Prognostic Factors of Hilar Cholangiocarcinoma Patients After Surgical Resection

Abstract Background Hilar cholangiocarcinoma (HC)is one of the most common malignancies in China with poor prognosis and its incidence rate is increasing. Surgical resection is the most possible curative treatment option. However, comprehensive knowledge of prognostic markers is less or not accurate. So, the aim of this study was to analyze the prognostic factors in the surgical resection of HC patients.Material/Methods A retrospective analysis of 85 cases of HC patients attending our hospital between January 2014 and December 2018 were included in the study. The patients was follow-up history at July 2019. Cox proportional hazards model analysis was performed to identify indexes of prognosis. All indicators were analyzed by univariate and multivariate analysis.Results The significantly related prognostic factors are imaging staging,blood loss during surgery, lymphatic metastasis and tumor size,TNM stage, surgical mar­gin and level of carbohydrate antigen 19–9(CA19-9) in blood. Among them, TNM stage, surgical mar­gin and level of CA19-9 in blood are independent prognostic factors.Conclusions Good prognosis in hilar cholangiocarcinoma patients is indicated by early stages of TNM staging, no resection margin invaded and low level of CA19-9.