Downregulation of SPOCK2 promotes the proliferation, adhesion, and invasion of endometrial epithelial cells

Fang Ren; Yizi Wang; Peng Chen; Cuishan Guo

doi:10.1080/09513590.2020.1812567

Downregulation of SPOCK2 promotes the proliferation, adhesion, and invasion of endometrial epithelial cells

Fang Ren, Yizi Wang, Peng Chen, Cuishan Guo

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2020 · vol. 37(3) , pp. 273–277 · doi:10.1080/09513590.2020.1812567 · PMID:32851893 · W3081055234

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Abstract

PURPOSE: A previous study found that a lack of SPOCK2 expression was an early event that occurs during the malignant transformation of endometriosis (EMS); however, the role played by SPOCK2 in the pathogenesis of endometriosis and its malignant transformation remains unclear. MATERIALS AND METHODS: In this study, SPOCK2 expression in human endometrial epithelial cells (hEECs) was downregulated by transfection with shRNA, and the biological behavior of the transfected cells was observed. RESULTS: We found that downregulation of SPOCK2 promoted cell proliferation, adhesion, and invasion. CONCLUSIONS: Our data suggest that downregulation of SPOCK2 might participate in the pathogenesis and progression of EMS, as well as its malignant transformation, by promoting the proliferation, adhesion, and invasion of endometrial epithelial cells.

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Condition tags

endometriosis

MeSH descriptors

Endometrium Epithelial Cells Proteoglycans Cell Adhesion Cell Adhesion Cell Movement Cell Movement Cell Proliferation Cell Proliferation Cells, Cultured Down-Regulation Down-Regulation Endometrium Endometrium Epithelial Cells Female Humans Matrix Metalloproteinase 2 Matrix Metalloproteinase 2 Matrix Metalloproteinase 2

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Cites (3)

References (8)

Bias versus causality: interpreting recent evidence of association between endometriosis and ovarian cancer via openalex
[Epigenetic inactivation of SPOCK2 in the malignant transformation of ovarian endometriosis]. via openalex
miR-194-3p Represses the Progesterone Receptor and Decidualization in Eutopic Endometrium From Women With Endometriosis via openalex
W2143573041 via openalex
W2146166948 via openalex
W2085207827 via openalex
W2559244128 via openalex
W2758430588 via openalex

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License: CC0 · commercial use OK

[1] miR-194-3p Represses the Progesterone Receptor and Decidualization in Eutopic Endometrium From Women With Endometriosis 2018

[2] Bias versus causality: interpreting recent evidence of association between endometriosis and ovarian cancer 2007

[3] [Epigenetic inactivation of SPOCK2 in the malignant transformation of ovarian endometriosis]. 2011