Pharmacologic Interventions for Endometriosis-Related Pain: A Systematic Review and Meta-analysis

Liqiu Kou, Chien-Jung Huang, Changyou Huang, Di Xiao, Songjie Liao, Yaling Li, Qing Wang
In: Obstetrical & Gynecological Survey · 2025 · vol. 80(11) , pp. 697–699 · doi:10.1097/ogx.0000000000001460 · PMID:41194364 · W4415946561
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This systematic review and meta-analysis evaluated pharmacologic interventions for endometriosis-related pain, synthesizing evidence on their effectiveness.

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This systematic review and meta-analysis evaluates pharmacologic interventions for managing pain associated with endometriosis, a condition affecting 10 to 15 percent of reproductive-age women. The study synthesizes evidence on treatments aimed at alleviating symptoms such as cyclical abdominal pain, dyspareunia, and excessive menstruation. It highlights the clinical burden of these symptoms and emphasizes the importance of effective management strategies to improve patient quality of life and reproductive health outcomes. This paper is centrally about endometriosis — specifically focusing on pharmacologic pain management strategies for the condition.

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Abstract

(Abstracted from Obstet Gynecol 2025;146(2):e23-e35) An estimated 10% to 15% of women who are of reproductive age are affected by endometriosis, defined as abnormal growth of endometrium-like tissue outside of the uterus. Symptoms can include cyclical or noncyclical abdominal pain, pain during intercourse, excessive menstruation, infertility, and others.
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Department of Pharmacy, Zigong Maternal and Child Health Care Hospital, Zigong; and Department of Pharmacy, The Affiliated Hospital of Southwest Medical University; and School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China (Abstracted from Obstet Gynecol 2025;146(2):e23–e35) An estimated 10% to 15% of women who are of reproductive age are affected by endometriosis, defined as abnormal growth of endometrium-like tissue outside of the uterus. Symptoms can include cyclical or noncyclical abdominal pain, pain during intercourse, excessive menstruation, infertility, and others. Plain Language SummaryEndometriosis is a condition affecting 10% to 15% of women of reproductive age, where tissue similar to the lining inside the uterus grows outside it. This can lead to various symptoms such as abdominal pain, painful intercourse, heavy periods, and infertility. Understanding these symptoms is crucial for diagnosis and management, as they can significantly impact a woman's quality of life and reproductive health. Text is machine generated and may contain inaccuracies. FAQ

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endometriosisinfertility

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last seen: 2026-06-10T17:14:06.276822+00:00
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