Resumption of the Treatment for Non-COVID-19 Gynecologic Patients after Lifting Lock down: Experiences from Wuhan

Resumption of the Treatment for Non-COVID-19 Gynecologic Patients after Lifting Lock down: Experiences from Wuhan | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Resumption of the Treatment for Non-COVID-19 Gynecologic Patients after Lifting Lock down: Experiences from Wuhan Weihong Dong, Rui Gao, Jing Cai, Shouhua Yang, Jianfeng Guo, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-63125/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background : To share our experiences of resumption of the treatment for gynecologic patients after lifting lockdown in a hotspot area of the Corona Virus Disease 2019 (COVID-19)pandemic. Methods : The triage process used to resume the medical activities for gynecologic patients at the Wuhan Union Hospital after a 76-day lockdown of the city is described and its effectiveness to avoid COVID-19 nosocomial transmission is shown. Results :The non-emergency patients are pre-triaged by contact history and body temperature at outpatient clinic and negative COVID-19 screening tests are required for an admissionin the buffering rooms at the gynecologic department. The buffering lastsfor at least three days for symptom monitoring and a second round of COVID-19 tests before they can be transferred to the regular gynecologic wards. For patients who need emergency surgery, the first screening should be completed at the quarantine wards after the surgery, followed by buffering at the gynecologic department. We received 19298 outpatient visits, admitted 326 patients, and performed 223 operations in the first two months after the lockdown was lifted, andno single COVID-19 case occurredin the hospitalized patients while the proportion of potentially high-risk patients with cancer and severe anemia were increased in comparison with the same period in 2019 and the latest two months before the lockdown. Conclusions :We provide an effective triage system with buffering at two levels to guarantee safe and timely treatment for non-COVID-19 gynecologic patients in a post-lockdown phase. Obstetrics & Gynecology Resumption non-COVID-19 Gynecologic patients Figures Figure 1 Background Since the end of 2019, the Corona Virus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been spreading rapidly, affecting over one hundred countries around the world. The novel corona virus is highly contagious, and effective antiviral drugs are absent. Vaccines against COVID-19,which are considered as the most promising measure to contain the pandemic, are still under development [1]. Lockdown is an effective public health measure to eliminate the coronavirus infection or flatten the outbreak curve [2,3] andmany countries significantly affected by the pandemichas been enforced to issue a stay-at-home order [4-6]. Unfortunately, a long-term lockdown could be associated with severe social problems, particularly economic recession. In some places,the lockdowns have beengraduallylifted, and social activities are gingerly reopened. However, the pandemic still continues, and the lockdowns will leave lasting impacts on clinical practice. Although social distancing of at least two meters is recommended to avoid the virus transmission between people amid COCID-19 pandemic,during treatment of gynecologic patients, close proximity of patient to gynecologist, particularlythe direct contact of vaginal mucosa and secrets of patient for a few minutes in a gynecologic examination, is inevitable and increases the risk of SARS-CoV-2 transmission. There are several guidelines published to give recommendations on the safe gynecologic practice and the treatment of gynecologic patients during the ongoing pandemic, focusing onthe management of cancer patients [7-12]. Whenthe outbreak peak is gone and the lockdown is lifted, the medical resources should be redirected to none-COVID-19 patients, while the threats of COVID-19 transmission still exist. In this context, an adapted triage strategy plays a central role. Wuhan, China, the first epicenter of the COVID-19 pandemic, was totally shut down between January 23, 2020 and April 8, 2020. As one of the largest medical centers in middle-south China, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, was assigned to treat none-COVID-19 patients since February 26, 2020. Here, we share our triage process supportingthe resumptionofmedical activities in a gynecologic department of a comprehensive hospital and outline the scenarios emerging at our gynecologic wards in the transitional period from lockdown to reopening of the city, which might offer important lessons for colleges who struggle to restart work after a COVID-19 lockdown. Methods The triage process used to triage non-COVID-19 gynecologic patients at the Department of Obstetrics and Gynecology, Wuhan Union Hospital after a 76-day lockdown of the city is described. To investigate its effectiveness to avoid COVID-19 nosocomial transmission, the resumption performance in the first two months immediately after the reopening (April and May 2020) was summarized. In addition, the characteristics of the inpatients in the gynecologic department running under the triage framework in April and May 2020 wereretrospectively compared with the same period last year(April and May 2019) and the latest two months before the lockdown (October and November 2020). Results Triage and treatment of non-emergency patients In the resumption period, all non-emergency patients undergo a screening for COVID-19 before being admitted. Before patients seeing their doctors in the outpatient clinic, they are primarily triaged by symptoms and epidemiologic history regarding COVID-19. Those asymptomatic women with no contact history are allowed to visit doctors, who are under defenselevel II. If patients need ambulatory surgery or hospitalization, they will be subjected to COVID-19 triple tests, i.e. nucleic acid test combined with chest computerized tomography (CT) scan and serologic test for specific antibodies to SARS-CoV-2, which take 4-6 hours. Only the patients without any positive results can be admitted, while those with confirmed or suspected COVID-19 are send to designated outpatient clinics. The gynecologic wards are under closed management, banning visits. After admission, patients live first in buffering wards for at least three days, which are single rooms physically separated from normal wards. During the buffering, a secondCOVID-19 triple-testis performed with a time interval of more than 24 hours to the previous test, and respiratory symptoms and body temperature are daily monitored. Thereafter, if no positive finding is present, patients are transferred to regular wards for receiving further disease-related treatment. During hospitalization, emerging fever (≥37.3℃ for three days or longer) or any respiratory syndromes are indications for a quarantine-in-place and a repeated screeningprogram. In addition, the antibody test is repeated every seven days during hospitalization routinely (Figure 1). As regard to elective surgery, a higher priority is given to patients with malignant tumors or benign diseases that significantly affect the quality of life, e.g. uterine submucous leiomyomas causing severe anemia, bulky pelvic tumors pressing the bladder or rectum, etc. Although there are recommendations on gynecological surgery and chemotherapy amid COVID-19 pandemic and debates about the COVID-19-related safety of open versus minimally invasive surgery [12-14], we do not change our surgery modalities or chemotherapy regimens because we havesufficient medical resources to provide standard care for patients and the evidence on the risk of SARS-CoV-2 transmission associated with surgery modalities is absent.Given that postponing chemotherapy may increase the risk of cancer progression, chemotherapies are administrated as scheduled as possible. Moreover, adverse effects of chemotherapy such as myelosuppression and hepatic dysfunction are prevented as far as possible to decrease the possibility of additional hospital visits for diagnosis and treatment of such severe side effects. Triage and treatment of emergency patients For emergency gynecologic patients, by whom a waiting time of 4 hours or longer for intervention is allowed, a COVID-19 triple-test screening program is also required before surgery; for those who need extremely urgent surgery or have positive results of COVID-19 screening tests, emergency surgery should be conducted in specific negative-pressure surgery rooms.After finishing surgery, patients are sent to thequarantine wards set up by the hospital with "three areas and two passages", i.e. clean, semi-clean, and contaminated zones, and separated patient passage and medical staff passage, where they are treated as suspected COVID-19 patients. In the quarantine wards, a COVID-19 triple-test screening should be completed and patients by whom COVID-19 is excluded aretransferred to the buffering rooms in the gynecologicwards(Figure 1).In case of confirmed infection, patients are transferred to designated hospitals for further treatment and the surgeons who performed the emergency surgery and the medical staff in operation rooms are informed. Personal protection of medical staffs It is mandatory for all medical staff to receive COVID-19 screening tests before coming back to work and report personal health status regarding fever and respiratory symptoms daily per a mobile phone app. The use of personal protective equipment is summarized in Table 1. Briefly, defense level I is recommended for low risk of exposure (gynecologic normal wards), and defense level II for moderate and high risk of exposure (outpatient department and gynecologic buffering rooms). The medical staffs who have contacted with confirmed or suspected individuals or COVID-19 symptoms are subjected to screening tests and required to undergo a 14-day medical surveillance. Resumption performance Under the triage framework described above, we received19298patient visits, admitted 326 patients, and performed 223 operations in the first two months after the lockdown is lifted (April and May 2020), less than 40% of that in the two months before the lockdown (October and November 2020) and the same period 2019 (April and May 2019, Table 2).Among them, 20121 patients received ambulatory COVID-19 screening, 95 underwent emergency surgery before completing screening, and 46 were transferred to designated hospitals because of confirmed or suspected infection. No single COVID-19 case occurred in the gynecologic department since reopening. In the early phase of the resumption, cancer patients called for more efforts, especially those suffering from cancers that progress rapidly, such as ovarian cancers. The proportion of cancer patients in April and May 2020 (58.6%) was increased compared to the pre-lockdown period (October and November 2020, 50.0%) and the same period in 2019(April and May 2019, 44.1%).Also, the percentage of cancer surgery was increased. Among the cancer patients, ovarian cancer became the most frequent disease, while the proportions of cervical cancer and endometrial cancer were decreased compared to the pre-COVID-19 periods (Table 2). The ovarian cancer patients with chemotherapy showed less myelosuppression (neutrophil count less than 1.5 G/L) in the post-lockdown cohort (16/47, 34.0%) compared to the pre-lockdown cohort (52/102, 51.0%) and the 2019 cohort (41/95, 43.2%), which may be due to the more frequent use of long-effective colony stimulating factor (PEG-rhG-CSF).However, there were more patients with leiomyoma or adenomyosis suffering from severe anemia in the post-lockdown cohort, that may be due to the postponed diagnosis and surgery and inadequate iron supplementation during the COVID-19 lockdown (Table 2). Discussion The battle against CIVID-19 seems unlikely to end soon. It is evident that the safety of patients and medical staffs is the key to resume the treatment for non-COVID-19 gynecologic patients.We found that, in the early stage of the resumption, the demands on medical care of gynecologic patients that were suppressed during COVID-19 lockdown are released gradually after lockdown easing rather than explosively, which may be partially due to the persistent concerns among patients about getting contagions in hospital. However,in the gynecologic department, the proportion of patients with cancer and severe anemia was increased, who are potentially associated with an increased risk of severe COVID-19 [15,16], underlining the importance of an effective triage system for the non-COVID-19 gynecologic patients. In the present study, we illustrated the workflow that we used to triage the gynecologic patients with or without a need for emergency surgery regarding to potential COVID-19. In our triage system, the hospital quarantine wards and the buffering rooms at gynecologic department are critical to cut off the transmission pathways of COVID-19 without delaying the required medical care for patients.Given the possible missed COVID-19 diagnosis in the primary screening conducted in the outpatient clinic or quarantine wards due to infection window period and false negative test results [17], thestay in buffering roomsand the second round of screening tests are necessaryto protect transmission as a secondary line of defense. In addition, emerging evidence showasymptomatic SARS-CoV-2 infection In the triage system we use, the screening tests include nucleic acid test, chest CT scan, and serologic testing for viral antibodies, which can be finished within 6 hours. Although the triage process costs medical resources and increases management burden, it minimizes the risk of nosocomial infections and reassures both patients and healthcare workers, laying the cornerstone for the resumption of medical treatment for non-COVID-19 patients. However, the use of this screening regimen demands adequate test capacity and relatively quick performance and might be unfeasible for settings with limited resources. In such cases, a simplified screening regimen with anyavailable nucleic acid test and/or serum antibody test could be considered [18,19]. Conclusions Given that the COVID-19 pandemic is a rapidly evolving situation in temporal and spatial context and the local healthcare systems can be disparate, there is no universal guideline appropriate for all. We provide a model of an effective triage system to avoid transmission and,at the same time, allow timely treatment for non-COVID-19 patients, which may be meaningful experiencesin a setting withrelatively sufficient test capacity and medical resources. Abbreviations COVID-19, Corona Virus Disease 2019 SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 CT, computerized tomography Declarations Ethics approval and consent to participate : The study was approved by the Ethical Review Committee of the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.Written informed consent was waived. Consent for publication : Not applicable. Availability of data and materials :The datasets used during the current study are available from the corresponding author on reasonable request. Competing interests : The authors declare that they have no competing interests. Funding : No. Author’s contributions :LC contributes to concept design. LC, RG and WD are major contributors in writing the manuscript. JC, SY, and JG collected and interpreted the clinical data. JZ and ZW performed the statistical analysis. All authors read and approved the final manuscript. Acknowledgements : Not applicable. References Thanh Le T, Andreadakis Z, Kumar A, et al. The COVID-19 vaccine development landscape. Nat Rev Drug Discov . 2020;19(5):305-306. doi:10.1038/d41573-020-00073-5 Lau H, Khosrawipour V, Kocbach P, et al. The positive impact of lockdown in Wuhan on containing the COVID-19 outbreak in China. J Travel Med. 2020;27(3):taaa037. doi:10.1093/jtm/taaa037 Moris D, Schizas D. Lockdown During COVID-19: The Greek Success. In Vivo. 2020;34(3 Suppl):1695-1699. doi:10.21873/invivo.11963 Salje H, Tran Kiem C, Lefrancq N, et al. Estimating the burden of SARS-CoV-2 in France [published correction appears in Science. 2020 Jun 26;368(6498):]. 2020;369(6500):208-211. doi:10.1126/science.abc3517 The Lancet. India under COVID-19 lockdown. 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Anti-cancer therapy and clinical trial considerations for gynecologic oncology patients during the COVID-19 pandemic crisis [published online ahead of print, 2020 Apr 23]. Gynecol Oncol. 2020;158(1):16-24. doi:10.1016/j.ygyno.2020.04.694 Wang Y, Zhang S, Wei L, et al. Recommendations on management of gynecological malignancies during the COVID-19 pandemic: perspectives from Chinese gynecological oncologists. J Gynecol Oncol. 2020;31(4):e68. doi:10.3802/jgo.2020.31.e68 Fader AN, Huh WK, Kesterson J, et al. When to Operate, Hesitate and Reintegrate: Society of Gynecologic Oncology Surgical Considerations during the COVID-19 Pandemic [published online ahead of print, 2020 Jun 6]. Gynecol Oncol. 2020;S0090-8258(20)31766-2. doi:10.1016/j.ygyno.2020.06.001 Monk BJ, Coleman RL, Moore KN, et al. COVID-19 and ovarian cancer: Exploring alternatives to intravenous (IV) therapies [published online ahead of print, 2020 Apr 29]. Gynecol Oncol. 2020;S0090-8258(20)31013-1. doi:10.1016/j.ygyno.2020.04.703 Morris SN, Fader AN, Milad MP, Dionisi HJ. Understanding the "Scope" of the Problem: Why Laparoscopy Is Considered Safe during the COVID-19 Pandemic. J Minim Invasive Gynecol. 2020;27(4):789-791. doi:10.1016/j.jmig.2020.04.002 Zhang L, Zhu F, Xie L, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China.Ann Oncol. 2020;31(7):894-901. doi:10.1016/j.annonc.2020.03.296 De Luna G, Habibi A, Deux JF, et al. Rapid and severe Covid-19 pneumonia with severe acute chest syndrome in a sickle cell patient successfully treated with tocilizumab. Am J Hematol. 2020;95(7):876-878. doi:10.1002/ajh.25833 Long DR, Gombar S, Hogan CA, et al. Occurrence and Timing of Subsequent SARS-CoV-2 RT-PCR Positivity Among Initially Negative Patients. Preprint. medRxiv. 2020;2020.05.03.20089151. Published 2020 May 8. doi:10.1101/2020.05.03.20089151 Zainol Rashid Z, Othman SN, Abdul Samat MN, et al. Diagnostic performance of COVID-19 serology assays.Malays J Pathol. 2020;42(1):13-21. Shyu D, Dorroh J, Holtmeyer C, et al. Laboratory Tests for COVID-19: A Review of Peer-Reviewed Publications and Implications for Clinical Use. Mo Med. 2020;117(3):184-195. Tables Table 1 Personal protective equipment for medical staff in the gynecologic department of Wuhan Union Hospital after lifting the lockdown in Wuhan. Zones Exposure Risk Defense Measures Defense Class Normal wards Low risk White coat Disposable surgical cap Surgical mask I Normal outpatient and gynecologic buffering wards Moderate risk Protective suite a Disposable surgical cap Medical protective mask Protective goggles Disposable gloves II Gynecologic emergency High risk Protective suite a or protective coverall b Disposable surgical cap Medical protective mask Protective goggles Disposable gloves II a, AAMI PB70 level 1-3; b, AAMI PB70 level 4. Table 2 Characteristics of inpatients before and after COVID-19 lockdown. Apr- May 2020 Oct - Nov 2019 Apr - May 2020 N (%) N (%) P N (%) P Inpatients Number of patients 326 834 844 Age, year (median, range) 48.5 (14-86) 47.0 (13-84) 0.012 a 47.0 (14-79) 0.024 a Hospital stay, day (median, range) 10.0 (1-29) 9.0 (1-51) <0.001 a 9.0 (1-14) <0.001 a Cancer patients 191 (58.6) 417 (50.0) 0.008 b 372 (44.1) <0.001 b Surgery Number of patients 223 622 606 Age, year (median, range) 46.0 (14-84) 45.0 (17-80) 0.107 a 45.0 (16-79) 0.180 a Cancer patients 101 (45.3) 244 (39.2) 0.114 b 194 (32.0) <0.001 b Comorbidities Severe anemia 4 (1.2) 1 (0.1) 0.010 b 2 (0.2) 0.034 b Hypertension 36 (11.0) 80 (9.6) 0.459 b 88 (10.4) 0.759 b Diabetes mellitus 11 (3.4) 37 (4.4) 0.414 b 38 (4.5) 0.388 b Cancer patients Cervical cancer 42 (22.0) 159 (38.1) <0.001 b 123 (33.1) <0.001 b Endometrial cancer 30 (15.7) 69 (16.5) 90 (24.2) Ovarian cancer 97 (50.8) 168 (40.3) 137 (36.8) Others 22 (11.5) 21 (5.0) 22 (5.9) P , compared to the Apr-May 2020 cohort; a, Mann-Whitney U test.; b, Chi-square test . 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emergency patients","description":"","filename":"Figure1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-63125/v1/Figure1.jpg"},{"id":13584839,"identity":"52186e34-5ea4-43dc-98e3-a95b8ed5d147","added_by":"auto","created_at":"2021-09-17 04:41:09","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":331045,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-63125/v1/71269488-d8b9-49cf-a712-a252d659212a.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eResumption of the Treatment for Non-COVID-19 Gynecologic Patients after Lifting Lock down: Experiences from Wuhan\u003c/p\u003e","fulltext":[{"header":"Background","content":"\u003cp\u003eSince the end of 2019, the Corona Virus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been spreading rapidly, affecting over one hundred countries around the world. The novel corona virus is highly contagious, and effective antiviral drugs are absent. Vaccines against COVID-19,which are considered as the most promising measure to contain the pandemic, are still under development [1]. Lockdown is an effective public health measure to eliminate the coronavirus infection or flatten the outbreak curve [2,3] andmany countries significantly affected by the pandemichas been enforced to issue a stay-at-home order [4-6]. Unfortunately, a long-term lockdown could be associated with severe social problems, particularly economic recession. In some places,the lockdowns have beengraduallylifted, and social activities are gingerly reopened. However, the pandemic still continues, and the lockdowns will leave lasting impacts on clinical practice.\u003c/p\u003e\n\u003cp\u003eAlthough social distancing of at least two meters is recommended to avoid the virus transmission between people amid COCID-19 pandemic,during treatment of gynecologic patients, close proximity of patient to gynecologist, particularlythe direct contact of vaginal mucosa and secrets of patient for a few minutes in a gynecologic examination, is inevitable and increases the risk of SARS-CoV-2 transmission. There are several guidelines published to give recommendations on the safe gynecologic practice and the treatment of gynecologic patients during the ongoing pandemic, focusing onthe management of cancer patients [7-12]. Whenthe outbreak peak is gone and the lockdown is lifted, the medical resources should be redirected to none-COVID-19 patients, while the threats of COVID-19 transmission still exist. In this context, an adapted triage strategy plays a central role.\u003c/p\u003e\n\u003cp\u003eWuhan, China, the first epicenter of the COVID-19 pandemic, was totally shut down between January 23, 2020 and April 8, 2020. As one of the largest medical centers in middle-south China, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, was assigned to treat none-COVID-19 patients since February 26, 2020. Here, we share our triage process supportingthe resumptionofmedical activities in a gynecologic department of a comprehensive hospital and outline the scenarios emerging at our gynecologic wards in the transitional period from lockdown to reopening of the city, which might offer important lessons for colleges who struggle to restart work after a COVID-19 lockdown.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003eThe triage process used to triage non-COVID-19 gynecologic patients at the Department of Obstetrics and Gynecology, Wuhan Union Hospital after a 76-day lockdown of the city is described. To investigate its effectiveness to avoid COVID-19 nosocomial transmission, the resumption performance in the first two months immediately after the reopening (April and May 2020) was summarized. In addition, the characteristics of the inpatients in the gynecologic department running under the triage framework in April and May 2020 wereretrospectively compared with the same period last year(April and May 2019) and the latest two months before the lockdown (October and November 2020).\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eTriage and treatment of non-emergency patients\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn the resumption period, all non-emergency patients undergo a screening for COVID-19 before being admitted. Before patients seeing their doctors in the outpatient clinic, they are primarily triaged by symptoms and epidemiologic history regarding COVID-19. Those asymptomatic women with no contact history are allowed to visit doctors, who are under defenselevel II. If patients need ambulatory surgery or hospitalization, they will be subjected to COVID-19 triple tests, i.e. nucleic acid test combined with chest computerized tomography (CT) scan and serologic test for specific antibodies to SARS-CoV-2, which take 4-6 hours. Only the patients without any positive results can be admitted, while those with confirmed or suspected COVID-19 are send to designated outpatient clinics.\u003c/p\u003e\n\u003cp\u003eThe gynecologic wards are under closed management, banning visits. After admission, patients live first in buffering wards for at least three days, which are single rooms physically separated from normal wards. During the buffering, a secondCOVID-19 triple-testis performed with a time interval of more than 24 hours to the previous test, and respiratory symptoms and body temperature are daily monitored. Thereafter, if no positive finding is present, patients are transferred to regular wards for receiving further disease-related treatment. During hospitalization, emerging fever (\u0026ge;37.3℃ for three days or longer) or any respiratory syndromes are indications for a quarantine-in-place and a repeated screeningprogram. In addition, the antibody test is repeated every seven days during hospitalization routinely (Figure 1).\u003c/p\u003e\n\u003cp\u003eAs regard to elective surgery, a higher priority is given to patients with malignant tumors or benign diseases that significantly affect the quality of life, e.g. uterine submucous leiomyomas causing severe anemia, bulky pelvic tumors pressing the bladder or rectum, etc. Although there are recommendations on gynecological surgery and chemotherapy amid COVID-19 pandemic and debates about the COVID-19-related safety of open versus minimally invasive surgery [12-14], we do not change our surgery modalities or chemotherapy regimens because we havesufficient medical resources to provide standard care for patients and the evidence on the risk of SARS-CoV-2 transmission associated with surgery modalities is absent.Given that postponing chemotherapy may increase the risk of cancer progression, chemotherapies are administrated as scheduled as possible. Moreover, adverse effects of chemotherapy such as myelosuppression and hepatic dysfunction are prevented as far as possible to decrease the possibility of additional hospital visits for diagnosis and treatment of such severe side effects.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTriage and treatment of emergency patients\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFor emergency gynecologic patients, by whom a waiting time of 4 hours or longer for intervention is allowed, a COVID-19 triple-test screening program is also required before surgery; for those who need extremely urgent surgery or have positive results of COVID-19 screening tests, emergency surgery should be conducted in specific negative-pressure surgery rooms.After finishing surgery, patients are sent to thequarantine wards set up by the hospital with \"three areas and two passages\", i.e. clean, semi-clean, and contaminated zones, and separated patient passage and medical staff passage, where they are treated as suspected COVID-19 patients. In the quarantine wards, a COVID-19 triple-test screening should be completed and patients by whom COVID-19 is excluded aretransferred to the buffering rooms in the gynecologicwards(Figure 1).In case of confirmed infection, patients are transferred to designated hospitals for further treatment and the surgeons who performed the emergency surgery and the medical staff in operation rooms are informed.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePersonal protection of medical staffs\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIt is mandatory for all medical staff to receive COVID-19 screening tests before coming back to work and report personal health status regarding fever and respiratory symptoms daily per a mobile phone app. The use of personal protective equipment is summarized in Table 1. Briefly, defense level I is recommended for low risk of exposure (gynecologic normal wards), and defense level II for moderate and high risk of exposure (outpatient department and gynecologic buffering rooms). The medical staffs who have contacted with confirmed or suspected individuals or COVID-19 symptoms are subjected to screening tests and required to undergo a 14-day medical surveillance.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResumption performance \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eUnder the triage framework described above, we received19298patient visits, admitted 326 patients, and performed 223 operations in the first two months after the lockdown is lifted (April and May 2020), less than 40% of that in the two months before the lockdown (October and November 2020) and the same period 2019 (April and May 2019, Table 2).Among them, 20121 patients received ambulatory COVID-19 screening, 95 underwent emergency surgery before completing screening, and 46 were transferred to designated hospitals because of confirmed or suspected infection. No single COVID-19 case occurred in the gynecologic department since reopening.\u003c/p\u003e\n\u003cp\u003eIn the early phase of the resumption, cancer patients called for more efforts, especially those suffering from cancers that progress rapidly, such as ovarian cancers. The proportion of cancer patients in April and May 2020 (58.6%) was increased compared to the pre-lockdown period (October and November 2020, 50.0%) and the same period in 2019(April and May 2019, 44.1%).Also, the percentage of cancer surgery was increased. Among the cancer patients, ovarian cancer became the most frequent disease, while the proportions of cervical cancer and endometrial cancer were decreased compared to the pre-COVID-19 periods (Table 2). The ovarian cancer patients with chemotherapy showed less myelosuppression (neutrophil count less than 1.5 G/L) in the post-lockdown cohort (16/47, 34.0%) compared to the pre-lockdown cohort (52/102, 51.0%) and the 2019 cohort (41/95, 43.2%), which may be due to the more frequent use of long-effective colony stimulating factor (PEG-rhG-CSF).However, there were more patients with leiomyoma or adenomyosis suffering from severe anemia in the post-lockdown cohort, that may be due to the postponed diagnosis and surgery and inadequate iron supplementation during the COVID-19 lockdown (Table 2).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe battle against CIVID-19 seems unlikely to end soon. It is evident that the safety of patients and medical staffs is the key to resume the treatment for non-COVID-19 gynecologic patients.We found that, in the early stage of the resumption, the demands on medical care of gynecologic patients that were suppressed during COVID-19 lockdown are released gradually after lockdown easing rather than explosively, which may be partially due to the persistent concerns among patients about getting contagions in hospital. However,in the gynecologic department, the proportion of patients with cancer and severe anemia was increased, who are potentially associated with an increased risk of severe COVID-19 [15,16], underlining the importance of an effective triage system for the non-COVID-19 gynecologic patients.\u003c/p\u003e\n\u003cp\u003eIn the present study, we illustrated the workflow that we used to triage the gynecologic patients with or without a need for emergency surgery regarding to potential COVID-19. In our triage system, the hospital quarantine wards and the buffering rooms at gynecologic department are critical to cut off the transmission pathways of COVID-19 without delaying the required medical care for patients.Given the possible missed COVID-19 diagnosis in the primary screening conducted in the outpatient clinic or quarantine wards due to infection window period and false negative test results [17], thestay in buffering roomsand the second round of screening tests are necessaryto protect transmission as a secondary line of defense. In addition, emerging evidence showasymptomatic SARS-CoV-2 infection\u003c/p\u003e\n\u003cp\u003eIn the triage system we use, the screening tests include nucleic acid test, chest CT scan, and serologic testing for viral antibodies, which can be finished within 6 hours. Although the triage process costs medical resources and increases management burden, it minimizes the risk of nosocomial infections and reassures both patients and healthcare workers, laying the cornerstone for the resumption of medical treatment for non-COVID-19 patients. However, the use of this screening regimen demands adequate test capacity and relatively quick performance and might be unfeasible for settings with limited resources. In such cases, a simplified screening regimen with anyavailable nucleic acid test and/or serum antibody test could be considered [18,19].\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eGiven that the COVID-19 pandemic is a rapidly evolving situation in temporal and spatial context and the local healthcare systems can be disparate, there is no universal guideline appropriate for all. We provide a model of an effective triage system to avoid transmission and,at the same time, allow timely treatment for non-COVID-19 patients, which may be meaningful experiencesin a setting withrelatively sufficient test capacity and medical resources.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eCOVID-19, Corona Virus Disease 2019\u003c/p\u003e\n\u003cp\u003eSARS-CoV-2, severe acute respiratory syndrome coronavirus 2\u003c/p\u003e\n\u003cp\u003eCT, computerized tomography\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e: The study was approved by the Ethical Review Committee of the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.Written informed consent was waived.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e: Not applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e:The datasets used during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e: The authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e: No.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor\u0026rsquo;s contributions\u003c/strong\u003e:LC contributes to concept design. LC, RG and WD are major contributors in writing the manuscript. JC, SY, and JG collected and interpreted the clinical data. JZ and ZW performed the statistical analysis. All authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e: Not applicable.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eThanh Le T, Andreadakis Z, Kumar A, et al. The COVID-19 vaccine development landscape.\u0026nbsp;\u003cem\u003eNat Rev Drug Discov\u003c/em\u003e. 2020;19(5):305-306. doi:10.1038/d41573-020-00073-5\u003c/li\u003e\n\u003cli\u003eLau H, Khosrawipour V, Kocbach P, et al. The positive impact of lockdown in Wuhan on containing the COVID-19 outbreak in China.\u0026nbsp;J Travel Med. 2020;27(3):taaa037. doi:10.1093/jtm/taaa037\u003c/li\u003e\n\u003cli\u003eMoris D, Schizas D. 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Published 2020 May 8. doi:10.1101/2020.05.03.20089151\u003c/li\u003e\n\u003cli\u003eZainol Rashid Z, Othman SN, Abdul Samat MN, et al. Diagnostic performance of COVID-19 serology assays.Malays J Pathol. 2020;42(1):13-21.\u003c/li\u003e\n\u003cli\u003eShyu D, Dorroh J, Holtmeyer C, et al. 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style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eZones\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eExposure Risk\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eDefense Measures\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.5pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eDefense Class\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.9pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNormal wards\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eLow risk\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eWhite coat\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eDisposable surgical cap\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eSurgical mask\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.5pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 17pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.9pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 37.1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNormal outpatient and gynecologic buffering wards\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 37.1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;text-indent: 1.45pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eModerate risk\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 37.1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eProtective suite\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eDisposable surgical cap\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eMedical protective mask\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eProtective goggles\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eDisposable gloves\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.5pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 37.1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eII\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.9pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 19.15pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eGynecologic emergency\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 19.15pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eHigh risk\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 19.15pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eProtective suite\u003csup\u003ea\u003c/sup\u003e or protective coverall\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eDisposable surgical cap\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eMedical protective mask\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eProtective goggles\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eDisposable gloves\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.5pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 19.15pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eII\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in;text-align: justify;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003ea, AAMI PB70 level 1-3; b, AAMI PB70 level 4.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in;text-align: justify;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eTable 2 Characteristics of inpatients before and after COVID-19 lockdown.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"width: 540.25pt;border-collapse: collapse;border: none;\" width=\"720\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border-style: solid none none;border-top-width: 1pt;border-top-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"30%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.5pt;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"14.166666666666666%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eApr- May 2020\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border-style: solid none none;border-top-width: 1pt;border-top-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"3.1944444444444446%\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 138.95pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"25.694444444444443%\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eOct - Nov 2019\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border-style: solid none none;border-top-width: 1pt;border-top-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"2.361111111111111%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 133.05pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"24.583333333333332%\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eApr - May 2020\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.5pt;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003eN\u003c/em\u003e\u0026nbsp;(%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003eN\u0026nbsp;\u003c/em\u003e(%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003eP\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003eN\u0026nbsp;\u003c/em\u003e(%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003eP\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"29.916897506925206%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.5pt;text-align: justify;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eInpatients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"14.12742382271468%\"\u003e\n \u003cp style=\"margin: 0in;font-size:16px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"3.185595567867036%\"\u003e\n \u003cp style=\"margin: 0in;font-size:16px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"15.789473684210526%\"\u003e\n \u003cp style=\"margin: 0in;font-size:16px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 53.7pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"9.97229916897507%\"\u003e\n \u003cp style=\"margin: 0in;font-size:16px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"2.3545706371191137%\"\u003e\n \u003cp style=\"margin: 0in;font-size:16px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"15.23545706371191%\"\u003e\n \u003cp style=\"margin: 0in;font-size:16px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"9.418282548476455%\"\u003e\n \u003cp style=\"margin: 0in;font-size:16px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"29.916897506925206%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.5pt;text-align: justify;font-size:16px;font-family: DengXian;text-indent: 14.15pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNumber of patients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"14.12742382271468%\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e326\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"3.185595567867036%\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"15.789473684210526%\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e834\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 53.7pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"9.97229916897507%\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"2.3545706371191137%\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"15.23545706371191%\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e844\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"9.418282548476455%\"\u003e\n \u003cp style=\"margin: 0in;text-align: center;font-size:16px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"29.916897506925206%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.5pt;text-align: justify;font-size:16px;font-family: DengXian;text-indent: 14.15pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eAge, year (median, range)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"14.12742382271468%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e48.5 (14-86)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"3.185595567867036%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"15.789473684210526%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e47.0 (13-84)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 53.7pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"9.97229916897507%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.012\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"2.3545706371191137%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"15.23545706371191%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e47.0 (14-79)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"9.418282548476455%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.024\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"29.916897506925206%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.5pt;text-align: justify;font-size:16px;font-family: DengXian;text-indent: 14.15pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eHospital stay, day (median, range)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"14.12742382271468%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e10.0 (1-29)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"3.185595567867036%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"15.789473684210526%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e9.0 (1-51)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 53.7pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"9.97229916897507%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026lt;0.001\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"2.3545706371191137%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"15.23545706371191%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e9.0 (1-14)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\" width=\"9.418282548476455%\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026lt;0.001\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in 8.6pt;font-size:16px;font-family: DengXian;text-indent: 0.1pt;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eCancer patients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e191 (58.6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e417 (50.0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.008\u003csup\u003e\u0026nbsp;b\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e372 (44.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026lt;0.001\u003csup\u003e\u0026nbsp;b\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in;font-size:16px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eSurgery\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.5pt;font-size:16px;font-family: DengXian;text-indent: 13.65pt;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNumber of patients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e223\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e622\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e606\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.5pt;font-size:16px;font-family: DengXian;text-indent: 13.65pt;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eAge, year (median, range)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e46.0 (14-84)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e45.0 (17-80)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.107\u003csup\u003e\u0026nbsp;a\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e11 (3.4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e37 (4.4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.414\u003csup\u003e\u0026nbsp;b\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e38 (4.5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.388\u003csup\u003e\u0026nbsp;b\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.5pt;font-size:16px;font-family: DengXian;text-indent: 4.4pt;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eCancer patients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.5pt;font-size:16px;font-family: DengXian;text-indent: 13.65pt;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eCervical cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e42 (22.0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e159 (38.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026lt;0.001\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e123 (33.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026lt;0.001\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 161.85pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.5pt;font-size:16px;font-family: DengXian;text-indent: 13.65pt;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eEndometrial cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e30 (15.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.1pt;border: none;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 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valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 82.25pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e22 (5.9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50.8pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 1pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0in -5.05pt;text-align: center;font-size:16px;font-family: DengXian;text-indent: 4.4pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in;text-align: justify;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003eP\u003c/em\u003e, compared to the Apr-May 2020 cohort; a, Mann-Whitney U test.; b,\u0026nbsp;\u003cspan style=\"background-color: white;\"\u003eChi-square test\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 10px; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003e.\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Resumption, non-COVID-19, Gynecologic patients","lastPublishedDoi":"10.21203/rs.3.rs-63125/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-63125/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e: To share our experiences of resumption of the treatment for gynecologic patients after lifting lockdown in a hotspot area of the Corona Virus Disease 2019 (COVID-19)pandemic.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: The triage process used to resume the medical activities for gynecologic patients at the Wuhan Union Hospital after a 76-day lockdown of the city is described and its effectiveness to avoid COVID-19 nosocomial transmission is shown.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e:The non-emergency patients are pre-triaged by contact history and body temperature at outpatient clinic and negative COVID-19 screening tests are required for an admissionin the buffering rooms at the gynecologic department. The buffering lastsfor at least three days for symptom monitoring and a second round of COVID-19 tests before they can be transferred to the regular gynecologic wards. For patients who need emergency surgery, the first screening should be completed at the quarantine wards after the surgery, followed by buffering at the gynecologic department. We received 19298 outpatient visits, admitted 326 patients, and performed 223 operations in the first two months after the lockdown was lifted, andno single COVID-19 case occurredin the hospitalized patients while the proportion of potentially high-risk patients with cancer and severe anemia were increased in comparison with the same period in 2019 and the latest two months before the lockdown.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e:We provide an effective triage system with buffering at two levels to guarantee safe and timely treatment for non-COVID-19 gynecologic patients in a post-lockdown phase.\u003c/p\u003e","manuscriptTitle":"Resumption of the Treatment for Non-COVID-19 Gynecologic Patients after Lifting Lock down: Experiences from Wuhan","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-08-24 22:52:36","doi":"10.21203/rs.3.rs-63125/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"9cc8282a-9bad-488a-943c-cdfabb2ac19e","owner":[],"postedDate":"August 24th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":336162,"name":"Obstetrics \u0026 Gynecology"}],"tags":[],"updatedAt":"2020-08-24T22:52:36+00:00","versionOfRecord":[],"versionCreatedAt":"2020-08-24 22:52:36","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-63125","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-63125","identity":"rs-63125","version":["v1"]},"buildId":"ehx78VzkSd0WSzXnipQa-","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}