Clinical Characteristics and Prognostic Factors of Ovarian Clear Cell Carcinoma

Objective:To evaluate the clinical characteristics and prognostic factors in the patients with clear cell carcinoma of the ovary.Methods: The medical records of 96 patients with ovarian clear cell carcinoma treated in our hospital from January 1999 to September 2005 were reviewed and analyzed retrospectively,with a follow-up by telephone until April 2011.Results: Most patients were younger than 55-year-old(71.9%).Majority of the group were in early stage.The five-year survival rate was 71.9% in stage I,50.0% in stage II,23.8% in stage III,0.0%in stage IV.Patients with pelvic endometriosis consist of 50% of all.Age of patients at diagnosis,histological type and differences of chemotherapy regimens were not prognostic factors.The International Federation of Gynecology and Obstetrics(FIGO) staging,carcinoma antigen 125(CA 125) expression levels before our therapy,residual tumor diameter status and sufficient chemotherapeutic cycles were prognostic factors in the patients.Conclusions: The patients of ovarian clear cell carcinoma are often of early stage at diagnosis,with poor prognosis,apt to be combined with endometriosis.In order to improve the prognosis,it's necessary to diagnose the disease early and perform an optimal cytoreductive surgery as well as sufficient postoperative chemotherapy on the patients.