Dose Rate Variations and Cellular Biological Effects in Tumor Control Probability for Head and Neck Cancers

Dose Rate Variations and Cellular Biological Effects in Tumor Control Probability for Head and Neck Cancers | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Dose Rate Variations and Cellular Biological Effects in Tumor Control Probability for Head and Neck Cancers Rany Nuraini, Mulyanto Mulyanto This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6018151/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract In radiotherapy, tumor control probability (TCP) is the probability of successfully eliminating tumor cells. The TCP value is influenced by factors such as fractionation and various cellular and biological processes. This includes repopulation, repair, redistribution, and reoxygenation. These biological effects on TCP are determined by the dose rate function, particularly in relation to sub-lethal damage, as described by the Lea-Catcheside function. In this paper, two variations of the Lea-Catcheside function were considered: one assuming a constant dose rate and the other based on an exponential fit dose rate function. The results demonstrated that the two variations in dose rate had a minimal impact on TCP values when assessing the biological effects of head and neck cancers. We also considered each biological effect on the TCP. The results showed that repair and repopulation processes prevent the complete elimination of tumor cells, while resensitization effects, such as reoxygenation and redistribution, enhance tumor cell death. Dose rate Lea-Catcheside function Tumor Control Probability Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6018151","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":427239720,"identity":"88f770fb-9f50-4030-856c-291bfda4bf8b","order_by":0,"name":"Rany Nuraini","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA7UlEQVRIiWNgGAWjYDADNgbGhgMJFUAWM3MD0VoaH3w4A9LCSKQWkFrDmW0gmoAW8/azx6QL2+7J80k3t0nzzquN5m8HavlRsQ2nFpkzeWnSM9uKDdtkDgK1bDueO+MwYwNjz5nbOLVIMOSYSfO2JTC2SSSCtBzLbQBqYWZsw6OF/w1Yiz1Ey5xjufMJapGA2JII1NJsOLOhJncDYS1vjK15ziUkA7UAA/nYgdyNQC0H8fqFP8fwNk9Zgu38GekPDiTU1OXOO3/44IMfFbi1AAGLBBLnMJg8gE89EDB/QOLUEVA8CkbBKBgFIxEAAJsMV6ec6eDIAAAAAElFTkSuQmCC","orcid":"","institution":"","correspondingAuthor":true,"prefix":"","firstName":"Rany","middleName":"","lastName":"Nuraini","suffix":""},{"id":427239721,"identity":"c71d8ec0-34d1-4580-8581-e91ffd994217","order_by":1,"name":"Mulyanto Mulyanto","email":"","orcid":"","institution":"Badan Riset dan Inovasi Nasional","correspondingAuthor":false,"prefix":"","firstName":"Mulyanto","middleName":"","lastName":"Mulyanto","suffix":""}],"badges":[],"createdAt":"2025-02-12 21:53:16","currentVersionCode":1,"declarations":{"humanSubjects":false,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-6018151/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6018151/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":88588680,"identity":"17d2c1ee-4820-48b9-a919-178f43ba8a4c","added_by":"auto","created_at":"2025-08-08 05:08:28","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":305860,"visible":true,"origin":"","legend":"","description":"","filename":"RanyManuscriptTCP.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6018151/v1_covered_a613020d-ac9b-4dbb-af64-d8ea138fb018.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Dose Rate Variations and Cellular Biological Effects in Tumor Control Probability for Head and Neck Cancers","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":true,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Dose rate, Lea-Catcheside function, Tumor Control Probability","lastPublishedDoi":"10.21203/rs.3.rs-6018151/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6018151/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"In radiotherapy, tumor control probability (TCP) is the probability of successfully eliminating tumor cells. 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