Endocrine treatment with anti-estrogen, anti-androgen or progestagen of advanced malignant melanoma: three consecutive phase II trials

Carsten Rose, C Rose, Lise Pedersen, L Pedersen, Henning T. Mouridsen, H T Mouridsen
European journal of cancer & clinical oncology · 1985 · vol. 21(10) , pp. 1171–1174 · doi:10.1016/0277-5379(85)90010-0 · PMID:2934258 · W2052704498
Non-randomised trial OA: closed CC0
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Three consecutive phase II trials demonstrated that endocrine treatment with tamoxifen, cyproterone acetate, or medroxyprogesterone acetate failed to induce objective remission in patients with advanced malignant melanoma.

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Abstract

Malignant melanoma is generally considered as a hormone-independent tumour. However, epidemiological, clinical and experimental data suggest that steroid hormones can influence the growth of this tumour. The therapeutic efficacy of endocrine treatment was evaluated in three consecutive phase II trials with the anti-estrogen tamoxifen, the anti-androgen cyproterone acetate and the progestagen medroxyprogesterone acetate. The 53 evaluable patients were mainly untreated with other forms of systemic therapy. Using response criteria in accord with WHO, none of the patients in the three trials obtained an objective remission. In summary, the present trials have demonstrated that the clinical course of advanced malignant melanoma is indifferent to competitive and additive endocrine treatment.

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MeSH descriptors

Antineoplastic Agents Cyproterone Hormone Antagonists Melanoma Progestins Adult Aged Androgen Antagonists Androgen Antagonists Antineoplastic Agents Cyproterone Cyproterone Cyproterone Acetate Female Hormone Antagonists Humans Male Medroxyprogesterone Medroxyprogesterone Medroxyprogesterone

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