PROTOCOL OF A SYSTEMATIC REVIEW AND METAANALYSIS OF CASE-SERIES AND CASE-REPORTS INVOLVING GLUCAGON IN BETA-BLOCKER OVERDOSE

The utility of glucagon in human myocardium remains controversial. In the past, some articles have reported inotropic and chronotropic effects of glucagon on the heart, but other studies have found no significant effects. The main cardiovascular indication for glucagon is beta-blocker toxicity (BB), which is listed as recommendation IIb in some guidelines on the basis of some experimental studies and case reports. To our knowledge, no systematic review has been published analyzing the outcomes of glucagon in reports of overdose. This study will attempt to incorporate findings from case series and reports to fill the gap on a topic where experimental and comparative studies have already been conducted. A protocol to the development of this work is provided.