u003e91\u003c/strong\u003e(3): p. 313-321.\u003c/li\u003e\n\u003cli\u003eLutz, B.R., P. 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study.\u003c/em\u003e Acta Neurochir (Wien), 2021. \u003cstrong\u003e163\u003c/strong\u003e(2): p. 447-454.\u003c/li\u003e\n\u003cli\u003eAbuhadi, M., et al., \u003cem\u003ePredictors and Outcome of Ventriculoperitoneal Shunt Infection: A Retrospective Single-Center Study.\u003c/em\u003e Cureus, 2022. \u003cstrong\u003e14\u003c/strong\u003e(7): p. e27494.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003e\u003cstrong\u003eTable 1: Comparison of baseline. patient characteristics between the MI (minimally invasive) placement cohort (n=25) and the standard placement cohort (n=103).\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cimg 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\"\u003e\u003c/p\u003e\n\u003cp\u003eSD= Standard deviation. IQR= Interquartile range. NPH= Normal Pressure Hydrocephalus. HC= Hydrocephalus. LMC= Leptomeningeal Carcinomatosis. \u003csup\u003ea\u003c/sup\u003eTwo-tailed student’s t-test,\u003csup\u003e\u0026nbsp;b\u003c/sup\u003eMann Whitney test, \u003csup\u003ec\u003c/sup\u003eChi-square test,\u003csup\u003e\u0026nbsp;d\u003c/sup\u003eFisher's exact test.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003cimg 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\"\u003e\u003c/p\u003e\n\u003cp\u003eTable 3 is available in the Supplementary Files section.\u003c/p\u003e\n"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"langenbecks-archives-of-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"laos","sideBox":"Learn more about [Langenbeck's Archives of Surgery](http://link.springer.com/journal/423)","snPcode":"423","submissionUrl":"https://submission.nature.com/new-submission/423/3","title":"Langenbeck's Archives of Surgery","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"ventriculoperitoneal, shunt, abdominal catheter, complication hydrocephalus","lastPublishedDoi":"10.21203/rs.3.rs-7368277/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7368277/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003ePurpose\u003c/h2\u003e\u003cp\u003eVentriculoperitoneal (VP) shunt placement represents one of the modalities for hydrocephalus (HC) requiring cerebrospinal fluid (CSF) flow diversion and is a complication-abundant procedure. Reducing VP-shunt placement procedure time and optimizing abdominal catheter placement could help surgical VP-shunt complication rates.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e\u003cp\u003eA 7-year, single-center retrospective analysis was performed on adult patients who underwent minimally invasive (MI) trocar-guided direct peritoneocentesis for abdominal catheter insertion during VP-shunt implantation. This was compared with a reference cohort undergoing standard insertion in 2018 pertaining to surgical procedure time and method related complication rates (abdominal catheter migration and surgical site or wound infection), with matched-pair analysis used to confirm the observations made.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e\u003cp\u003eBetween 2015 and 2022, 25 adult patients (average age: 57 years) underwent VP-shunt insertion with MI abdominal catheter placement and showed a significantly shorter average procedure time (35.1 minutes\u0026thinsp;\u0026plusmn;\u0026thinsp;16.3) compared to 59.2\u0026thinsp;\u0026plusmn;\u0026thinsp;16.2 minutes in the reference cohort (n\u0026thinsp;=\u0026thinsp;103) undergoing standard insertion (p\u0026thinsp;\u0026lt;\u0026thinsp;0.001). The rate of abdominal catheter migration or shunt infections in the MI group was 0%, while the standard insertion cohort showed rates of 16% and 8% respectively (p\u0026thinsp;\u0026lt;\u0026thinsp;0.001). No cases of bowel injury were reported in any of the cohorts. After a cohort-matched analysis of n\u0026thinsp;=\u0026thinsp;25 MI and n\u0026thinsp;=\u0026thinsp;25 standard method patients, significant differences in surgical procedure time were confirmed (35.1 vs 75.1 minutes, p\u0026thinsp;\u0026lt;\u0026thinsp;0.001). In addition, a higher rate of abdominal catheter migration (0% vs 8%, p\u0026thinsp;\u0026lt;\u0026thinsp;0.001) and infection rate (0% vs 8%, p\u0026thinsp;\u0026lt;\u0026thinsp;0.001) in the standard reference cohort was observed.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e\u003cp\u003eUsing a direct MI trocar-based peritoneocentesis approach was associated with a decreased surgical duration time and subsequently reduced abdominal catheter migration and shunt infection rate compared to a standard insertion cohort. These findings highlight an alternative approach that could help reduce VP-shunt complications in adult patients.\u003c/p\u003e","manuscriptTitle":"Minimally invasive abdominal catheter placement in ventriculoperitoneal shunt patients is associated with lower abdominal catheter complications: A single center experience","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-08-22 11:52:50","doi":"10.21203/rs.3.rs-7368277/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-09-05T07:29:29+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-08-30T12:41:35+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-08-23T15:40:52+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"7390286344030280573279190278894657038","date":"2025-08-20T11:30:20+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"138201871986855588260384902761153791912","date":"2025-08-18T06:36:20+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"87672245992414595806749445837266126656","date":"2025-08-17T08:31:04+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"149086620286889557386186088857386814899","date":"2025-08-15T21:16:58+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"293082782747619593119362046596319305704","date":"2025-08-15T13:01:45+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"267572193715667036895212653292062499739","date":"2025-08-15T12:35:53+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-08-15T10:56:36+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-08-14T11:40:04+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-08-14T07:33:04+00:00","index":"","fulltext":""},{"type":"submitted","content":"Langenbeck's Archives of Surgery","date":"2025-08-13T22:01:13+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"langenbecks-archives-of-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"laos","sideBox":"Learn more about [Langenbeck's Archives of Surgery](http://link.springer.com/journal/423)","snPcode":"423","submissionUrl":"https://submission.nature.com/new-submission/423/3","title":"Langenbeck's Archives of Surgery","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"7115f38d-2815-4e62-aa8a-d973e6470d6a","owner":[],"postedDate":"August 22nd, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2026-01-26T16:05:21+00:00","versionOfRecord":{"articleIdentity":"rs-7368277","link":"https://doi.org/10.1007/s00423-025-03949-5","journal":{"identity":"langenbecks-archives-of-surgery","isVorOnly":false,"title":"Langenbeck's Archives of Surgery"},"publishedOn":"2026-01-23 15:58:33","publishedOnDateReadable":"January 23rd, 2026"},"versionCreatedAt":"2025-08-22 11:52:50","video":"","vorDoi":"10.1007/s00423-025-03949-5","vorDoiUrl":"https://doi.org/10.1007/s00423-025-03949-5","workflowStages":[]},"version":"v1","identity":"rs-7368277","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7368277","identity":"rs-7368277","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}