Efficacy and safety of ultrasound-guided high-intensity focused ultrasound for uterine adenomyosis: Preliminary experience from a case series

Cheung, Vincent Y.T., Lam, Tina P.W., Shuk Wan Lam
2022 · doi:10.5281/zenodo.6349815 · W6893938092
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-14 ⓘ

Ultrasound-guided high-intensity focused ultrasound reduced pain and uterine/lesion volumes in adenomyosis patients but had complications and required surgery in some.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-14 · read from full text ⓘ

This prospective cohort case series evaluated ultrasound-guided high-intensity focused ultrasound (HIFU) in 10 premenopausal women with symptomatic uterine adenomyosis, assessing changes in symptom severity scores at 3, 6, and 12 months and comparing uterine and adenomyotic lesion volumes at 6 months using MRI. Menstrual pain scores decreased by 45.5%, 57.3%, and 27.9% at 3, 6, and 12 months, and modified uterine fibroid symptom and quality-of-life scores decreased by 50.0%, 40.9%, and 39.5% at the same time points. Uterus volume fell by 24.4% and adenomyosis volume by 46.3% at 6 months, but 20% experienced significant treatment-related complications and 30% required subsequent surgical interventions. The authors conclude that longer-term effectiveness and safety need evaluation in a larger cohort. This paper is centrally about endometriosis and/or adenomyosis — specifically ultrasound-guided HIFU for uterine adenomyosis.

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Abstract

Objective: This prospective cohort study was to evaluate the efficacy and safety of ultrasound-guided High-Intensity Focused Ultrasound (HIFU) in the treatment of uterine adenomyosis. Methods: Ten premenopausal women with symptomatic adenomyosis underwent ultrasound-guided HIFU therapy. Their symptoms were compared using symptom severity scores before and at 3, 6 and 12 months after treatment. The sizes of their uteri and adenomyotic lesions at 6 months after treatment were compared with those of pre-treatment as determined by magnetic resonance imaging. Results: The menstrual pain scores were reduced by 45.5% (-83.3–100%) at 3-month, 57.3% (-83.3–100%) at 6-month and 27.9% (-100–100%) at 12-month after treatment. The modified Uterine Fibroid Symptom and Quality of Life scores were reduced by 50.0% (9.1–69.7%) at 3-month, 40.9% (27.3–66.7%) at 6-month and 39.5% (0–70.0%) at 12-month after treatment. The uterus and adenomyosis volumes were reduced by 24.4% (1.2–42.0%) and 46.3% (2.1-78.4%) at 6-month after treatment, respectively. Two patients (20%) had significant treatment-related complications and three patients (30%) required subsequent surgical interventions. Conclusions: Although ultrasound-guided HIFU appears to provide symptomatic relief to most patients with adenomyosis, its long-term effectiveness and safety require further evaluation in a larger cohort of patients, and may improve with clinical experience.
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Objective

This prospective cohort study was to evaluate the efficacy and safety of ultrasound-guided High-Intensity Focused Ultrasound (HIFU) in the treatment of uterine adenomyosis.

Methods

Ten premenopausal women with symptomatic adenomyosis underwent ultrasound-guided HIFU therapy. Their symptoms were compared using symptom severity scores before and at 3, 6 and 12 months after treatment. The sizes of their uteri and adenomyotic lesions at 6 months after treatment were compared with those of pre-treatment as determined by magnetic resonance imaging.

Results

The menstrual pain scores were reduced by 45.5% (-83.3–100%) at 3-month, 57.3% (-83.3–100%) at 6-month and 27.9% (-100–100%) at 12-month after treatment. The modified Uterine Fibroid Symptom and Quality of Life scores were reduced by 50.0% (9.1–69.7%) at 3-month, 40.9% (27.3–66.7%) at 6-month and 39.5% (0–70.0%) at 12-month after treatment. The uterus and adenomyosis volumes were reduced by 24.4% (1.2–42.0%) and 46.3% (2.1-78.4%) at 6-month after treatment, respectively. Two patients (20%) had significant treatment-related complications and three patients (30%) required subsequent surgical interventions.

Conclusions

Although ultrasound-guided HIFU appears to provide symptomatic relief to most patients with adenomyosis, its long-term effectiveness and safety require further evaluation in a larger cohort of patients, and may improve with clinical experience. Files WJARR-2022-0158.pdf Files (1.3 MB) | Name | Size | Download all | |---|---|---| | md5:d94014484a063c2b090464e50dcf3008 | 1.3 MB | Preview Download |

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