AMeta-analysis of blood miRNA as a diagnostic biomarker for endometriosis

Objective The value of blood miRNA for the diagnosis of endometriosis was evaluated by Metaanalysis, for which it was identified as a non-invasive diagnostic biomarker to distinguish endometriosis. Methods English and Chinese language databases were searched for relevant literature on blood miRNAs for the diagnosis of endometriosis reported up until September 2022. The appropriate data was derived from the literature and analyzed and assessed using Stata14.0 and RevMan5.4. Results A total of 24 relevant papers were included. As a diagnostic tool for endometriosis, blood miRNA has an overall sensitivity of 0.86, specificity of 0.84, positive likelihood ratio of 5.3, negative likelihood ratio of 0.17, diagnostic odds ratio (DOR) of 31, and area under the curve (AUC) of 0.91. The research featured meta-regression and subgroup analysis, and the upregulation of expression by miRNA in blood serum, Asian and African populations had a higher accuracy value for diagnosing endometriosis. Conclusion Blood miRNAs can thus be used as diagnostic biomarkers for endometriosis, with the miRNAs upregulation in serum expression having a higher diagnostic value for diagnosing endometriosis in Asian and African populations.