Factors influencing variable symptoms of COVID-19 patients and proposed revision of public policy for COVID-19 pandemic

The uncertainty of the symptoms in those who are SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) positive is an issue that should be discussed in order to reconsider a comprehensive way to deal with this virus outbreak. For the time being, controversy regarding the necessity to vaccinate still exists in the public and might be a significant impact on the global economy and safety of human beings. This article proposes that a variety of cellular molecules (viral receptors/co-receptors) and MHCs (major histocompatibility complex) could be crucial factors explaining the uncertain symptoms in those who infected with viruses. The understanding of these host factors should encourage further research studies and pave the way to develop a new public health policy to deal with COVID-19 and emergent viral epidemic in the future.