Emerging Antimicrobial Peptides as Novel Agents in Combating Drug-Resistant Pathogens

Emerging Antimicrobial Peptides as Novel Agents in Combating Drug-Resistant Pathogens | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 7 March 2025 V1 Latest version Share on Emerging Antimicrobial Peptides as Novel Agents in Combating Drug-Resistant Pathogens Authors : Fei Yang and Qi Ma 0009-0006-9798-8060 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174133992.21020497/v1 139 views 72 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The phenomenon of antimicrobial resistance (AMR) has reached a critical point, threatening to render traditional antibiotics ineffective and jeopardizing decades of medical progress. At the same time, in the context of the novel coronavirus pneumonia (COVID-19) pandemic, the majority of patients receive antimicrobial treatments that may not be indicated, which may also exacerbate drug-resistant infections globally. Antimicrobial peptides (AMPs) have emerged as a promising alternative, heralding a new era in the fight against drug-resistant infections. This review provides a comprehensive overview of AMPs, demonstrating their potential to revolutionize antimicrobial therapies through unique mechanisms of action that are quite different from those of conventional antibiotics. This review provides insights into the mechanism of action of AMPs and briefly enumerates the clinical applications of AMPs. It focuses on the advances made in peptide engineering to enhance AMPs efficacy, stability and delivery. It also discusses the efficacy of AMPs against pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), mucin-resistant Escherichia coli and multidrug-resistant tuberculosis (MDR-TB). This reveals their potential to overcome current antimicrobial therapy. Furthermore, this review examines the challenges associated with the development of AMPs for clinical use, including issues related to toxicity, stability, and drug resistance. It also outlines strategies to reduce these barriers. Finally, it emphasizes the importance of innovation, interdisciplinary research, and global collaboration to advance AMPs development. Through research, AMPs will be the cornerstone of the ongoing development of antimicrobial therapies, offering hope for addressing the looming threat of drug-resistant infections. Supplementary Material File (emerging antimicrobial peptides as novel agents in combating drug-resistant pathogens.docx) Download 615.78 KB Information & Authors Information Version history V1 Version 1 07 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords antibiotic resistance lantibiotics Authors Affiliations Fei Yang Binzhou Medical University - Yantai Campus View all articles by this author Qi Ma 0009-0006-9798-8060 [email protected] Binzhou Medical University - Yantai Campus View all articles by this author Metrics & Citations Metrics Article Usage 139 views 72 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Fei Yang, Qi Ma. Emerging Antimicrobial Peptides as Novel Agents in Combating Drug-Resistant Pathogens. Authorea . 07 March 2025. DOI: https://doi.org/10.22541/au.174133992.21020497/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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