Changes of monocyte chemoattractant protein-1 levels in serum and abdominal cavity fluid in women with endometriosis

Objective:To investigate the relationship of monocyte chemoattractant protein-l(MCP-1) to endometriosis(EM).Methods:Levels of MCP-1 in serum and in abdominal cavity fluid were determined by a solid quantitative sandwich enzyme immunoassay technique(Sandwich ELISA) both in EM group and in controls,and relationship of MCP-1 levels in serum and in abdominal cavity fluid were analyzed.Results:Serum concentrations of MCP-l were increasd(P0.01) in EM group(207±76) pg/ml than that of controls(148±56) pg/L.Concentrations of MCP-1 in abdominal cavity fluid were increasd(P0.01) in EM group(292± 98) pg/ml than that in controls(164±65) pg/ml.In EM,nonparametric correlations analysis demonstrated that concentrations of serum MCP-1 were positively correlated with those in abdominal cavity fluid(r=0.471,P=0.002),but such a correlation did not be found in controls.Conclusion:Serum levels of MCP-l in EM increase significantly and higher concentrations of MCP-1 may be partly responsible for EM in a special way.