FEATURES PERITONEAL FACTORS IN EXTERNAL GENITAL ENDOMETRIOSIS

FEATURES PERITONEAL FACTORS IN EXTERNAL GENITAL ENDOMETRIOSIS Barinov S.V.1, Novikova E.I.1,2, Novikov D.G.1, Indutnyj A.V.1, Vasilenko L.N.2 1 Omsk State Medical University, Omsk 1 Clinical medical hospital � 9, Omsk Summary Objective. To determine the diagnostic value of the concentration of cytokines and growth factors contained in the biological fluids of patients with external genital endometriosis (EGE). Materials and Methods. Clinical data were evaluated and the concentration of IL-1β, IL-6, IL-8, IL-10, α2-macroglobulin, vascular endothelial growth factor (VEGF) in 18 patients with EGE. Results. Significant differences were found between the concentration of the studied markers in venous blood and peritoneal fluid (PF). We found a relationship between pain of patients with EGE and the concentration of IL-10 (r=0,480 p=0,135), VEGF (r=0,478 p=0,277) and α2-macroglobulin in the PF (r=0,554, p=0,049). The dependence between the concentration of IL-6 in the PF and the prevalence of pathological process in EGE (r=0,560, p=0,005). We found significant increase of the concentration VEGF in the PF of patients with EG compared with the control group. Conclusion. The data obtained allow the use of research concentration of markers in the peritoneal fluid of patients with EGE to predict the future course of the disease. Key words External genital endometriosis, peritoneal fluid, pain, cytokines, VEGF. Received: 26.05.2015; in the revised form: 20.11.2015; accepted: 18.12.2015. Conflict of interests The authors declared that they do not have anything to disclosure regarding funding or conflict of interests with respect to this manuscript. All authors contributed equally to this article. For citation Barinov S.V., Novikova E.I., Novikov D.G., Indutnyj A.V., Vasilenko L.N. Features peritoneal factors in external genital endometriosis. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2015; 4: 18-24 (in Russian). Capobianco A., Rovere-Querini P. Endometriosis, a diseaseofthemacrophage. Front Immunol. 2013; 4: 9. Deal L.S., Di Benedetti D.B., Williams V.S., Fehnel S.E. The development and validation of the daily electronic Endometriosis Pain and Bleeding Diary. Health Qual Life Outcomes. 2010; 2 (8): 64. Domagala-Kulawik J. The role of the immune system in non-small cell lung carcinoma and potential for therapeutic intervention. Transl Lung Cancer Res. 2015; 4 (2): 177-90. Gurian M.B., Mitidieri A.M., Rosa E., Silva J.C., PoliNeto O.B., Nogueira A.A., Candido Dos Reis F.J. Measures Used to Assess Chronic Pelvic Pain in Randomized Controlled Clinical Trials: A Systematic Review. J EvalClinPract. 2015; Epub a head of print. Kicielinska J., Pajtasz-Piasecka E. The role of IL-10 in the modulation of the immune response in normal conditions and the tumor environment. PostepyHig Med Dosw (Online). 2014; 68: 879-92. Kianpour M., Nematbakhsh M., Ahmadi S.M., Jafarzadeh M., Hajjarian M., Pezeshki Z., Safari T., Eshraghi-Jazi F. Serum and peritoneal fluid levels of vascular endothelial growth factor in women with endometriosis. Int J FertilSteril. 2013; 7 (2): 96-9. Lv D., Song H., Shi G. Anti-TNF-alpha treatment for pelvic pain associated with endometriosis. Cochrane Database Syst Rev. 2010; (3): CD008088. Panel P., Renouvel F. Management of endometriosis: clinical and biological assessment. J GynecolObstetBiolReprod (Paris). 2007; 36 (2): 119-28. Papanicolaou D.A., Petrides J.S, Tsigos C., Bina S., Kalogeras K.T., Wilder R. et al. Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Am J Physiol. 1996; 271 (3): 601-5. Rizner T.L. Diagnostic potential of peritoneal fluid biomarkers of endometriosis. Expert Rev MolDiagn. 2015; 15 (4): 557-80. Selcuk I., Bozdag G. Recurrence of endometriosis; risk factors, mechanisms and biomarkers; review of the literature. J Turk GerGynecol Assoc. 2013; 14 (2): 98-103. Stull D.E., Wasiak R., Kreif N., Raluy M., Colligs A., Seitz C., Gerlinger C. Validation of the SF-36 in patients with endometriosis. Qual Life Res. 2014; 23 (1): 103-17. Vercellini P., Fedele L., Aimi G., Pietropaolo G., Consonni D., Crosignani P.G. Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic painsymptoms: a multivariate analysis of over 1000 patients. Hum Reprod. 2007; 22 (1): 266-71. Varma R., Rollason T., Gupta J.K., Maher E.R. Endometriosis and the neoplastic process. Reproduction. 2004; 127 (3): 293-304. Wickiewicz D., Chrobak A., Gmyrek G.B., Halbersztadt A., Gabrys M.S., Goluda M. et al. Diagnostic accuracy of interleukin-6 levels in peritoneal fluid for detection of endometriosis. Arch Gynecol Obstet. 2013; 288 (4): 805-14. Yeo S.G., Won Y.S., Lee H.Y., Kim Y.I., Lee J.W., Park D.C. Increased Expression of Pattern Recognition Receptors and Nitric Oxide Synthase in Patients with Endometriosis. Int J Med Sci. 2013; 10 (9): 1199-208. References: Adamjan L.V., Kulakov V.I. Endometriosis: A Guide for Physicians [Jendometriozy: rukovodstvodljavrachej (In Russian)]. Moscow. 2006; 320 s. CherkasovaN.Yu., Fomina A.V., Filippova O.V. FARMAKOEKONOMIKA. Sovremennayafarmakoekonomikaifarmakoepidemiologiya / PHARMACOECONOMICS. Modern pharmacoeconomics and pharmacoepidemiology. 2013; 6 (3): 36-39. Capobianco A., Rovere-Querini P. Endometriosis, a disease of the macrophage. Front Immunol. 2013; 4: 9. Deal L.S., Di Benedetti D.B., Williams V.S., Fehnel S.E. The development and validation of the daily electronic Endometriosis Pain and Bleeding Diary. Health Qual Life Outcomes. 2010; 2 (8): 64. Domagala-Kulawik J. The role of the immune system in non-small cell lung carcinoma and potential for therapeutic intervention. Transl Lung Cancer Res. 2015; 4 (2): 177-90. Gurian M.B., Mitidieri A.M., Rosa E., Silva J.C., PoliNeto O.B., Nogueira A.A., Candido Dos Reis F.J. Measures Used to Assess Chronic Pelvic Pain in Randomized Controlled Clinical Trials: A Systematic Review. J EvalClinPract. 2015; Epub a head of print. Kicielinska J., Pajtasz-Piasecka E. The role of IL-10 in the modulation of the immune response in normal conditions and the tumor environment. PostepyHig Med Dosw (Online). 2014; 68: 879-92. Kianpour M., Nematbakhsh M., Ahmadi S.M., Jafarzadeh M., Hajjarian M., Pezeshki Z., Safari T., Eshraghi-Jazi F. Serum and peritoneal fluid levels of vascular endothelial growth factor in women with endometriosis. Int J FertilSteril. 2013; 7 (2): 96-9. Lv D., Song H., Shi G. Anti-TNF-alpha treatment for pelvic pain associated with endometriosis. Cochrane Database Syst Rev. 2010; (3): CD008088. Panel P., Renouvel F. Management of endometriosis: clinical and biological assessment. J GynecolObstetBiolReprod (Paris). 2007; 36 (2): 119-28. Papanicolaou D.A., Petrides J.S, Tsigos C., Bina S., Kalogeras K.T., Wilder R. et al. Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Am J Physiol. 1996; 271 (3): 601-5. Rizner T.L. Diagnostic potential of peritoneal fluid biomarkers of endometriosis. Expert Rev MolDiagn. 2015; 15 (4): 557-80. Selcuk I., Bozdag G. Recurrence of endometriosis; risk factors, mechanisms and biomarkers; review of the literature. J Turk GerGynecol Assoc. 2013; 14 (2): 98-103. Stull D.E., Wasiak R., Kreif N., Raluy M., Colligs A., Seitz C., Gerlinger C. Validation of the SF-36 in patients with endometriosis. Qual Life Res. 2014; 23 (1): 103-17. Vercellini P., Fedele L., Aimi G., Pietropaolo G., Consonni D., Crosignani P.G. Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic painsymptoms: a multivariate analysis of over 1000 patients. Hum Reprod. 2007; 22 (1): 266-71. Varma R., Rollason T., Gupta J.K., Maher E.R. Endometriosis and the neoplastic process. Reproduction. 2004; 127 (3): 293-304. Wickiewicz D., Chrobak A., Gmyrek G.B., Halbersztadt A., Gabrys M.S., Goluda M. et al. Diagnostic accuracy of interleukin-6 levels in peritoneal fluid for detection of endometriosis. Arch Gynecol Obstet. 2013; 288 (4): 805-14. Yeo S.G., Won Y.S., Lee H.Y., Kim Y.I., Lee J.W., Park D.C. Increased Expression of Pattern Recognition Receptors and Nitric Oxide Synthase in Patients with Endometriosis. Int J Med Sci. 2013; 10 (9): 1199-208. Barinov Sergej Vladimirovich − MD, Professor, Head of the department of Obstetrics and Gynecology � 2, Omsk State Medical University. Address: Lenina St, 12, Omsk, Russia, 644043. E-mail: [email protected]. Novikova Elena Igorevna − a graduate student Department of Obstetrics and Gynecology number 2, Omsk State Medical University, doctor of Clinical medical hospital � 9. Address: 5-th Kordnaja St, 73, Omsk, Russia, 644018. E-mail: [email protected]. Novikov Dmitry Georgievich − PhD, Head of the Central Scientific Research Laboratory, Omsk State Medical University. Address: Lenina St, 12, Omsk, Russia, 644043. E-mail: [email protected]. Indutny Anton Vasil'evich − MD, Head of the department of laboratory diagnostics, Omsk State Medical University. Address: Lenina St, 12, Omsk, Russia, 644043. E-mail: [email protected]. Vasilenko Ljudmila Nikolaevna − PhD, Head of the department of Gynecology � 2, Clinical medical hospital � 9. Address: 5-th Kordnaja St, 73, Omsk, Russia, 644018. E-mail: [email protected].