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This study examined the clinical and morphological characteristics of combined uterine hyperplastic diseases in premenopausal women presenting with chronic abnormal uterine bleeding. Researchers analyzed 62 patients undergoing surgery alongside a control group of 30 women, utilizing anthropometric data, ultrasound imaging, metabolic assessments, and histological examinations to identify correlations between comorbidities and disease severity. The findings indicated that disturbances in lipid and carbohydrate metabolism, such as dyslipidemia and metabolic syndrome, exacerbated the clinical course of the primary condition. Furthermore, histological analysis revealed that the activity of adenomyosis foci correlated directly with the intensity of symptoms like pain and bleeding, as well as the presence of concurrent pathologies including endometrial hyperplasia and fibroids. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.
Abstract
Rozhkovskaya N. M., Sitnikova V. O., Sivyi S. M., Lomakina I. S. Clinical and morphological features of combined hyperplastic diseases of the uterus against the background of adenomyosis. Journal of Education, Health and Sport. 2020;10(4):226-233. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.04.025 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.04.025 https://zenodo.org/record/3844131 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 06.04.2020. Revised: 23.04.2020. Accepted: 30.04.2020. CLINICAL AND MORPHOLOGICAL FEATURES OF COMBINED HYPERPLASTIC DISEASES OF THE UTERUS AGAINST THE BACKGROUND OF ADENOMYOSIS N. M. Rozhkovskaya, V. O. Sitnikova, S. M. Sivyi, I. S. Lomakina Odessa National Medical University, Ukraine Abstract To determine clinical and morphological features of combined uterine hyperplastic diseases in premenopausal women at the background of adenomyosis, 62 patients operated on for chronic abnormal uterine bleeding were examined. The control group consisted of 30 premenopausal patients who applied for preventive examination. Anthropometric and ultrasound examinations, assessment of carbohydrate and lipid metabolism, histologic examination were done. It has been established that uterine hyperplasia patients often had lipid metabolism damages (dislipidemy) and damages of carbohydrate one (alimentary – constitutional obesity, metabolic syndrome) which worsen the clinical course of the main disease. According to histological examination data, the activity of adenomyosis foci in patients with comorbid uterine pathology correlated with the severity of clinical manifestations (abnormal uterine bleeding, pain) and the presence of comorbid lesions (concomitant endometrial hyperplasia, chronic endometriosis, fibroids, endometriosis). Key words: hyperplastic diseases of the uterus; adenomyosis; endometriosis; dislipidemy; metabolic syndrome.
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Clinical and morphological features of combined hyperplastic diseases of the uterus against the background of adenomyosis
Authors/Creators
- 1. Odessa National Medical University
Description
Rozhkovskaya N. M., Sitnikova V. O., Sivyi S. M., Lomakina I. S. Clinical and morphological features of combined hyperplastic diseases of the uterus against the background of adenomyosis. Journal of Education, Health and Sport. 2020;10(4):226-233. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.04.025
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.04.025
https://zenodo.org/record/3844131
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2020;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 06.04.2020. Revised: 23.04.2020. Accepted: 30.04.2020.
CLINICAL AND MORPHOLOGICAL FEATURES OF COMBINED HYPERPLASTIC DISEASES OF THE UTERUS AGAINST THE BACKGROUND OF ADENOMYOSIS
N. M. Rozhkovskaya, V. O. Sitnikova, S. M. Sivyi, I. S. Lomakina
Odessa National Medical University, Ukraine
Abstract
To determine clinical and morphological features of combined uterine hyperplastic diseases in premenopausal women at the background of adenomyosis, 62 patients operated on for chronic abnormal uterine bleeding were examined. The control group consisted of 30 premenopausal patients who applied for preventive examination. Anthropometric and ultrasound examinations, assessment of carbohydrate and lipid metabolism, histologic examination were done. It has been established that uterine hyperplasia patients often had lipid metabolism damages (dislipidemy) and damages of carbohydrate one (alimentary – constitutional obesity, metabolic syndrome) which worsen the clinical course of the main disease. According to histological examination data, the activity of adenomyosis foci in patients with comorbid uterine pathology correlated with the severity of clinical manifestations (abnormal uterine bleeding, pain) and the presence of comorbid lesions (concomitant endometrial hyperplasia, chronic endometriosis, fibroids, endometriosis).
Key words: hyperplastic diseases of the uterus; adenomyosis; endometriosis; dislipidemy; metabolic syndrome.
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