A Case of Severe Ovarian Hyperstimulation Syndrome

Moushumi Lodh, Jheelam Mukhopadhyay, Vikas Sharma
In: Indian Journal of Clinical Biochemistry · 2013 · vol. 29(3) , pp. 386–389 · doi:10.1007/s12291-013-0390-4 · PMID:24966492 · W2057149489
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This case report describes a 35-year-old patient who presented with severe ovarian hyperstimulation syndrome, characterized by abdominal pain, ascites, respiratory distress, and amenorrhea following embryo transfer, and was managed symptomatically.

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Abstract

Ovulation induction has been an important mode of treatment of infertility. Ovarian stimulation may result in a supraphysiologic response leading to an iatrogenic complication known as the ovarian hyperstimulation syndrome (OHSS). This syndrome is potentially a lethal condition, the pathophysiologic hallmark of which is the accumulation of massive extravascular exudate combined with profound intravascular volume depletion and hemoconcentration. We report a case of severe OHSS with very large ovaries in a 35 year old case of embryo transfer. The patient presented to the emergency department with abdominal pain, massive ascites, respiratory distress and amenorrhea. The patient was managed symptomatically with no complications. Although ovarian hyperstimulation is a rare entity, it is important that the physician recognizes this condition. Prompt diagnosis and successful management is likely to avoid serious and rapid development of complications.

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