COMPARISON OF MORPHOMETRIC AND MORPHOLOGY OOCYTES AFTER IN VITRO MATURATION BETWEEN HEALTHY WOMEN AND PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME.

Allahveisi A, Yousefian E, Rezaie MJ, Nikkhoo B
Acta endocrinologica (Bucharest, Romania : 2005) · 2019 · doi:10.4183/aeb.2019.295 · PMID:32010346 · PMC6992407
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This study compared the morphometric and morphological characteristics of oocytes following in vitro maturation (IVM) between women with polycystic ovarian syndrome (PCOS) and healthy controls. The researchers analyzed 108 immature oocytes from sixteen PCOS patients and sixteen normal women, assessing maturation rates and structural features after 24 to 48 hours of incubation. Results indicated that while total oocyte diameter did not differ significantly between groups, PCOS patients exhibited higher rates of morphological abnormalities such as ooplasmic vacuolization and granulation, alongside lower maturation success compared to the control group. This paper is centrally about polycystic ovarian syndrome rather than endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

ObjectivesPolycystic ovarian syndrome (PCOS) occurs in 6-10% of all women in their reproductive age. In women with PCOS, controlled ovarian hyperstimulation (COH) often results in an increased risk of ovarian hyperstimulation syndrome (OHSS). In vitro maturation (IVM) of human oocyte is an alternative technique for in vitro fertilization (IVF). The aim of this study was to compare the morphometric analysis and morphology of oocytes after in- vitro maturation (IVM) between normal women and those suffering from polycystic ovary syndrome (PCOS).Material and methodsThirty two women of 20 to 35 years of age that were undergoing controlled ovarian stimulation by the ICSI/IVF protocol were chosen for the study. The immature oocytes (n=108) were divided into two groups: the first oocyte group was comprised of 16 normal women (n=54); and the second group included 16 women with PCOS (n=54); then the oocytes were matured in vitro. After 24-48h of incubation, the oocyte maturation rate and morphometric and morphological characteristics were assessed using an inverted microscope, and then the images were compared.ResultsThere were significant differences in the maturity of oocytes between normal women and those with PCOS after IVM (P<0.05). Moreover, morphometric assessments revealed that there were no significant difference in the total diameter (μm) (zona thickness (ZPT) + perivitelline space width (PVS) + cytoplasm (CD) of oocytes between normal women and those with PCOS (156.3±6.8 and 137.7±9.9), respectively (P>0.05). Evaluation of morphological oocytes showed that morphological abnormalities, including ooplasmic vacuolization and granulation were higher in PCOS women compared to normal women (P<0.05).ConclusionThe increased quality of oocytes after IVM reflected a positive impact of IVM oocytes on normal women as compared to women with PCOS.
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Material

and Methods. Thirty two women of 20 to 35 years of age that were undergoing controlled ovarian stimulation by the ICSI/IVF protocol were chosen for the study. The immature oocytes (n=108) were divided into two groups: the first oocyte group was comprised of 16 normal women (n=54); and the second group included 16 women with PCOS (n=54); then the oocytes were matured in vitro. After 24-48h of incubation, the oocyte maturation rate and morphometric and morphological characteristics were assessed using an inverted microscope, and then the images were compared. Results. There were significant differences in the maturity of oocytes between normal women and those with PCOS after IVM (P<0.05). Moreover, morphometric assessments revealed that there were no significant difference in the total diameter (μm) (zona thickness (ZPT) + perivitelline space width (PVS) + cytoplasm (CD) of oocytes between normal women and those with PCOS (156.3±6.8 and 137.7±9.9), respectively (P>0.05). Evaluation of morphological oocytes showed that morphological abnormalities, including ooplasmic vacuolization and granulation were higher in PCOS women compared to normal women (P<0.05). Conclusion. The increased quality of oocytes after IVM reflected a positive impact of IVM oocytes on normal women as compared to women with PCOS.

Keywords

Polycystic Ovarian Syndrome (PCOS), In vitro maturation (IVM), Human oocytes Correspondence: Azra Allahveisi, Infertility Center of Beassat Hospital, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran, E-mail: [email protected]

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