Atrial Natriuretic Peptide Deterioration Diabetic Nephropathy via Stimulating Secretion of Cytokines

Abstract Background: Atrial natriuretic peptide (ANP) refers to a cardiovascular and metabolic hormone that has been identified recently for chronic kidney disease (CKD) without diabetes. Cytokines (e.g., interleukin-6 (IL-6), tumor necrosis element-α (TNF-α) as well as adiponectin (ADP)) contribute to development of diabetes of type 2 (T2DM). The aim here was at investigating ANP and some cytokines extents for a systematic analysis of relationship level in T2DM nephropathy patients. Methods: Plasma samples from T2DM patients (n=81) in accordance with albuminuria were split into normoalbuminuria (n=37), microalbuminuria (n=23) and macroalbuminuria (n=21), as collected after the consent was received. Based on enzyme-associated immunosorbent test, ANP, TNF-α, IL-6 and ADP in plasma underwent the quantification, and the data received the analysis for determining the correlation between ANP and cytokines among 3 cohorts. Results: The present study reported that macroalbuminuria patients exhibited higher plasma levels of ANP, TNF-α, IL-6, ADP, serum creatinine (Cr), blood urea nitrogen (BUN) and duration of diabetes mellitus (DM) than the cases subjected to normoalbuminuria and microalbuminuria. Plasma ANP level was significantly associated with TNF-α, IL-6 and ADP, independently of duration of DM and BUN. Conclusion: Elevated serum ANP levels are likely to impact the metabolism of adipose tissue and inflammation which involved in the pathogenesis and progression of DN.