Pathology of Non-neoplastic and Neoplastic Gynaecological Diseases

In: Part 1 MRCOG Synoptic Revision Guide · 2023 · pp. 293–302 · doi:10.1017/9781108644464.030 · W4385287247
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This paper reviews the pathology of non-neoplastic and neoplastic gynecological diseases, including infections, endometriosis, polyps, and ovarian cysts, which can cause symptoms like discharge, bleeding, pain, and prolapse.

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This MRCOG synoptic revision guide chapter provides an overview of the pathology of non-neoplastic and neoplastic gynaecological diseases, framing common female genital tract symptoms such as vaginal discharge, abnormal bleeding, pelvic pain, and prolapse in terms of underlying pathological conditions. It describes broad categories of disease including infections, endometriosis, polyps, and ovarian cysts among causes of non-neoplastic symptoms, alongside related pathology topics for gynaecological cancers. A major caveat is that the provided text is a high-level chapter outline rather than a detailed study with methods, results, or explicit limitations. Relevance to endometriosis: the chapter explicitly lists endometriosis as an underlying pathological condition causing common gynaecological symptoms, though the paper’s main focus is a general revision guide on gynaecological pathology.

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Abstract

Non-neoplastic disease of the female genital tract can be the underlying cause of morbidity. Common gynaecological symptoms include vaginal discharge, bleeding (irregular periods, heavy periods, post-coital bleeding and postmenopausal bleeding), pelvic pain and prolapse. The pathological conditions underlying some of these symptoms include infections, endometriosis, polyps and ovarian cysts.
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- Part 1 MRCOG Synoptic Revision Guide - Part 1 MRCOG Synoptic Revision Guide - Copyright page - Contents - Contributors - Chapter 1 Physiology of Pregnancy and Labour - Chapter 2 Fetal Physiology - Chapter 3 Acid-Base Balance - Chapter 4 Female Reproductive Physiology - Chapter 5 Male Reproductive Physiology - Chapter 6 The Pituitary, Adrenal, Thyroid and Pancreas - Chapter 7 Congenital Infections - Chapter 8 Data Interpretation in Obstetrics - Chapter 9 Clinical Management in Obstetrics - Chapter 10 Concise Anatomy of the Urinary, Intestinal and Reproductive Tracts within the Pelvic Cavity - Chapter 11 Concise Anatomy of the Pelvic Floor and Perineum - Chapter 12 Concise Anatomy of the Pelvic Girdle - Chapter 13 Concise Anatomy of the Abdominal Walls - Chapter 14 Early Embryonic Development - Chapter 15 Development of the Gastrointestinal and Urogenital Tracts - Chapter 16 Problems in Early Pregnancy - Chapter 17 Human Immunodeficiency Virus and Other Sexually Transmitted Infections - Chapter 18 Pharmacokinetics, Pharmacodynamics and Teratogenesis - Chapter 19 Non-hormonal Therapy in Obstetrics and Gynaecology - Chapter 20 Drugs in Gynaecology and Contraception - Chapter 21 Surgical Site Surveillance - Chapter 22 Data Interpretation in Gynaecology - Chapter 23 Clinical Management in Gynaecology - Chapter 24 Carbohydrate Metabolism - Chapter 25 Fat Metabolism - Chapter 26 Steroid Hormones and Prostaglandins - Chapter 27 Calcium Homeostasis and Bone Health - Chapter 28 Cell Structure and Function - Chapter 29 Cellular Responses in Disease - Chapter 30 Pathology of Non-neoplastic and Neoplastic Gynaecological Diseases - Chapter 31 Implantation and Placental Structure and Function - Chapter 32 Basic and Reproductive Immunology - Chapter 33 Molecular Biology - Chapter 34 Single-Gene and Chromosome Abnormalities - Chapter 35 Genetic Screening and Diagnosis - Chapter 36 Biophysics - Chapter 37 Statistics - Chapter 38 Clinical Trials, Audit and Meta-analysis - Appendix: Answers to SBA Questions - Index - References Published online by Cambridge University Press: 27 July 2023 Book contents - Part 1 MRCOG Synoptic Revision Guide - Part 1 MRCOG Synoptic Revision Guide - Copyright page - Contents - Contributors - Chapter 1 Physiology of Pregnancy and Labour - Chapter 2 Fetal Physiology - Chapter 3 Acid-Base Balance - Chapter 4 Female Reproductive Physiology - Chapter 5 Male Reproductive Physiology - Chapter 6 The Pituitary, Adrenal, Thyroid and Pancreas - Chapter 7 Congenital Infections - Chapter 8 Data Interpretation in Obstetrics - Chapter 9 Clinical Management in Obstetrics - Chapter 10 Concise Anatomy of the Urinary, Intestinal and Reproductive Tracts within the Pelvic Cavity - Chapter 11 Concise Anatomy of the Pelvic Floor and Perineum - Chapter 12 Concise Anatomy of the Pelvic Girdle - Chapter 13 Concise Anatomy of the Abdominal Walls - Chapter 14 Early Embryonic Development - Chapter 15 Development of the Gastrointestinal and Urogenital Tracts - Chapter 16 Problems in Early Pregnancy - Chapter 17 Human Immunodeficiency Virus and Other Sexually Transmitted Infections - Chapter 18 Pharmacokinetics, Pharmacodynamics and Teratogenesis - Chapter 19 Non-hormonal Therapy in Obstetrics and Gynaecology - Chapter 20 Drugs in Gynaecology and Contraception - Chapter 21 Surgical Site Surveillance - Chapter 22 Data Interpretation in Gynaecology - Chapter 23 Clinical Management in Gynaecology - Chapter 24 Carbohydrate Metabolism - Chapter 25 Fat Metabolism - Chapter 26 Steroid Hormones and Prostaglandins - Chapter 27 Calcium Homeostasis and Bone Health - Chapter 28 Cell Structure and Function - Chapter 29 Cellular Responses in Disease - Chapter 30 Pathology of Non-neoplastic and Neoplastic Gynaecological Diseases - Chapter 31 Implantation and Placental Structure and Function - Chapter 32 Basic and Reproductive Immunology - Chapter 33 Molecular Biology - Chapter 34 Single-Gene and Chromosome Abnormalities - Chapter 35 Genetic Screening and Diagnosis - Chapter 36 Biophysics - Chapter 37 Statistics - Chapter 38 Clinical Trials, Audit and Meta-analysis - Appendix: Answers to SBA Questions - Index - References Non-neoplastic disease of the female genital tract can be the underlying cause of morbidity. Common gynaecological symptoms include vaginal discharge, bleeding (irregular periods, heavy periods, post-coital bleeding and postmenopausal bleeding), pelvic pain and prolapse. The pathological conditions underlying some of these symptoms include infections, endometriosis, polyps and ovarian cysts. - Type - Chapter - Information - Part 1 MRCOG Synoptic Revision Guide , pp. 293 - 302Publisher: Cambridge University PressPrint publication year: 2023 Mutter, G, Prat, J, eds. Pathology of the Female Genital Tract. 3rd ed. Churchill Livingstone, 2014.Google Scholar Kumar, V, Abbas, AK, Aster, JC. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Elsevier Saunders, 2014.Google Scholar Underwood, JCE, Cross, SS. General and Systemic Pathology. 5th ed. Churchill Livingstone, 2009.Google Scholar Stoler, MH. Human papillomaviruses and cervical neoplasia: a model for carcinogenesis. Int J Gynaecol Pathol. 2000;19:16–28.Google Scholar Pignatelli, M, Gallagher, P, eds. Molecular testing for human papilloma virus. In Recent Advances in Histopathology 23, ed. Denton, K, pp. 159–167. JP Medical Ltd, 2014.Google Scholar Sreenan, JJ, Hart, WR. Carcinosarcomas of the female genital tract. A pathologic study of 29 metastatic tumours: further evidence for the dominant role of the epithelial component and the conversion theory of histogenesis. Am J Surg Pathol. 1995;19:666–674.Google Scholar Lee, C-H, Nucci, MR. Endometrial stroma sarcoma – the new genetic paradigm. Histopathology. 2015;67:1–19.CrossRefGoogle ScholarPubMed Kurman, RJ, Shih, I-M. The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am J Surg Pathol. 2010;34:433–443.CrossRefGoogle ScholarPubMed Salvador, S, Gilks, B, Kobel, M, Huntsman, D, Rosen, B, Miller, D. The fallopian tube: primary site of most pelvic high-grade serous carcinomas. Int J Gynecol Cancer. 2009;19:58–64.CrossRefGoogle Scholar Accessibility compliance for the HTML of this chapter is currently unknown and may be updated in the future. To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle. Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. 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