Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study

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However, GIC holds certain undesirable properties. In order to overcoming the major drawback of moisture sensitivity, surface coatings like petroleum jelly, varnish are applied over GIC restoration. Thus, the present study was planned to compare efficacy of newly formulated nano silver fluoride resin coat with G Coat Plus and petroleum jelly on microhardness and microleakage of Type IX GIC. Methods Class V cavities were prepared on the buccal surface of thirty-six non carious premolars and restored with type IX GIC. The restored teeth were divided into 3 groups: Petroleum gel, G Coat plus and Nano silver fluoride resin coat. Protective surface coatings were applied over the restorations, dried for 2 minutes and thermocycled. Teeth were then placed in 1% methylene blue for 24 hours. Longitudinally sections were prepared and were observed under stereomicroscope at 25x magnification for dye penetration. Forty-five blocks of PVC were prepared and restored with GIC. Samples were divided into three groups equally as mentioned earlier and a layer of each coating was applied on all samples according to the groups and dried for 2 minutes. Further, surface microhardness (SMH) of the samples was tested by Vickers microhardness machine under a load of 50 grams for 10 seconds at 3 sites and a mean was calculated. Statistical analysis was conducted using post hoc and one way-ANOVA tests. Results The microleakage scores of three groups were statistically insignificant. The mean microhardness of all samples in the three groups showed no statistically significant difference. The mean surface microhardness of group 1 was 66.44±4.57 whereas for group 2 and group 3 it was 76.15±3.02 and 79.22±4.03 respectively. Conclusions The novel agent containing nano silver fluoride is showed superior results and is intended to augment the properties of GIC. 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Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.12688/f1000research.140417.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Research Article Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] Dr. Pranjali Vilas Deulkar https://orcid.org/0000-0003-4189-7814 1 , Dr. Nilesh V Rathi 2 , Dr Nilima Thosar 3 , Dr Chitrika Subhadarsanee https://orcid.org/0000-0001-5894-6286 4 Dr. Pranjali Vilas Deulkar https://orcid.org/0000-0003-4189-7814 1 , Dr. Nilesh V Rathi 2 , Dr Nilima Thosar 3 , Dr Chitrika Subhadarsanee https://orcid.org/0000-0001-5894-6286 4 PUBLISHED 16 Feb 2024 Author details Author details 1 Assistant Professor, Department of Pediatric And Preventive Dentistry, Dr. D. Y. PATIL DENTAL COLLEGE AND HOSPITAL, PIMPRI, PUNE, Maharashtra, 411018, India 2 Professor and Head, Department of Pediatric And Preventive Dentistry, Dr. D. Y. PATIL DENTAL COLLEGE AND HOSPITAL, PIMPRI, PUNE, Maharashtra, 411018, India 3 Professor and Head, Department of Pediatric And Preventive Dentistry, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, 441207, India 4 Assistant Professor, Department of Periodontology and Implantology, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, 441207, India Dr. Pranjali Vilas Deulkar Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Dr. Nilesh V Rathi Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Dr Nilima Thosar Roles: Conceptualization, Data Curation, Formal Analysis, Resources, Software, Supervision, Validation, Visualization Dr Chitrika Subhadarsanee Roles: Formal Analysis, Resources, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Datta Meghe Institute of Higher Education and Research collection. Abstract Background Glass ionomer cement (GIC) is a widely used tooth coloured material. However, GIC holds certain undesirable properties. In order to overcoming the major drawback of moisture sensitivity, surface coatings like petroleum jelly, varnish are applied over GIC restoration. Thus, the present study was planned to compare efficacy of newly formulated nano silver fluoride resin coat with G Coat Plus and petroleum jelly on microhardness and microleakage of Type IX GIC. Methods Class V cavities were prepared on the buccal surface of thirty-six non carious premolars and restored with type IX GIC. The restored teeth were divided into 3 groups: Petroleum gel, G Coat plus and Nano silver fluoride resin coat. Protective surface coatings were applied over the restorations, dried for 2 minutes and thermocycled. Teeth were then placed in 1% methylene blue for 24 hours. Longitudinally sections were prepared and were observed under stereomicroscope at 25x magnification for dye penetration. Forty-five blocks of PVC were prepared and restored with GIC. Samples were divided into three groups equally as mentioned earlier and a layer of each coating was applied on all samples according to the groups and dried for 2 minutes. Further, surface microhardness (SMH) of the samples was tested by Vickers microhardness machine under a load of 50 grams for 10 seconds at 3 sites and a mean was calculated. Statistical analysis was conducted using post hoc and one way-ANOVA tests. Results The microleakage scores of three groups were statistically insignificant. The mean microhardness of all samples in the three groups showed no statistically significant difference. The mean surface microhardness of group 1 was 66.44±4.57 whereas for group 2 and group 3 it was 76.15±3.02 and 79.22±4.03 respectively. Conclusions The novel agent containing nano silver fluoride is showed superior results and is intended to augment the properties of GIC. READ ALL READ LESS Keywords NANO SILVER FLUORIDE, GLASS IONIMER CEMENT, G C COAT PLUS, VASELINE Corresponding Author(s) Dr. Pranjali Vilas Deulkar ( [email protected] ) Close Corresponding author: Dr. Pranjali Vilas Deulkar Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2024 Deulkar DPV et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Deulkar DPV, Rathi DNV, Thosar DN and Subhadarsanee DC. Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.12688/f1000research.140417.1 ) First published: 16 Feb 2024, 13 :99 ( https://doi.org/10.12688/f1000research.140417.1 ) Latest published: 16 Feb 2024, 13 :99 ( https://doi.org/10.12688/f1000research.140417.1 ) Introduction Glass ionomer cement (GIC) is a widely used fluoride releasing tooth coloured material. 1 It has good dimensional stability and coefficient of thermal expansion similar to the tooth structure. However, GIC holds certain undesirable properties like early moisture sensitivity, low strength, poor marginal integrity, and wear resistance. 2 – 4 In order to overcome the major drawback of moisture sensitivity, various surface coatings like petroleum jelly, varnish, cocoa butter are applied over the GIC restoration. 5 – 7 The nanofilled, self-adhesive agent G-Coat Plus (GC Corp., Tokyo, Japan) has a single dispersion nano-filler technology for dispersion of silica particles. This gives internal protection to the restorations against cracks and voids for increased fracture toughness. It also reinforces the outer layer for increased wear resistance and protection against acid erosion. G-Coat Plus lamination strengthens, protects and enhances the glass ionomer restorations by giving it a finished superficial surface. However, recent literature evaluating the efficacy of G-Coat Plus states that its application over GIC severely impede its fluoride releasing property. This may predispose it to restoration failure and secondary caries. Nano silver fluoride is a unique material with amalgamation of silver and fluoride, making it an antibacterial and remineralising agent. The silver nano particles (AgNPs) are claimed to act as fillers and increase the wear resistance of any surface. The incorporation of nano silver fluoride in a resin base was presumed to be a good surface coating over glass ionomer cement and thus, the present study was performed to compare the efficacy of newly formulated nano silver fluoride resin coat with commercially available G Coat Plus and petroleum jelly on microhardness and microleakage of Type IX GIC, under in vitro conditions. Methods The present study was carried out in the Department of Pediatric & Preventive Dentistry, Sharad Pawar Dental College, Wardha after obtaining the institutional ethical approval on 29th August 2019 with the reference number DMIMS (DU)IEC/Aug-2019/8298. Sample size was calculated using the following formula: n= Zα + Zβ [ P 1 1 − P 1 + P 2 1 − P 2 ] P 1 − P 2 2 and it came down to 15 in each group. Non-carious premolar teeth were taken from healthy patients who underwent extraction for orthodontic purpose. Microleakage assessment Thirty-six non-carious premolars extracted for orthodontic purpose were collected from the patients after taking a written informed consent. The teeth were cleaned with sodium hypochlorite for 10 minutes and stored in 0.1% thymol solution at 4°C, till needed. A Class V cavity was prepared on the buccal surface of each tooth with 4 mm length, 2 mm width and 0.75 mm depth using No.1 round bur, No. 57 straight fissure bur with high-speed air rotor headpiece under water irrigation. All cavosurface margins were kept at 90° without bevel and burs were changed for each preparation. A William’s graduated periodontal probe (Hu-friedy, Chicago, IL, USA) was used to gauge the dimensions of the cavity. These prepared samples were divided into 3 groups: Group 1: Petroleum jelly (Vaseline™), Group 2: G Coat plus and Group 3: Nano silver fluoride resin coat. Protective surface coatings were applied over the restorations, dried for 2 minutes and placed in artificial saliva mimicking the clinical conditions. Thermocycling of all the samples was carried out at 5°C and 55°C for 500 cycles with a dwelling time of 30 seconds. The restored teeth were placed in 1% methylene blue for 24 hours. The longitudinal sections were prepared in a bucco-lingual plane using a double sided disc (Horico, Berlin, Germany) in a straight headpiece and were observed under stereomicroscope (M9; Wild Heerbrugg, Switzerland) at 25× magnification for dye penetration. Assessment Criteria Score (Saboi et al. 2002) No dye penetration 0 Dye penetration up to 1/3 cavity depth 1 Dye penetration 1/3-2/3 cavity depth 2 Dye penetration >2/3 of cavity depth or full extent of axial wall 3 Microhardness assessment Forty-five blocks of PVC were prepared and restored with glass ionomer cement using a spatula. The blocks were overfilled to some extent, covered with mylar strips and compressed with glass slab, allowing proper condensation. The samples were divided into three equal groups: Group 1: Petroleum jelly, Group 2: G Coat plus and Group 3: Nano silver fluoride resin coat and a layer of each coating was applied on all the samples according to the groups and dried for 2 minutes. Further, the surface microhardness (SMH) of all the samples was tested by Vickers micro hardness testing machine under a load of 50 grams for 10 seconds at 3 different sites and a mean for each sample was calculated. Results Table 1 : The mean microleakage levels of all the samples in the three groups are compared. In Group 1, all the samples showed dye penetration. Of which, 60% of the samples showed dye penetration of more than 2/3 of cavity depth. Indicating a poor coverage over the GIC surface. 33.3% samples in Group 2 also showed no dye penetration. Remaining samples showed some amount of penetration, however the extent was less than 2/3 depth of the cavity. In Group 3, 46.7% of the samples showed no dye penetration. Remaining 40% and 13.3% samples showed less than 1/3 and 1/3-2/3 penetration respectively. Though Group 3 showed best results, the difference between the all groups is statistically insignificant. Table 1. The microleakage levels of all the samples in the three groups are compared. The difference between the groups is statistically insignificant. Group Microleakage scores Total p value 0 1 2 3 Group 1 0 (0%) 1 (6.7%) 5 (33.3%) 9 (60%) 15 (100%) 0.001 * Group 2 5 (33.3%) 7 (46.7%) 3 (20%) 0 (0%) 15 (100%) Group 3 7 (46.7%) 6 (40%) 2 (13.3%) 0 (0%) 15 (100%) * p <0.001 – statistically significant. Table 2 : The mean micro hardness levels of all the samples in the three groups are compared. The comparison between Group 1 (66.44±4.57) and Group 2 (76.15±3.02) showed no statistically significant difference (p<0.001). The mean microhardness values of Group 2 (76.15±3.02) and Group 3 (79.22±4.03) has no statistical difference (p=0.095). The difference between Group 1 (66.44±4.57) and Group 3 (79.22±4.03) has no statistical difference (<0.001). Table 2. Comparison of micro hardness level. Group Mean ± SD p value Group 1–Group 2 66.44±4.57–76.15±3.02 <0.001 * Group 2–Group 3 76.15±3.02–79.22±4.03 0.095 Group 1–Group 3 66.44±4.57–79.22±4.03 <0.001 * * p <0.001 – statistically significant. Discussion Conventional glass ionomer cement (GIC) is a fluoride releasing cement which sets by acid base reaction. 8 , 9 Water content in GIC is critical in attaining optimal properties. It acts as a medium for the dissolution of the polymeric acid, and allows it to ionise and donate protons, thereby behaving as a Bronsted-Lowry acid. The cations are released from the glass and are hydrated unbound water. The unbound water hydrates the cations released from the glass to form a sheath of water around aluminium, magnesium and silica ions. The bound water sheath matures in a centripetal fashion to polymerise the cement. 8 Maintaining the water balance early in the life of the cement is important. Loss of water leads to formation of microscopic cracks by local contraction as the water escapes. 10 Similarly, contamination with excessive water leaches out the ions causing dissolution of the cement. To prevent this, clinicians are advised to cover the surface of newly placed glass ionomer cement with a protective coating. Various studies are in agreement with this fact that surface protective coatings over Glass ionomer cement are helpful to avoid loss and gain of water during the setting reaction. 5 , 7 , 11 , 12 In the present study, G-Coat plus group showed better results when compared to Petroleum jelly group with respect to both microhardness and microleakage. This is in congruence with studies conducted by Mandikos MN et al. 13 ; Tantbirojn D et al. 14 and Arthilakshmi et al. who assessed the microhardness. 15 A study done by Tyagi S. et al. assessed microleakage of dye using spectrophotometer and showed results analogous to the present study. 16 This can be attributed to the even dispersion of nanofillers (30 nm) that have a ‘micro-lamination effect’ giving it an uniform flow over the cement forming a protective coating of about 35-40 μm. 17 , 18 Though Petroleum jelly is the most commonly used surface protective agent, studies depict its limited efficacy as it gets easily washed away. It may also leave its residues in between the restoration and cavosurface margins leading to persistence of the nanogaps. In the present study, efficacy of a novel preparation containing nano silver fluoride, resin and tartaric acid was assessed. 19 , 20 The microhardness of GIC was highest when coated with NSF resin followed by G Coat Plus and Petroleum jelly. This is accredited to the addition of d-tartaric acid which acts as an accelerator aiding in the extraction of ions from the aluminosilicate glass and facilitates their binding to the polyanion chains. 21 Tartaric acid, also acts as a crosslinking agent in the matrix formation of GIC acting as a base in the setting reaction, thereby accelerating early maturation. This action depends on its concentration. Low concentrations accelerate the development of viscosity of the cement paste, while high concentrations retard it. Literature suggests that enhancement of physical properties of GIC occurs on the addition of 10% (w/w) tartaric acid. 21 At intermediate concentrations, tartaric acid has an interesting, uniquely favorable effect on setting characteristics. First, it induces a lag period in the setting process during which the viscosity of the cement paste remains constant. This lag period is followed by a sharp, almost exponential, increase in viscosity. Thus, tartaric acid is found to have a dual effect on setting, first inhibiting gelation and then accelerating it. The practical effect is to prolong working time and sharpen setting. A study conducted by Ahmadi Jaya Permana et al. found that addition of tartaric acid enhanced compressive strength of GIC and quoted similar reasons for it. 22 On assessing microleakage, it was found that NSF resin coat had the best results in the present study. However, the difference between G Coat plus group and NSF resin coat group was not statistically significant. NSF resin coat is a self-cured adhesive, hydrophilic resin which polymerises within 20 seconds of application to form a thin film over the restored GIC. It provides convenience of handling and prevents the probability of contamination. The low viscosity aids in sealing the microgaps in between the margins and restoration. The uniformly dispersed nano silver particles present in the coat may also protect the resinous coat from abrasive wear. Researchers claim that AgNPs are more potent in having bactericidal and bacteriostatic action than silica nano particles present in G Coat Plus. 22 The indigenious product used in the present study has additive antibacterial and fluoride releasing property. Application of nano silver fluoride resin coat will aid in halting the initiation secondary caries in the restored teeth by having an anti-plaque action. 23 A study conducted by Rekhalakshmi K. et al. compared the fluoride release after application of Petroleum jelly and G Coat plus, and stated that there was a remarkable decrease in the fluoride release after coating the tooth with G Coat Plus. 16 However, nano silver fluoride resin coat overcomes this shortcoming because of the presence of fluoride in it. It can provide a sustained fluoride release after application. The present study concluded that nano silver fluoride resin coat over Glass ionomer cement restoration demonstrated better mechanical properties than G Coat Plus and Petroleum jelly, within the limitations. Conclusion The novel surface protecting agent containing nano silver fluoride is a self-cured adhesive possessing antibacterial and fluoride releasing properties is thereby intended to augment the properties of glass ionomer cement. Data availability Underlying data Figshare: Comparative evaluation of surface microhardness and microleakage after application of petroleum jelly, commercially available G-Coat plus and Nano silver fluoride resin coat over Glass ionomer cement restoration: An in vitro study, https://doi.org/10.6084/m9.figshare.23290592.v1 . 24 This project contains the following underlying data: - Masterchart.xlsx (microhardness and microleakage) Figshare: Comparative evaluation of surface microhardness and microleakage after application of petroleum jelly, commercially available G-Coat plus and Nano silver fluoride resin coat over Glass ionomer cement restoration: An in vitro study, https://doi.org/10.6084/m9.figshare.23305895.v1 . 25 This project contains the following extended data: - tables.docx Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0). References 1. Kamatham R, Reddy S: Surface coatings on glass ionomer restorations in Pediatric dentistry-Worthy or not? J. Indian Soc. Pedod. Prev. Dent. 2013; 31 (4): 229–233. PubMed Abstract | Publisher Full Text 2. Wilson AD, Kent BE: A new translucent cement for dentistry: the glass ionomer cement. Br. Dent. J. 1972; 132 : 133–135. Publisher Full Text 3. Croll TP, Nicholson JW: Glass ionomer cement in pediatric dentistry - review of the literature. Pediatr. Dent. 2002; 24 : 423–429. PubMed Abstract 4. Mount GJ: Glass-ionomer cements: Past, present and future. Oper. Dent. 1994; 19 : 82–90. PubMed Abstract 5. Brito CR, Velasco LG, Bonini GAVC, et al. : Glass ionomer cement hardness after different materials for surface protection. J. Biomed. Mater. Res. A. 2009; 93A : 243–246. Publisher Full Text 6. Pilo R: The effect of resin coating on the shear punch strength of restorative glass ionomer cements. Clin. Oral Investig. 2017; 21 : 1079–1086. Publisher Full Text 7. Williams JA, Billington RW, Pearson GJ: Effect of moisture protective coatings on the strength of a modern metal reinforced glass ionomer cement. J. Oral Rehabil. 1998; 25 : 535–540. PubMed Abstract | Publisher Full Text 8. Barry TI, Clinton DJ, Wilson AD: The structure of a glass ionomer cement and its relationship to the setting process. J. Dent. Res. 1979; 58 : 1072–1079. PubMed Abstract | Publisher Full Text 9. Wilson AD, Mclean JW: Glass Ionomer Cements. Vol. 164 . . Chicago: Quintes Pub Co. Inc; 1988; pp. 293–300. Publisher Full Text 10. Earl MSA, Hume WR, Mount GJ: Effect of varnishes and other surface treatments on water movement across the glass ionomer cement surface. Aust. Dent. J. 1985; 30 : 298–301. Publisher Full Text 11. Valera V, Navarro MFL, Taga EM, et al. : Effect of nail varnishes and petroleum jelly combination on glass ionomer dye uptake. Am. J. Dent. 1997; 10 : 253–351. 12. Hattab FN, Amin WM: Fluoride release from glass ionomer restorative materials and the effects of surface coating. Biomaterials. 2001 Jun; 22 (12): 1449–1458. PubMed Abstract | Publisher Full Text 13. Mandikos MN, McGivney GP, Davis E, et al. : A comparison of the wear resistance and hardness of indirect composite resins. J. Prosthet. Dent. 2001; 85 : 386–395. PubMed Abstract | Publisher Full Text 14. Tantbirojn D, Versluis A, Cheng Y, et al. : Fracture toughness and microhardness of a composite: do they correlate? J. Dent. 2003; 31 : 89–95. PubMed Abstract | Publisher Full Text 15. Arthilakshmi VC, Annamalai S, Baghkomeh PN, et al. : Effect of protective coating on microleakage of conventional glass ionomer cement and resin-modified glass ionomer cement in primary molars: An in vitro study. Indian J. Dent. Res. 2018; 29 : 744–748. Publisher Full Text 16. Tyagi S, Thomas AM, Sinnappah-Kang ND: A comparative evaluation of resin- and varnish-based surface protective agents on glass ionomer cement – a spectrophotometric analysis. Biomater. Investig. Dent. 2020; 7 (1): 25–30. PubMed Abstract | Publisher Full Text | Free Full Text 17. Ninawe N: A comparative evaluation of microleakage of glass ionomer restoration with different surface protectors - an in-vitro study. DJAS. 2014; 02 (II): 105–108. Publisher Full Text 18. Bagheri R, Taha N, Azar M, et al. : Effect of G-Coat Plus on the mechanical properties of glass-ionomer cements. Aust. Dent. J. 2013 Dec; 58 (4): 448–453. PubMed Abstract | Publisher Full Text 19. Zhang K, Cheng L, Imazato S, et al. : Effects of dual antibacterial agents MDPB and nano-silver in primer on microcosm biofilm, cytotoxicity and dentine bond properties. J. Dent. 2013; 41 : 464–474. PubMed Abstract | Publisher Full Text | Free Full Text 20. Targino AGR, Flores MAP, dos Santos Junior VE , et al. : An innovative approach to treating dental decay in children. A new anti-caries agent. J. Mater. Sci. Mater. Med. 2014 Aug; 25 (8): 2041–2047. PubMed Abstract | Publisher Full Text 21. Crisp S: Reactions in Glass lonomer Cements: V. Effect of Incorporating Tartaric Acid in the Cement Liquid. J. Dent. Res. November-December 1976; 55 : 1023–1031. Publisher Full Text 22. Permana AJ: The Influence of Dicarboxylic Acids: Oxalic Acid And Tartaric Acid On The Compressive Strength Of Glass Ionomer Cements. Basic and Applied Sciences (ICOWOBAS 2015). 050003–050006. 23. Deulkar PV, Rathi N, Thosar N, et al. : Impact of sodium fluoride and nano silver fluoride-based varnishes on remineralisation of enamel caries: an in-vitro study [version 2; peer review: 1 approved with reservations]. F1000Res. 2023; 12 : 643. Publisher Full Text 24. Deulkar PV, Rathi N, Thosar N, et al. : Comparative evaluation of surface microhardness and microleakage after application of petroleum jelly, commercially available G-Coat plus and Nano silver fluoride resin coat over Glass ionomer cement restoration: An in vitro study. Dataset. figshare. 2023. Publisher Full Text 25. Deulkar PV, Rathi N, Bane S: Comparative evaluation of surface microhardness and microleakage after application of petroleum jelly, commercially available G-Coat plus and Nano silver fluoride resin coat over Glass ionomer cement restoration: An in vitro study. figshare. Figure. 2023. Publisher Full Text Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 16 Feb 2024 ADD YOUR COMMENT Comment Author details Author details 1 Assistant Professor, Department of Pediatric And Preventive Dentistry, Dr. D. Y. PATIL DENTAL COLLEGE AND HOSPITAL, PIMPRI, PUNE, Maharashtra, 411018, India 2 Professor and Head, Department of Pediatric And Preventive Dentistry, Dr. D. Y. PATIL DENTAL COLLEGE AND HOSPITAL, PIMPRI, PUNE, Maharashtra, 411018, India 3 Professor and Head, Department of Pediatric And Preventive Dentistry, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, 441207, India 4 Assistant Professor, Department of Periodontology and Implantology, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, 441207, India Dr. Pranjali Vilas Deulkar Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Dr. Nilesh V Rathi Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Dr Nilima Thosar Roles: Conceptualization, Data Curation, Formal Analysis, Resources, Software, Supervision, Validation, Visualization Dr Chitrika Subhadarsanee Roles: Formal Analysis, Resources, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (1) version 1 Published: 16 Feb 2024, 13:99 https://doi.org/10.12688/f1000research.140417.1 Copyright © 2024 Deulkar DPV et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Deulkar DPV, Rathi DNV, Thosar DN and Subhadarsanee DC. Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.12688/f1000research.140417.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 1 VERSION 1 PUBLISHED 16 Feb 2024 Views 0 Cite How to cite this report: Abbas MJ. Reviewer Report For: Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.5256/f1000research.153764.r292768 ) The direct URL for this report is: https://f1000research.com/articles/13-99/v1#referee-response-292768 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 09 Jul 2024 Maha Jamal Abbas , pedodontic-orthodontic-prevention department, Mustansiryah University, hay al jamma, Baghdad, Iraq Approved VIEWS 0 https://doi.org/10.5256/f1000research.153764.r292768 Dear authors, The subject of the study is interesting that deals with efficacy of newly formulated nano silver fluoride resin coat with G Coat Plus and petroleum jelly on microhardness and microleakage of Type IX GIC. This ... Continue reading READ ALL Dear authors, The subject of the study is interesting that deals with efficacy of newly formulated nano silver fluoride resin coat with G Coat Plus and petroleum jelly on microhardness and microleakage of Type IX GIC. This study investigates the effects of G-Coat Plus, nano silver fluoride resin coat, and petroleum jelly on the microhardness and microleakage of Type IX glass ionomer cement restorations. The article's strength lies in its relevant and timely exploration of new treatments for enhancing restoration durability. Major strengths include the comprehensive methodology and clear presentation of results. However, minor weaknesses include referencing issues in the introduction and methodology sections. Summary of Findings : The findings indicate that all three coatings influence the surface properties of the glass ionomer cement, with varying impacts on microhardness and microleakage. The study concludes with recommendations for further research and clinical implications. Title: The title is so long so the title prefers as following: Comparative Evaluation of Surface Microhardness and Microleakage in Glass Ionomer Cement Restorations Treated with G-Coat Plus, Nano Silver Fluoride Resin Coat, and Petroleum Jelly: An In Vitro Study The abstract a study of high clinical relevance and the methodology adequately answers the initial question. I suggest a minor review Introduction: Line 6-14 need reference Line 14-18 need reference Material and method: Sample size was calculated using the following formula: n= (Zα+Zβ)[P1(1−P1)+P2(1−P2)](P1−P2)2 need more explanation about formula for other researcher Conclusion: The conclusion needs to be rewritten because it does not reflect the research results as it did not mention the results about microhardness and microleakage. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Partly Are the conclusions drawn adequately supported by the results? No Competing Interests: No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Abbas MJ. Reviewer Report For: Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.5256/f1000research.153764.r292768 ) The direct URL for this report is: https://f1000research.com/articles/13-99/v1#referee-response-292768 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Suprabha BS. Reviewer Report For: Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.5256/f1000research.153764.r268024 ) The direct URL for this report is: https://f1000research.com/articles/13-99/v1#referee-response-268024 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 05 Jun 2024 Baranya Shrikrishna Suprabha , Manipal College of Dental Sciences Mangalore, Mangalore, India Not Approved VIEWS 0 https://doi.org/10.5256/f1000research.153764.r268024 1. Introduction: reference not provided for the details on nano silver fluoride 2. Methods: A. For the sample size, instead of the formula, the assumptions on the effect size and/or error margin, power and confidence interval should be stated ... Continue reading READ ALL 1. Introduction: reference not provided for the details on nano silver fluoride 2. Methods: A. For the sample size, instead of the formula, the assumptions on the effect size and/or error margin, power and confidence interval should be stated in a sentence. B. Brand name, Company name, place and country details to be specified for all the products used in the study, including the Stereomicroscope and the Vicker Hardness Tester. C. What type of GIC was used for restorations prepared for microleakage testing? Details on manipulation of the material needs to be explained. Similarly specify details of the GIC used for microhardness measurement D. The authors claim that "Nano silver fluoride coat" is novel. How was the solution prepared? Details on its composition required. E. How do authors justify using the term "microhardness" over "hardness" based on the procedure used for testing? F. Details of the statistical methods used not provided. How was the percentage of the microleakage arrived at? The scoring criteria used suggests it to be nominal data. Specify the software used for statistical analysis. G. How was the reliability of the readings ascertained for microleakage and microhardness assessment? Was the assessor blinded to the groups? 3. Results: should be in past tense at all places. Please check and correct the write up under Table 1 for the correct tense. The result write up for microhardness contradicts the tables: It should be corrected as "There was statistically significant difference between Group 1 and 2, Group 1 and 3 for microhardness with no statistically significant difference between Groups 2 and 3." Page 5 Last paragraph: " This can be attributed to the even dispersion of nanofillers" Specify what " This" means here. 4. Discussion: what do authors mean by "indigenous product" in reference to the nano silver fluoride? What is the basis for this: "However, nano silver fluoride resin coat overcomes this shortcoming because of the presence of fluoride in it." Provide a reference. Provide literature evidence for fluoride release after nano silver fluoride coat. What are the suggestions for future research based on the current study results? What are the study limitations? Conclusion is not in accordance with the study objective/ study results. Please change in both abstract and main text. Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? Partly Are sufficient details of methods and analysis provided to allow replication by others? Partly If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? No Competing Interests: No competing interests were disclosed. Reviewer Expertise: Pediatric and Preventive Dentistry I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Suprabha BS. Reviewer Report For: Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.5256/f1000research.153764.r268024 ) The direct URL for this report is: https://f1000research.com/articles/13-99/v1#referee-response-268024 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Vilela H. Reviewer Report For: Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.5256/f1000research.153764.r268023 ) The direct URL for this report is: https://f1000research.com/articles/13-99/v1#referee-response-268023 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 29 Apr 2024 Handially Vilela , Universidade de São Paulo, São Paulo, Brazil Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.153764.r268023 The authors proposed a study of high clinical relevance and the methodology adequately answers the initial question. I suggest a minor review: INTRODUCTION • In the statement: “However, recent literature evaluating the efficacy of G-Coat Plus ... Continue reading READ ALL The authors proposed a study of high clinical relevance and the methodology adequately answers the initial question. I suggest a minor review: INTRODUCTION • In the statement: “However, recent literature evaluating the efficacy of G-Coat Plus states that its application over GIC severely impedes its fluoride releasing property”, what is the reference? • “Nano silver fluoride is a unique material with amalgamation of silver and fluoride, making it an antibacterial and remineralizing agent.” What is the reference? There are studies proving that the release of fluoride from glass ionomer cement, as it is low, does not act as a remineralizing agent. It works by hindering the demineralization process. I understand that this contradiction present in the literature should be mentioned in the text. I suggest the following articles demonstrating the failure of glass ionomer cement in the remineralization process [Ref 1,2] METHODOLOGY • It would be interesting to add an illustration to the topic “Microleakage assessment”. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes References 1. Kim YK, Yiu CK, Kim JR, Gu L, et al.: Failure of a glass ionomer to remineralize apatite-depleted dentin. J Dent Res . 2010; 89 (3): 230-5 PubMed Abstract | Publisher Full Text 2. Vilela HS, Trinca RB, Alves TVM, Scaramucci T, et al.: Effect of a calcium silicate cement and experimental glass ionomer cements containing calcium orthophosphate particles on demineralized dentin. Clin Oral Investig . 2024; 28 (1): 97 PubMed Abstract | Publisher Full Text Competing Interests: No competing interests were disclosed. Reviewer Expertise: Remineralization dentin / Glass ionomer cement I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Vilela H. Reviewer Report For: Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.5256/f1000research.153764.r268023 ) The direct URL for this report is: https://f1000research.com/articles/13-99/v1#referee-response-268023 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 16 Feb 2024 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 3 Version 1 16 Feb 24 read read read Handially Vilela , Universidade de São Paulo, São Paulo, Brazil Baranya Shrikrishna Suprabha , Manipal College of Dental Sciences Mangalore, Mangalore, India Maha Jamal Abbas , Mustansiryah University, hay al jamma, Iraq Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Abbas M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 09 Jul 2024 | for Version 1 Maha Jamal Abbas , pedodontic-orthodontic-prevention department, Mustansiryah University, hay al jamma, Baghdad, Iraq 0 Views copyright © 2024 Abbas M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Dear authors, The subject of the study is interesting that deals with efficacy of newly formulated nano silver fluoride resin coat with G Coat Plus and petroleum jelly on microhardness and microleakage of Type IX GIC. This study investigates the effects of G-Coat Plus, nano silver fluoride resin coat, and petroleum jelly on the microhardness and microleakage of Type IX glass ionomer cement restorations. The article's strength lies in its relevant and timely exploration of new treatments for enhancing restoration durability. Major strengths include the comprehensive methodology and clear presentation of results. However, minor weaknesses include referencing issues in the introduction and methodology sections. Summary of Findings : The findings indicate that all three coatings influence the surface properties of the glass ionomer cement, with varying impacts on microhardness and microleakage. The study concludes with recommendations for further research and clinical implications. Title: The title is so long so the title prefers as following: Comparative Evaluation of Surface Microhardness and Microleakage in Glass Ionomer Cement Restorations Treated with G-Coat Plus, Nano Silver Fluoride Resin Coat, and Petroleum Jelly: An In Vitro Study The abstract a study of high clinical relevance and the methodology adequately answers the initial question. I suggest a minor review Introduction: Line 6-14 need reference Line 14-18 need reference Material and method: Sample size was calculated using the following formula: n= (Zα+Zβ)[P1(1−P1)+P2(1−P2)](P1−P2)2 need more explanation about formula for other researcher Conclusion: The conclusion needs to be rewritten because it does not reflect the research results as it did not mention the results about microhardness and microleakage. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Partly Are the conclusions drawn adequately supported by the results? No Competing Interests No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Abbas MJ. Peer Review Report For: Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.5256/f1000research.153764.r292768) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-99/v1#referee-response-292768 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Suprabha B. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 05 Jun 2024 | for Version 1 Baranya Shrikrishna Suprabha , Manipal College of Dental Sciences Mangalore, Mangalore, India 0 Views copyright © 2024 Suprabha B. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Not Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions 1. Introduction: reference not provided for the details on nano silver fluoride 2. Methods: A. For the sample size, instead of the formula, the assumptions on the effect size and/or error margin, power and confidence interval should be stated in a sentence. B. Brand name, Company name, place and country details to be specified for all the products used in the study, including the Stereomicroscope and the Vicker Hardness Tester. C. What type of GIC was used for restorations prepared for microleakage testing? Details on manipulation of the material needs to be explained. Similarly specify details of the GIC used for microhardness measurement D. The authors claim that "Nano silver fluoride coat" is novel. How was the solution prepared? Details on its composition required. E. How do authors justify using the term "microhardness" over "hardness" based on the procedure used for testing? F. Details of the statistical methods used not provided. How was the percentage of the microleakage arrived at? The scoring criteria used suggests it to be nominal data. Specify the software used for statistical analysis. G. How was the reliability of the readings ascertained for microleakage and microhardness assessment? Was the assessor blinded to the groups? 3. Results: should be in past tense at all places. Please check and correct the write up under Table 1 for the correct tense. The result write up for microhardness contradicts the tables: It should be corrected as "There was statistically significant difference between Group 1 and 2, Group 1 and 3 for microhardness with no statistically significant difference between Groups 2 and 3." Page 5 Last paragraph: " This can be attributed to the even dispersion of nanofillers" Specify what " This" means here. 4. Discussion: what do authors mean by "indigenous product" in reference to the nano silver fluoride? What is the basis for this: "However, nano silver fluoride resin coat overcomes this shortcoming because of the presence of fluoride in it." Provide a reference. Provide literature evidence for fluoride release after nano silver fluoride coat. What are the suggestions for future research based on the current study results? What are the study limitations? Conclusion is not in accordance with the study objective/ study results. Please change in both abstract and main text. Is the work clearly and accurately presented and does it cite the current literature? Partly Is the study design appropriate and is the work technically sound? Partly Are sufficient details of methods and analysis provided to allow replication by others? Partly If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? No Competing Interests No competing interests were disclosed. Reviewer Expertise Pediatric and Preventive Dentistry I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. reply Respond to this report Responses (0) Suprabha BS. Peer Review Report For: Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.5256/f1000research.153764.r268024) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-99/v1#referee-response-268024 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Vilela H. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions. 29 Apr 2024 | for Version 1 Handially Vilela , Universidade de São Paulo, São Paulo, Brazil 0 Views copyright © 2024 Vilela H. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions. format_quote Cite this report speaker_notes Responses (0) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The authors proposed a study of high clinical relevance and the methodology adequately answers the initial question. I suggest a minor review: INTRODUCTION • In the statement: “However, recent literature evaluating the efficacy of G-Coat Plus states that its application over GIC severely impedes its fluoride releasing property”, what is the reference? • “Nano silver fluoride is a unique material with amalgamation of silver and fluoride, making it an antibacterial and remineralizing agent.” What is the reference? There are studies proving that the release of fluoride from glass ionomer cement, as it is low, does not act as a remineralizing agent. It works by hindering the demineralization process. I understand that this contradiction present in the literature should be mentioned in the text. I suggest the following articles demonstrating the failure of glass ionomer cement in the remineralization process [Ref 1,2] METHODOLOGY • It would be interesting to add an illustration to the topic “Microleakage assessment”. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes References 1. Kim YK, Yiu CK, Kim JR, Gu L, et al.: Failure of a glass ionomer to remineralize apatite-depleted dentin. J Dent Res . 2010; 89 (3): 230-5 PubMed Abstract | Publisher Full Text 2. Vilela HS, Trinca RB, Alves TVM, Scaramucci T, et al.: Effect of a calcium silicate cement and experimental glass ionomer cements containing calcium orthophosphate particles on demineralized dentin. Clin Oral Investig . 2024; 28 (1): 97 PubMed Abstract | Publisher Full Text Competing Interests No competing interests were disclosed. Reviewer Expertise Remineralization dentin / Glass ionomer cement I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (0) Vilela H. Peer Review Report For: Comparative evaluation of surface microhardness and microleakage after application of commercially available G-Coat Plus, nano silver fluoride resin coat and petroleum jelly over glass ionomer cement restoration: an in vitro study [version 1; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2024, 13 :99 ( https://doi.org/10.5256/f1000research.153764.r268023) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-99/v1#referee-response-268023 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. 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