The nationwide SoPsy-Depression cohort: study rationale, design, and baseline patient characteristics

The nationwide SoPsy-Depression cohort: study rationale, design, and baseline patient characteristics | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The nationwide SoPsy-Depression cohort: study rationale, design, and baseline patient characteristics Héloïse Rach, Julia Maruani, Renaud Cornic, Stéphanie Bioulac, and 16 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-9347007/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Depressive disorders are among the most prevalent and disabling psychiatric conditions, affecting up to 20% of the general population. Diagnosis still relies on clinical evaluation, and efforts to identify robust biomarkers are limited by the marked phenotypic heterogeneity of depressive disorders. Sleep and circadian disturbances are highly prevalent in major depressive episode (MDE) and represent promising candidate markers, yet their characterization across depressive subtypes remains incomplete. The SoPsy-Depression cohort is a nationwide, prospective, multicenter study designed to harmonize multimodal assessment of sleep and circadian alterations across depressive disorders in routine care. The cohort aims to enroll more than 1000 participants (adults and children) with a current MDE over 10 years across an expanding network of French psychiatric and sleep centres. A Delphi consensus established a standardized set of clinician-administered and self-report questionnaires assessing psychiatric symptoms, sleep, circadian rhythms and substance use. Subjective measures are complemented by objective assessments including actigraphy, polysomnography and biological circadian markers. This report presents the study rationale, design and first descriptive data after two years of inclusion. As of November 2025, 158 participants were enrolled (82% unipolar, 18% bipolar). Completion rates for adult mandatory questionnaires currently approach 70%. Preliminary data reveal high rates of insomnia, hypersomnia, poor sleep quality and psychiatric comorbidities. Objective sleep measures suggest alterations in sleep continuity and circadian patterns, consistent with previous reports in depression. The SoPsy-Depression cohort demonstrates the feasibility of large-scale harmonized multimodal assessment of sleep and circadian disturbances and provides a framework to identify clinically meaningful profiles across depressive phenotypes. Major depressive episode Sleep disturbances Circadian rhythms Cohort study Biomarkers Precision psychiatry Full Text Additional Declarations Tables 1 to 7 are available in the Supplementary Files section. Supplementary Files Table1.pdf Table2.pdf Table3.pdf Table4.pdf Table5.pdf Table6.pdf Table7.pdf TableS1.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-9347007","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":622046384,"identity":"2a3af37e-170c-4726-b803-30aab0558599","order_by":0,"name":"Héloïse 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Precision psychiatry","lastPublishedDoi":"10.21203/rs.3.rs-9347007/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-9347007/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Depressive disorders are among the most prevalent and disabling psychiatric conditions, affecting up to 20% of the general population. Diagnosis still relies on clinical evaluation, and efforts to identify robust biomarkers are limited by the marked phenotypic heterogeneity of depressive disorders. Sleep and circadian disturbances are highly prevalent in major depressive episode (MDE) and represent promising candidate markers, yet their characterization across depressive subtypes remains incomplete. The SoPsy-Depression cohort is a nationwide, prospective, multicenter study designed to harmonize multimodal assessment of sleep and circadian alterations across depressive disorders in routine care. The cohort aims to enroll more than 1000 participants (adults and children) with a current MDE over 10 years across an expanding network of French psychiatric and sleep centres. A Delphi consensus established a standardized set of clinician-administered and self-report questionnaires assessing psychiatric symptoms, sleep, circadian rhythms and substance use. Subjective measures are complemented by objective assessments including actigraphy, polysomnography and biological circadian markers. This report presents the study rationale, design and first descriptive data after two years of inclusion. As of November 2025, 158 participants were enrolled (82% unipolar, 18% bipolar). Completion rates for adult mandatory questionnaires currently approach 70%. Preliminary data reveal high rates of insomnia, hypersomnia, poor sleep quality and psychiatric comorbidities. Objective sleep measures suggest alterations in sleep continuity and circadian patterns, consistent with previous reports in depression. The SoPsy-Depression cohort demonstrates the feasibility of large-scale harmonized multimodal assessment of sleep and circadian disturbances and provides a framework to identify clinically meaningful profiles across depressive phenotypes.","manuscriptTitle":"The nationwide SoPsy-Depression cohort: study rationale, design, and baseline patient characteristics","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-04-20 05:16:19","doi":"10.21203/rs.3.rs-9347007/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"d38d05e7-b70b-4411-a0d5-fcda672467aa","owner":[],"postedDate":"April 20th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-04-24T12:44:23+00:00","versionOfRecord":[],"versionCreatedAt":"2026-04-20 05:16:19","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-9347007","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-9347007","identity":"rs-9347007","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}