OPTIMIZING MULTIDISCIPLINARY STRATEGIES FOR ALLEVIATING PELVIC DISCOMFORT IN WOMEN WITH PERSISTENT ENDOMETRIAL INFLAMMATION

Tursoatova Sh.M, Tilyavova S.A
2025 · doi:10.5281/zenodo.15226832 · W6949381488
article OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher

Abstract

Persistent endometrial inflammation, or chronic endometritis (CE), affects 12–25% of women seeking reproductive care, often manifesting as debilitating pelvic discomfort that disrupts daily life. In Uzbekistan, where CE is diagnosed in 10–18% of gynecological patients, fragmented care exacerbates suffering. This randomized controlled trial (RCT) explored innovative multidisciplinary strategies—targeted antibiotics, acupuncture, and mindfulness-based stress reduction (MBSR)—to relieve pelvic discomfort in 160 women aged 20–40 across Tashkent, Fergana, and Bukhara clinics from March 2023 to December 2024. Participants were randomized into four groups: antibiotics, acupuncture, integrated (antibiotics-acupuncture-MBSR), and usual care (control). Primary outcomes were discomfort severity (Pelvic Pain Impact Questionnaire, PPIQ) and inflammatory resolution (biopsy-confirmed). Secondary outcomes included emotional well-being (PHQ-9), fertility potential (ovulatory cycles), and intervention uptake at 8 weeks and 6 months. The integrated group reduced PPIQ scores by 50% (8.5 ± 1.5 to 4.3 ± 1.0, p<0.001) and achieved 80% inflammatory resolution versus 50% in controls (p<0.01). Acupuncture alone eased discomfort by 35%, and antibiotics resolved inflammation in 65%. Emotional well-being improved markedly in the integrated group (PHQ-9 6 ± 2 vs. 12 ± 3 in controls, p<0.001). These results champion a holistic approach, offering Uzbekistan a practical framework to enhance women’s health and informing global CE care.
Full text 2,494 characters · extracted from oa-doi-fallback · click to expand
OPTIMIZING MULTIDISCIPLINARY STRATEGIES FOR ALLEVIATING PELVIC DISCOMFORT IN WOMEN WITH PERSISTENT ENDOMETRIAL INFLAMMATION Authors/Creators - 1. Samarkand State Medical University Description Persistent endometrial inflammation, or chronic endometritis (CE), affects 12–25% of women seeking reproductive care, often manifesting as debilitating pelvic discomfort that disrupts daily life. In Uzbekistan, where CE is diagnosed in 10–18% of gynecological patients, fragmented care exacerbates suffering. This randomized controlled trial (RCT) explored innovative multidisciplinary strategies—targeted antibiotics, acupuncture, and mindfulness-based stress reduction (MBSR)—to relieve pelvic discomfort in 160 women aged 20–40 across Tashkent, Fergana, and Bukhara clinics from March 2023 to December 2024. Participants were randomized into four groups: antibiotics, acupuncture, integrated (antibiotics-acupuncture-MBSR), and usual care (control). Primary outcomes were discomfort severity (Pelvic Pain Impact Questionnaire, PPIQ) and inflammatory resolution (biopsy-confirmed). Secondary outcomes included emotional well-being (PHQ-9), fertility potential (ovulatory cycles), and intervention uptake at 8 weeks and 6 months. The integrated group reduced PPIQ scores by 50% (8.5 ± 1.5 to 4.3 ± 1.0, p<0.001) and achieved 80% inflammatory resolution versus 50% in controls (p<0.01). Acupuncture alone eased discomfort by 35%, and antibiotics resolved inflammation in 65%. Emotional well-being improved markedly in the integrated group (PHQ-9 6 ± 2 vs. 12 ± 3 in controls, p<0.001). These results champion a holistic approach, offering Uzbekistan a practical framework to enhance women’s health and informing global CE care. Files 532-538_Tursoatova Sh.M Tilyavova S.A .pdf Files (994.0 kB) | Name | Size | Download all | |---|---|---| | md5:7ae440e548e2134bebac01cdf78559a2 | 994.0 kB | Preview Download | Additional details References - 1. Ticconi C, Inversetti A, Marraffa S, Campagnolo L, Arthur J, Zambella E, Di Simone N. Chronic endometritis and recurrent reproductive failure: a systematic review and meta-analysis. Front Immunol. 2024 Aug 16;15:1427454. doi: 10.3389/fimmu.2024.1427454. PMID: 39286255; PMCID: PMC11403846. - 2. Brölmann, H.A.M. & Van der Linden, Paul & Bongers, Marlies & Moret, E & Meuwissen, J. (1993). [Ultrasonographic diagnosis of endometrial disorders: correlation with the histological results in 112 patients]. Nederlands tijdschrift voor geneeskunde. 137. 1823-7.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

disambig:endometritis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

openalex
last seen: 2026-05-10T11:26:16.120872+00:00
License: CC0 · commercial use OK