КЛИНИЧЕСКИЕ И ЭХОГРАФИЧЕСКИЕ ПРИЗНАКИ, ПРЕДСКАЗЫВАЮЩИЕ НЕДОСТАТОЧНЫЙ ЭФФЕКТ ДИЕНОГЕСТА ПРИ АДЕНОМИОЗЕ
This 2021–2025 review identifies age, CA-125 levels, uterine volume, diffuse adenomyosis, and coexisting myoma as predictors of dienogest inefficacy in adenomyosis.
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This study analyzed clinical and ultrasound data from 2021 to 2025 to identify predictors of insufficient response to dienogest therapy in patients with adenomyosis. The findings indicate that older age, elevated CA-125 levels, uterine volume exceeding 352.7 cm³, diffuse adenomyosis, and coexisting fibroids are associated with poorer long-term outcomes. Additionally, specific morphological measurements such as uterine length and myometrial thickness were found to predict heavy bleeding, which is the primary reason for discontinuing the medication. Based on these results, the authors propose a minimal set of indicators to evaluate treatment suitability before initiating dienogest prescription. This paper is centrally about adenomyosis — specifically focusing on identifying clinical and sonographic factors that predict poor therapeutic response to dienogest.
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