Expression patterns of HDAC6 in correlation to ARID1A status in different subtypes of endometriosis: A retrospective tissue microarray analysis
Joelle Zingg,
Dimitrios R Kalaitzopoulos,
Agnieszka A Karol,
Nicolas Samartzis,
Paula Stancl,
Juliane Hutmacher,
Rosa Karlic,
Aurelia Noske,
Mathias Choschzick,
Isabell Witzel,
Eleftherios P Samartzis
other
OA: green
CC-BY-NC-ND-4.0
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by claude@2026-06, 2026-06-08
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This study found that HDAC6 expression patterns vary with ARID1A status and endometriosis subtype, showing higher epithelial HDAC6 in ARID1A-negative endometriosis, particularly in ovarian lesions.
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by claude@2026-06, 2026-06-09
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The provided paper text does not include any study details (e.g., population, methods, results, or stated limitations) and instead contains an anti-bot “Anubis” page, so the manuscript’s findings cannot be determined from the content available here. Because the actual tissue microarray analysis content is missing, I cannot extract what HDAC6 expression patterns were measured or how they correlated with ARID1A status across endometriosis subtypes. The paper’s relationship to endometriosis cannot be substantiated from the supplied text alone. The paper is centrally about endometriosis — it is titled as an analysis of HDAC6 expression patterns in relation to ARID1A status across different endometriosis subtypes.
Abstract
Endometriosis is a disease affecting approximately 10% of reproductive age women. Loss of the tumor suppressor gene AT-rich interactive domain-containing protein 1A (ARID1A) occurs in some endometriosis cases. Histone deacetylase 6 (HDAC-6) is an enzyme with implication in several diseases including different cancer types and immunological disorders, where it is involved in protein trafficking and degradation, cell shape, and migration. In ARID1A-deficient ovarian cancer increased HDAC-6 expression lead to apoptosis-inhibiting post-translational modification of p53. It is not known if HDAC-6 expression is also altered in ARID1A-deficient endometriosis. The aim of this study was to assess HDAC-6 expression in endometriotic lesions in correlation to ARID1A-status. Two tissue-microarrays with 168 endometriotic lesions, including ovarian (64/168, 38 %), peritoneal (66/168, 39 %) and deep-infiltrating (38/168, 23 %) subtypes, and 73 endometrium of women without endometriosis were assessed. Mean ARID1A immunoreactivity score (IRS) in endometriosis group was 10.83 (±2.36) and 10.78 (±1.94) in the epithelium and stroma, respectively, while the respective mean HDAC6 IRS were 9.16 (±2.76) and 5.94 (±2.88). The comparison of the HDAC6 expression between endometriosis subtypes showed higher expression in deep-infiltrating endometriosis, in both, epithelium (p = 0.032) and stroma (p = 0.007). In ARID1A negative cases, epithelial expression of HDAC6 was higher in endometriosis compared to women without endometriosis (p = 0.031), and this was also specifically observed in the subset of ovarian endometriosis (p = 0.037). There were no significant differences in the stromal expression of HDAC6. In conclusion, our results demonstrate a complex expression pattern of HDAC6 depending on ARID1A status in different endometriosis subtypes. Further studies on HDAC6 and ARID1A are important to elucidate mechanisms involved in malignant transformation of endometriosis.
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Condition tags
endometriosis
MeSH descriptors
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
DNA-Binding Proteins
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Source provenance
- europepmc
- last seen: 2026-06-19T06:14:56.452680+00:00
- pubmed
- last seen: 2026-06-19T06:12:37.312664+00:00
- unpaywall
- last seen: 2026-05-11T08:34:28.763810+00:00
License: CC-BY-NC-ND-4.0
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Courtesy of the U.S. National Library of Medicine