The expression of Sema 3A, Plexin A1 and NRP-1 in eutopic endometrium from patients with endometriosis and patients without endometriosis.

Yanchun Liang (213593), Wei Wang (17594), Jiaming Huang (840570), Hao Tan (117484), Tianyu Liu (529994), Chunliang Shang (840571), Duo Liu (758674), Luyan Guo (442591), Shuzhong Yao (840572)
2016 · doi:10.1371/journal.pone.0146027.g001 · W6922956650
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This study investigated the expression levels of Semaphorin 3A, Plexin A1, and NRP-1 in eutopic endometrial tissue samples. Researchers compared these protein markers between patients diagnosed with endometriosis and a control group without the condition using immunohistochemical staining and semi-quantitative analysis. The results indicated statistically significant differences in the expression of these proteins within glandular epithelial and stromal cells between the two groups. This paper is centrally about endometriosis — specifically examining molecular markers associated with aberrant sympathetic innervation in peritoneal and deep infiltrating lesions.

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Abstract

A: Immunohistochemical staining of three proteins in eutopic endometrium. EuE-EM: Eutopic Endometrium from patients with Endometriosis; EuE-NEM: Eutopic Endometrium from patients without Endometriosis (immunohistochemical stain, 200 × magnification). B and C: Semi-quantitative expression of Sema 3A, Plexin A1 and NRP-1 of glandular epithelial cells (B) as well as stromal cells (C) from eutopic endometrium from patients with endometriosis (EM) and without endometriosis (NEM). *P<0.05 (Mann–Whitney).
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Potential Role of Semaphorin 3A and Its Receptors in Regulating Aberrant Sympathetic Innervation in Peritoneal and Deep Infiltrating Endometriosis Fig 1 The expression of Sema 3A, Plexin A1 and NRP-1 in eutopic endometrium from patients with endometriosis and patients without endometriosis. A: Immunohistochemical staining of three proteins in eutopic endometrium. EuE-EM: Eutopic Endometrium from patients with Endometriosis; EuE-NEM: Eutopic Endometrium from patients without Endometriosis (immunohistochemical stain, 200 × magnification). B and C: Semi-quantitative expression of Sema 3A, Plexin A1 and NRP-1 of glandular epithelial cells (B) as well as stromal cells (C) from eutopic endometrium from patients with endometriosis (EM) and without endometriosis (NEM). *P<0.05 (Mann–Whitney).

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endometriosis

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