Clinical Value of Early-pregnancy Glycated Hemoglobin, Fasting Plasma Glucose, and Body Mass Index in Screening Gestational Diabetes Mellitus

Objective: To investigate the clinical value of early-pregnancy glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and body mass index (BMI) in screening gestational diabetes mellitus (GDM). Methods: : 216 pregnant women with GDM who underwent oral glucose tolerance test (OGTT) at 24-28 weeks were selected as the study (GDM) group, and 278 cases were randomly selected as the control group. FPG and glycated hemoglobin in early pregnancy were detected, and body mass index in early pregnancy was measured. The correlation between FPG, glycated hemoglobin and BMI in early pregnancy and the incidence of GDM was analyzed by binary Logistic regression, and the value of each index in predicting GDM alone or in combination was evaluated. Results: : FPG, glycated hemoglobin and BMI in early pregnancy in GDM group were higher than those in control group, and the differences were statistically significant (P<0.05). Binary logistic regression analysis showed that FPG, glycated hemoglobin and BMI were risk factors for GDM in early pregnancy [OR values were 3.374 (P<0.05), 4.644 (P < 0.05), and 1.077 (P<0.05), respectively]. The area under the ROC curve of FBG, glycated hemoglobin and BMI in early pregnancy for predicting the occurrence of GDM were 0.647, 0.661 and 0.608, respectively, while the area under the ROC curve of the combination of FBG, HBA1C and BMI for predicting GDM was 0.736, which showed higher diagnostic efficacy than that of the single indicator. Conclusions: : FPG, glycated hemoglobin and BMI in early pregnancy were risk factors for the occurrence of GDM, and their combination has certain clinical value of prediction.