EKSPRESI LEUKEMIA INHIBITORY FACTOR (LIF) DI ENDOMETRIUM PADA MENCIT MODEL ENDOMETRIOSIS DENGAN DAN TANPA PAPARAN LIPOPOLYSACCHARIDE (LPS) E. COLI

Akhmad Risdianto
2018 · W2910264656
dissertation OA: green CC0
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This experimental study analyzed Leukemia Inhibitory Factor (LIF) expression in the endometrium of mice subjected to an endometriosis model with and without exposure to Escherichia coli lipopolysaccharide. The researchers divided thirty-two mice into four groups, including a control group, an endometriosis-only group, an LPS-treated group, and a combined endometriosis and LPS group, measuring LIF levels across all subjects. Results indicated that LIF expression was significantly lower in the endometriosis model compared to controls, while exposure to LPS significantly increased LIF expression in both normal and endometriotic mice. This paper is centrally about endometriosis — specifically investigating how inflammatory triggers like LPS modulate endometrial cytokine expression in a murine model of the disease.

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Abstract

Menganalisis ekspresi Leukemia Inhibitory Factor (LIF) di endometrium \npada mencit model endometriosis yang diberiLipopolysaccharide (LPS) E. coli. \nMetode: Desain penelitian ini bersifat eksperimental laboratorium pada Mus \nmusculus. Subyek penelitian sebanyak 32 mencit dibagi menjadi 4 kelompok. \nKelompok1: mencit tanpa perlakuan / kontrol, K2: kelompok mencit model \nendometriosis, K3: kelompok mencit yang diberi LPS E. coli, dan K4: kelompok \nmencit model endometriosis yang kemudian diberi LPS E. coli.kemudian \ndilakukan pemeriksaan LIFdi endometrium pada semua kelompok \nHasil: \nEkspresi LIF di endometriumpada kelompok mencit model endometriosis lebih \nrendah dibandingkan dengan kelompok mencit kontrol ( 0,26+0,30 vs 2,2+1,54), \ndan didapatkan perbedaan signifikan (p=0,024). \nEkspresi LIF di endometriumpada kelompok mencit yang diberi LPS E. coli lebih \ntinggi dibandingkan dengan kelompok mencit kontrol ( 4,2+2,63 vs 2,2+1,54), \ndan didapatkan perbedaan signifikan (p=0,021). \nEkspresi LIF di endometriumpada kelompok mencit model endometriosis yang \ndiberi LPS E. coli lebih tinggi dibandingkan dengan kelompok mencit kontrol \n(2,9+1,12 vs 2,2+1,54), namun tidak didapatkan perbedaan signifikan (p=0,441). \nEkspresi LIF di endometriumpada kelompok mencit model endometriosis yang \ndiberi LPS E. coli lebih tinggi dibandingkan dengan kelompok mencit model \nendometriosis ( 2,9+1,12 vs 0,26+0,30), dan didapatkan perbedaan signifikan \n(p=0,004). \nKesimpulan: Didapatkan perbedaan ekspresi LIF di endometriumpada mencit \nmodel endometriosis dan mencit model endometriosis yang diberi LPS E. coli.
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IR-PERPUSTAKAAN UNIVERSITAS AIRLANGGA xvii TESIS EKSPRESI LEUKIMIA INH…. AKHMAD R. EKSPRESI LEUKEMIA INHIBITORY FACTOR (LIF) DI ENDOMETRIUM PADA MENCIT MODEL ENDOMETRIOSIS DENGAN DAN TANPA PAPARAN LIPOPOLYSACCHARIDE (LPS) E. COLI Akhmad Risdianto,1, Ashon Sa’adi2, Widjiati3 1 PPDS-1 Departemen/SMF Obstetri dan Ginekologi 2 Staf Pengajar Departemen/SMF Obstetri dan Ginekologi 3 Staf Pengajar fakultas kedokteran hewan Universitas Airlangga RSUD Dr. Soetomo, Fakultas Kedokteran Universitas Airlangga, Surabaya Abstrak Tujuan: Menganalisis ekspresi Leukemia Inhibitory Factor (LIF) di endometrium pada mencit model endometriosis yang diberiLipopolysaccharide (LPS) E. coli. Metode: Desain penelitian ini bersifat eksperimental laboratorium pada Mus musculus. Subyek penelitian sebanyak 32 mencit dibagi menjadi 4 kelompok. Kelompok1: mencit tanpa perlakuan / kontrol, K2: kelompok mencit model endometriosis, K3: kelompok mencit yang diberi LPS E. coli, dan K4: kelompok mencit model endometriosis yang kemudian diberi LPS E. coli.kemudian dilakukan pemeriksaan LIFdi endometrium pada semua kelompok Hasil: Ekspresi LIF di endometriumpada kelompok mencit model endometriosis lebih rendah dibandingkan dengan kelompok mencit kontrol ( 0,26+0,30 vs 2,2+1,54), dan didapatkan perbedaan signifikan (p=0,024). Ekspresi LIF di endometriumpada kelompok mencit yang diberi LPS E. coli lebih tinggi dibandingkan dengan kelompok mencit kontrol ( 4,2+2,63 vs 2,2+1,54), dan didapatkan perbedaan signifikan (p=0,021). Ekspresi LIF di endometriumpada kelompok mencit model endometriosis yang diberi LPS E. coli lebih tinggi dibandingkan dengan kelompok mencit kontrol (2,9+1,12 vs 2,2+1,54), namun tidak didapatkan perbedaan signifikan (p=0,441). Ekspresi LIF di endometriumpada kelompok mencit model endometriosis yang diberi LPS E. coli lebih tinggi dibandingkan dengan kelompok mencit model endometriosis ( 2,9+1,12 vs 0,26+0,30), dan didapatkan perbedaan signifikan (p=0,004). Kesimpulan: Didapatkan perbedaan ekspresi LIF di endometriumpada mencit model endometriosis dan mencit model endometriosis yang diberi LPS E. coli. Kata Kunci:Endometriosis, Endometrium, Lipopolisakarida,Leukemia Inhibitory Factor IR-PERPUSTAKAAN UNIVERSITAS AIRLANGGA xviii TESIS EKSPRESI LEUKIMIA INH…. AKHMAD R. EXPRESSION OF LEUKEMIA INHIBITORY FACTOR (LIF) IN ENDOMETRIUM OF ENDOMETRIOSIS MICEMODEL WITH AND WITHOUT EXPOSURE OF LIPOPOLYSACCHARIDE (LPS) E. COLI Akhmad Risdianto,1, Ashon Sa’adi2, Widjiati3 1 PPDS-1 Departemen/SMF Obstetri dan Ginekologi 2 Staf Pengajar Departemen/SMF Obstetri dan Ginekologi 3 Staf Pengajar fakultas kedokteran hewan Universitas Airlangga RSUD Dr. Soetomo, Fakultas Kedokteran Universitas Airlangga, Surabaya Abstract Objective: To analize the comparasion of Leukemia Inhibitory Factor (LIF) in endometrium of endometriosis mice model after exposure of Lipopolysaccharide (LPS) E. coli Methods: Exprimental laboratory, 32 mice were seprated into 4 groups, Group 1 mice controle, Group 2 endometriosis mice model, Group 3: LPS treated mice models, and group:4 endometriosis mice model treatment with LPS E. coli. All groups we analized the LIF in endometrium. Results: LIF expression in the endometrium of endometriosis mice model was lower than in the control group (0,26+0,30 vs 2,2+1,54), statistically significant (p = 0.024). LIF expression in the endometrium of LPS treated mice was higher than in the control group (4,2+2,63 vs 2,2+1,54), statistically significant (p = 0.021). LIF expression in the endometrium of endometriosis mice model with LPS was higher than in the control group (2,9+1,12 vs 2,2+1,54), no statistically significant (p = 0.441). LIF expression in the endometrium of endometriosis mice model with LPS was higher than in the endometriosis mice model (2,9+1,12 vs 0,26+0,30), statistically significant (p = 0.004). Conclusion: There were significant differences in LIF expression in the endometrium endometriosis mice model and endometriosis mice model treated LPS E. coli. Keywords: Endometriosis, Endometrium, Lipopolysaccharide,Leukemia Inhibitory Factor

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