Cytohormonal and histomorphologic patterns in endometrium in symptomatic premenopausal women.

Endometrial histology in the premenopausal symptomatic group revealed hyperplastic endometrium in 29.1 percent of the cases. Cytohormonal evaluation has shown hyperesterin activity reflected by a high Karyopyknotic Index in cystic glandular and adenomatous hyperplasia. A fairly good positive correlation is seen between colpocytology and endometrial histology. In few patients vaginal cytology has revealed regressive activity which was not evident on histology alone. It is felt that cases showing regressive smears are the ones where treatment including estrogens should be most effective.