Beyond the Fracture – A Diagnostic Approach to Paget’s Disease

Beyond the Fracture – A Diagnostic Approach to Paget’s Disease | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Beyond the Fracture – A Diagnostic Approach to Paget’s Disease Ignacio Javier Gómez Adiego This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6859776/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract This case report presents a 66-year-old woman recently emigrated from Peru to Spain, who was diagnosed with a stress fracture of the left tibia. Radiological fi ndings revealed a saber-shaped angulation of both tibia and fi bula, suggesting an underlying metabolic bone disease. Laboratory tests showed elevated alkaline phosphatase and low phosphorus levels. The diagnostic process considered Paget’s disease, osteomalacia, hyperparathyroidism, and phosphorus defi ciency. This case emphasizes the importance of early diagnosis and a multidisciplinary approach in managing atypical stress fractures in older adults. Categories : Family/General Practice, Rheumatology, Trauma Orthopedics stress-fracture vitamin d level family community medicine fracture tibia paget’s disease of bone (pdb) Full Text Additional Declarations The authors declare no competing interests. I confirm that informed consent for publication was obtained from the patient described in the case report. The patient has agreed to the publication of her clinical information. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6859776","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":469005982,"identity":"99f71924-c47c-4ddf-ae7e-39de2b90bfd9","order_by":0,"name":"Ignacio Javier Gómez Adiego","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABFElEQVRIiWNgGAWjYPACZh4o4wADP4hKKCBFi2QDSIsBYS0wxgEGgwMgGo8WeffuxIc/aqxl+PkXH3vwo+aOnPH51YkfHhgwyPOLHcCqxfDM2c0GEsfSeSRnPEs37Dn2zNjsxtvNEkCHGc6cnYBdy4zcbRIGbId5DG6cMZPgbTicuO3G2Q0gLQkGt3Fq2f4j4d9hHnugFsm/QC2bZ5zd/AOfFnmJ3G0MB9uAtvD3mEmDbNnA37sNry0GPGc3Szb2pfNI3GBLk5Y5dthY4gbvNosEAwmcfpFv79348cc3a3v+/sPHJN/UHJbj7z+7+eaPCht5fmkcthyAsSQSUBgSWJWDbWmAsfgPoDNGwSgYBaNgFEAAAM6wZnbUoQWVAAAAAElFTkSuQmCC","orcid":"","institution":"Hospital Universitario Puerta de Hierro","correspondingAuthor":true,"prefix":"","firstName":"Ignacio","middleName":"Javier Gómez","lastName":"Adiego","suffix":""}],"badges":[],"createdAt":"2025-06-10 06:39:43","currentVersionCode":1,"declarations":{"humanSubjects":true,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":true,"humanSubjectConsent":true,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":true,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-6859776/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6859776/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":84438854,"identity":"7d5fd800-5f3b-43f2-9ebf-b4a518a84314","added_by":"auto","created_at":"2025-06-12 03:22:15","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":196462,"visible":true,"origin":"","legend":"","description":"","filename":"PublicacinBeyondtheFracture.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6859776/v1_covered_fa9fa500-1062-454b-94eb-b870d5e261a7.pdf"}],"financialInterests":"\u003cp\u003eThe authors declare no competing interests.\u003c/p\u003e\n\u003cp\u003eI confirm that informed consent for publication was obtained from the patient described in the case report. 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