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by qwen3.7-flash, 2026-09-13
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This paper describes the RENDO protocol, an integrated pre-, intra-, and post-surgical system for ovarian reserve preservation and fertility restoration following endometrioma excision.
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by qwen3.7-flash, 2026-09-19
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This paper introduces the RENDO™ Clinical Protocol v3.0, an integrated pre-, intra-, and post-surgical framework designed to preserve ovarian reserve and restore fertility following endometrioma excision. The authors propose a six-module system spanning four weeks before surgery to twelve months after, combining anti-adhesion surgical techniques with targeted nutraceuticals, psychosomatic stabilization, and digital tracking tools. A single-arm prospective implementation evaluated primary endpoints such as relative AMH change at three months alongside secondary metrics like AFC recovery and ART attrition rates. This paper is centrally about endometriosis — specifically focusing on optimizing outcomes for patients undergoing surgical treatment of ovarian endometriomas.
Abstract
Ovarian endometrioma excision remains a double-edged intervention: it improves pelvic pain and ART access, yet bilateral or repeated stripping surgery is associated with measurable decline in anti-Müllerian hormone (AMH) and antral follicle count (AFC), a phenomenon conceptually framed by the author as surgical ovarian aging. Contemporary protocols address the surgical act itself but neglect the pre-operative metabolic window, the first 72 postoperative hours, and the neuro-motivational dimension of the 12-month fertility trajectory, where attrition from ART programs reaches 25–40%. Objective. To describe and standardize RENDO™ (Reproductive Endo-Neuro-Dynamic Optimization), a six-module integrated protocol — PREP, SURG, RECOVER, MIND, DRIVE, TRACK — spanning 4–8 weeks before surgery to 12 months after, combining anti-adhesion excisional technique, targeted nutraceutical matrices, polyvagal-informed psychosomatic stabilization, dopamine-based behavioral architecture, and a digital companion with composite outcome indices. Methods. Single-arm prospective implementation; eligibility per ICD-10 N80.1–N80.3 / ICD-11 GA10.Z–GA10.3; primary endpoint: relative AMH change at 3 months; secondary endpoints: AFC recovery ratio, Ovarian Shock Index (OSI) at post-op day 3, RENDO™ Score (0–100), RPS-SCORE dynamics, ART attrition rate. Conclusion. RENDO™ reframes post-endometrioma care from a passive convalescence model to an active, measurable, patient-facing recovery system.
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RENDO™ CLINICAL PROTOCOL v3.0 Reproductive Endo-Neuro-Dynamic Optimization: an integrated pre-, intra- and post-surgical protocol for ovarian reserve preservation and fertility restoration after endometrioma excision
Authors/Creators
- 1. Hudziak Academy
- 2. Victoria Gudziak Fertility Management Center
Description
Ovarian endometrioma excision remains a double-edged intervention: it improves pelvic pain and ART access, yet bilateral or repeated stripping surgery is associated with measurable decline in anti-Müllerian hormone (AMH) and antral follicle count (AFC), a phenomenon conceptually framed by the author as surgical ovarian aging. Contemporary protocols address the surgical act itself but neglect the pre-operative metabolic window, the first 72 postoperative hours, and the neuro-motivational dimension of the 12-month fertility trajectory, where attrition from ART programs reaches 25–40%.
Objective. To describe and standardize RENDO™ (Reproductive Endo-Neuro-Dynamic Optimization), a six-module integrated protocol — PREP, SURG, RECOVER, MIND, DRIVE, TRACK — spanning 4–8 weeks before surgery to 12 months after, combining anti-adhesion excisional technique, targeted nutraceutical matrices, polyvagal-informed psychosomatic stabilization, dopamine-based behavioral architecture, and a digital companion with composite outcome indices.
Methods. Single-arm prospective implementation; eligibility per ICD-10 N80.1–N80.3 / ICD-11 GA10.Z–GA10.3; primary endpoint: relative AMH change at 3 months; secondary endpoints: AFC recovery ratio, Ovarian Shock Index (OSI) at post-op day 3, RENDO™ Score (0–100), RPS-SCORE dynamics, ART attrition rate.
Conclusion. RENDO™ reframes post-endometrioma care from a passive convalescence model to an active, measurable, patient-facing recovery system.
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RENDO_Clinical_Protocol_v3.0_Hudziak_Viktoriya.pdf
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