Simultaneous Estimation of Ketorolac Tromethamine and Moxifloxacin Hydrochloride in Ophthalmic Formulation by Hptlc Method Using DOE Approach

Simultaneous Estimation of Ketorolac Tromethamine and Moxifloxacin Hydrochloride in Ophthalmic Formulation by Hptlc Method Using DOE Approach | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Simultaneous Estimation of Ketorolac Tromethamine and Moxifloxacin Hydrochloride in Ophthalmic Formulation by Hptlc Method Using DOE Approach Anchal Shukla, Hitaishi Kashyap, Kalpana Patel, Devang Tandel, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7593588/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Ketorolac Tromethamine inhibits mainly the COX-2 enzyme pathway which leads to Analgesia and reduces inflammation and Moxifloxacin hydrochloride blocks the enzyme topoisomerase II. The Combination of these two drugs is used in the treatment of post-operative inflammatory condition. For estimation of Ketorolac Tromethamine and Moxifloxacin hydrochloride in bulk and in ophthalmic formulation, an HPTLC method was developed and validated which is accurate as well as precise. The method was optimized using Box- Behnken Design, Aluminium plate pre-coated with silica gel 60 F 254 as stationary phase and Mobile Phase used was n – Butanol: Methanol: Ammonia (4.5:1:1 v/v/v). The analytical wavelength detected for both Ketorolac tromethamine and Moxifloxacin hydrochloride was 305 nm. The R f value was found to be 0.74 and 0.28 with linearity range of 400–1200 ng/ band and 500–1500 ng/band for Ketorolac tromethamine and Moxifloxacin hydrochloride respectively. Ketorolac Tromethamine Moxifloxacin hydrochloride HPTLC Box- Behnken Design Full Text Additional Declarations No competing interests reported. Supplementary Files HPTLCgraphicalabstract.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7593588","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":528013656,"identity":"0442e4f6-d523-4dfb-89a9-ca6b3f11f5e4","order_by":0,"name":"Anchal 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