PENGARUH PEMBERIAN EKSTRAK MENIRAN (Phyllanthus niruri L.) TERHADAP EKSPRESI IGF-1 DAN KETEBALAN ENDOMETRIUM PADA MENCIT (Mus musculus) BETINA MODEL ENDOMETRIOSIS

EKA DEVIANY WIDYAWATY, 011524653001
2018 · W7042444642
dissertation OA: green CC0
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This study investigated the effects of Phyllanthus niruri L. extract on Insulin-like Growth Factor 1 (IGF-1) expression and endometrial thickness in a murine model of endometriosis. Female mice with induced endometriosis were divided into control and treatment groups receiving varying doses of the extract, with outcomes assessed via immunohistochemistry and histological staining after fourteen days of administration. The results demonstrated that the extract significantly increased both IGF-1 expression and endometrial thickness compared to the control group, suggesting a potential therapeutic role for the flavonoid-rich herb in mitigating implantation issues associated with low IGF-1 levels. This paper is centrally about endometriosis, specifically examining the impact of herbal intervention on endometrial parameters in an animal model of the disease.

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Abstract

Latar belakang : Endometriosis menyebabkan 10-15% dari nyeri panggul dan \ninfertilitas pada wanita usia reproduksi. Pada penderita endometriosis, terjadi \npenurunan ekspresi IGF-1 yang berpengaruh pada gangguan implantasi. Meniran \nyang mengandung flavonoid berguna sebagai menghambat inflamasi yang terjadi. \nTujuan : Untuk mengetahui pengaruh pemberian ekstrak (Phyllanthus niruri L.) \nterhadap ekspresi IGF-1 dan ketebalan endometrium pada mencit (Mus musculus) \nbetina model endometriosis. \nBahan dan cara : Sampel penelitian ini adalah mencit (Mus Musculus) betina \nmodel endometriosis yang dibagi menjadi 4 kelompok (1 kelompok kontrol dan 3 \nkelompok perlakuan). Pada hari ke-15, Kelompok Kontrol (K1) diberi Na CMC \n0,5 %, Kelompok perlakuan diberi ekstrak meniran (Phyllanthus niruri L.) dengan \ndosis 14 mg/20gBB, 28 mg/20gBB dan 56 mg/20gBB. Pada hari ke-29 dilakukan \npembedahan dan pengambilan sampel endometrium dengan pemeriksaan \nimunohistokia pada ekspresi IGF-1 dan pewarnaan Hematoxylin-eosin pada \nketebalan endometrium. \nHasil : Uji statistik menunjukkan bahwa ada pengaruh pemberian ekstrak meniran \n(Phyllantinus niruri L.) terhadap ekspresi IGF-1 dengan nilai p = 0,041 < 0,05 dan \nada pengaruh pemberian ekstrak meniran (Phyllantinus niruri L.) terhadap \nketebalan endometrium dengan nilai p = 0,021 < 0,05. \nKesimpulan : Pemberian ekstrak meniran (Phyllanthus niruri L.) pada mencit \n(Mus musculus) betina model endometriosis dapat meningkatkan ekspresi IGF-1 \ndan ketebalan endometriosis.
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Abstract

EFFECT EXTRACT OF MENIRAN (Phyllanthus niruri L.) ON EXPRESSION OF IGF-1 AND ENDOMETRIAL THICKNESS IN FEMALE MICE (Mus musculus) OF ENDOMETRIOSIS MODEL Eka Deviany Widyawaty

Background

Endometriosis were caused 10-15% of pelvic pain and infertility in women of reproductive age. In patients with endometriosis, there is a decrease in IGF-1 expression that affects implantation. Meniran containing flavonoids was useful as inhibiting inflammation.

Objective

determined the effect of meniran (Phyllantinus ni ruri L.) extract on expression of IGF-1 and endometrial thickness female mice ( Mus musculus ) model of endometriosis.

Materials and methods

The sample of this study were mice ( Mus Musculus ) female endometriosis models which were divided into 4 groups (1 c ontrol group and 3 treatment groups). On the 15 th day, the Control Group (K1) was given Na CMC 0.5%, the treatment group were given meniran extract at dose of 14 mg / 20gBW, 28 mg / 20gBW and 56 mg / 20gBW . On day 29 th, surgery and endometrial sampling wer e performed with immunohistochemistry on expression of IGF-1 and colouring Hematoxylin-eosin on endometrial thickness.

Results

Statistical test showed that there was an effect of meniran (Phyllantinus niruri L.) extract on expression of IGF-1 with p value = 0.041 <0.05 and there was an effect of meniran (Phyllantinus niruri L.) extract dose level of endometrial thickness with a value of p = 0.021 <0.05.

Conclusion

meniran (Phyllantinus niruri L.) extract dosage increased in female mice (Mus musculus) model of endometriosis can increase d expression of IGF-1 and endometrial thickness.

Keywords

meniran extract, expression of IGF-1, endometrial thickness IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH PEMBERIAN EKSTRAK ... EKA DEVIANY W.

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Condition tags

endometriosis

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