Persistent organic pollutants (POPs) and fibroids: results from the ENDO study

Britton Trabert, Zhen Chen, Kurunthachalam Kannan, C Matthew Peterson, Anna Z Pollack, Liping Sun, Germaine M Buck Louis
Journal of exposure science & environmental epidemiology · 2014 · vol. 25(3) , pp. 278–285 · doi:10.1038/jes.2014.31 · PMID:24802554 · W2019640054
article OA: bronze CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

Serum p,p′-DDE was associated with fibroids, and several PCBs measured in fat were associated with fibroids in women without endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This paper used previously collected data from 473 women aged 18–44 who underwent laparoscopy or laparotomy across 14 hospital centers to examine whether persistent organic pollutant (POPs) concentrations in omental fat and serum were associated with uterine fibroids, defined by postoperative diagnosis. POPs were quantified and unconditional logistic regression adjusted for identified covariates estimated odds ratios for each POP, with concentrations generally higher in omental fat than serum. Serum p,p′-DDE was the only POP significantly associated with fibroids (per 1-SD increase in log-transformed serum p,p′-DDE OR 1.37, 95% CI 1.05–1.80), while excluding women diagnosed with endometriosis led to multiple omental-fat PCBs (e.g., PCB 153) showing associations. The study’s exploratory findings emphasize that media-specific effects emerged, but the results are observational and limited by the cross-sectional exposure measurement and the smaller fibroid subsample. Relevance to endometriosis: the authors report analyses excluding women with endometriosis and interpret PCB–fibroid associations as emerging in the absence of other gynecologic disorders such as endometriosis, though the paper’s main focus is POP exposure and uterine fibroids.

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MeSH descriptors

Environmental Pollutants Hydrocarbons, Chlorinated Leiomyoma Uterine Neoplasms Adolescent Adult Cohort Studies Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene Environmental Monitoring Environmental Pollutants Environmental Pollutants Female Humans Hydrocarbons, Chlorinated Hydrocarbons, Chlorinated Intra-Abdominal Fat Intra-Abdominal Fat Leiomyoma

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