Effect of Medical Assistance in the Treatment of Endometriosis After Surgery

Objective To observe the curative effect, untoward effect and relapse rate after drug withdrawal in the patients with endometriosis who accepted the medical assistance of gestrinone, leuprorelin acetate microspheres, and placement of left acetylene progesterone intrauterine birth control system after three months' leuprorelin acetate microspheres therapy with laparotomy or laparoscopic surgery. Methods A total of 80 cases with endometriosis from March 2010 to June 2013 in Avic 363 hospital that went under the surgery were divided into (according to the patient's wishes) gestrinone group (n =28) , leuprorelin acetate microspheres group (n =32) and leuprorelin acetate microspheres with left acetylene progesterone intrauterine birth control system group (n =20) . The curative effect, untoward effect and relapse rate were compared among 3 groups. The study protocol was approved by the Ethical Review Board of Investigation in Human Beings of Avic 363 Hospital. Informed consent was obtained from each participating patient. Results There had no significant differences among 3 groups in the curative effect and relapse rate (P>0.05) meanwhile also had no significant differences in the untoward effect which performed as weight gain (P>0.05) . Transaminase lifted higher in gestrinone group and fever occurred more in leuprorelin acetate microspheres group than that in other 2 groups and had significant differences (P<0.01) . Conclusions Endometriosis after surgery and treated with gestrinone, leuprorelin acetate microspheres and leuprorelin acetate microspheres 3 months then with left acetylene progesterone intrauterine birth control system have similar curative effect. Placement of left acetylene progesterone intrauterine birth control system after three months' treatment with leuprorelin acetate microspherehas has small effect on liver function and can reduce hot flashes and can be a long-term treatment for endometriosis and reduce the recurrence Key words: Endometriosis; Surgery; Drug therapy