Az adhaesioképződés mechanizmusa és modellezésének lehetőségei – Előkísérleti modellek

G Szabó, Mohamed Gamal El‐Din, Eldin Mohamed Gamal, József Sándor, Andrea Ferencz, Bernadett Lévay, Domokos Csukás, Titanilla Dankó, György Wéber
In: Magyar Sebészet · 2013 · vol. 66(5) , pp. 263–269 · doi:10.1556/maseb.66.2013.5.6 · PMID:24144819 · W1924407634
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Abstract

A huge number of factors play a significant role in the process of adhesion formation, like bleeding, the presence of foreign bodies, tissue injury, tissue destruction, ischemia and hypoxia. Adhesions are present in 95% of the cases following abdominal surgery. As a result of adhesions a large number of postoperative complications can occur, such as abdominal pain, bowel motility disturbances and infertility. Hence, it is important to know the precise mechanism of adhesion formation process and establish a suitable animal model to investigate the underlying mechanisms. Molecules which play a part in the process of adhesion formation were collected from the international literature. Male Wistar rats were used to create the adhesion model. Bleeding, implantation of foreign bodies, creation of ischemic areas and tissue destructions were carried out. Within this experiment the tiny bleeding and ischemic areas did not result in adhesion formation. The adhesion formation due to foreign body implantation depends on the type of the materials. Due to the inhibitory mechanism of adhesion formation there was no adhesion detectable due to tiny peritoneal destruction. The most reliable model was the one when gross tissue destruction of the abdominal wall was applied and the resulting bleeding initiated the adhesion formation process. It is also extremely important to know the key participants in the complex process of adhesion formation. This reliable model can help to work out the proper method of prevention.

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