On the pathogenesis of endometriosis

This doctoral dissertation from Maastricht University investigates the pathogenesis of endometriosis, examining the underlying mechanisms that drive the development and progression of the disease. The work synthesizes existing research on retrograde menstruation, immune system dysfunction, and hormonal influences to construct a comprehensive model of how ectopic endometrial tissue establishes itself outside the uterus. It highlights the complex interplay between genetic predisposition and environmental factors in the initiation of lesions. This paper is centrally about endometriosis — specifically exploring the fundamental biological pathways responsible for its origin and persistence.

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