Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels

Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels Ruonan Shao, Danchen Meng, Beibei Gao, Lu Zhang, Qingqi Meng, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4540155/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 24 Jan, 2025 Read the published version in Scientific Reports → Version 1 posted 12 You are reading this latest preprint version Abstract Objective It has been documented that D-dimer levels have potential utility as a measure of tumor activity in diffuse large B-cell lymphoma (DLBCL), however whether it can be used as a predictive marker of treatment outcome has not been established. This study means to retrospectively evaluate the role of D-dimer in prediction of treatment efficacy in patients with DLBCL. Materials and methods 151 patients with newly diagnosed DLBCL were enrolled. Blood samples were taken from those patients during the initial visit to our hospital and again after two cycles of chemotherapy to measure D-dimer levels. The link between plasma D-dimer concentrations and patients' clinical characteristics was explored before and after treatment. Results Patients showed statistically different plasma D-dimer levels at initial consultation across the four treatment-response groups [ complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD)]. Those in CR group had significantly lower D-dimer levels at initial consultation than those in PR and PD groups (p < 0.05). After chemotherapy, the PR group had considerably lower D-dimers than the SD and PD groups did (p < 0.05). The D-dimer difference percentage was lower in PR group than that in PD group (p < 0.05). Conclusion Patients who respond well to chemotherapy typically exhibit lower D-dimer levels at the initial diagnosis. Those in the SD or PD groups usually experience a greater increase in D-dimer levels following chemotherapy. Consequently, variations in plasma D-dimer levels before and after treatment may offer valuable insights for evaluating the efficacy of chemotherapy treatment. Biological sciences/Cancer/Haematological cancer Biological sciences/Cancer/Tumour biomarkers Health sciences/Medical research D-dimer level DLBCL Efficacy evaluation Prediction Therapeutic value Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 24 Jan, 2025 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 13 Nov, 2024 Reviews received at journal 04 Nov, 2024 Reviews received at journal 01 Nov, 2024 Reviewers agreed at journal 28 Oct, 2024 Reviewers agreed at journal 25 Oct, 2024 Reviews received at journal 30 Sep, 2024 Reviewers agreed at journal 15 Sep, 2024 Reviewers invited by journal 10 Sep, 2024 Editor assigned by journal 03 Sep, 2024 Editor invited by journal 10 Jun, 2024 Submission checks completed at journal 10 Jun, 2024 First submitted to journal 06 Jun, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4540155","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":318481790,"identity":"d85fdf02-f518-4a96-8639-323add93b706","order_by":0,"name":"Ruonan Shao","email":"","orcid":"","institution":"the Second Affiliated Hospital of Nanjing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Ruonan","middleName":"","lastName":"Shao","suffix":""},{"id":318481791,"identity":"14b48915-9e33-4885-bbdb-24c14feb3fd2","order_by":1,"name":"Danchen Meng","email":"","orcid":"","institution":"the First Affiliated Hospital of Anhui Medical University","correspondingAuthor":false,"prefix":"","firstName":"Danchen","middleName":"","lastName":"Meng","suffix":""},{"id":318481792,"identity":"56fe0ed9-7829-427c-b134-223a09b1249c","order_by":2,"name":"Beibei Gao","email":"","orcid":"","institution":"Liaoning Medical Center for Hematopoietic Stem Cell Transplantation, Second Hospital of Dalian Medical University","correspondingAuthor":false,"prefix":"","firstName":"Beibei","middleName":"","lastName":"Gao","suffix":""},{"id":318481794,"identity":"361d1ec6-25a7-4227-84d1-0dd33e76db75","order_by":3,"name":"Lu Zhang","email":"","orcid":"","institution":"the Second Affiliated Hospital of Nanjing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Lu","middleName":"","lastName":"Zhang","suffix":""},{"id":318481796,"identity":"059c2cda-d793-416d-b1e0-d4445583195c","order_by":4,"name":"Qingqi Meng","email":"","orcid":"","institution":"the Second Affiliated Hospital of Nanjing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Qingqi","middleName":"","lastName":"Meng","suffix":""},{"id":318481798,"identity":"7e5aacc8-f571-4767-8a49-2120dc99b47d","order_by":5,"name":"Yanqiu Hou","email":"","orcid":"","institution":"the Second Affiliated Hospital of Nanjing Medical University","correspondingAuthor":false,"prefix":"","firstName":"Yanqiu","middleName":"","lastName":"Hou","suffix":""},{"id":318481799,"identity":"95826bb4-dc29-4961-9ccb-f55f0827e6ad","order_by":6,"name":"Zhangbiao Long","email":"","orcid":"","institution":"the First Affiliated Hospital of Anhui Medical University","correspondingAuthor":false,"prefix":"","firstName":"Zhangbiao","middleName":"","lastName":"Long","suffix":""},{"id":318481800,"identity":"864e0fe9-559c-4bcd-882e-8b02f2d47a39","order_by":7,"name":"Jinsong Yan","email":"","orcid":"","institution":"Liaoning Medical Center for Hematopoietic Stem Cell Transplantation, Second Hospital of Dalian Medical University","correspondingAuthor":false,"prefix":"","firstName":"Jinsong","middleName":"","lastName":"Yan","suffix":""},{"id":318481801,"identity":"7d123e33-c4a1-47df-8e64-93112c83e961","order_by":8,"name":"Xiaofeng Shi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABCklEQVRIie2RP0vDQBTALwSuy2HXFyrmK5y4FvSjvFuapQXHDiJXApdFnFMsfgzndxw4ZXAM6BAQnBzsIpmqCR06Jc0oeL/lveH9eP8Y83j+IhBohoyN25y2u58zPspokBJpxgKb8/DiRBR4RNmHVgmd4KF6hCvZa8QPqYHqZgrjSfbihOCJgaZrvXzqVOSbTSU+zyDaFNd2A2JhJisK7orXbgXUqkLubmU5R/qUsDCnhGFgupU4V5pw5+CyVQTKhAPKXoWVTRdlHEhIyApCPKrIUqVS3c8Ayjmza03npjmy7dslzpOPqP5uLpYn719bTXGcZbaqlz2DHRCHd9CQ+oZRNbDQ4/F4/hu/66dfq4TpG8sAAAAASUVORK5CYII=","orcid":"","institution":"the Second Affiliated Hospital of Nanjing Medical University","correspondingAuthor":true,"prefix":"","firstName":"Xiaofeng","middleName":"","lastName":"Shi","suffix":""}],"badges":[],"createdAt":"2024-06-06 11:54:38","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4540155/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4540155/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41598-025-87273-4","type":"published","date":"2025-01-24T15:57:42+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":74859144,"identity":"77281e4c-2b67-477e-b3d0-9257797f6277","added_by":"auto","created_at":"2025-01-27 16:13:37","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":390607,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4540155/v1_covered_e441d3e1-1ea6-401a-8968-312910fab99b.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"D-dimer level, DLBCL, Efficacy evaluation, Prediction, Therapeutic value","lastPublishedDoi":"10.21203/rs.3.rs-4540155/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4540155/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eObjective\u003c/h2\u003e \u003cp\u003eIt has been documented that D-dimer levels have potential utility as a measure of tumor activity in diffuse large B-cell lymphoma (DLBCL), however whether it can be used as a predictive marker of treatment outcome has not been established. This study means to retrospectively evaluate the role of D-dimer in prediction of treatment efficacy in patients with DLBCL.\u003c/p\u003e\u003ch2\u003eMaterials and methods\u003c/h2\u003e \u003cp\u003e151 patients with newly diagnosed DLBCL were enrolled. Blood samples were taken from those patients during the initial visit to our hospital and again after two cycles of chemotherapy to measure D-dimer levels. The link between plasma D-dimer concentrations and patients' clinical characteristics was explored before and after treatment.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003ePatients showed statistically different plasma D-dimer levels at initial consultation across the four treatment-response groups [ complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD)]. Those in CR group had significantly lower D-dimer levels at initial consultation than those in PR and PD groups (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05). After chemotherapy, the PR group had considerably lower D-dimers than the SD and PD groups did (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05). The D-dimer difference percentage was lower in PR group than that in PD group (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05).\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003ePatients who respond well to chemotherapy typically exhibit lower D-dimer levels at the initial diagnosis. Those in the SD or PD groups usually experience a greater increase in D-dimer levels following chemotherapy. Consequently, variations in plasma D-dimer levels before and after treatment may offer valuable insights for evaluating the efficacy of chemotherapy treatment.\u003c/p\u003e","manuscriptTitle":"Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-06-25 08:49:20","doi":"10.21203/rs.3.rs-4540155/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2024-11-13T10:49:44+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-11-04T17:01:01+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-11-02T03:38:40+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"116899302974860265118871626348260120579","date":"2024-10-28T11:18:38+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"294992331633386023488333616567998378505","date":"2024-10-25T23:03:35+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-09-30T17:30:47+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"84960409458004184376448425923235551883","date":"2024-09-15T12:53:03+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2024-09-10T06:48:19+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-09-03T06:22:12+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2024-06-10T05:02:55+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-06-10T04:45:21+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scientific Reports","date":"2024-06-06T11:53:11+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"a3c8f56c-6bdb-4227-afca-362c0e9bb5db","owner":[],"postedDate":"June 25th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":33676489,"name":"Biological sciences/Cancer/Haematological cancer"},{"id":33676490,"name":"Biological sciences/Cancer/Tumour biomarkers"},{"id":33676491,"name":"Health sciences/Medical research"}],"tags":[],"updatedAt":"2025-01-27T16:09:50+00:00","versionOfRecord":{"articleIdentity":"rs-4540155","link":"https://doi.org/10.1038/s41598-025-87273-4","journal":{"identity":"scientific-reports","isVorOnly":false,"title":"Scientific Reports"},"publishedOn":"2025-01-24 15:57:42","publishedOnDateReadable":"January 24th, 2025"},"versionCreatedAt":"2024-06-25 08:49:20","video":"","vorDoi":"10.1038/s41598-025-87273-4","vorDoiUrl":"https://doi.org/10.1038/s41598-025-87273-4","workflowStages":[]},"version":"v1","identity":"rs-4540155","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4540155","identity":"rs-4540155","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}