Anaphylactoid reactions associated with menstruation affecting two sisters

Graham Simpson, David Roomes, M Humphrey
In: Medical Journal of Australia · 2001 · vol. 175(8) , pp. 415–417 · doi:10.5694/j.1326-5377.2001.tb143647.x · PMID:11700834 · W115710759
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Two sisters experienced cyclical anaphylactoid reactions related to menstruation, which were treated by suppressing menstruation and using a COX-2 inhibitor, possibly due to abnormal prostaglandin reactions.

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Abstract

Cyclical anaphylactoid reactions associated with menstruation are exceedingly rare. We report two sisters who were both affected, one severely and one mildly. Treatment involved suppression of menstruation and use of a cyclooxygenase-2 (COX-2) inhibitor. An abnormal reaction to prostaglandins, perhaps produced by COX-2 enzyme activity in the endometrium, is a possible mechanism.

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last seen: 2026-06-10T17:14:06.276822+00:00
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