Reproductive hormonal changes and catamenial pattern in adolescent females with epilepsy

Hamed A. El‐Khayat, Hamed A El-Khayat, Nancy A Soliman, Nancy Soliman, Hoda Tomoum, Hoda Y Tomoum, Maher A. Omran, Amany S El-Wakad, Amany S. El‐Wakad, Rania H Shatla, Rania Shatla
Epilepsia · 2008 · vol. 49(9) , pp. 1619–1626 · doi:10.1111/j.1528-1167.2008.01622.x · PMID:18435756 · W2060862028
Observational OA: bronze CC0 ⤵ 6 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-11 ⓘ

Epilepsy disrupted reproductive hormones in adolescent females, showing lower FSH and progesterone and a higher E/P ratio, with 31% exhibiting catamenial seizure patterns linked to progesterone withdrawal.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

PURPOSE: We aimed to evaluate the effect of epilepsy on the reproductive hormones levels among female patients, and to investigate the frequency of catamenial pattern of seizures. METHODS: A total of 42 female patients with epilepsy and 21 healthy females (control group) were included. Subjects were at least 2 years postmenarche with regular cycles. Symptoms of premenstrual syndrome (PMS) were assessed using calendar of premenstrual experience scoring. Patients were evaluated for catamenial pattern of seizures. Levels of FSH, LH, estradiol (E), and progesterone (P) were assessed for all subjects in the three phases of the cycles. Pelvi-abdominal ultrasound was performed near time of ovulation, to follow up size of mature follicle. RESULTS: Symptoms of PMS were not different in patients and controls, or in patients with and those without catamenial tendency. In both perimenstrual (M) and midluteal phases, FSH and P levels were lower and E/P ratio higher in patients group. There was a catamenial pattern of seizures in 31% of patients (53.8% M C(1); 46.15% inadequate luteal phase C(3)pattern). Patients with C(3)pattern showed lower P levels in the midluteal phase compared to patients with noncatamenial pattern, to those with C(1)pattern or to controls. Patients with C(1)pattern had lower P levels than controls in the M phase. CONCLUSION: There was evident disruption in the reproductive hormones in female patients with epilepsy with lower FSH and P levels and higher E/P ratio. A total of 31% of patients showed catamenial pattern of seizures (C(1)and C(3)patterns) that was significantly related to P withdrawal.

My notes (saved in your browser only)

MeSH descriptors

Epilepsy Estradiol Follicle Stimulating Hormone Luteinizing Hormone Progesterone Adolescent Electroencephalography Epilepsy Epilepsy Estradiol Female Follicle Stimulating Hormone Humans Luteinizing Hormone Progesterone Reproduction

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

Cited by (4)

References (38)

Cited by (4)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T21:05:19.467219+00:00
License: CC0 · commercial use OK