Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia

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Its benefits are frequently considered as being less intrusive, giving superior cosmetic outcomes, and needing a shorter hospital stay because they are based on surgical knowledge and cutting-edge technology. However, laparoscopic surgery under general anaesthesia and pneumoperitoneum may result in adverse pulmonary physiological alterations. This study will make choosing between volume control ventilation and pressure control ventilation for patients undergoing laparoscopic surgeries under general anaesthesia feasible. Method 82 participants of both male and female gender and of the age between 18 and 70, with 41 in each group, will be randomly allotted with pressure control or volume control ventilation. The hemodynamic parameters and ventilatory parameters will be assessed. Data collection and analysis will be done. Expected outcomes To conclude if volume control ventilation or pressure control ventilation is effective in laparoscopic surgeries and which has less hemodynamic responses and better patient outcomes. " } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/13-678", "name": "Comparative study of the efficacy of volume control ventilation vs..." } } ] } Home Browse Comparative study of the efficacy of volume control ventilation vs... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Dhakshinamurthy DP and Singam DA. Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2024, 13 :678 ( https://doi.org/10.12688/f1000research.152186.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Study Protocol Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia [version 1; peer review: 1 approved, 1 approved with reservations] Dr. Poornima Dhakshinamurthy https://orcid.org/0009-0006-2027-4916 1 , Dr. Amol Singam 1 Dr. Poornima Dhakshinamurthy https://orcid.org/0009-0006-2027-4916 1 , Dr. Amol Singam 1 PUBLISHED 24 Jun 2024 Author details Author details 1 ANAESTHESIOLOGY, DATTA MEGHE INSTITUTE OF HIGHER EDUCATION AND RESEARCH, WARDHA, MAHARASHTRA, 442001, India Dr. Poornima Dhakshinamurthy Roles: Conceptualization, Data Curation, Investigation, Methodology, Writing – Original Draft Preparation Dr. Amol Singam Roles: Conceptualization, Methodology, Supervision, Validation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Datta Meghe Institute of Higher Education and Research collection. Abstract Background A variety of disorders are surgically treated with laparoscopy. Its benefits are frequently considered as being less intrusive, giving superior cosmetic outcomes, and needing a shorter hospital stay because they are based on surgical knowledge and cutting-edge technology. However, laparoscopic surgery under general anaesthesia and pneumoperitoneum may result in adverse pulmonary physiological alterations. This study will make choosing between volume control ventilation and pressure control ventilation for patients undergoing laparoscopic surgeries under general anaesthesia feasible. Method 82 participants of both male and female gender and of the age between 18 and 70, with 41 in each group, will be randomly allotted with pressure control or volume control ventilation. The hemodynamic parameters and ventilatory parameters will be assessed. Data collection and analysis will be done. Expected outcomes To conclude if volume control ventilation or pressure control ventilation is effective in laparoscopic surgeries and which has less hemodynamic responses and better patient outcomes. READ ALL READ LESS Keywords Pressure control ventilation, volume control ventilation, laparoscopic surgeries, pneumoperitoneum, general anaesthesia. Corresponding Author(s) Dr. Poornima Dhakshinamurthy ( [email protected] ) Close Corresponding author: Dr. Poornima Dhakshinamurthy Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2024 Dhakshinamurthy DP and Singam DA. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Dhakshinamurthy DP and Singam DA. Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2024, 13 :678 ( https://doi.org/10.12688/f1000research.152186.1 ) First published: 24 Jun 2024, 13 :678 ( https://doi.org/10.12688/f1000research.152186.1 ) Latest published: 24 Jun 2024, 13 :678 ( https://doi.org/10.12688/f1000research.152186.1 ) Introduction Background and Rationale Analgesia, or the inability to feel pain, is one of the many goals of general anaesthesia, along with immobility (loss of reflexes), paralysis, amnesia (loss of memory), and unconsciousness (loss of awareness) (muscle relaxation). The main ventilation mode used during surgery is volume-controlled ventilation (VCV). However, when dealing with elevated peak airway pressure, it is crucial to establish the tidal volume and respiratory rate beforehand to ensure effective ventilation. Although pressure-controlled ventilation offers better management of airway pressure, it is not the preferred choice for intraoperative use. 1 Lung compliance, functional residual and vital lung capacity decrease during general anaesthesia. The pneumoperitoneum can increase intra-abdominal and intrathoracic pressure, whereas the Trendelenburg position, favoured during laparoscopic surgery, can further reduce these values. Atelectasis may result from recurrent minor airway closures. The majority of patients should be able to adapt to these changes without too much trouble if they are otherwise healthy, but obese patients and those with long-term respiratory issues are more likely to experience issues with intraoperative hypoxia, barotrauma, and volutrauma during laparoscopic procedures. 2 With more surgeries being performed laparoscopically in the previous ten years our understanding of the effects of pneumoperitoneum on the cardiopulmonary physiology has also increased. Among the most noticeable ventilatory effects, along with cardiovascular consequences, is increased peak airway pressure (Ppeak). The anaesthesiologist could change the ventilation control mechanism from volume-controlled (VC) to pressure-controlled (PC) for the patient’s respiratory rate (RR), tidal volume, or both. PC ventilation is being employed regularly in operating rooms to handle patients with elevated Ppeak, despite a paucity of knowledge about its ventilatory and hemodynamic effects and potential downsides. 3 The objective of this study is to compare volume control ventilation (VCV) and pressure control ventilation (PCV) in laparoscopic surgery patients, specifically examining their impact on ventilatory and hemodynamic responses. In PCV, the ventilator is responsible for regulating inspiratory flow and flow waveform to maintain a square inspiratory pressure profile while the physician adjusts the inspiratory pressure based on the measured tidal volume. VCV is commonly used in general anaesthesia to maintain steady minute ventilation during pulmonary resistance and compliance impact airway pressure. Volume-controlled ventilation (VCV) utilizes a steady flow to administer tidal volume. Nevertheless, this method can result in elevated airway pressures. 4 During laparoscopic surgeries, the presence of pneumoperitoneum can lead to decreased tidal volumes in patients. This is attributed to the increased pressure within the abdomen, which negatively affects the compliance of the chest wall and lungs. Consequently, the functional residual capacity decreases, leading to a reduction in alveolar ventilation. 5 The study will assess the efficacy of ventilation by measuring various parameters such as end-tidal carbon dioxide (ETCO2), mean airway pressure (Pmean), peak inspiratory pressure (Ppeak), and expiratory tidal volume. Its primary goal is to determine whether VCV or PCV offers superior ventilation and preserves hemodynamic stability in patients undergoing laparoscopic procedures with pneumoperitoneum. Protocol Aim This study’s aim is to compare the efficacy of volume control ventilation with pressure control ventilation in patients undergoing laparoscopic surgery under general anaesthesia. Objectives 1. The primary goal is to assess the effectiveness of ventilation by examining expiratory tidal volume, high peak pressure, and mean inspiratory pressure (Ppeak) (Pmean). 2. The secondary goal is to compare the efficacy of hemodynamic response by evaluating variables such as heart rate (HR), oxygen saturation (SPO 2 ), systolic blood pressure, diastolic blood pressure, and mean arterial pressure (MAP). Methods and analysis ▪ Study design : 1. Study duration: Two years of research. 2. Study area: JNMC and AVBRH’s anaesthesia department. 3. Research design: Interventional parallel group randomised study 4. Patients of either gender between the ages of 18 and 70 make up the study population. ▪ Study setting The research study has obtained ethical approval from the Ethics and Screening Committee of The Jawaharlal Nehru Medical College (JNMC), Datta Meghe Institute of Higher Education and Research, to be carried out at Acharya Vinoba Bhave Rural Hospital (AVBRH), Sawangi (M), Wardha. The study will involve 82 participants, and prior to their surgical procedures, all patients will be requested to provide written consent after receiving comprehensive information about the study. ▪ Participants : Criteria for inclusion : 1. Patients of any gender, ages 18 to 70. 2. Patients in ASA Classes I and II. 3. All patients who are willing to provide written, fully informed permission. 4. The surgery duration is between 60 and 120 minutes. Criteria of exclusion : 1. ASA Class III and higher. 2. Patients’ rejection. 3. Male or female, between the ages of 18 and 70. 4. Patients who shouldn’t have laparoscopic procedures. 5. People who experience allergic responses to anaesthetics. ▪ Data analysis : 1. Haemodynamic parameters, including heart rate, blood pressure, and blood oxygen level 2. Mean inspiratory pressure (Pmean), Tidal volume, High peak pressure (Ppeak), and End-tidal CO 2 (etco 2 ) ▪ Materials requirement : 1. Appropriately sized cuffed endotracheal tubes and masks. 2. Anaesthesia workstation Drager. 3. Monitors with ECG, pulse oximetry, and non-invasive blood pressure. ▪ Recruitment : 1. Patient Counselling and Explanation: Prospective research volunteers will be identified and given in-depth counselling regarding the goals, methods, and possible advantages of the study during the pre-anaesthetic check-up. Patients will be made aware of the need for the study as well as its expected results. 2. Informed Consent: A thorough informed consent form will be given to patients who indicate an interest in taking part. This form will provide a detailed description of the goals, methods, possible hazards, and advantages of the study. Patients will be able to voice any concerns and ask questions. Enrollment in the study will only be granted to individuals who furnish legitimate written consent. 3. Patient Selection: Subjects must fulfil the required ASA and Mallampati classifications, fall within the given age range, and undergo laparoscopic procedures under general anaesthesia in order to be chosen for participation. 4. Preoperative Evaluation: The day before surgery, every chosen patient will go through a thorough preoperative evaluation to determine their general health and suitability for the treatment. The study protocol contains specific measurements and assessments that will be part of this evaluation. 5. Randomization: Subjects will be assigned at random to either Group A (pressure control ventilation) or Group B (volume control ventilation), which are the two study groups. To ensure impartial allocation, the randomization will be performed by staff members who are not directly involved in the study using a specified technique, such as computer-generated random numbers. 6. Blinding: The patients and the anesthesiologist who records perioperative data will be unaware of the particular study medication that is given in order to preserve the study’s integrity. ▪ Sample design & size : The study will be conducted among 82 adult patients of both sexes (41 patients in each group) fulfilling all inclusion criteria. They will be allotted randomly using a computer generated sequence: •GROUP A (n=41): Patients receiving pressure control ventilation. •GROUP B (n=41): Patients receiving volume control ventilation. ▪ Rationale for selected sample size : The formula for sample size from the difference between two means was used to calculate the sample size of this study. The MAP after 15 mins of tracheal intubation was chosen to calculate the sample size. 2 N = ( Zα + Zβ ) 2 ( δ 1 2 + δ 2 2 / K ) Zα: level of significance at 5%-95% confidence level Zβ is the power of test = 80% = 0.84 δ 1 = SD of MAP in PCV = 15 δ 2 = SD of MAP in VCV = 10 K = 1 Δ = Difference between two means In order to calculate sample size for comparing two means, data that was inputted. • Confidence Interval (2-sided): 80% • Power: 80% • The ratio of sample size (Group 2/Group 1): 1 • MAP: 97 mmHg (Group A), 91 mmHg (Group B) • Standard deviation: 15 (Group A), 10 (Group B) Substituting: • Zα = 1.28 • Zβ = 0.84 • δ 1 = 15 • K = 1 • δ 2 = 10 • Δ = (97-91 = 6) N = ( 1.28 + 0.84 ) 2 ( 15 2 + 10 2 ) 6 2 = 40.57 = 41 Methods After giving written informed consent, 82 patients between the ages of 18 and 70 who will have laparoscopic surgery under general anaesthesia will be enrolled in the study. An intravenous line with an 18-gauge cannula will be started as soon as the patient enters the operating room, and monitors will be linked to them for continuous monitoring of their heart rate, ECG, non-invasive blood pressure, breathing rate, and oxygen saturation (SpO 2 ). The baseline vitals will be noted. As part of a typical premedication protocol, patients will get 0.2 mg of Injection glycopyrrolate (Supplier: NEON; Catalogue Number: 6612; 0.004 mg/kg), 1 milligram of intravenous midazolam (Supplier: NEON; Catalogue Number: V304510; 0.05 mg/kg), and 1 milligram of injection butorphanol (Supplier: NEON; Catalogue number: KP094033; 0.04 mg/kg). Injection vecuronium 6 milligram intravenous (Supplier: NEON; Catalogue Number: 385376; 0.1 mg/kg) and injection propofol 100 milligram (Supplier: NEON; Catalogue Number: 338419; 0.2 mg/kg) will be used to induce anaesthesia in the patient. The patient will be connected to a ventilator after being intubated with an acceptable internal diameter cuffed endotracheal tube. A total of 41 people will receive PCV (Group A), and a total of 41 people will receive VCV (Group B). Regular monitoring will be done periodically using the ET CO2 Pmean and Ppeak, NIBP, ECG, and pulse oximetry. Systolic blood pressure, Diastolic blood pressure, and respiratory parameters like respiratory rate, and saturation will be measured at the time of induction and every five minutes post-induction till 45 minutes ( Table 1 ). Table 1. Hemodynamic and respiratory parameters compared every 15 minutes. TIME AFTER INDUCTION HR (BPM) SYSTOLIC BP (mmHg) DIASTOLIC BP (mmHg) MEAN ARTERIAL PRESSURE (mmHg) SPO 2 (%) PMEAN (cmH 2 O) PEAK (cmH 2 O) ETCO 2 (mmHg) VTe (mL) 0 MINS 15 MINS 30 MINS 45 MINS Statistics methods The Statistical analysis will be done using SPSS version 16. The statistical analysis conducted in this study will encompass both inferential and descriptive statistics. Inferential statistics, such as the chi-square test and unpaired t-test, will be utilized to analyze the data and make inferences about the broader population. Descriptive statistics, including measures like the mean, standard deviation, and standard error of the mean, will be computed to summarize and describe the data. A significance level of 5% will be applied to evaluate the statistical significance of the results. Discussion In 2011 Tyagi et al. did a study titled “A comparison between volume control and pressure control ventilation for laparoscopic cholecystectomy”, where they randomly assigned volume control ventilation and pressure control ventilation. The ventilator settings were assigned accordingly to match the parameters. The initial 5 minutes had no difference in peak and mean airway pressure. The peak airway pressure decreased after 10 and 30 minutes, and the mean pressure increased in PCV more than in VCV. This, they explained, is due to decelerating inspiratory flow rate. However, they could not see any differences in the ETCO 2 , gas exchange, or PaCO 2 . 1 In a 2017 study conducted by Mihalj et al., the effects of pressure-controlled ventilation (PCV) and volume-controlled ventilation (VCV) on respiratory and hemodynamic parameters were examined during laparoscopic cholecystectomy. The study included 60 patients aged 18 to 70, with ASA scores ranging from 1 to 3, a body mass index (BMI) below 35 kg/m 2 , and no history of chronic respiratory disorders. The patients were randomly divided into two groups: one receiving protective pressure-controlled mechanical ventilation and the other receiving volume-controlled mechanical ventilation. Initially, no significant differences in respiratory and hemodynamic measures were observed between the two groups. However, when specifically comparing patients with a BMI of 25, it was found that the PCV group exhibited significantly lower peak inspiratory pressure (Ppeak) at 15, 30, and 45 minutes after tracheal intubation. Similar trends were observed in other measured parameters. The study concluded that PCV and VCV effectively maintained appropriate ventilation, oxygenation, and hemodynamic stability in the observed patient groups. 2 In a 2007 study conducted by Balick et al., titled “Respiratory and hemodynamic effects of volume-controlled vs. pressure-controlled breathing during laparoscopy: a cross-over study with echocardiographic assessment,” the objective was to compare the respiratory and hemodynamic effects of volume-controlled (VC) and pressure-controlled (PC) ventilation in laparoscopic urological procedures. The study included twenty-one patients who underwent VC ventilation initially and then switched to PC ventilation. Tidal volume, respiratory rate, and fraction of inspired oxygen (FIO2) were maintained constant across both ventilation modes. The study findings indicated that pressure-controlled (PC) ventilation resulted in better outcomes in peak airway pressure, peak inspiratory flow, and dynamic compliance compared to volume-controlled (VC) ventilation. However, no significant differences were observed in static airway pressure, static compliance, or arterial oxygenation. The systolic and diastolic heart performance assessment also showed no notable changes. Therefore, the study concluded that PC ventilation had no immediate benefits over traditional VC ventilation in patients undergoing laparoscopic procedures with pneumoperitoneum. 3 In a 2020 study conducted by Salah et al. titled “Comparison Between Volume Controlled Ventilation and Pressure Controlled Ventilation in Laparoscopic Bariatric Surgeries,” the researchers aimed to investigate how different ventilation modes impact respiratory parameters and the need for postoperative ventilation in laparoscopic bariatric surgeries. The study revealed that pneumoperitoneum during these surgeries led to a significant increase of 68% in inspiratory resistance and a decrease of 30% in compliance among obese patients compared to normal-weight patients. These changes reduced arterial oxygenation due to decreased functional residual capacity, pulmonary shunting, ventilation-perfusion mismatch, and increased atelectasis, particularly in obese patients. However, no significant differences in oxygenation levels between volume-controlled and pressure-controlled ventilation modes were observed. Interestingly, the study showed that pressure-controlled ventilation resulted in significantly lower levels of arterial carbon dioxide (PaCO 2 ) after pneumoperitoneum, at the end of the surgery, and in the postoperative period. This was the case despite similar preoperative PaCO 2 levels between the two groups. In another study from 2014 titled “Comparison of pressure and volume-controlled ventilation in laparoscopic cholecystectomy operations,” researchers specifically examined the effects of pressure-controlled ventilation (PCV) and volume-controlled ventilation (VCV) during the surgery. The study concluded that based on patient characteristics, surgical procedures, anaesthesia, pneumoperitoneum, and recovery period there were no significant changes. Hemodynamic data and blood gas values were also similar. However, both groups experienced decreased lung compliance after pneumoperitoneum, with a more pronounced effect observed in the PCV group. The VCV group showed a significant increase in tidal volume at 10 and 20 minutes after insufflation. According to the study, the group receiving pressure-controlled ventilation (PCV) exhibited higher values of alveolar dead space ventilation to tidal volume ratio before pneumoperitoneum and a higher alveolar-arterial oxygen gradient after pneumoperitoneum compared to the group receiving volume-controlled ventilation (VCV). However, the dynamic compliance of the respiratory system was similar between the two groups. The study results showed that by using volume-controlled ventilation for laparoscopic surgeries required tidal volumes to be on higher side and alveolar-arterial oxygen was less after pneumoperitoneum. These findings suggest that VCV may offer improved alveolar ventilation compared to PCV in laparoscopic cholecystectomy procedures. 5 Pelosi et al.’s (1998) study, “The Influence of Body Mass on Gas Exchange, Lung Volumes, and Respiratory Mechanics,” looked at how body mass index (BMI) impacts respiratory variables under general anaesthesia. Their method entailed analysing compliance, resistance, gas exchange, and the effort needed to inhale one litre of air using the oesophageal balloon technique and rapid airway obstruction. At the same time, functional residual capacity (FRC) was calculated using the helium dilution technique. The study included 24 participants randomly selected in a supine position before surgery, divided into three groups based on BMI: normal BMI (40 kilograms per square metre). The results of the study revealed the following changes as BMI increased: The compliance of the chest wall was marginally impacted, while the compliance of the lung and the overall respiratory system dropped dramatically. 6 “Haemodynamic and respiratory outcomes for pressure-controlled ventilation versus volume-controlled ventilation in patients undergoing laparoscopic surgery” was a study by Martinez et al. conducted in 2007. This study involved 40 Class I/II ASA patients with elective laparoscopic surgery. The patients were given fentanyl (2 mg/kg), propofol (2 mg/kg), and atracurium (150 mg/kg) to produce anaesthesia while they fasted starting at midnight the night before the procedure. Following a thorough relaxation assessment, endotracheal intubation was carried out and scored with a train of four (TOF). Sevoflurane (1 MAC) was used to keep the anaesthesia in place. PCV or VCV was administered to patients at random. Both groups’ hemodynamic parameters during the various period records were comparable. Mean, systolic, and diastolic pressures were comparable. In comparison to 97.25 + 1.2 for VCV, SpO 2 increased during pneumoperitoneum up to 97.61 + 1.29 for PCV. SpO 2 levels for both groups remained identical ten minutes after insufflation. Both PCV and VCV were well-tolerated treatment options for individuals undergoing laparoscopic surgery. 7 In a study by Gupta et al., the effects of volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) on oxygenation 8 in obese patients undergoing laparoscopic cholecystectomy were investigated. The study included 102 adult patients with a 30-40 kg/m 2 BMI. Initially, all patients received VCV, but after pneumoperitoneum, they were randomly assigned to continue with VCV or switch to PCV. The results showed that the PCV group had significantly higher arterial oxygen partial pressure (PaO 2 ) levels and lower alveolar-arterial oxygen gradient (PAO 2 -PaO 2 ) values than the VCV group. The VCV group required higher tidal volume and minute ventilation to maintain appropriate CO 2 levels. In contrast, the PCV group improved lung ventilation by using higher flow rates in the early inspiratory phase. Despite lower tidal volume and minute ventilation in the PCV group, adequate carbon dioxide elimination was achieved. PCV was found to reduce the adverse effects of high tidal volumes. Another study by Sen et al. also compared VCV and PCV in patients undergoing laparoscopic cholecystectomy and found that the PCV group had lower peak airway pressure levels, reduced systemic stress response, and improved oxygenation compared to the VCV group. Overall, these findings indicate that PCV might be an improved option for laparoscopic surgery in terms of oxygenation and lowering stress reaction. 9 By comparing the effects of pressure-controlled ventilation (PCV) and volume-controlled ventilation (VCV) on oxygenation parameters in obese patients having laparoscopic cholecystectomy, Movassagi et al. conducted a randomised prospective trial. Seventy patients with ASA physical status I-II and a BMI of 30 to 40 were enrolled in the study. Initially, VCV was used, and after pneumoperitoneum was established, patients were randomly assigned to either the PCV or VCV group. The results revealed that the VCV group required larger tidal volumes and respiratory rates to maintain the necessary CO2 levels at specific intervals. Following pneumoperitoneum, the VCV group exhibited significantly higher peak airway pressure compared to the PCV group. However, the two groups had no significant changes in plateau pressure and mean airway pressure. Oxygenation parameters, such as PO2, PCO2, and pH, showed no significant differences between the two groups, except for a few instances after pneumoperitoneum, where the PCV group displayed higher PO2 levels. The study concluded no clinically significant differences between PCV and VCV in obese patients undergoing laparoscopic cholecystectomy. Although PCV demonstrated some improvements in plateau pressure, mean airway pressure, and oxygenation parameters, it may be beneficial to consider using a dual-mode strategy to mitigate complications effectively. 10 Ethical considerations The ethics and screening committee has approved the research proposal at Jawaharlal Nehru Medical College in accordance with guidelines prescribed by Central Ethics Committee on Human Research (CECHR). Patients will be informed verbally at the time of hospital admission about the nature of the study. This will include a description of the procedures involved, potential discomforts and risks, anticipated benefits, alternative treatment options, monitoring and support methods, and the responsible staff members. The information will be conveyed in clear and accessible language. Patients will receive explanations both before and during the study about its methodology, explicitly stating that a placebo group will not be used and that participation in a control group is possible. They will be informed of their right to decline participation or withdraw from the study at any point without any penalties or negative impact on their care. They will be assured of the confidentiality of their data, the absence of expense reimbursement for participating in the research, and the forms of compensation available in case of any harm resulting from the study, following the ethical standards and regulations for human studies as outlined in the Helsinki Declaration (2014). Written informed consent will be obtained from all participants to ensure their understanding and voluntary participation in the research. REF NO.: DMIMS (DU)/IEC/2022/90 Date: 20/07/2022 Dissemination The findings of the study will be shared with participants and relevant organisations, as well as published in an acceptable scholarly journal. Study status Control group data collection is ongoing. Data availability No data are associated with this article. Extended data Reporting guidelines: Repository name: Zenodo,Checklist for Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia: DOI: 10.5281/zenodo.11530839 . 11 Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0). Acknowledgements The writer wishes to thank the personnel at the Department of Anaesthesia in JNMC, AVBRH, Sawangi, Wardha, India, for their assistance. References 1. Tyagi A, Kumar R, Sethi A, et al. : A comparison of pressure-controlled and volume-controlled ventilation for laparoscopic cholecystectomy. Anaesthesia. 2011; 66 (6): 503–508. PubMed Abstract | Publisher Full Text 2. Mihalj M: Effects of Pressure-Controlled vs. Volume-Controlled Ventilation on Hemodynamic and Respiratory Parameters in Patients During Laparoscopic Cholecystectomy. Acta Clin. Croat. 2017 [cited 2023 May 17]; 56 : 555–560. PubMed Abstract | Publisher Full Text Reference Source 3. Balick-Weber CC, Nicolas P, Hedreville-Montout M, et al. : Respiratory and haemodynamic effects of volume-controlled vs pressure-controlled ventilation during laparoscopy: a cross-over study with echocardiographic assessment. Br. J. Anaesth. 2007 Sep; 99 (3): 429–435. PubMed Abstract | Publisher Full Text 4. Salah A, Shonoda AM, Khalaf K, et al. : Comparison between volume controlled ventilation and pressure controlled ventilation as regards effects on respiratory parameters and need of postoperative ventilation in laparoscopic bariatric surgeries. Ain Shams Med. J. 2020 Sep 1; 71 (3): 635–646. Publisher Full Text 5. Aydın V, Kabukcu HK, Sahin N, et al. : Comparison of pressure and volume-controlled ventilation in laparoscopic cholecystectomy operations: laparoscopic cholecystectomy operations. Clin. Respir. J. 2016 May; 10 (3): 342–349. PubMed Abstract | Publisher Full Text 6. Pelosi P, Ravagnan I, Tredici S, et al. : The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia. Anesth. Analg. 1998; 87 : 654–660. PubMed Abstract 7. Martínez-Leyva E: Haemodynamic and respiratory outcomes for pressure-controlled ventilation and volume-controlled ventilation in patients submitted to laparoscopic surgery. 8. Gupta S, Kundu S, Ghose T, et al. : A comparison between volume-controlled ventilation and pressure-controlled ventilation in providing better oxygenation in obese patients undergoing laparoscopic cholecystectomy. Indian J. Anaesth. 2012; 56 (3): 276–282. PubMed Abstract | Publisher Full Text | Free Full Text 9. Sen O, Umutoglu T, Aydın N, et al. : Effects of pressure-controlled and volume-controlled ventilation on respiratory mechanics and systemic stress response during laparoscopic cholecystectomy. Springerplus. 2016 Dec; 5 (1): 298. PubMed Abstract | Publisher Full Text | Free Full Text 10. Movassagi R, Montazer M, Mahmoodpoor A, et al. : Comparison of pressure vs. volume controlled ventilation on oxygenation parameters of obese patients undergoing laparoscopic cholecystectomy. Pak. J. Med. Sci. 2017 Oct 9 [cited 2023 May 17]; 33 (5): 1117–1122. PubMed Abstract | Publisher Full Text | Free Full Text Reference Source 11. Dhakshinamurthy P, Singam A: Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia (Version 1). Zenodo. 2024. Publisher Full Text Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 24 Jun 2024 ADD YOUR COMMENT Comment Author details Author details 1 ANAESTHESIOLOGY, DATTA MEGHE INSTITUTE OF HIGHER EDUCATION AND RESEARCH, WARDHA, MAHARASHTRA, 442001, India Dr. Poornima Dhakshinamurthy Roles: Conceptualization, Data Curation, Investigation, Methodology, Writing – Original Draft Preparation Dr. Amol Singam Roles: Conceptualization, Methodology, Supervision, Validation, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (1) version 1 Published: 24 Jun 2024, 13:678 https://doi.org/10.12688/f1000research.152186.1 Copyright © 2024 Dhakshinamurthy DP and Singam DA. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Dhakshinamurthy DP and Singam DA. Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2024, 13 :678 ( https://doi.org/10.12688/f1000research.152186.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 1 VERSION 1 PUBLISHED 24 Jun 2024 Views 0 Cite How to cite this report: Sterke F. Reviewer Report For: Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2024, 13 :678 ( https://doi.org/10.5256/f1000research.166915.r312147 ) The direct URL for this report is: https://f1000research.com/articles/13-678/v1#referee-response-312147 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 11 Sep 2024 Frank Sterke , University Medical Center Rotterdam, Rotterdam, The Netherlands; Delft University of Technology, Delft, The Netherlands Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.166915.r312147 This study aims to determine which ventilation mode is superior for patients undergoing laparoscopic surgery with a pneumoperitoneum. Firstly, I want to commend the authors for addressing an important issue in the context of laparoscopic surgery with ... Continue reading READ ALL This study aims to determine which ventilation mode is superior for patients undergoing laparoscopic surgery with a pneumoperitoneum. Firstly, I want to commend the authors for addressing an important issue in the context of laparoscopic surgery with pneumoperitoneum. The choice to compare volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) is highly relevant given the increasing number of laparoscopic procedures and the potential for pulmonary complications. Overall, your protocol provides a strong foundation for an important study. These suggestions aim to further refine and clarify the research approach to maximize its potential impact. To further enhance the study and its presentation, I have a few suggestions: 1) Introduction: Emphasize it is a protocol paper. 2) Aim: focus on etCO2 to evaluate efficacy of ventilation. One would expect oxygenation as well to assess efficacy. 3) Methods and analysis: Study design, of either gender --> just all patients. 4) Methods and analysis: Study setting, ethical approval statement is somewhat scattered over the paper. (Considerations in the discussion and in the protocol) I would advise to keep al the ethics in one section. 5) Methods and analysis: Participants, type in the criteria of exclusion 6) Methods and analysis: Data analysis. I would suggest to include Peak inspiratory pressure, respiratory frequency and I:E ratio. These are known to affect the mechanical efficiency. 7) Methods and analysis: Data analysis. I would suggest to include evaluate lung compliance and airway resistance as patient characteristic. 8) Methods and analysis: Data analysis. I would suggest to include insufflation settings and body position. These can affect the interaction between surgical cavity and respiratory system. 9) Methods and analysis: Materials requirement: For repeatability one would expect the sizes types and brands of the used materials and measurement devices. 10) Methods and analysis: Recruitment, "A thorough informed". I would leave out thorough, not because I don't think it is being thorough but because it is an arbitrary/vague word. I think your description already emphasizes your thoroughness. 11) Methods and analysis: Recruitment, clarify the Randomization sections. It is somewhat unclear whether you intend to randomize or if/how you actually randomized. Specifying the technique is enough I would say. 12) Methods and analysis: Rationale for selected sample size, this one is important to me. If I understand correctly, the sample size is estimated based on MAP. Yet MAP is not a primary outcome in this study. I believe it is required to use primary outcome for sample size calculation. 13) Discussion: I believe the author has an excellent overview of the relevant literature. It would help the reader to summarize the discussion and evaluate the potential implications of this study and compare the strengths and limitations of the protocol to the existing protocols described in literature. This will help to emphasize the importance of this study. 14) Out of curiosity, perhaps worthy to add to the discussion, what outcome does the author hypothesize. Which mode does the author expect to be superior and what's the reasoning behind it. 15) References: "Modeling intra-abdominal volume and respiratory driving pressure during pneumoperitoneum insufflation-a patient-level data meta-analysis" by Mazzinari et al. [ref 1] could be of interest to you. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Partly Are sufficient details of the methods provided to allow replication by others? Partly Are the datasets clearly presented in a useable and accessible format? Not applicable References 1. Mazzinari G, Diaz-Cambronero O, Serpa Neto A, Martínez AC, et al.: Modeling intra-abdominal volume and respiratory driving pressure during pneumoperitoneum insufflation-a patient-level data meta-analysis. J Appl Physiol (1985) . 2021; 130 (3): 721-728 PubMed Abstract | Publisher Full Text 2. Malbrain ML, Peeters Y, Wise R: The neglected role of abdominal compliance in organ-organ interactions. Crit Care . 2016; 20 : 67 PubMed Abstract | Publisher Full Text Competing Interests: Frank Sterke is partially employed by an Erasmus MC spin-off developing an enhanced insufflator. Reviewer Expertise: Biomedical engineering, abdominal dynamics and interaction with mechanical ventilation I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Sterke F. Reviewer Report For: Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2024, 13 :678 ( https://doi.org/10.5256/f1000research.166915.r312147 ) The direct URL for this report is: https://f1000research.com/articles/13-678/v1#referee-response-312147 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Aditianingsih D. Reviewer Report For: Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2024, 13 :678 ( https://doi.org/10.5256/f1000research.166915.r301211 ) The direct URL for this report is: https://f1000research.com/articles/13-678/v1#referee-response-301211 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 25 Jul 2024 Dita Aditianingsih , Universitas Indonesia, Jakarta, Indonesia; Rumah Sakit Dr Cipto Mangunkusumo (Ringgold ID: 364090), Central Jakarta, Jakarta, Indonesia Approved VIEWS 0 https://doi.org/10.5256/f1000research.166915.r301211 The manuscript entitled "Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia" is written with an acceptable language, has a clear study objective and well-defined protocol is. A couple ... Continue reading READ ALL The manuscript entitled "Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia" is written with an acceptable language, has a clear study objective and well-defined protocol is. A couple of things to consider: 1. In the first paragraph of background, "muscle relaxation" is the definition of paralysis, please place the definitions accordingly. 2. Please provide the values of intraabdominal pressure that will be applied during laparoscopic surgery, whether it is variable or as a set value for all patients, as it may have an effect on hemodynamics. 3. In the exclusion criteria you stated, "Male or female, between the ages of 18 and 70". Please confirm if you meant below 18 and above 70 years of age. 4. Please consider to include in your exclusion criteria, patients who undergo conversion to laparotomy during laparoscopy, or patients who encounter complication during surgery which may result in hemodynamic instability. 5. Will there be any monitoring of the depth of anesthesia and neuromuscular blocking, to make sure that it is constant throughout the duration of operation? 6. Please provide the hypothesis of this study. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? Yes Are the datasets clearly presented in a useable and accessible format? Not applicable Competing Interests: No competing interests were disclosed. Reviewer Expertise: Anesthesiology and Critical Care Medicine I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Aditianingsih D. Reviewer Report For: Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2024, 13 :678 ( https://doi.org/10.5256/f1000research.166915.r301211 ) The direct URL for this report is: https://f1000research.com/articles/13-678/v1#referee-response-301211 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 24 Jun 2024 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 Version 1 24 Jun 24 read read Dita Aditianingsih , Universitas Indonesia, Jakarta, Indonesia; Rumah Sakit Dr Cipto Mangunkusumo (Ringgold ID: 364090), Central Jakarta, Indonesia Frank Sterke , University Medical Center Rotterdam, Rotterdam, The Netherlands; Delft University of Technology, Delft, The Netherlands Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Sterke F. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 11 Sep 2024 | for Version 1 Frank Sterke , University Medical Center Rotterdam, Rotterdam, The Netherlands; Delft University of Technology, Delft, The Netherlands 0 Views copyright © 2024 Sterke F. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions This study aims to determine which ventilation mode is superior for patients undergoing laparoscopic surgery with a pneumoperitoneum. Firstly, I want to commend the authors for addressing an important issue in the context of laparoscopic surgery with pneumoperitoneum. The choice to compare volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) is highly relevant given the increasing number of laparoscopic procedures and the potential for pulmonary complications. Overall, your protocol provides a strong foundation for an important study. These suggestions aim to further refine and clarify the research approach to maximize its potential impact. To further enhance the study and its presentation, I have a few suggestions: 1) Introduction: Emphasize it is a protocol paper. 2) Aim: focus on etCO2 to evaluate efficacy of ventilation. One would expect oxygenation as well to assess efficacy. 3) Methods and analysis: Study design, of either gender --> just all patients. 4) Methods and analysis: Study setting, ethical approval statement is somewhat scattered over the paper. (Considerations in the discussion and in the protocol) I would advise to keep al the ethics in one section. 5) Methods and analysis: Participants, type in the criteria of exclusion 6) Methods and analysis: Data analysis. I would suggest to include Peak inspiratory pressure, respiratory frequency and I:E ratio. These are known to affect the mechanical efficiency. 7) Methods and analysis: Data analysis. I would suggest to include evaluate lung compliance and airway resistance as patient characteristic. 8) Methods and analysis: Data analysis. I would suggest to include insufflation settings and body position. These can affect the interaction between surgical cavity and respiratory system. 9) Methods and analysis: Materials requirement: For repeatability one would expect the sizes types and brands of the used materials and measurement devices. 10) Methods and analysis: Recruitment, "A thorough informed". I would leave out thorough, not because I don't think it is being thorough but because it is an arbitrary/vague word. I think your description already emphasizes your thoroughness. 11) Methods and analysis: Recruitment, clarify the Randomization sections. It is somewhat unclear whether you intend to randomize or if/how you actually randomized. Specifying the technique is enough I would say. 12) Methods and analysis: Rationale for selected sample size, this one is important to me. If I understand correctly, the sample size is estimated based on MAP. Yet MAP is not a primary outcome in this study. I believe it is required to use primary outcome for sample size calculation. 13) Discussion: I believe the author has an excellent overview of the relevant literature. It would help the reader to summarize the discussion and evaluate the potential implications of this study and compare the strengths and limitations of the protocol to the existing protocols described in literature. This will help to emphasize the importance of this study. 14) Out of curiosity, perhaps worthy to add to the discussion, what outcome does the author hypothesize. Which mode does the author expect to be superior and what's the reasoning behind it. 15) References: "Modeling intra-abdominal volume and respiratory driving pressure during pneumoperitoneum insufflation-a patient-level data meta-analysis" by Mazzinari et al. [ref 1] could be of interest to you. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Partly Are sufficient details of the methods provided to allow replication by others? Partly Are the datasets clearly presented in a useable and accessible format? Not applicable References 1. Mazzinari G, Diaz-Cambronero O, Serpa Neto A, Martínez AC, et al.: Modeling intra-abdominal volume and respiratory driving pressure during pneumoperitoneum insufflation-a patient-level data meta-analysis. J Appl Physiol (1985) . 2021; 130 (3): 721-728 PubMed Abstract | Publisher Full Text 2. Malbrain ML, Peeters Y, Wise R: The neglected role of abdominal compliance in organ-organ interactions. Crit Care . 2016; 20 : 67 PubMed Abstract | Publisher Full Text Competing Interests Frank Sterke is partially employed by an Erasmus MC spin-off developing an enhanced insufflator. Reviewer Expertise Biomedical engineering, abdominal dynamics and interaction with mechanical ventilation I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (0) Sterke F. Peer Review Report For: Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2024, 13 :678 ( https://doi.org/10.5256/f1000research.166915.r312147) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-678/v1#referee-response-312147 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Aditianingsih D. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 25 Jul 2024 | for Version 1 Dita Aditianingsih , Universitas Indonesia, Jakarta, Indonesia; Rumah Sakit Dr Cipto Mangunkusumo (Ringgold ID: 364090), Central Jakarta, Jakarta, Indonesia 0 Views copyright © 2024 Aditianingsih D. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The manuscript entitled "Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia" is written with an acceptable language, has a clear study objective and well-defined protocol is. A couple of things to consider: 1. In the first paragraph of background, "muscle relaxation" is the definition of paralysis, please place the definitions accordingly. 2. Please provide the values of intraabdominal pressure that will be applied during laparoscopic surgery, whether it is variable or as a set value for all patients, as it may have an effect on hemodynamics. 3. In the exclusion criteria you stated, "Male or female, between the ages of 18 and 70". Please confirm if you meant below 18 and above 70 years of age. 4. Please consider to include in your exclusion criteria, patients who undergo conversion to laparotomy during laparoscopy, or patients who encounter complication during surgery which may result in hemodynamic instability. 5. Will there be any monitoring of the depth of anesthesia and neuromuscular blocking, to make sure that it is constant throughout the duration of operation? 6. Please provide the hypothesis of this study. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? Yes Are the datasets clearly presented in a useable and accessible format? Not applicable Competing Interests No competing interests were disclosed. Reviewer Expertise Anesthesiology and Critical Care Medicine I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Aditianingsih D. Peer Review Report For: Comparative study of the efficacy of volume control ventilation vs pressure control ventilation on patients undergoing laparoscopic surgeries under general anaesthesia [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2024, 13 :678 ( https://doi.org/10.5256/f1000research.166915.r301211) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. 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