Enantioselective Alkyl C−H Sulfimidation Enabled by Copper Catalysis

Enantioselective Alkyl C−H Sulfimidation Enabled by Copper Catalysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Enantioselective Alkyl C−H Sulfimidation Enabled by Copper Catalysis Liu-Zhu Gong, Yue-Die Zhu, Tianran Deng, Hua-Jie Jiang, Ning-Yi Lu This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7172655/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Enantioselective transformation of alkanes into functional chiral molecules constitutes an ultimate goal for chemists that however, has been a grand challenge over more than half century. Although remarkable advances have been made in the stereoselective C-C, C-N and C-O bonds formation enabled by either metal or enzyme catalysis, the alkyl C-H sulfimidation for building up a stereogenic sulfur center from alkanes has not previously been accomplished. Herein, we describe a photoinduced copper-catalyzed enantioselective C−H sulfimidation of alkanes, allowing for a straightforward synthesis of highly enantioenriched sulfilimines from alkane feedstocks. Computational studies and mechanistic investigations unveil the reaction mechanism and the origin of stereoselectivity. Physical sciences/Chemistry/Organic chemistry/Synthetic chemistry methodology Physical sciences/Chemistry/Catalysis/Asymmetric catalysis Physical sciences/Chemistry/Catalysis/Photocatalysis Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Introduction The transformation of carbon-hydrogen (C-H) bonds of alkanes into functionalized molecules has been a long-term dream of synthesis and catalysis community 1-5 . In particular, the enantioselective assembly of carbon-heteroatom (C-X) bond from alkane C-H bonds 6-9 represents a pivotal synthetic strategy, owing to its capacity to bypass laborious substrate pre-activation steps, directly converting abundant hydrocarbon feedstocks into structurally complex bioactive molecules and functional materials. Although a great deal of effort has been continuously invested in this field since Shilov discovered the first homogeneous system for alkane C-H bond 1 , achieving regioselective activation and stereoselective conversion of such inert C(sp³)-H bonds persists as a paramount challenge, rooted in the intrinsic chemical inertness of C-H bonds, too much similarity in polarity, and the absence of functional directing groups—factors that pose limitations on selectivity control and reaction design 10,11 . Recently, several concepts and strategies have emerged that enable the direct construction of chiral C-X bonds from inert C(sp 3 )-H bonds, such as the construction of chiral C-N 12-15 and C-O bonds 16-18 . However, enantioselective formation of C-S bond and a stereogenic sulfur center from alkanes C-H bonds remains unexplored (Figure 1A). Over the past decade, organosulfur compounds have garnered widespread attention in synthetic chemistry 19 . Chiral sulfilimines, as aza analogues of sulfoxides and representative S(IV) organosulfur compounds, have emerged as multifunctional scaffolds with broad application in medicinal chemistry 20 and ligand design 21-23 , owing to distinctive electronic and structural characteristics. As such, great effort has been devoted to the catalytic asymmetric construction of sulfur stereocenters in sulfilimines 24,25 . One of elegant strategies to access chiral sulfilimines is the stereoselective C-S bond formation from sulfenamides. In previous studies, carbon electrophiles undergoing enantioselective C-S bond forming event were basically derived from highly activated precursors, such as diazo compounds 26 , alkyl halides 27-29 , arylboronic acids 30 , diaryliodonium salts 31,32 and aryl diazonium salts 33 (Figure 1B). A general approach to access sulfilimines with stereogenic S(IV) centers directly from massively available alkanes, devoid of pre-functionalization or directing group, turns out to be of great importance, but has not been established, yet. Building on our previous success in the alkane C-H functionalization enabled by copper catalysts and peroxide 34,35 , we hypothesized that the alkyl radicals generated from a similar process might be able to participate in an enantioselective alkyl sulfimidation with sulfenamides facilitated by copper catalyst, affording chiral sulfilimines (Figure 1C). In this scenario, the alkoxy radicals generated from di- tert -butyl peroxide (DTBP) undergo HAT process with alkanes to generate the active alkyl radicals 36-38 . The prevalence of highly reactive species in the reaction system brings up substantial difficulties. Firstly, it is an inherent challenge to inhibit the over-oxidation of sulfenamides 39,40 and sulfilimines 28,41 under strong oxidizing conditions. Furthermore, discriminating C-S bond formation over competing C-N coupling pathways 30,42 and avoiding the cleavage of S-N bond 43-46 were central to ensure this transformation proceeding smoothly. Moreover, oxidative conditions could promote over-oxidation of the newly formed carbon-centered radicals to carbocations, which spontaneously undergo intramolecular nucleophilic substitution without the assistance of any catalyst, thereby diminishing enantioselectivity 35,47,48 . Consequently, identification of a robust chiral catalyst system capable of rendering a highly enantioselective C-S bond formation and suppressing the potential background reaction under oxidative conditions constitutes pivotal determinants to realize the proposed reaction. Results and discussion To validate the feasibility for the aforementioned process, toluene ( 2a , BDE = 88 kcal/mol) 8 2a was selected as the initial model substrate to react with N -benzoyl sulfenamide 1a (Table 1). By using di- tert -butyl peroxide (DTBP) as the oxidant and HAT radical precursor, and Cu(CH 3 CN) 4 PF 6 as a pre-catalyst, we screened a series of chiral bidentate bisoxazolines ( L1-L3 ) (see Supplementary Information Table S1 for more results), which generated product 3a in moderate to good yield but with poor enantioselectivity (< 16% ee). The replacement of bisoxazoline ligands with Dixon’s N , N , P -ligand L4 49 led to a slightly lower yield of 3a and even poorer enantioselectivity (for additional N , N , P -ligand screening results, see Table S1). To our delight, N , N , N -ligand L5 50 turned out to be the optimal ligand among L1-5 , which enabled the desired product 3a to be obtained in 77% yield and with 95% ee. Then, a ligand modification study by finely tuning the substituent on C2 position of the quinoline motif was carried out. These studies showed that ligand L5 without any substituent on the C2 position was superior in terms of both efficiency and enantioselectivity. Evaluation of different copper pre-catalysts (entries 2-4) revealed that coordinating halide anions of copper pre-catalysts such as bromide, chloride and iodide had a negative impact on the yield of 3a . Solvent screening studies indicated that fluorobenzene turned out to be an optimal solvent (entries 5-8, and Table S2 in the Supplementary Information). Furthermore, control experiments confirmed that the blue LED irradiation and the presence of DTBP were both requisite for the success of this reaction (entries 9- 10). Table 1. Optimization of the reaction conditions. a Reaction conditions: 1a (0.1 mmol, 1.0 equiv), 2a (60 equiv), Cu(MeCN) 4 PF 6 (4 mol%), ligand (5 mol%), DTBP (4.0 equiv), and fluorobenzene (0.1 M), 10 W Blue LED (λ max = 455 nm) at 25 ℃ for 48 h under nitrogen atmosphere. The yield was determined via 1 H NMR analysis using 1,3,5-triacetylbenzene as an internal standard, and the ee value was determined by HPLC using a chiral stationary phase. b Isolated yield. c DTBP = di- tert -butyl peroxide. With the optimized conditions in hand, a variety of sulfenamides were initially examined (Figure 2). The reaction exhibited excellent compatibility with the N -acyl groups on sulfenamides ( 3a - 3t ). Both linear ( 3b - 3d ) and cyclic ( 3e ) amides provided good yields and stereoselectivities. The electronic properties and substitution patterns of the phenyl group of sulfenamides exerted little impact on the enantioselectivity of the S -benzylation reaction. As a consequence, the presence of either an electron- donating or electron-withdrawing substituent at para - or meta -position of aryl amides was nicely tolerated to furnish the sulfilimines with high levels of enantioselectivity ( 3f - 3q ). Other sulfenamides bearing a naphthalene ring ( 3r ) or heterocyclic rings ( 3s-3t ) were also tested under the optimized conditions and engaged in the reaction seamlessly, providing the desired products in moderate to good yield (56%-80%) and excellent enantioselectivities (86%-97% ee). Subsequently, the variations in the thiol moiety of the sulfenamides was evaluated under optimal conditions. As shown in Figure 2, both the electron-donating and electron-withdrawing substituents at ortho -, meta -, para - positions ( 3u - 3ae ) were all compatible with the reaction conditions delivering the desired sulfilimines in decent yields with good to excellent enantioselectivities (75-96% ee). Sulfenamides featuring di-substituted aryls in the thiol moiety were also well-tolerated in the asymmetric S -benzylation reaction, furnishing 3af – 3ag with remarkable stereo-control (87-94% ee). Simultaneously, sulfenamides derived from simple thiophenol underwent the transformation smoothly, producing 3ah with outstanding efficiency and enantioselectivity (96% yield, 94% ee). We next focused on examining the scope of hydrocarbon partner under the optimized reaction conditions. All the examined monosubstituted toluene derivatives ( 3ai - 3ay ) successfully participated in the reaction, yielding the desired product in appreciable yields (up to 91% yield) and with high to excellent enantioselectivities (up to 98% ee). Notably, a broad range of functional groups proved to be compatible with this reaction, including halides ( 3al - 3an , 3at , 3aw - 3ay ), boron ester ( 3ar ), ester ( 3aq ), methoxy ( 3au ) and trifluoromethoxy( 3ap ) substituent. Both di- and tetra-substituted toluene derivatives reacted efficiently ( 3az - 3bb ; 68-95% yield, 90-95% ee). Surprisingly, even 3-methylthiophene, known for its sensitivity to oxidative conditions, was compatible ( 3bc ). To establish the broad applicability of this methodology, we investigated aliphatic C(sp³)-H bonds (bond dissociation energy (BDE) = ~100 kcal/mol 8 stronger than benzylic C-H bonds (typically ~85 kcal/mol)). Notably, cycloalkanes with ring size ranging from five to seven were also amenable to the reaction ( 3bd - 3bf , 72%-76% yield, 96% ee). Linear alkane such as pentane was also able to undergo the desired transformation to give 3bh in good yield and with regioselectivity of 1:2.8:1.8 r.r.. Notably, when 2,3-dimethylbutane was examined as hydrocarbon partner, the major product ( 3bg ) resulting from isopropyl radical (generated from β-cleavage of terminal C-H bonds) was observed. Synthetic Applications To demonstrate the synthetic applicability of this methodology, a 2 mmol-scale reaction was carried out with N -benzoyl sulfenamide 1a and benzene 2a (Figure 3), furnishing the desired product 3a in 56% yield and 93% ee. The enantiomeric excess (ee) could be improved to 99% via recrystallization (DCM/hexane solvent system). The corresponding product 3a (99% ee) was directly oxidized to sulfoximine 4 by RuCl 3 -catalyzed oxidation protocol, achieving high yield with retained enantioselectivity (99% ee) 51 . Subsequently, the N -benzoyl group was efficiently removed through basic hydrolysis, delivering the unprotected sulfoximine 5 in excellent yield (96%) and enantioselectivity (>99% ee) 33 . The resulting chiral S(VI) sulfoximine 5 demonstrated significant utility as a versatile synthetic building block, readily adaptable to the construction of a diverse array of valuable molecular structures. For example, N -trifluoromethylated sulfoximine derivatives 6 could be directly formed in the presence of a silver catalyst and trifluoromethylation agent Me 3 SiCF 3 52 . Mechanistic Investigations To elucidate the reaction mechanism, a set of related experimental studies were conducted (Figure 4). Radical trapping experiments with 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) under To further clarify the relationship between light and DTBP homolysis and the cause of background reaction suppression, a series of electron paramagnetic resonance (EPR) spectroscopy, UV-vis absorption spectra and Stern-Volmer experiments were conducted (Figure 4d-4f). As depicted in Figure 4d, irradiation of DTBP in the presence of 5,5- dimethyl-1-pyrroline N-oxide (DMPO) generated radical species, which were identified as DMPO adducts with tert -butoxy radicals ( tert -BuO•) 35,54 . No significant EPR signal was observed for DTBP in the absence of light. However, in the presence of Cu(I)/ L5/1a , the EPR signal intensity was significantly diminished compared with DTBP alone, likely due to the primary inner filter effect 55,56 of the other light-absorbing substances in this system. Subsequent UV-vis absorption spectra (Figure 4e) revealed distinct absorption peaks at 455 nm for both the Cu(I)/ L5/1a complex I and the reaction system, demonstrating competitive light absorption by the copper complex 35 (further EPR spectrum and UV-vis absorption spectra in the Supplementary Information). We assumed that the background reaction was effectively suppressed in the presence of the Cu(I)/ L5/1a complex I , which indicated that DTBP underwent alternative cleavage pathways beyond directly photoinduced homolysis 57 . As predicted, a clear quenching of the emission from the copper complexes by DTBP was observed in Stern-Volmer experiment (Figure 4d), indicating that the decomposition of DTBP was induced by the excited state of copper complexes( Cu(I)/L5/1a ) I* 58 . DFT Calculation. DFT calculations were conducted to gain insights into the C-S bond formation mechanism and the origins of the enantioselectivity using the reaction of 1a and 2a as the model system ( Figure 5 ). Conformational analysis of int 1 suggested that the most stable coordination mode between Cu(I), 1a and ligand L5 is a six-coordinate complex. The HAT process between int 1 and tert -butoxy radical to form Cu(II)- 1a species int 2 is exergonic. Intermediate int 2 then undergoes an outer-sphere radical coupling with benzyl radical via ts 2 with a barrier of 8.2 kcal/mol to form int 3 . Alternatively, the pathway involving inner-sphere radical addition to generate Cu(III) intermediate int 4 requires a barrier of 16.7 kcal/mol, which is much less favorable. Finally, a coordination substitution of the int 3 with 1a releases the prodct 3a and the int 1 . The optimized structures for the key C-S bond formation transition states were shown in Figure 6 . The formation of ( S ) -3a is the most favorable pathway among the two competitive routes. In this C-S formation step, the favored transition state ( S )- ts 2 , 2.4 kcal/mol more favorable than ( R )- ts 2 , leads to the major product ( S ) -3a , which is consistent with experimental selectivity. Notably, in ( S )- ts 2 , there are π-π interactions between quinoline of ligand L5 and p - tert -butylphenyl of 3a , which might contribute to the lower energy barrier. The optimized structures for the key C-S bond formation transition states were shown in Figure 6 . The formation of ( S ) -3a is the most favorable pathway among the two competitive routes. In this C-S formation step, the favored transition state ( S )- ts 2 , 2.4 kcal/mol more favorable than ( R )- ts 2 , leads to the major product ( S ) -3a , which is consistent with experimental selectivity. Notably, in ( S )- ts 2 , there are π-π interactions between quinoline of ligand L5 and p - tert -butylphenyl of 3a , which might contribute to the lower energy barrier. In conclusion, we have successfully established a photoinduced copper-catalyzed enantioselective alkyl C-H sulfilimidation. This strategy allows for highly efficient enantioselective synthesis of chiral sulfilimines through C-H functionalization from unactivated alkanes without pre-functionalization. The success of this method fills the gap in asymmetric synthesis of C-S bond and a stereogenic sulfur center from inert C-H bonds. The broad applicability of this approach has been validated through the functionalization of various aliphatic C-H, including diverse toluene derivatives, cycloalkanes and linear alkanes. Mechanistic experiments and computational studies have elucidated comprehensive mechanistic details of the asymmetric C-S bond formation through an outer-sphere radical addition. We anticipate that this report will inspire further advancements in building up the chiral C-X bond from inert C-H bond. Declarations Data Availability Statement All data generated or analyzed during this study are included in this published article and its supplementary information files. Crystallographic data for compound 3a was deposited in the Cambridge Structural Data Centre (CCDC) under deposition number: 2444210. Crystallographic data for compound 5 was deposited in the Cambridge Structural Data Centre (CCDC) under deposition number: 2444213. Acknowledgements We are grateful for the financial support from National Key R&D Program of China (2021YFA1500100) and the National Natural Science Foundation of China (22188101). We thank Dr. Yunzhi Lin (Shanghai institute of Organic Chemistry) for his guidance in DFT calculations. Author Contributions L.-Z.G. conceived the project. Y.-D.Z. designed and developed the reactions. T.D. performed theoretical calculations. N.-Y.L. prepared the materials. L.-Z.G. supervised the project. Y.-D.Z., T.D. and L.-Z.G. contributed to write and edit the paper. Competing Interests The authors declare no competing financial interests. Materials & Correspondence Supplementary Information is available in the online version of the paper. Reprints and permissions information is available online. Correspondence and requests for materials should be addressed to L.-Z.G. ( [email protected] ). References Shilov, A. E. & Shul'pin, G. B. Activation of C-H bonds by metal complexes. Chem. 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Supplementary Files 2444213cifreport.pdf cifreport of of 5 2444210cifreport.pdf cifreport of of 3a 2444213.cif cif data of 5 2444210.cif cif data of 3a SupplementaryInformationOP.pdf Supplementary Information TOC.jpg Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7172655","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":494259528,"identity":"2e173d4f-8377-4497-b492-5e31d32e7f64","order_by":0,"name":"Liu-Zhu Gong","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAz0lEQVRIiWNgGAWjYLCCBww2UBYbsVoSGNKgqknQcpgELfLuvYdfJPw5nzh/fvMDhg9lhxn4Zzfg12J45lyaRQLP7cQNx9gMGGecO8wgcecAAS0zcswMEiSAWth4GJh52w4zGEgkEKPF4Fzi/Daglr/EaJGXyDF+kJBwILHhGFALIzFaDHjOmDEkHEg23nAszeBgz7l0HokbhGxp7zH+8OGPnez85sMPH/wos5bjn0HIlgMMbBIwzgEg5sGvHmRLAwPzB4KqRsEoGAWjYGQDABD9Q6OVO6NIAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0001-6099-827X","institution":"University of Science and Technology of China","correspondingAuthor":true,"prefix":"","firstName":"Liu-Zhu","middleName":"","lastName":"Gong","suffix":""},{"id":494259529,"identity":"7d1bcdc4-6961-4cb6-b188-be94f5fc106b","order_by":1,"name":"Yue-Die Zhu","email":"","orcid":"","institution":"University of Science and Technology of China","correspondingAuthor":false,"prefix":"","firstName":"Yue-Die","middleName":"","lastName":"Zhu","suffix":""},{"id":494259530,"identity":"f2899451-cacf-4c04-bd9c-699964a6bd3d","order_by":2,"name":"Tianran Deng","email":"","orcid":"https://orcid.org/0000-0002-1604-4740","institution":"Southwest University of Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Tianran","middleName":"","lastName":"Deng","suffix":""},{"id":494259531,"identity":"22137968-225b-477e-8f23-89dc3301e3d7","order_by":3,"name":"Hua-Jie Jiang","email":"","orcid":"https://orcid.org/0000-0001-5165-5072","institution":"Anhui Agricultural University","correspondingAuthor":false,"prefix":"","firstName":"Hua-Jie","middleName":"","lastName":"Jiang","suffix":""},{"id":494259532,"identity":"1876dcf5-d128-46ab-9c51-28b4f3757ea9","order_by":4,"name":"Ning-Yi Lu","email":"","orcid":"","institution":"University of Science and Technology of China","correspondingAuthor":false,"prefix":"","firstName":"Ning-Yi","middleName":"","lastName":"Lu","suffix":""}],"badges":[],"createdAt":"2025-07-21 03:05:38","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7172655/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7172655/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":88244737,"identity":"d98fb0cf-b398-4a01-ab35-db2f352ed50e","added_by":"auto","created_at":"2025-08-04 12:11:06","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":117629,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eBackground introduction. A\u003c/strong\u003e, Common strategies for direct constructing chiral C(sp\u003csup\u003e3\u003c/sup\u003e)-X bond from inert C(sp\u003csup\u003e3\u003c/sup\u003e)-H bond.\u003cstrong\u003e B\u003c/strong\u003e, Previous enantioselective synthesis methods for sulfilimines from sulfenamides. \u003cstrong\u003eC\u003c/strong\u003e, Proposed enantioselective synthesis method for sulfilimines \u003cem\u003evia\u003c/em\u003e direct C(sp\u003csup\u003e3\u003c/sup\u003e)-H functionalization.\u003c/p\u003e","description":"","filename":"1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/b96d2b006860cf7438199802.jpg"},{"id":88243894,"identity":"ad94106c-4b5a-4490-83d2-ff75eec31749","added_by":"auto","created_at":"2025-08-04 12:03:06","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":133207,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eSubstrate scope\u003c/strong\u003e\u003csup\u003e\u003cem\u003e\u003cstrong\u003ea\u003c/strong\u003e\u003c/em\u003e\u003c/sup\u003e. \u003csup\u003e\u003cem\u003ea\u003c/em\u003e\u003c/sup\u003eReaction conditions: \u003cstrong\u003e1\u003c/strong\u003e (0.1 mmol, 1.0 equiv), \u003cstrong\u003e2\u003c/strong\u003e (60 equiv), Cu(MeCN)\u003csub\u003e4\u003c/sub\u003ePF\u003csub\u003e6\u003c/sub\u003e (4 mol%), \u003cstrong\u003eL5\u003c/strong\u003e (5 mol%), DTBP (4.0 equiv), and fluorobenzene (0.1 M), 10 W Blue LED (λ\u003csub\u003emax\u003c/sub\u003e = 455 nm) at 25 ℃ for 48 h under nitrogen atmosphere. Isolated yield and the ee value were determined by HPLC using a chiral stationary phase. \u003csup\u003e\u003cem\u003eb\u003c/em\u003e\u003c/sup\u003eAddition: 0.5 mL acetone. \u003csup\u003e\u003cem\u003ec\u003c/em\u003e\u003c/sup\u003emethyl 4-methylbenzoate (30 equiv). \u003csup\u003e\u003cem\u003ed\u003c/em\u003e\u003c/sup\u003e\u003cem\u003eN\u003c/em\u003e-[(9\u003cem\u003eR\u003c/em\u003e)-6′-Methoxycinchonan-9-yl]-8-quinolinesulfonamide as ligand. \u003csup\u003e\u003cem\u003ee\u003c/em\u003e\u003c/sup\u003e2,3-dimethylbutane as hydrocarbon partner. \u003csup\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sup\u003eThe ratio of regioselectivity was determined by \u003csup\u003e1\u003c/sup\u003eHNMR.\u003c/p\u003e","description":"","filename":"2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/19ac35379e7cfe074e084ecf.jpg"},{"id":88245008,"identity":"b7137af4-6607-4189-814f-2364354f4b95","added_by":"auto","created_at":"2025-08-04 12:19:06","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":68414,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eSynthetic applications\u003c/strong\u003e. \u003cstrong\u003eA\u003c/strong\u003e, Scale-up of Cu-catalyzed enantioselective alkyl C-H sulfimidation. \u003cstrong\u003eB\u003c/strong\u003e, Synthetic transformation of chiral S(IV) sulfilimines.\u003c/p\u003e","description":"","filename":"3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/762d3d81f1aedfac5d666d50.jpg"},{"id":88243897,"identity":"00bfb73c-f49c-46fd-8939-eb996f7a6972","added_by":"auto","created_at":"2025-08-04 12:03:06","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":102553,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eMechanistic investigation. a\u003c/strong\u003e,\u003cstrong\u003e \u003c/strong\u003eRadical-trapping experiment. \u003cstrong\u003eb\u003c/strong\u003e, Control experiment. \u003cstrong\u003ec\u003c/strong\u003e, Time-course experiment. \u003cstrong\u003ed\u003c/strong\u003e, EPR spectrum. \u003cstrong\u003ee\u003c/strong\u003e, UV-vis absorption spectra. \u003cstrong\u003ef\u003c/strong\u003e,\u003cstrong\u003e \u003c/strong\u003eStern-Volmer experiment.\u003c/p\u003e\n\u003cp\u003estandard conditions resulted in complete suppression of the formation of \u003cstrong\u003e3a\u003c/strong\u003e. In addition, high-resolution mass spectrometry (HRMS) also confirmed the generation of radical-trapping products (\u003cstrong\u003e9\u003c/strong\u003e-\u003cstrong\u003e11\u003c/strong\u003e) (Figure 4a). These results demonstrated that the benzyl radical, generated \u003cem\u003evia\u003c/em\u003e hydrogen atom transfer (HAT) between toluene and the \u003cem\u003etert\u003c/em\u003e-butoxyl radical, serves as the reactive intermediate throughout the transformation. Furthermore, the formation of radical-trapping product \u003cstrong\u003e11\u003c/strong\u003e verified the occurrence of the hydrogen atom transfer (HAT) process between substrate \u003cstrong\u003e1a\u003c/strong\u003e and the \u003cem\u003etert\u003c/em\u003e-butoxyl radical. Interestingly, we observed an induction period in the time course experiment (Figure 4c) under standard conditions. Control experiments in the absence of either the copper catalyst or the ligand showed that the reaction proceeded efficiently to completion (Figure 4b) and no induction period was observed (Figure 4c). However, by premixing Cu(CH\u003csub\u003e3\u003c/sub\u003eCN)\u003csub\u003e4\u003c/sub\u003ePF\u003csub\u003e6\u003c/sub\u003e/\u003cstrong\u003eL5/1a\u003c/strong\u003e at room temperature under 10 W 455 nm LEDs for 12 h, the induction period could be sufficiently suppressed (Figure 4c). Therefore, the formation of Cu(I)/\u003cstrong\u003eL5/1a\u003c/strong\u003e complex \u003cstrong\u003eI\u003c/strong\u003e from Cu(CH\u003csub\u003e3\u003c/sub\u003eCN)\u003csub\u003e4\u003c/sub\u003ePF\u003csub\u003e6\u003c/sub\u003e pre-catalyst, ligand \u003cstrong\u003eL5\u003c/strong\u003e and substrate \u003cstrong\u003e1a\u003c/strong\u003e might be responsible for the observed induction period and also might be the active catalyst account for the desired transformation. \u0026nbsp;\u003c/p\u003e","description":"","filename":"4.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/f6da82dac0026f3b393a53a1.jpg"},{"id":88244739,"identity":"fa3cd965-9d5f-4188-8514-40834c7fa494","added_by":"auto","created_at":"2025-08-04 12:11:06","extension":"jpg","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":78074,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eFree Energy Profile of the Catalytic Cycle.\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"5.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/442b234516867ec5ebd3f10c.jpg"},{"id":88244741,"identity":"dbae5e47-bd33-4e75-8ad7-a221c33e53b0","added_by":"auto","created_at":"2025-08-04 12:11:07","extension":"jpg","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":95623,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003ePossible C-S bond formation pathways\u003c/strong\u003e via (\u003cem\u003eS\u003c/em\u003e)-\u003cstrong\u003ets 2\u003c/strong\u003e and (\u003cem\u003eR\u003c/em\u003e)-\u003cstrong\u003ets 2\u003c/strong\u003etransition states. Energies are relative to (\u003cem\u003eS\u003c/em\u003e)-\u003cstrong\u003eint 2\u003c/strong\u003e (Unit: kcal/mol).\u003c/p\u003e","description":"","filename":"6.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/2b90301cc507c3f1db1759cd.jpg"},{"id":88243906,"identity":"cb78181c-19ce-4b36-b671-273c4d69d7d8","added_by":"auto","created_at":"2025-08-04 12:03:07","extension":"jpg","order_by":7,"title":"Figure 7","display":"","copyAsset":false,"role":"figure","size":54327,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eThe Catalytic Cycle.\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"7.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/86eb9e5bea366dc6169b68a3.jpg"},{"id":104398518,"identity":"a6a2904e-af1e-4e69-ac56-b0cc034a01d4","added_by":"auto","created_at":"2026-03-11 12:02:44","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1632214,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/76c88896-e683-41c7-9d4c-c179e53592ff.pdf"},{"id":88243899,"identity":"cc34021f-f175-4497-8426-769bf5b88417","added_by":"auto","created_at":"2025-08-04 12:03:06","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":80785,"visible":true,"origin":"","legend":"cifreport of of 5","description":"","filename":"2444213cifreport.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/376fc608aead7953b91373f6.pdf"},{"id":88244740,"identity":"a34b5491-d8e2-4123-acf6-ff224dafd9c4","added_by":"auto","created_at":"2025-08-04 12:11:06","extension":"pdf","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":90210,"visible":true,"origin":"","legend":"cifreport of of 3a","description":"","filename":"2444210cifreport.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/fc4851fce566f975a3397917.pdf"},{"id":88245009,"identity":"78ab11a3-a803-4e44-a071-97f6745aaa4d","added_by":"auto","created_at":"2025-08-04 12:19:07","extension":"cif","order_by":3,"title":"","display":"","copyAsset":false,"role":"supplement","size":438158,"visible":true,"origin":"","legend":"cif data of 5","description":"","filename":"2444213.cif","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/af11565afc126400dae1fba0.cif"},{"id":88243902,"identity":"d93666d7-d7ba-4a0c-8d99-779d6ee73658","added_by":"auto","created_at":"2025-08-04 12:03:07","extension":"cif","order_by":4,"title":"","display":"","copyAsset":false,"role":"supplement","size":618263,"visible":true,"origin":"","legend":"cif data of 3a","description":"","filename":"2444210.cif","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/c05744a76a8d2c15257a1d0b.cif"},{"id":88243907,"identity":"c6997153-2cda-4f23-9e30-d17e7447a699","added_by":"auto","created_at":"2025-08-04 12:03:07","extension":"pdf","order_by":5,"title":"","display":"","copyAsset":false,"role":"supplement","size":25371605,"visible":true,"origin":"","legend":"Supplementary Information","description":"","filename":"SupplementaryInformationOP.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/35809108482f082fec0cb870.pdf"},{"id":88243901,"identity":"5d9c21f7-d412-43a3-822d-b2653eb18dc1","added_by":"auto","created_at":"2025-08-04 12:03:07","extension":"jpg","order_by":6,"title":"","display":"","copyAsset":false,"role":"supplement","size":54035,"visible":true,"origin":"","legend":"","description":"","filename":"TOC.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7172655/v1/af974db1780e4f98bcda7557.jpg"}],"financialInterests":"There is \u003cb\u003eNO\u003c/b\u003e Competing Interest.","formattedTitle":"Enantioselective Alkyl C−H Sulfimidation Enabled by Copper Catalysis","fulltext":[{"header":"Introduction","content":"\u003cp\u003eThe transformation of carbon-hydrogen (C-H) bonds of alkanes into functionalized molecules has been a long-term dream of synthesis and catalysis community\u003csup\u003e1-5\u003c/sup\u003e. In particular, the enantioselective assembly of carbon-heteroatom (C-X) bond from alkane C-H bonds\u003csup\u003e6-9\u003c/sup\u003e represents a pivotal synthetic strategy, owing to its capacity to bypass laborious substrate pre-activation steps, directly converting abundant hydrocarbon feedstocks into structurally complex bioactive molecules and functional materials. Although a great deal of effort has been continuously invested in this field since Shilov discovered the first homogeneous system for alkane C-H bond\u003csup\u003e1\u003c/sup\u003e, achieving regioselective activation and stereoselective conversion of such inert C(sp\u0026sup3;)-H bonds persists as a paramount challenge, rooted in the intrinsic chemical inertness of C-H bonds, too much similarity in polarity, and the absence of functional directing groups\u0026mdash;factors that pose limitations on selectivity control and reaction design\u003csup\u003e10,11\u003c/sup\u003e. Recently, several concepts and strategies have emerged that enable the direct construction of chiral C-X bonds from inert C(sp\u003csup\u003e3\u003c/sup\u003e)-H bonds, such as the construction of chiral C-N\u003csup\u003e12-15\u003c/sup\u003e and C-O bonds\u003csup\u003e16-18\u003c/sup\u003e.\u003csup\u003e\u0026nbsp;\u003c/sup\u003eHowever, enantioselective formation of C-S bond and a stereogenic sulfur center from alkanes C-H bonds remains unexplored (Figure 1A).\u003c/p\u003e\n\u003cp\u003eOver the past decade, organosulfur compounds have garnered widespread attention in synthetic chemistry\u003csup\u003e19\u003c/sup\u003e. Chiral sulfilimines, as aza analogues of sulfoxides and representative S(IV) organosulfur compounds, have emerged as multifunctional scaffolds with broad application in medicinal chemistry\u003csup\u003e20\u003c/sup\u003e and ligand design\u003csup\u003e21-23\u003c/sup\u003e, owing to distinctive electronic and structural characteristics.\u0026nbsp;As such,\u0026nbsp;great effort has been devoted to the catalytic asymmetric construction of sulfur stereocenters in sulfilimines\u003csup\u003e24,25\u003c/sup\u003e. One of elegant strategies to access chiral sulfilimines is the stereoselective C-S bond formation from sulfenamides. In previous studies, carbon electrophiles undergoing enantioselective C-S bond forming event were basically derived from highly activated precursors, such as diazo compounds\u003csup\u003e26\u003c/sup\u003e, alkyl halides\u003csup\u003e27-29\u003c/sup\u003e, arylboronic acids\u003csup\u003e30\u003c/sup\u003e, diaryliodonium salts\u003csup\u003e31,32\u003c/sup\u003e and aryl diazonium salts\u003csup\u003e33\u003c/sup\u003e (Figure 1B). A general approach to access sulfilimines with stereogenic S(IV) centers directly from massively available alkanes, devoid of pre-functionalization or directing group, turns out to be of great importance, but has not been established, yet.\u003c/p\u003e\n\u003cp\u003eBuilding on our previous success in the alkane C-H functionalization enabled by copper catalysts and peroxide \u003csup\u003e34,35\u003c/sup\u003e, we hypothesized that the alkyl radicals generated from a similar process might be able to participate in an enantioselective alkyl sulfimidation with sulfenamides facilitated by copper catalyst, affording chiral sulfilimines (Figure 1C). In this scenario, the alkoxy radicals generated from di-\u003cem\u003etert\u003c/em\u003e-butyl peroxide (DTBP) undergo HAT process with alkanes to generate the active alkyl radicals\u003csup\u003e36-38\u003c/sup\u003e. The prevalence of highly reactive species in the reaction system brings up substantial difficulties. Firstly, it is an inherent challenge to inhibit the over-oxidation of sulfenamides\u003csup\u003e39,40\u003c/sup\u003e and sulfilimines\u003csup\u003e28,41\u003c/sup\u003e under strong oxidizing conditions. Furthermore, discriminating C-S bond formation over competing C-N coupling pathways\u003csup\u003e30,42\u003c/sup\u003e and avoiding the cleavage of S-N bond\u003csup\u003e43-46\u003c/sup\u003e were central to ensure this transformation proceeding smoothly. Moreover, oxidative conditions could promote over-oxidation of the newly formed carbon-centered radicals to carbocations, which spontaneously undergo intramolecular nucleophilic substitution without the assistance of any catalyst, thereby diminishing enantioselectivity\u003csup\u003e35,47,48\u003c/sup\u003e. Consequently, identification of a robust chiral catalyst system capable of rendering a highly enantioselective C-S bond formation and suppressing the potential background reaction under oxidative conditions constitutes pivotal determinants to realize the proposed reaction.\u003c/p\u003e"},{"header":"Results and discussion","content":"\u003cp\u003eTo validate the feasibility for the aforementioned process, toluene (\u003cstrong\u003e2a\u003c/strong\u003e, BDE = 88 kcal/mol)\u003csup\u003e8\u003c/sup\u003e \u003cstrong\u003e2a\u003c/strong\u003e was selected as the initial model substrate to react with \u003cem\u003eN\u003c/em\u003e-benzoyl sulfenamide \u003cstrong\u003e1a\u0026nbsp;\u003c/strong\u003e(Table 1). By using di-\u003cem\u003etert\u003c/em\u003e-butyl peroxide (DTBP) as the oxidant and HAT radical precursor, and Cu(CH\u003csub\u003e3\u003c/sub\u003eCN)\u003csub\u003e4\u003c/sub\u003ePF\u003csub\u003e6\u003c/sub\u003e as a pre-catalyst, we screened a series of chiral bidentate bisoxazolines (\u003cstrong\u003eL1-L3\u003c/strong\u003e) (see Supplementary Information Table S1 for more results), which generated product \u003cstrong\u003e3a\u003c/strong\u003e in moderate to good yield but with poor enantioselectivity (\u0026lt; 16% ee). The replacement of bisoxazoline ligands with Dixon\u0026rsquo;s \u003cem\u003eN\u003c/em\u003e,\u003cem\u003eN\u003c/em\u003e,\u003cem\u003eP\u003c/em\u003e-ligand \u003cstrong\u003eL4\u003c/strong\u003e\u003csup\u003e49\u003c/sup\u003e led to a slightly lower yield of \u003cstrong\u003e3a\u0026nbsp;\u003c/strong\u003eand even poorer enantioselectivity (for additional \u003cem\u003eN\u003c/em\u003e,\u003cem\u003eN\u003c/em\u003e,\u003cem\u003eP\u003c/em\u003e-ligand screening results, see Table S1). To our delight, \u003cem\u003eN\u003c/em\u003e,\u003cem\u003eN\u003c/em\u003e,\u003cem\u003eN\u003c/em\u003e-ligand \u003cstrong\u003eL5\u003c/strong\u003e\u003csup\u003e50\u003c/sup\u003e turned out to be the optimal ligand among \u003cstrong\u003eL1-5\u003c/strong\u003e, which enabled the desired product \u003cstrong\u003e3a\u003c/strong\u003e to be obtained in 77% yield and with 95% ee. Then, a ligand modification study by finely tuning the substituent on C2 position of the quinoline motif was carried out. These studies showed that ligand \u003cstrong\u003eL5\u003c/strong\u003e without any substituent on the C2 position was superior in terms of both efficiency and enantioselectivity. Evaluation of different copper pre-catalysts (entries 2-4) revealed that coordinating halide anions of copper pre-catalysts such as bromide, chloride and iodide had a negative impact on the yield of \u003cstrong\u003e3a\u003c/strong\u003e. Solvent screening studies indicated that fluorobenzene turned out to be an optimal solvent (entries 5-8, and Table S2 in the Supplementary Information). Furthermore, control experiments confirmed that the blue LED irradiation and the presence of DTBP were both requisite for the success of this reaction (entries 9- 10).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1. Optimization of the reaction conditions.\u0026nbsp;\u003c/strong\u003e\u003cem\u003e\u003csup\u003ea\u003c/sup\u003e\u003c/em\u003eReaction conditions: \u003cstrong\u003e1a\u003c/strong\u003e (0.1 mmol, 1.0 equiv), \u003cstrong\u003e2a\u003c/strong\u003e (60 equiv), Cu(MeCN)\u003csub\u003e4\u003c/sub\u003ePF\u003csub\u003e6\u003c/sub\u003e (4 mol%), ligand (5 mol%), DTBP (4.0 equiv), and fluorobenzene (0.1 M), 10 W Blue LED (\u0026lambda;\u003csub\u003emax\u003c/sub\u003e = 455 nm) at 25 ℃ for 48 h under nitrogen atmosphere. The yield was determined \u003cem\u003evia\u003c/em\u003e \u003csup\u003e1\u003c/sup\u003eH NMR analysis using 1,3,5-triacetylbenzene as an internal standard, and the ee value was determined by HPLC using a chiral stationary phase. \u003cem\u003e\u003csup\u003eb\u003c/sup\u003e\u003c/em\u003eIsolated yield. \u003cem\u003e\u003csup\u003ec\u003c/sup\u003e\u003c/em\u003eDTBP = di-\u003cem\u003etert\u003c/em\u003e-butyl peroxide.\u003c/p\u003e\n\u003cp\u003e\u003cimg 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\" width=\"774\" height=\"289\"\u003e\u003c/p\u003e\n\u003cp\u003eWith the optimized conditions in hand, a variety of sulfenamides were initially examined (Figure 2). The reaction exhibited excellent compatibility with the \u003cem\u003eN\u003c/em\u003e-acyl groups on sulfenamides (\u003cstrong\u003e3a\u003c/strong\u003e-\u003cstrong\u003e3t\u003c/strong\u003e). Both linear (\u003cstrong\u003e3b\u003c/strong\u003e-\u003cstrong\u003e3d\u003c/strong\u003e) and cyclic (\u003cstrong\u003e3e\u003c/strong\u003e) amides provided good yields and stereoselectivities. The electronic properties and substitution patterns of the phenyl group of sulfenamides exerted little impact on the enantioselectivity of the \u003cem\u003eS\u003c/em\u003e-benzylation reaction. As a consequence, the presence of either an electron- donating or electron-withdrawing substituent at \u003cem\u003epara\u003c/em\u003e- or \u003cem\u003emeta\u003c/em\u003e-position of aryl amides was nicely tolerated to furnish the sulfilimines with high levels of enantioselectivity (\u003cstrong\u003e3f\u003c/strong\u003e-\u003cstrong\u003e3q\u003c/strong\u003e). Other sulfenamides bearing a naphthalene ring (\u003cstrong\u003e3r\u003c/strong\u003e) or heterocyclic rings (\u003cstrong\u003e3s-3t\u003c/strong\u003e) were also tested under the optimized conditions and engaged in the reaction seamlessly, providing the desired products in moderate to good yield (56%-80%) and excellent enantioselectivities (86%-97% ee).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eSubsequently, the variations in the thiol moiety of the sulfenamides was evaluated under optimal conditions. As shown in Figure 2, both the electron-donating and electron-withdrawing substituents at \u003cem\u003eortho\u003c/em\u003e-, \u003cem\u003emeta\u003c/em\u003e-, \u003cem\u003epara\u003c/em\u003e- positions (\u003cstrong\u003e3u\u003c/strong\u003e-\u003cstrong\u003e3ae\u003c/strong\u003e) were all compatible with the reaction conditions delivering the desired sulfilimines in decent yields with good to excellent enantioselectivities (75-96% ee).\u0026nbsp; Sulfenamides featuring di-substituted aryls in the thiol moiety were also well-tolerated in the asymmetric \u003cem\u003eS\u003c/em\u003e-benzylation reaction, furnishing \u003cstrong\u003e3af\u003c/strong\u003e\u0026ndash;\u003cstrong\u003e3ag\u003c/strong\u003e with remarkable stereo-control (87-94% ee). Simultaneously, sulfenamides derived from simple thiophenol underwent the transformation smoothly, producing \u003cstrong\u003e3ah\u003c/strong\u003e with outstanding efficiency and enantioselectivity (96% yield, 94% ee).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eWe next focused on examining the scope of hydrocarbon partner under the optimized reaction conditions. All the examined monosubstituted toluene derivatives (\u003cstrong\u003e3ai\u003c/strong\u003e-\u003cstrong\u003e3ay\u003c/strong\u003e) successfully participated in the reaction, yielding the desired product in appreciable yields (up to 91% yield) and with high to excellent enantioselectivities (up to 98% ee). Notably, a broad range of functional groups proved to be compatible with this reaction, including halides (\u003cstrong\u003e3al\u003c/strong\u003e-\u003cstrong\u003e3an\u003c/strong\u003e, \u003cstrong\u003e3at\u003c/strong\u003e, \u003cstrong\u003e3aw\u003c/strong\u003e-\u003cstrong\u003e3ay\u003c/strong\u003e), boron ester (\u003cstrong\u003e3ar\u003c/strong\u003e), ester (\u003cstrong\u003e3aq\u003c/strong\u003e), methoxy (\u003cstrong\u003e3au\u003c/strong\u003e) and trifluoromethoxy(\u003cstrong\u003e3ap\u003c/strong\u003e) substituent. Both di- and tetra-substituted toluene derivatives reacted efficiently (\u003cstrong\u003e3az\u003c/strong\u003e-\u003cstrong\u003e3bb\u003c/strong\u003e; 68-95% yield, 90-95% ee). Surprisingly, even 3-methylthiophene, known for its sensitivity to oxidative conditions, was compatible (\u003cstrong\u003e3bc\u003c/strong\u003e). To establish the broad applicability of this methodology, we investigated aliphatic C(sp\u0026sup3;)-H bonds (bond dissociation energy (BDE) = ~100 kcal/mol\u003csup\u003e8\u003c/sup\u003e stronger than benzylic C-H bonds (typically ~85 kcal/mol)). Notably, cycloalkanes with ring size ranging from five to seven were also amenable to the reaction (\u003cstrong\u003e3bd\u003c/strong\u003e-\u003cstrong\u003e3bf\u003c/strong\u003e, 72%-76% yield, 96% ee). Linear alkane such as pentane was also able to undergo the desired transformation to give \u003cstrong\u003e3bh\u003c/strong\u003e in good yield and with regioselectivity of 1:2.8:1.8 r.r.. Notably, when 2,3-dimethylbutane was examined as hydrocarbon partner, the major product (\u003cstrong\u003e3bg\u003c/strong\u003e) resulting from isopropyl radical (generated from \u0026beta;-cleavage of terminal C-H bonds) was observed.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSynthetic Applications\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo demonstrate the synthetic applicability of this methodology, a 2 mmol-scale reaction was carried out with \u003cem\u003eN\u003c/em\u003e-benzoyl sulfenamide \u003cstrong\u003e1a\u003c/strong\u003e and benzene \u003cstrong\u003e2a\u003c/strong\u003e (Figure 3), furnishing the desired product \u003cstrong\u003e3a\u003c/strong\u003e in 56% yield and 93% ee. The enantiomeric excess (ee) could be improved to 99% \u003cem\u003evia\u003c/em\u003e recrystallization (DCM/hexane solvent system). The corresponding product \u003cstrong\u003e3a\u0026nbsp;\u003c/strong\u003e(99% ee)\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003ewas directly oxidized to sulfoximine \u003cstrong\u003e4\u003c/strong\u003e by RuCl\u003csub\u003e3\u003c/sub\u003e-catalyzed oxidation protocol, achieving high yield with retained enantioselectivity (99% ee)\u003csup\u003e51\u003c/sup\u003e. Subsequently, the \u003cem\u003eN\u003c/em\u003e-benzoyl group was efficiently removed through basic hydrolysis, delivering the unprotected sulfoximine \u003cstrong\u003e5\u003c/strong\u003e in excellent yield (96%) and enantioselectivity (\u0026gt;99% ee)\u003csup\u003e33\u003c/sup\u003e. The resulting chiral S(VI) sulfoximine \u003cstrong\u003e5\u003c/strong\u003e demonstrated significant utility as a versatile synthetic building block, readily adaptable to the construction of a diverse array of valuable molecular structures. For example, \u003cem\u003eN\u003c/em\u003e-trifluoromethylated sulfoximine derivatives \u003cstrong\u003e6\u0026nbsp;\u003c/strong\u003ecould be directly formed in the presence of a silver catalyst and trifluoromethylation agent Me\u003csub\u003e3\u003c/sub\u003eSiCF\u003csub\u003e3\u003c/sub\u003e\u003csup\u003e52\u003c/sup\u003e.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanistic Investigations\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo elucidate the reaction mechanism, a set of related experimental studies were conducted (Figure 4). Radical trapping experiments with 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) under\u003c/p\u003e\n\u003cp\u003eTo further clarify the relationship between light and DTBP homolysis and the cause of background reaction suppression, a series of electron paramagnetic resonance (EPR) spectroscopy, UV-vis absorption spectra and Stern-Volmer experiments were conducted (Figure 4d-4f). As depicted in Figure 4d, irradiation of DTBP in the presence of 5,5- dimethyl-1-pyrroline N-oxide (DMPO) generated radical species, which were identified as DMPO adducts with \u003cem\u003etert\u003c/em\u003e-butoxy radicals (\u003cem\u003etert\u003c/em\u003e-BuO\u0026bull;)\u003csup\u003e35,54\u003c/sup\u003e. No significant EPR signal was observed for DTBP in the absence of light. However, in the presence of Cu(I)/\u003cstrong\u003eL5/1a\u003c/strong\u003e, the EPR signal intensity was significantly diminished compared with DTBP alone, likely due to the primary inner filter effect\u003csup\u003e55,56\u003c/sup\u003e of the other light-absorbing substances in this system. Subsequent UV-vis absorption spectra (Figure 4e) revealed distinct absorption peaks at 455 nm for both the Cu(I)/\u003cstrong\u003eL5/1a\u003c/strong\u003e complex \u003cstrong\u003eI\u003c/strong\u003e and the reaction system, demonstrating competitive light absorption by the copper complex\u003csup\u003e35\u003c/sup\u003e (further EPR spectrum and UV-vis absorption spectra in the Supplementary Information). We assumed that the background reaction was effectively suppressed in the presence of the Cu(I)/\u003cstrong\u003eL5/1a\u003c/strong\u003e complex \u003cstrong\u003eI\u003c/strong\u003e, which indicated that DTBP underwent alternative cleavage pathways beyond directly photoinduced homolysis\u003csup\u003e57\u003c/sup\u003e. As predicted, a clear quenching of the emission from the copper complexes by DTBP was observed in Stern-Volmer experiment (Figure 4d), indicating that the decomposition of DTBP was induced by the excited state of copper complexes(\u003cstrong\u003eCu(I)/L5/1a\u003c/strong\u003e) \u003cstrong\u003eI*\u003c/strong\u003e\u003csup\u003e58\u003c/sup\u003e.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDFT Calculation.\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDFT calculations were conducted to gain insights into the C-S bond formation mechanism and the origins of the enantioselectivity using the reaction of \u003cstrong\u003e1a\u003c/strong\u003e and \u003cstrong\u003e2a\u003c/strong\u003e as the model system (\u003cstrong\u003eFigure 5\u003c/strong\u003e). Conformational analysis of \u003cstrong\u003eint 1\u003c/strong\u003e suggested that the most stable coordination mode between Cu(I), \u003cstrong\u003e1a\u003c/strong\u003e and ligand \u003cstrong\u003eL5\u003c/strong\u003e is a six-coordinate complex. The HAT process between \u003cstrong\u003eint 1\u003c/strong\u003e and \u003cem\u003etert\u003c/em\u003e-butoxy radical to form Cu(II)-\u003cstrong\u003e1a\u003c/strong\u003e species \u003cstrong\u003eint 2\u003c/strong\u003e is exergonic. Intermediate \u003cstrong\u003eint 2\u003c/strong\u003e then undergoes an outer-sphere radical coupling with benzyl radical \u003cem\u003evia\u003c/em\u003e\u003cstrong\u003ets 2\u003c/strong\u003e with a barrier of 8.2 kcal/mol to form \u003cstrong\u003eint 3\u003c/strong\u003e. Alternatively, the pathway involving inner-sphere radical addition to generate Cu(III) intermediate \u003cstrong\u003eint 4\u003c/strong\u003e requires a barrier of 16.7 kcal/mol, which is much less favorable. Finally, a coordination substitution of the \u003cstrong\u003eint 3\u003c/strong\u003e with \u003cstrong\u003e1a\u003c/strong\u003e releases the prodct \u003cstrong\u003e3a\u0026nbsp;\u003c/strong\u003eand the \u003cstrong\u003eint 1\u003c/strong\u003e.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe optimized structures for the key C-S bond formation transition states were shown in \u003cstrong\u003eFigure 6\u003c/strong\u003e. The formation of (\u003cem\u003eS\u003c/em\u003e)\u003cstrong\u003e-3a\u003c/strong\u003e is the most favorable pathway among the two competitive routes. In this C-S formation step, the favored transition state (\u003cem\u003eS\u003c/em\u003e)-\u003cstrong\u003ets 2\u003c/strong\u003e, 2.4 kcal/mol more favorable than (\u003cem\u003eR\u003c/em\u003e)-\u003cstrong\u003ets 2\u003c/strong\u003e, leads to the major product (\u003cem\u003eS\u003c/em\u003e)\u003cstrong\u003e-3a\u003c/strong\u003e, which is consistent with experimental selectivity. Notably, in (\u003cem\u003eS\u003c/em\u003e)-\u003cstrong\u003ets 2\u003c/strong\u003e, there are \u0026pi;-\u0026pi; interactions between quinoline of ligand \u003cstrong\u003eL5\u003c/strong\u003e and \u003cem\u003ep\u003c/em\u003e-\u003cem\u003etert\u003c/em\u003e-butylphenyl of \u003cstrong\u003e3a\u003c/strong\u003e, which might contribute to the lower energy barrier.\u003c/p\u003e\n\u003cp\u003eThe optimized structures for the key C-S bond formation transition states were shown in \u003cstrong\u003eFigure 6\u003c/strong\u003e. The formation of (\u003cem\u003eS\u003c/em\u003e)\u003cstrong\u003e-3a\u003c/strong\u003e is the most favorable pathway among the two competitive routes. In this C-S formation step, the favored transition state (\u003cem\u003eS\u003c/em\u003e)-\u003cstrong\u003ets 2\u003c/strong\u003e, 2.4 kcal/mol more favorable than (\u003cem\u003eR\u003c/em\u003e)-\u003cstrong\u003ets 2\u003c/strong\u003e, leads to the major product (\u003cem\u003eS\u003c/em\u003e)\u003cstrong\u003e-3a\u003c/strong\u003e, which is consistent with experimental selectivity. Notably, in (\u003cem\u003eS\u003c/em\u003e)-\u003cstrong\u003ets 2\u003c/strong\u003e, there are \u0026pi;-\u0026pi; interactions between quinoline of ligand \u003cstrong\u003eL5\u003c/strong\u003e and \u003cem\u003ep\u003c/em\u003e-\u003cem\u003etert\u003c/em\u003e-butylphenyl of \u003cstrong\u003e3a\u003c/strong\u003e, which might contribute to the lower energy barrier.\u003c/p\u003e\n\u003cp\u003eIn conclusion, we have successfully established a photoinduced copper-catalyzed enantioselective alkyl C-H sulfilimidation. This strategy allows for highly efficient enantioselective synthesis of chiral sulfilimines through C-H functionalization from unactivated alkanes without pre-functionalization. The success of this method fills the gap in asymmetric synthesis of C-S bond and a stereogenic sulfur center from inert C-H bonds. The broad applicability of this approach has been validated through the functionalization of various aliphatic C-H, including diverse toluene derivatives, cycloalkanes and linear alkanes. Mechanistic experiments and computational studies have elucidated comprehensive mechanistic details of the asymmetric C-S bond formation through an outer-sphere radical addition. We anticipate that this report will inspire further advancements in building up the chiral C-X bond from inert C-H bond.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eData Availability Statement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll data generated or analyzed during this study are included in this published article and its supplementary information files. Crystallographic data for compound \u003cstrong\u003e3a\u003c/strong\u003e was deposited in the Cambridge Structural Data Centre (CCDC) under deposition number: 2444210. Crystallographic data for compound \u003cstrong\u003e5\u003c/strong\u003e was deposited in the Cambridge Structural Data Centre (CCDC) under deposition number: 2444213.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe are grateful for the financial support from National Key R\u0026amp;D Program of China (2021YFA1500100) and the National Natural Science Foundation of China (22188101).\u003c/p\u003e\n\u003cp\u003eWe thank Dr. Yunzhi Lin (Shanghai institute of Organic Chemistry) for his guidance in DFT calculations.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor Contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eL.-Z.G. conceived the project. Y.-D.Z. designed and developed the reactions. T.D. performed theoretical calculations. N.-Y.L. prepared the materials. L.-Z.G. supervised the project. Y.-D.Z., T.D. and L.-Z.G. contributed to write and edit the paper.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting Interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no competing financial interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaterials \u0026amp; Correspondence\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSupplementary Information is available in the online version of the paper. Reprints and permissions information is available online. Correspondence and requests for materials should be addressed to L.-Z.G. ([email protected]).\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eShilov, A. E. \u0026amp; Shul\u0026apos;pin, G. B. Activation of C-H bonds by metal complexes. \u003cem\u003eChem. Rev.\u003c/em\u003e \u003cstrong\u003e97\u003c/strong\u003e, 2879-2932 (1997).\u003c/li\u003e\n\u003cli\u003eZheng, C. \u0026amp; You, S. L. 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Soc.\u003c/em\u003e \u003cstrong\u003e146\u003c/strong\u003e, 27196-27203 (2024).\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-7172655/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7172655/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eEnantioselective transformation of alkanes into functional chiral molecules constitutes an ultimate goal for chemists that however, has been a grand challenge over more than half century. Although remarkable advances have been made in the stereoselective C-C, C-N and C-O bonds formation enabled by either metal or enzyme catalysis, the alkyl C-H\u003cstrong\u003e \u003c/strong\u003esulfimidation\u003cstrong\u003e \u003c/strong\u003efor building up a stereogenic sulfur center from alkanes has not previously been accomplished. Herein, we describe a photoinduced copper-catalyzed enantioselective C−H sulfimidation of alkanes, allowing for a straightforward synthesis of highly enantioenriched sulfilimines from alkane feedstocks. Computational studies and mechanistic investigations unveil the reaction mechanism and the origin of stereoselectivity.\u003c/p\u003e","manuscriptTitle":"Enantioselective Alkyl C−H Sulfimidation Enabled by Copper Catalysis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-08-04 12:03:02","doi":"10.21203/rs.3.rs-7172655/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"13d126ca-013c-4aa7-b771-9d4262e32664","owner":[],"postedDate":"August 4th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":52493874,"name":"Physical sciences/Chemistry/Organic chemistry/Synthetic chemistry methodology"},{"id":52493875,"name":"Physical sciences/Chemistry/Catalysis/Asymmetric catalysis"},{"id":52493876,"name":"Physical sciences/Chemistry/Catalysis/Photocatalysis"}],"tags":[],"updatedAt":"2026-02-27T11:45:33+00:00","versionOfRecord":[],"versionCreatedAt":"2025-08-04 12:03:02","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7172655","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7172655","identity":"rs-7172655","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}