Solvent extraction of Ac-225 in nano-layer coated, solvent resistant PDMS microfluidic chips

Solvent extraction of Ac-225 in nano-layer coated, solvent resistant PDMS microfluidic chips | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Solvent extraction of Ac-225 in nano-layer coated, solvent resistant PDMS microfluidic chips Svenja Trapp, Albert Santoso, Yassine Hounat, Elisabeth Paulssen, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5103696/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 02 Dec, 2024 Read the published version in Scientific Reports → Version 1 posted 10 You are reading this latest preprint version Abstract Separating medical radionuclides from their targets is one of the most critical steps in radiopharmaceutical production. Among many separation methods, solvent extraction has a lot of potential due to its simplicity, high selectivity, and high efficiency. Especially with the rise of polydimethylsiloxane (PDMS) microfluidic chips, this extraction process can take place in a simple and reproducible chip platform continuously and automatically. Furthermore, the microfluidic chips can be coated with metal-oxide nano-layers, increasing their resistance against the employed organic solvents. We fabricated such chips and demonstrated a parallel flow at a considerably large range of flow rates using the aqueous and organic solutions commonly used in medical radionuclide extraction. In our following case study for the separation of Ac-225 from radium with the chelator di(2-ethylhexyl)phosphoric acid (D2EHPA), a remarkable extraction efficiency of 97.1% ± 1.5% was reached within 1.8 seconds of contact time, while maintaining a near perfect phase separation of the aqueous and organic solutions. This method will enable the automation of solvent extraction and faster target recycling, and serves, therefore, as a proof-of-concept for the applicability of microfluidic chip solvent extraction of (medical) radionuclides. Physical sciences/Chemistry/Nuclear chemistry Physical sciences/Chemistry/Process chemistry Physical sciences/Materials science/Materials for devices Full Text Additional Declarations No competing interests reported. Supplementary Files TrappSantosoSupplements.pdf Cite Share Download PDF Status: Published Journal Publication published 02 Dec, 2024 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 22 Oct, 2024 Reviews received at journal 21 Oct, 2024 Reviews received at journal 11 Oct, 2024 Reviewers agreed at journal 03 Oct, 2024 Reviewers agreed at journal 01 Oct, 2024 Reviewers invited by journal 30 Sep, 2024 Editor assigned by journal 30 Sep, 2024 Editor invited by journal 30 Sep, 2024 Submission checks completed at journal 27 Sep, 2024 First submitted to journal 17 Sep, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5103696","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":368947806,"identity":"d9637564-853c-42d4-90d6-f504942decb3","order_by":0,"name":"Svenja Trapp","email":"","orcid":"","institution":"Department of Radiation Science and Technology, Delft University of Technology","correspondingAuthor":false,"prefix":"","firstName":"Svenja","middleName":"","lastName":"Trapp","suffix":""},{"id":368947807,"identity":"057f1632-2d65-4d9e-8a05-29e8cd1e0a35","order_by":1,"name":"Albert Santoso","email":"","orcid":"","institution":"Department of Chemical Engineering, Delft University of Technology","correspondingAuthor":false,"prefix":"","firstName":"Albert","middleName":"","lastName":"Santoso","suffix":""},{"id":368947808,"identity":"7e732aeb-d45b-4396-871b-e86e6ca87864","order_by":2,"name":"Yassine Hounat","email":"","orcid":"","institution":"Department of Chemical Engineering, Delft University of Technology","correspondingAuthor":false,"prefix":"","firstName":"Yassine","middleName":"","lastName":"Hounat","suffix":""},{"id":368947809,"identity":"47aee64b-edba-4923-a1f7-eaee45bbee2d","order_by":3,"name":"Elisabeth Paulssen","email":"","orcid":"","institution":"Department of Chemistry and Biotechnology, Aachen University of Applied Science","correspondingAuthor":false,"prefix":"","firstName":"Elisabeth","middleName":"","lastName":"Paulssen","suffix":""},{"id":368947810,"identity":"6af09619-4813-4843-b833-3c70312155e4","order_by":4,"name":"J. 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Among many separation methods, solvent extraction has a lot of potential due to its simplicity, high selectivity, and high efficiency. Especially with the rise of polydimethylsiloxane (PDMS) microfluidic chips, this extraction process can take place in a simple and reproducible chip platform continuously and automatically. Furthermore, the microfluidic chips can be coated with metal-oxide nano-layers, increasing their resistance against the employed organic solvents. We fabricated such chips and demonstrated a parallel flow at a considerably large range of flow rates using the aqueous and organic solutions commonly used in medical radionuclide extraction. In our following case study for the separation of Ac-225 from radium with the chelator di(2-ethylhexyl)phosphoric acid (D2EHPA), a remarkable extraction efficiency of 97.1% ± 1.5% was reached within 1.8 seconds of contact time, while maintaining a near perfect phase separation of the aqueous and organic solutions. 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