Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies

Kara L. Cushing‐Haugen, Celeste Leigh Pearce, Jennifer A. Doherty, Hoda Anton‐Culver, Penelope M. Webb, Linda Titus, Wendy R. Brewster, Brooke L. Fridley, Allison F. Vitonis, Melissa C. Larson, Susanne K. Kjær, Jenny Chang‐Claude, Argyrios Ziogas, Kristine G. Wicklund, Mary Anne Rossing, Marc T. Goodman, Galina Lurie, Kirsten B. Moysich, Christina M. Nagle, Ellen L. Goode, Claire Templeman, Rebecca Hein, Lynne R. Wilkens, Alice A. Lee, Joellen M. Schildkraut, Aimee M. Near, Daniel W. Cramer, Kathryn L. Terry, Rachel T. Palmieri, Allan Jensen, Estrid Høgdall, Michael E. Carney
2021 · doi:10.17615/zn9f-0969 · W4300142699
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the association between endometriosis and the risk of developing specific invasive histological subtypes and borderline tumors of ovarian cancer by pooling data from case-control studies.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

This pooled analysis of case–control studies examined whether endometriosis is associated with the risk of ovarian cancer across different histological subtypes, using data compiled from multiple study populations and pooled statistical models to estimate subtype-specific associations. The key finding was that endometriosis was not associated uniformly across ovarian cancer types; rather, the relationship differed by histologic subtype. A major caveat is that case–control designs rely on retrospective exposure assessment, and pooling across studies can introduce heterogeneity in study methods and exposure definitions. Relevance to endometriosis: the paper is centrally about endometriosis and its relationship to risk of histological ovarian cancer subtypes.

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Abstract

Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We undertook an international collaborative study to assess the association between endometriosis and histological subtypes of ovarian cancer.
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MLA Pearce, Celeste Leigh, et al. Association Between Endometriosis and Risk of Histological Subtypes of Ovarian Cancer: a Pooled Analysis of Case–control Studies. 2012. https://doi.org/10.17615/zn9f-0969 APA Pearce, C., Templeman, C., Rossing, M., Lee, A., Near, A., Webb, P., Nagle, C., Doherty, J., Cushing Haugen, K., Wicklund, K., Chang Claude, J., Hein, R., Lurie, G., Wilkens, L., Carney, M., Goodman, M., Moysich, K., Kjaer, S., Hogdall, E., Jensen, A., Goode, E., Fridley, B., Larson, M., Schildkraut, J., Palmieri, R., Cramer, D., Terry, K., Vitonis, A., Titus, L., Ziogas, A., Brewster, W., & Anton Culver, H. (2012). Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies. https://doi.org/10.17615/zn9f-0969 Chicago Pearce, Celeste Leigh, Claire Templeman, Mary Anne Rossing, Alice Lee, Aimee M Near, Penelope M Webb, Christina M Nagle et al. 2012. Association Between Endometriosis and Risk of Histological Subtypes of Ovarian Cancer: a Pooled Analysis of Case–control Studies. https://doi.org/10.17615/zn9f-0969

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