JO'O. eds. Diagnostic Molecular Pathology: A Practical Approach. Vcl. 2. Oxford:

W.R. Bezwoda, Lesley Seymour, Roger Dansey, D. Dajee, N. Mansoor
1995 · W2737875348
article OA: closed CC0 Metadata only
View on OpenAlex

Abstract

PostmenopausalLong disease-freeintervalBone, skin, nodeAdditive hormonal treatment (Table I) became availableduring the 1950s with the commercial production of steroidhormones. Since involution ofthe embryological breast budwhich develops in all early, sexually undifferentiatedembryos3 was known to occur under the influence ofandrogens it was perhaps not surprising that androgenscould cause regression of female breast Moresurprising perhaps was the finding that oestrogens; whichappeared to be necessary forthe maintenance and growthof breast cancer in younger women, could also bebeneficial, albeit usually in older, postmenopausal women.Other steroid hormones such as the gestagens and modifiedandrogens such as danazol are also active.The term 'changing the hormonal milieu' was coined toindicate a hypothetical alteration between growth­stimulatory and as yet (undefined) growth-inhibitoryhormonal influences.During the 1960s much effort went into attempts to definelevels of plasma hormones or oftotal hormone productionas measured by urinary excretion of sex steroids; this wasintended to provide an index of hormone responsivenessand prognosis in breast cancer. Ultimately none of thesetests achieved any real measure of success since theseinvestigations focused on patient determinants rather thanthe nature of the tumour. However, several clinical featureswere defined which provided some guidelines for hormonetreatment of breast cancer (Table

My notes (saved in your browser only)

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (46)

Source provenance

openalex
last seen: 2026-05-10T10:53:49.850436+00:00
License: CC0 · commercial use OK