Active colonisers of the gastrointestinal tract of Atlantic salmon farmed in a warm water region

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Atlantic salmon ( Salmo salar ) farmed in seawater in Tasmania ( lutruwita ) can experience temper-atures close to their thermotolerance limit during summer and Vibrionaceae are a major component of their gut microbiome. This study focuses on understanding the microbiome of the Atlantic salmon gastrointestinal tract via the taxonomy, population dynamics, and traits of the main colonists. Results. Multiyear survey and co-occurrence network analyses confirmed novel members of Aliivibrio reliably colonise the gut microbiome in Atlantic salmon farmed in marine pens in Tasmania when the confounding influences of DNA and bacteria from feed and water was considered. Aliivibrio and Mycoplasma were the main taxa found to colonise the gut mucosal layers. Warm water temperature(19°C) experiments performed in seawater tanks indicated Aliivibrio and Vibrio rapidly become predominant in the digesta of Atlantic salmon that had reduced feeding and high faecal cast production while Mycoplasma were found to be mostly absent. Salmon-associated Aliivibrio isolates were found to share many genes required for host colonisation with that of the faunal mutualist Aliivibrio fischeri . Though most salmon digesta isolates seem to lack obvious virulence factors, strains of two abundant novel colonising Aliivibrio strain groups possessed the genes for cytolethal distending toxin (CDT). Conclusions. Multiyear surveys confirm Atlantic salmon farmed in the relatively warm conditions of Tasmania are persistently colonised by the same, largely novel, Aliivibrio species and a restricted range of other Vibrionaceae . Some of these species were found to be particularly adept at colonising salmon in warm water conditions. Though some Aliivibrio coloniser strains possessed CDT-genes it is yet unknown whether CDT-gene-positive Aliivibrio negatively impact Atlantic salmon . Since the strains studies possess a range of different colonization enabling mechanisms, interactions between Vibrionaceae in the gut of Atlantic salmon could be important for overall fish health, especially when they are exposed to stressful conditions, such as elevated sea surface temperatures. Atlantic salmon microbiome Aliivibrio Mycoplasma colonisation Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Background Aquaculture, in particular finfish aquaculture, has greatly expanded in the last three decades to overtake wild caught fish for human consumption on a volume production basis [1] This trend is fuelled by the limited capacity of capture fisheries to feed global population growth and increasing per capita consumption, with aquaculture offering an efficient source of protein due to a high feed efficiency and the development of improved production technologies [2,3]. Some farmed species, such as Atlantic salmon ( Salmo salar ) and Pacific salmon ( Oncorhynchus tshawytscha ), are mainly sold in premium markets. The expansion of aquaculture and volatility of prices in recent years [4] has lead farming practices to try to achieve improved production efficiencies, especially in relation to feed sustainability [5-7]. To preserve product quality, improve social acceptability and feed ingredient production, improvements that guarantee farm performance, feed efficiency, and animal welfare is an ongoing effort by the salmon industry. There has been a rapid shift in freshwater hatchery production towards recirculation aquaculture systems (RAS) that have enabled larger smolt (the salmon life stage adapting to seawater) to be stocked to sea [8], thus shortening the marine production phase. Development of land based RAS as an alternative to sea pens for production of harvest sized fish faces several technical and economic challenges [9]. At the same time off-shore farming has been contemplated where aquaculture can be coupled to renewable energy generation [10]. Part of the reason for the latter trend is to reduce coastal environmental impacts and improve the scale of efficiency of aquaculture production. Increasing sea surface temperatures nevertheless present a future challenge to aquaculturists, in particular to the Atlantic salmon industry; with temperature optima for adult fish of between 13 to 16°C [11, 12]. In Tasmania (Australia), the Atlantic salmon industry relies on sea cage farming. The industry operates at the high end of the temperature scale owing to summer sea surface temperatures being on average 16-18°C [13]. For example, a 117-day “heat wave” during the summer of 2015/16, where surface (5 m depth) temperatures of the Tamar River Estuary averaged above 18°C (maximum 22.9°C) had significant effects on farmed salmon health and downstream marketability [14]. The main sign of thermal stress to Atlantic salmon and other salmonid species is lethargic behaviour and reduced or no voluntary feeding, resulting in substantial size and condition variation within cohorts. Lack of feeding may also lead to inconsistent flesh colour due to uneven deposition of dietary astaxanthin into white muscle [15]. Thermal stress and inappetence could be partly due to impacts on renal, liver and osmoregulatory functions and has also been associated with a steep increase in the excretion of pale yellow sloughed intestinal mucosal layer referred to as “pseudofaeces” or faecal casts [16]. These issues are managed in farms with other summer seasonal phenomena, in particular amoebic gill disease, which requires reiterative freshwater bathing [17]. Gut microbiome studies on Atlantic salmon and other farmed fish species, including the full production cycle and related to ecological, health, farm performance and diet-related questions, have greatly increased in recent years. Several recent salmon-specific studies are summarised in Supplementary Table S1 summarising gut microbiome composition of Atlantic and Chinook salmon in a range of scenarios. Fish have a gut microbiome that reflects their environment [18], however in farmed fish It is necessary to first decipher microbiome data to determine what bacterial taxa actually make up the active microbiome rather than bacteria simply transiting through via water or detected as remnant DNA associated with feed [19]. Smolt, when transferred to sea pens, are physiologically adapted to the marine environment via smoltification, however their gut microbiota dynamically changes over time [20-22]. As fish grow in sea pens the microbiome changes have been related to fish age and/or weight gain [23]. Diet by comparison typically represents a more subtle influence on the community composition [24]. Bacteria in the gut that are autochthonous would typically be highly predominant, associated with the mucosal layer and/or the digesta to different degrees. A major autochthonous species present in wild Atlantic salmon is “Candidatus Mycoplasma salmoninae salar” [25]. In sea farmed salmon this species and other members of the Mycoplasmatales can be readily detected [16, 20, 21, 23, 24]. Recent evidence confirms this species is co-diversified within wild Atlantic salmon populations. Other core taxa attributed to salmon usually include Lactobacillaceae [22] in smolt in hatcheries, which could be feed ingredient associated, while Photobacterium is typically the most abundant member of the Vibrionaceae in salmon from cold waters, consistent with its psychrophilic adaptations. In temperate conditions (sea surface temperature 10-20°C) surveys have shown that the gut bacteria changes from a predominance of lactic acid bacteria to Vibrionaceae ( Aliivibrio and Vibrio ) after fish experience their first summer, with Vibrionaceae remaining predominant thereafter [20]. Atlantic salmon fed diets where energy content and protein/lipid ratios and fish meal contents were contrasted had only transient impacts on gut community structure, in the end Vibrionaceae and other core taxa always predominated suggesting particular taxa have traits enabling stable colonisation of the gut of sea cage reared salmon GI tract [24]. High abundances of taxa such as Aliivibrio are suspected to be more predominant in fish expressing casts and faeces with a watery composition [13, 22], though the connection to dysbiosis [26] is yet to be shown conclusively. Aliivibrio are of particular interest due to their potential to cause disease [27, 28] but also as beneficial bacteria [29, 30]. Significant knowledge of host interactions obtained for the model species Aliivibrio fischeri provides a foundation for functional comparison of different Aliivibrio species. Photobacterium and Vibrio are also of interest for similar reasons, due to the abundance of these genera in maricultured salmon and known pathogenic traits amongst some strains. Little is yet known about salmon-associated Vibrionaceae , however due to their predominance in farmed salmon and the anecdotal links with fish health there is a need to understand the underlying biology with farmed salmon, particularly in warmer regions. This includes understanding capabilities related to persistent colonisation, growth in vivo and response to sea surface temperature. In this study we examined the colonisation of Atlantic salmon reared in marine pens, located in the D’Entrecasteaux Channel region of Tasmania, utilising data collected between 2010 to 2018 (Table 1). To enhance this we isolated strains from salmon digesta samples and sequenced their genomes. This data was used to track 16S rRNA gene amplicon operational taxonomic units (OTUs) and to also assess differential abundance throughout the gut of marine farmed Atlantic salmon in winter and in summer using data from the feeding study of Reid et al. [16]. To assess the effect of water temperature the hind gut distributions of Vibrionaceae were determined in Atlantic salmon reared in seawater tanks. The tank water temperature was raised into a temperature range that eventually induced reduced voluntary feeding to determine which species predominated during thermal stress. We finally examined the genome biology of representative strains of abundant species to link the gut ecology with traits linked to host colonisation and also discover any traits that have potential links to dysbiosis or disease. Results Aliivibrio and other Vibrionaceae predominate annually in sea cage Atlantic salmon Gut microbiome taxonomic profiles (supplementary datafile 1) of Atlantic salmon surveyed from different farms between 2010-2018 in D’Entrecasteaux Channel region (supplementary data Fig. S1 shows locations) are shown in Figure 1. The profiles are arranged temporally from the point when smolt are placed in sea pens. On an individual fish level the presence of Vibrionaceae exhibits a high level of variability, however a clear pattern of increase can be visually observed (Figure 1). When abundances are normalised to CLR values instead, which helps deal with the influence of sampling depth, Vibrionaceae taxa have sigmoidal growth-like responses (Figure 2). From a low starting abundance at the point of smolt input in winter there is an increase in abundance in the spring to mid-summer period (September to December) after which point populations plateau. Aliivibrio CLR values, where Aliivibrio OTUs have been amalgamated, had the most definable sigmoidal response with average CLR values reaching a maximal level in the late summer or early autumn, about 6 to 9 months after smolt transfer (Figure 2). The findings are supported by bacterial TVC data, measured between smolt transfer and the first summer period for some of the survey years. TVC was determined on marine agar as a non-specific medium given the digesta content is saline (~20-25 psu) and also utilised TCBS as a selective medium for members of family Vibrionaceae. The TVC data indicates that measurable populations reach a maximum level (8 to 9 log CFU/g sample wet weight) within 7 months after smolt transfer (Figure 2). The similarity observed between marine and TCBS count data indicates most of the TVC data come from bile salts-tolerant marine bacteria, expected to mostly belong to family Vibrionaceae . For the 2018 survey period 40 feed pellet samples were analysed for microbiota profiles since it was expected that the feeds contain substantial levels of bacterial DNA from the ingredients [19], which in turn originate from both plant and animal sources. The feed profile is shown in summary in Figure 1 and in detail in Supplementary datafile 1. Salmon-associated Aliivibrio and Mycoplasma OTUs were either absent or present at only low levels (<0.03% of total reads) in the feed samples investigated. The levels of Vibrio and Photobacterium in the feed were comparatively higher (0.17% and 0.70% of reads, respectively ) and 16 out of 62 OTUs of these genera could be found that occur in both digesta and feed (supplementary datafile 1) but not in laboratory blank and extraction kit elution buffer control samples. The detections of the same OTUs in digesta and feed samples possibly arises from cross contamination within the farms but it seems more logical that many if not most OTUs arise from trace DNA from feed ingredients, especially for OTUs occurring at relatively high proportions, such as Lactobacillales OTUs, which represented 46% of total reads in the feed samples. The results confirm Aliivibrio and some other Vibrionaceae are predominant microbiota in Atlantic salmon gut samples year-on-year and exhibit a growth-like increase in population through the summer into the autumn. Feeds do not seem to be a significant source of Aliivibrio or Mycoplasma but could be a source for some other Vibrionaceae. Taxa found in feeds, water and which may be fish colonists To further understand the associative patterns of the microbial community, co-occurrence network analysis was utilised. The network was visualised using Gephi [31]. Specifically this was done to observe if any taxa have an association with feed-only OTUs or to seawater derived OTUs than with the Atlantic salmon GI tract digesta and mucosa. Feed only OTUs consist of 16S rRNA genes from chloroplasts and mitochondria of the feed plant sourced ingredients, i.e. wheat, lupins, Pisum sativa meals while seawater OTUs include oligotrophic bacteria adapted to growth under low nutrient conditions or are obligately phototrophic, for example taxa of orders “Candidatus Pelagibacterales” and Synechococcales. The results (Figure 3) show that the occurrence of Aliivibrio , Photobacterium , Vibrio and also Mycoplasma did not correlate or were only weakly negatively correlated ( r < 0.20) with most other taxa detected. By comparison, the majority of the microbiota were positively correlated with each other and with feed chloroplast and mitochondria derived sequences. This relationship was strongest ( r 0.61-0.80) for anaerobic taxa including Lactobacillales, Bacteroidales, Clostridiales, and Fusobacteriales. Furthermore, seawater oligotrophic and phototrophic taxa were most positively correlated with each other but also were associated positively with chloroplast and mitochondrial-derived sequences and the other linked feed associated taxa. Since the samples had high water content, especially in summer [16], this could be a reason why seawater specialists are readily detected and show broadly similar distribution patterns to each other. The results also indicated that feed and water seem to contribute to a large proportion of the bacterial diversity. Based on the network analysis taxa that are not associated with seawater or feeds, including Aliivibrio , Vibrio , Photobacterium and Mycoplasma , represent only a small portion of the total diversity. Genome sequencing of Vibrionaceae species of the Atlantic salmon gut reveals novel diversity. Short read amplicon sequencing has limits in resolving taxonomic details in microbial assemblages. We attempted to overcome this by isolating and sequencing the genomes of bacteria from Atlantic salmon digesta samples. Doing this has the advantage of confirming isolate distributions in comparison to the sequence data since it allows determination of all 16S rRNA gene variants on genomes, which was investigated in the next experimental section. The isolates obtained included five genetic groups of Aliivibrio designated A2, A9, A32, S2MY1 and S4TY1 strain groups. The relationship of these strains to relatives was determined using OrthoANI [32] (Figure 4) and by use of GGDC 3.0 model 2 [33], which simulates DNA:DNA hybridization in silico (Figure S2). Groups A2, A9 and A32 may represent groups within a single species and are most closely related to the A. finisterrensis type strain (LMG 23689 T ) which was isolated from the manila clam ( Lajonkairia lajonkairii , also called Ruditapes phillipinarum ). Though there is a possible common species relationship of the salmon strains with A. finisterrensis with genome-level comparisons are at the species boundary (ANI 95%, in silico DNA:DNA hybridization 58-65%). The S4TY1 group is further separated from A. finisterrensis (94% ANI, 55% DNA:DNA hybridization), while S2MY1 is a definitely a distinct species with ANI at 80-87% with other Aliivibrio species. Of the salmon Photobacterium strains, these were found to belong to Photobacterium piscicola , P. toruni and an apparently novel species represented by strain S4TG1. Strain S4TG1 had ANI at 92% and 87% to P. piscicola and P. toruni type strains, respectively. Vibrio isolates obtained were all closely related to V. scophthalmi . Aliivibrio coloniser species can be tracked using their 16S rRNA gene variants from genome data. Two of three distinct 16S rRNA gene variants that occur amongst salmon Aliivibrio occur in the V1-V3 region. These two variants have a nucleotide similarity of only 96% and thus resolve as distinct OTUs in the analysis. The second variant (V1-V3 region – 506 bp length) has a distinct 15 bp insert at position 200/201 ( E. coli numbering). This is shown contrasted to variant 1 (V1-V3 region – 491 bp length) in Supplementary Figure S3. The third distinct variant is located in the hypervariable palindrome of the V9 region. OTUs of Aliivibrio from salmon samples along with genome derived V1-V3 regions were clustered into a phylogenetic tree. The ability to resolve OTUs was determined based on the relation with type strain sequences or representative sequences for placeholder names [34] (Figure 5). Both 16S rRNA sequence variants were found to occur in all of the Aliivibrio salmon isolates after inspection of raw genome sequence data. Based on this analysis the second variant represents 1 copy within the full set of 10-12 copies present in one of the strain’s two chromosomes. Proportionally, the second variant read detection was less than expected. Its occurrence versus the common variant theoretically should be a ratio of approximately 1:10-12. Read data, however indicated it was 20-60 (average 44)-fold less abundant than the more common variant. This disparity between the expected ratio could be potentially due to biases in the forward/reverse read joining process or the sequence clustering process. The V1-V3 region Aliivibrio variants were used for tracking Aliivibrio OTUs in digesta and other samples so they could be linked to the isolates. The same approach was performed for available Photobacterium and Vibrio colonisers that had genomic data available (data not shown). Examining the survey data and comparing reads to the 16S rRNA gene sequences of isolates we determined all of the Aliivibrio diversity and a portion of the Photobacterium diversity could be accounted for amongst the main colonising taxa, however based on the data, several genetic groups of Photobacterium likely remain to be isolated since we could not link isolate genome-derived 16S rRNA genes sequence variants to several Photobacterium OTUs. Data for Vibrio colonisers remains virtually incomplete being hampered by lacking isolate genomes as a reference point. By tracking OTUs we could determine the main species compositions of Aliivibrio in Atlantic salmon farmed in south east Tasmania in significantly more detail (Figure 5), though there are notable limitations. In this respect, groups A2, A9 and A32 along with A. finisterrensis LMG 23689 (the type strain) cannot be separated, however S2MY1, S4TY1 and A. fischeri formed distinct clusters. A. fischeri occurred at low abundance in the samples, but OTUs were retrieved for strains in both of the A. fischeri clusters evident from the 16S rRNA gene data (Figure 5). The remaining Aliivibrio species and species placeholders cluster into a single large clade that includes lower abundance taxa also detected in the salmon surveys (Figure 5). Due to the lack of resolution reliable identification of these latter species is not possible with the data available. Distribution of bacteria in GI tract of post-smolt to adult Atlantic salmon farmed in Tasmania. Raw sequence data was utilised from the study of Reid et al. [16], previously focused on the effect of feeding and relation of digesta consistency on Atlantic salmon gut community profiles. The data was here used to assess the specific distributions of microbiota through the Atlantic salmon GI tract, comparing paired fore-, mid- and hindgut (also referred to as the distal gut) mucosa and digesta samples collected in summer and winter. The results are shown in a heat map (Figure 6) that is based on the average of CLR differences (DCLR) between 27 pairs of samples. In essence, the DCLR calculation was used to compare the abundances of OTUs in either the mid-gut or hind-gut samples to the fore-gut samples from the same source fish rather than comparing samples as groups. By requiring non-parametric effect size ( r >0.5) and DCLR (>0.4 or <-0.3) to be large avoided false positives emerging form the paired data being slightly asymmetrical. Taxa shown in the heat map had DCLR that passed this criteria and had significant W-values (p<0.05, FDR) for at least one of the dataset comparisons. Furthermore, the OTUs that fulfilled significance were present in at least 20-25% of total samples. Based on the results the contrast between summer and winter samples was distinctive based on hierarchical clustering, which used uncentered correlations, of the overall dataset comparisons. In addition clustering indicated 4 groups of OTUs were formed. The first group included both 16S rRNA gene variants of Aliivibrio finisterrensis and S2MY1 strains, Aliivibrio S4TY1 group, “Cand. Mycoplasma salmoninae”, and a Vibrio OTU related to V. scophthalmi . These species are likely colonist species since they show positive DCLR for mid- and hind-gut mucosa samples and we can show these OTUs occur at high abundance (Figures 1 and 2, Supplementary data file 1). The data points to these species being active in attachment and growth within the salmon gut. A second group of OTUs, the most abundant being of the genera Pelomonas and Cutibacterium , show positive DCLR values for digesta samples collected during winter and to a lesser extent summer. In addition, seawater taxa show a similar response but increases in the midgut and hindgut are restricted to the summer. All of these taxa show reduced or unchanged DCLR for mucosa. This suggests these taxa potentially grow in the digesta or the difference relates to the water content of the digesta [16], especially in the case of the seawater taxa. The final group showed reduced DCLR values for both digesta and mucosa and mainly included Lactobacillales, Clostridia, Tissierellia, Bacteroidales, Enterobacteriaceae and Fusobacteriales. Based on the network analysis the correlations between these taxa and feed-derived plant chloroplasts is particularly strong (correlations of 0.6-0.8), thus the bacterial DNA almost certainly derives from the feed. The observations again suggest relatively few taxa actively colonise the mucosal layer in Atlantic salmon. Secondly, what we think as feed derived taxa exhibit a dilution trend when progressing through the GI tract, a response previously predicted for bacterial DNA sourced from feed [19]. It is likely many taxa grow or persist within the digesta that remain viable but no data is available to enable estimates of what these species are and what viable numbers actually occur. Only the most abundant taxa can be observed to have a recognisable growth trend i.e. higher abundances in the hind gut relative to the fore gut and this appears most clear in winter samples when gut residence times are longer [35]. Warm water temperatures promote colonisation of Vibrionaceae . Tank trials were performed in three successive years (trial 1, 2 and 3) to determine whether exposure to elevated temperatures affects Atlantic salmon GI tract microbiota in a predictable manner. More than 90% of digesta samples from 1.5 kg salmon kept at 15°C had faecal consistency scores between 1 to 3 (solid to watery consistency, no faecal casts) in the scheme described by Zarkasi et al. [24]. The microbial composition of these initial samples (15°C) show that most specimens possess Vibrionaceae and a high feed DNA background as indicated by the relatively high abundance of feed chloroplast-derived 16S rRNA genes (median CLR 1.2 to 1.8, Figure 7). Vibrio was much more predominant in trials 1 and 2 (median CLR 0.3 to 1.0) at the initial stage than Aliivibrio or Photobacterium (CLR <-1.0) (Figure 7). Most digesta samples (65-87%)at the end of the elevated temperature (19°C) phase contained faecal casts with consistency scores being mostly 3, 3.5 (faecal casts plus digesta) or 4 (only faecal casts; [24]). The feed derived background remained relatively stable or declined slightly, based on the chloroplast-derived CLR values (median 0.5 to 1.1). This is also suggested by the CLR values for taxa positively correlated in the sea cage community co-occurrence network (Fig. 2). It is assumed that not all detected reads of these groups purely arise from the feed but could be also received from the tank environment, which was not assessed. The microbial compositions after the warm water phase differed each time and Vibrionaceae populations were less diverse compared to those observed in fish from sea pens. In trials 1 and 2 Vibrio increased in predominance (median CLRs 2.4, 3.1). In trial 2 Aliivibrio exhibited a distinct abundance increase (median CLR <-2.0 to -0.6), while in trial 3 Aliivibrio was the only predominant taxon (median CLR 2.9). The warm water phase was followed by a 4 week “recovery” phase at 15°C. In samples collected after this phase the proportion of faecal cast samples was between 40-60% for the three trials. Vibrionaceae CLR abundance levels did not increase further, except for Aliivibrio in trial 2 with median CLR -0.6 becoming 1.7, equivalent to 1% of reads increasing to up to 30% of reads. Species-level analysis (as explained above) was also conducted and two OTUs most similar to Vibrio scophthlami made up virtually all Vibrionaceae reads in trial1 1 (99.8% of Vibrionaceae reads; 69.6% of total reads), while the A. finisterrensis group (including A2, A9 and A32 groups) made up almost all reads in trial 3 (99.2% of Vibrionaceae reads; 84.1% of total reads). In trial 2 most Aliivibrio reads were closely related to Aliivibrio sifiae or other species in its clade (12.8% of total reads) (Figure 5) or belonged to V. scophthalmi or a close relative (76.3% of total reads). Aliivibrio attributes that enable colonisation of the Atlantic salmon gut. Overall, Aliivibrio represented about half of the sequence reads obtained from Atlantic salmon isolates when all the farm cage survey data was combined. Aliivibrio has also been observed in many other surveys of Atlantic salmon, as well as Chinook salmon ( Oncorhynchus tshawytscha ) [23], as summarised in Supplementary Data Table S1, though the species identification is absent due to the16S rRNA primers being utilised having low resolution. These data prompted an analysis on basic growth and phenotypic properties (Table 2) of the Atlantic salmon strains as well as colonisation traits based on genome annotations. The salmon isolates have several features in common: Gram-negative cell wall; mesophilic growth range (8 to 30°C) with an optimum at 20-25°C; halophilic, optimal growth is with 2-3% NaCl or sea salts; bile salt tolerance (tolerates 1-3% ox bile salts); chitinolytic; and facultatively anaerobic being able to ferment D-glucose. The strains are likely able to respire anaerobically using various alternative electron acceptors based on genome data, including at least nitrate, trimethylamine N-oxide, and fumarate. The strains are able to form biofilms on glass or polystyrene to different degrees, with only the S4TY1 and A2 group strains able to form significant biofilm on polystyrene within 2-3 d (Table 2), and most of the strains are non-bioluminescent except for two strains of the A32 group. One of the key results is that the specific growth rate is relatively slow below 10°C (≤0.6 d -1 , Fig. 2). This suggests that in vivo Aliivibrio in spring and summer when water temperatures are on average 15°C growth rates exceed 1.0 d -1 while in winter water temperatures (~10-11°C in south east Tasmania) and salmon core body temperature are still well within the biokinetic growth range. The tank experimental results suggest that warm water condition result in relatively rapid colonisation albeit this reflects a situation where fewer species become dominant. Genome annotation data provides indications of colonisation mechanisms. In regard to assessment of traits that enable colonisation if the Atlantic salmon gut the focus was placed only on Aliivibrio as well as Vibrio scophthalmi (Table 3) since these taxa show strong colonisation capabilities based on the tank experiments. Most if not all Aliivibrio possess an array of traits that are likely the basis for adherence and virulence in animal hosts and thus the analysis here relies heavily on what has been previously shown for A. fischeri [36-38], A. salmonicida [27] and various Vibrio spp., in particular V. cholerae [39]. A near universal trait for Vibrionaceae is motility, which is needed for initial adherence in the gut as well as spreading throughout [40] [Homma et al. 2022 ]. The salmon associated bacterial strains examined were all motile and based on the genome data this only is driven by polar flagella. Homologs of flagellin genes forming lateral flagella (Laf proteins), which could aid spread in viscous fluids, in or on the host [40] were not found in any Aliivibrio genome. Vibrionaceae also produce pili and a range of other specific proteins to enable stable adherence to host gut cells and mucosa. Lytic chitin monooxygenase proteins LPM010A and LPM010B [27, 41], chitin-regulated pili [42], an MSHA-type pili [43], were found in all Aliivibrio strains and seem to be mechanistic elements for adherence and establishing populations in fish and squid host GI tracts (Table 3). Most salmon isolates also possess genes for curli fibre synthesis ( csg operon) [44] while 1 or 2 alleles for the tight adherence pili (Tad operon) [45] were present in specific strain groups (A32, S4TY1 groups). Toxin co-regulated pilus genes ( tcp operon) [46] were only found in a minority of A. fischeri strains. Potentially other proteins could be involved as well for adherence as found for V. cholerae and that are broadly conserved in Vibrionaceae e.g., IlpA/MetQ, OmpU, MAM7/PqiB [47-50]. A homolog of outer membrane accessory colonization factor gene afcA, which influences spreading in the host [51, 52], is universally present. Homologs of the other accessory colonization genes ( afcB , afcC , afcD ), putatively linked to mucin chemotaxis and degradation [53] are not evident in most Aliivibrio strains, but occur as diverged (35-40% identity) homologs. Most of the salmon isolates possess a number of putative mucinases, including YghJ/SslE/AfcD [54, 55] and/or StcE/TagA [56] family lipoprotein metallopeptidases. Adding to a probable capability of colonising and degrading mucin and other proteins making up the gut epithelial layer are putative chondroitinase -like enzymes (polysaccharide lyase family 8). These glycosaminoglycan degradative enzymes are co-located with genes coding enzymes for D-glucuronate, N-acetyl-D-glucosamine and N-acetyl-D-galactosamine degradation in several Aliivibrio species. Chondroitinase activity ( eroS gene) by A. fischeri has been shown to induce sexual reproduction in a choanaflagellate [56, 57], but the role in colonisation is unclear. The eroS gene and associated metabolic pathway genes are strain group specific being absent in most of the salmon isolates, except the A2 group. The potential ability to utilize N-acetylneuraminate and other carbohydrates liberated from mucins (N-acetyl-D-glucosamine, D-galactose, L-fucose) is also present in many Aliivibrio species (e.g. the nanA operon [58]). Amongst the salmon isolates the nanA operon is found in the A2 group strains. All genomes surveyed have a katA homolog shown to be needed by A. fischeri for dealing with host-driven peroxide defences [59]. Inferred biofilm formation mechanisms of salmon Aliivibrio include conserved and species-dependent features. Biofilm formation and compatibility with the host is likely key for bacteria to establish stable populations in fish. Bacteria not native to the host, such as commercial probiotic strains, may only colonise transiently and less efficiently due to inability to form a stable biofilm [60]. As mentioned above model species, especially A. fischeri was used as an exemplar based on research on biofilm formation in squid hosts [61]. From this the salmon strains have genes that code proteins required for biofilm establishment, build-up and dispersal as found in A. fischeri for colonisation of squid hosts [62]. Fundamentally the mechanisms enables population to expand in vivo since the colonising bacteria needs to spread spatially on mucosal surfaces. As found in A. fischeri and Aliivibrio in general, the salmon isolates have a type I secretion system (T1SS) which delivers the adhesin LapV and proteins of the Lap adhesin delivery system (operon lapBCEDG [62]). In addition the salmon isolates also possess a conserved T2SS for exopolysaccharide (EPS) delivery. EPS in the salmon isolates like that of A. fischeri includes the syp polysaccharide, coded by the syp gene cluster which includes defined regulators (e.g. vspR ) [63]. Similarly, conserved regulators are present for biofilm matrix formation, such as the quorum sensing/competence repressor HapR/LitR [64,65]. These genes are prevalent in most Aliivibrio species and homologs also occur in V. scophthalmi suggesting a degree of conservation of the fundamental biofilm formation mechanism. The gene locus of the syp polysaccharide was found to be syntenic in the salmon strains as well as most other Aliivibrio species (data not shown). Beyond conserved traits, several genes were noted to be specific to species or sub-species strain groups (Table 3). These traits likely contribute to colonization in several ways. These could determine host specificity, an area that remains largely unresearched. For example, cellulose synthesis genes ( bsc operon, [66]) are present in genomes of 75% of Aliivibrio genetic groups while homologs for the VPS polysaccharide locus of V. cholerae [67] were found only in the genomes of salmon colonising Aliivibrio . The VPS polysaccharide contributes to a viscous polysaccharide that enables V. cholerae and other Vibrio spp. colonisation of a range of ecosystems and hosts [61]. Some genes in this locus are different in the salmon isolates compared to V. cholerae and the synteny is not fully preserved suggesting the polysaccharide formed conceivably could have different chemical properties. Furthermore, the same strains possess adjacent genes that may regulate colony rugosity and biofilm thickness and structure as found for V. cholerae ( rbmABD , rbmC/bap1 ) [68]. Many of the indicated systems are regulated by quorum sensing systems controlled by synthesis of different acylated homoserine lactones (AHLs) and autoinducer-2 (LuxS system) [69]. The salmon strains, all possess LuxS and possess genes for two AinS, LasI or LuxI family AHL synthetases [70] (Table 3). This suggests the salmon isolates (and most other Aliivibrio ) likely can form an array of quorum sensing-related chemical messengers. Most salmon associated Aliivibrio species completely lack virulence genes but some possess cytolethal distending toxin genes. Virulence gene distribution was of considerable interest, in particular to discover genes that might be linked to faecal cast production. The survey conducted examined genes flagged generically as virulence factors but also cross-referenced this with proteins known to directly cause cytotoxicity of some form. This includes T6SS systems that have been suggested to sometimes be involved in host virulence as well as interbacterial competition [71]. In this respect, all of the salmon strains possess a T6SS system, except the S2MY1 group, and also possess multiple associated effectors (i.e., hcp , vgrG ) [72, 73]. Strains A9 and A21 possess both hcp and S-type pyocin-like [74] homologs on a contig that is likely a large plasmid. T6SS is prevalent amongst most other Aliivibrio species. It is so far unknown if T6SS has any effect on hosts directly, however the T6SS in A. fischeri is used to effectively to become predominant in squid hosts [75]. By comparison toxin genes are sporadically distributed across Aliivibrio . For example, a minority of A. fischeri strains possess genes for CNF-1, Tdh, Ace, VCC/VvhA-like leucocidin and/or Zot/Zot-like proteins found in various pathogenic Vibrio [52]. Surprisingly, cdtABC genes coding the subunits for CTD [76] occur in one S2MY1 group strain (S2MY1, but not S3MY1) and all six of the S4TY1 group strains. The gene nucleotide and the amino acid sequences for the three Cdt subunits were surprisingly found to be identical between the isolates but are more distantly related to homologs from E. coli and Salmonella (~50-55% amino acid homology) and are also distinct from homologs found to occur in a single V. cholerae isolate 633012 (supplementary data Fig. S5). The genes occur in a region of chromosome II where extensive transposase/integrase gene decay has occurred. The most populous salmon groups (A2, A9 and A32) completely lack any known genes linked to a known cytotoxic function. Discussion DNA present in feeds, which can confound analysis of fish gut microbiomes, was specifically studied by Karlsen and colleagues [19]. We observed a predominance of Lactobacillales classified reads in feeds, which could derive from feed ingredients but also might be due to deliberate probiotic addition that aids growth of juvenile salmon in hatcheries [77, 78]. The decline in abundance of bacteria that occurs from the fore-gut to the hind-gut as shown with the DCLR data (Figure 6) could be due to Vibrionaceae, Mycoplasma and other bacterial populations increasing across the same sections. We cannot exclude the possibility many bacteria could be transiently colonising and growing to lesser extent in the digesta as well as in the mucosa. A group of bacteria were found to show increased abundance in the digesta in the hind-gut relative to the fore gut digesta during winter while seawater specialist taxa do the same in summer. There is a distinct possibility the abundance increase could be due to water concentration effects. Since intestinal residence time is longer at lower temperatures [35] there is more time for water absorption within the gut especially in the foregut area (pyloric caeca). The “drinking” rate is increased in salmon adapted to seawater and during active feeding and is used for the purposes of osmoregulation [79] maintaining a level of salinity in the gut lumen. This occurrence has been suggested a reason that presumably seawater dwelling Vibrionaceae are able to colonise the gut [80]. In addition, this process affects digesta water content with summer fish having more water content in their digesta than those examined during the winter [16] potentially due to the residence time difference [35]. The seawater specialists observed are common in Tasmanian waters during summer but less common in winter when ammonia-oxidizing and rhodopsin-containing heterotrophic archaea are more predominant [81]. Since most sea-going wild salmon and those that have returned to rivers also possess considerable levels of Vibrionaceae (Supplementary data Table S1, [82]), colonisation by Vibrionaceae is clearly a natural process and certainly not a peculiarity of aquaculture systems. An interesting observation made here is that Aliivibrio , Mycoplasma and probably also Vibrio scophthalmi -related strains are the only taxa able to colonise the mucosa, at least for the data utilised here. This specificity likely requires a chemotactic element not simply a random process of water transfer. Also interesting is the fact that few if any of the taxa that show an increase in the hindgut digesta during winter (“digesta associated” in Figure 6) are marine specialists or even halophilic. Of the 14 taxa of this set shown in Figure 6 only Pseudoalteromonas is mostly found only in marine environments and requires salt for growth. The other taxa are not specifically associated with marine ecosystems and might be considered ubiquitous. The most abundant of these taxa were OTUs closely related to the species Cutibacterium acnes and Pelomonas saccharophila . The first species is a major member of the skin microbiome and found associated with a range of fish species, potentially as a pathogen [83] while P. saccharophila and its relatives are common in the gut of fish and other vertebrates from freshwater to brackish ecosystems (e.g. 23, 84]. More research is needed to determine where the “digesta-associated” bacteria actually come from. The taxa are likely able to survive in smolt that have undergone smoltification as well as marine transfer due to being able to grow at the environmental temperatures (10-20°C), halotolerant and able to tolerate basic host defences, such as bile secretions. The digesta associated taxa do not seem to derive from the feed but do show an association with feed, possibly because they are largely restricted to the digesta. In regards, to mucosal colonising taxa this study indicates there are other important deciding factors, one of the clearest being that the taxa involved have traits that allow them to actively colonise and thrive in the salmon GI tract, not merely persist. The data presented here also suggests that faunal GI tracts are their preferred habitat. The species that colonise are not random in nature and can be defined and studied. A large proportion of abundant Lactobacillales OTUs originated in the feed, as did many other typically gut-associated anaerobic taxa. Most if not all of these probably arise from trace DNA in the feed ingredients due to the dilution trend they demonstrate between gut sections. Trace bacterial DNA levels in feeds is very poorly researched and most analysis veers towards the presence of harmful bacteria [85]. Because feeds are sourced from raw ingredients from many supply chains, especially with the push towards improved industry sustainability it would be expected that the bacterial DNA present will vary considerably and also lead to a high level of background diversity. Of the >3500 OTUs detected in the samples [16] as much as 90% could be just from diet DNA with the vast majority only occurring at very low abundances. As feed is extruded and steam cooked (~120°C, 20 min) when made into pellets most feed bacterial DNA is likely from remnant cells though various thermoduric spore-formers may remain viable, e.g. Geobacillus , Ureibacillus [22]. DNA could also be contributed to bacteria covering the surface of feed when it is stored, though the low water activity would be restrictive to growth. Our focus on the V1-V3 region of 16S rRNA genes supported by addition of gene variants from isolate genome sequences helped to improve pinpointing colonising taxa and defining their diversity. This approach was successful for Aliivibrio but much more work is needed to examine other possible colonists , besides Mycoplasma [25]. Full length 16S rRNA gene sequences is required for such analysis, in particular for A. sifiae , A.logei , A. salmonicida and related species with placeholder designations [34]. Taxonomically unresolved Aliivibrio spp., along with A. fischeri , were readily detected in most salmon samples of this study. Thus the data suggests Aliivibrio as a whole is adapted to be able to colonise Atlantic salmon and presumably other fish. The array of taxa found in this study could be peculiar to Tasmanian waters, different species likely are important colonists in salmon in other regions of the world. As the data analysed here included summer and winter sampling and there was also concern of longer term implications of ocean warming since temperature seems a key factor when considering fish host colonisation. In colder waters, typical for northern hemisphere salmon farming regions, the species of Vibrionaceae detected will most likely differ from those observed here. Based on summer and winter data the salmon Vibrionaceae taxa observed in this study seem to prefer comparatively warmer conditions, but persist in the Tasmanian winter, which is relatively warm (10 – 12°C) compared to sub-Arctic salmon farming regions. This is suggested by the slow build-up of populations and the peak level of biomass being mostly maintained after the first summer (as shown in Fig. 2, and also discussed in [20]). Some Aliivibrio and Photobacterium taxa seem to have higher relative abundances in winter than summer (Fig. S4). By comparison most if not all Vibrio spp. preferred summer conditions (Fig S4) based on the abundance trends. The neutral response between summer and winter by the abundant Aliivibrio colonisers is possibly due to these taxa being well-established in the gut mucosal layer. The persistence in the gut may also be aided by external temperatures still being growth permissive even though growth rates are relatively slow. In salmon production areas, such as Norway, taxa adapted to the lower temperatures (psychrotolerant or psychrophilic species) of sub-polar waters could be more predominant. We hypothesise that which species end up being most common is also driven by the ability to successfully compete, for example using T6SS systems. T6SS and associated effector proteins (Hcp, VgrG, MIX family) were found in most Aliivibrio genomes (Table 3) and are suspected to shape the intestinal microbiomes of fish [85]. Aliivibrio seems widespread in wild and marine farmed salmonids due to being a good competitor. For example, in chinook salmon grown in marine farms in New Zealand, which has similar water temperatures as Tasmania, Aliivibrio was abundant in stripped faecal samples [23]. However, Photobacterium piscicola was also highly abundant and even present in fish reared in alpine canals and in hatcheries [23], suggesting a combination of colonising bacterial and host features could be influential in what species occur. We have hypothesised previously Aliivibrio colonisers are a possible cause of the production of faecal casts in fish sampled during summer [16]. Faecal cast production in finfish has been attributed to disease or stress [86-90]. The expected higher growth rates and biomass of Aliivibrio and Vibrio spp. in summer may increase the risk of dysbiosis or disease, but this relies on the species having some capacity to affect the host negatively. At this point in time the causal relationships remain completely unclear. The tank trials were intended to create a situation in which fish were thermally stressed and it was found that the thermally stressed experimental fish had high faecal cast production, at least equal or higher than what was found for sea pen fish in summer [16, 24]. The experiments could demonstrate certain Vibrionaceae respond strongly to warm water conditions alongside the high incidence in faecal cast production. However, different species predominated in each of the three trials performed. Thus at this stage no conclusion can be made so far on whether Vibrionaceae are specifically responsible for inducing faecal cast production or it is instead a more general response. A cell biology-based approach is needed to unravel these phenomena. A survey of the genomes of the salmon isolates and other Aliivibrio species provides an indication of the range of possible colonisation-relevant mechanisms and traits that these bacteria possess. However, the data does not provide a “smoking gun” for dysbiosis or other forms of deleterious host interactions as we simply know too little at this stage. The results indicated Aliivibrio possess various colonisation-relevant genes as a whole but there are also group or species specific genes. This suggests that coloniser genetic groups seem to have particular features that could result in colonisation specificity and preferences. Many features are also shared with Vibrio scophthalmi , a very successful coloniser of fish that is sometimes an opportunistic pathogen [91]. The differences that could be highlighted may affect adherence, mucin/mucosal interactions, signal transduction, and biofilm structure within different hosts thus determining specificity, success rate and persistence. The mechanisms of colonisation are presently obscure but the data is suggestive of some proteins that could be further researched in this respect. For example, putative mucinases were detected in the salmon colonisers. The Vibrio cholerae HapA mucinase facilitates penetration and detachment into the mucosal layer and also may release substrate sugars and amino acids [92]. Few of the Atlantic salmon isolates seem to be able to degrade neuraminate, a major glycocomponent of intestinal mucins of Atlantic salmon [93]. Mucinase activity by coloniser strains could instead mainly allow persistence in the mucosal layer [92]. However, the coloniser community combined mucinase secretion activity could liberate a range of glycopeptides, amino acids, and sugar residues that can be used as nutrients by the microbiome as a whole. In this respect all coloniser strains could grow on chitin and possessed chitinolytic enzymes (e.g., LPMO10A, LPMO10B, Table 3) shown to be important in mucosal layer adherence and required for virulence in some strains [27, 41]. Gut mucins of Atlantic salmon typically contain N-acetyl-D-glucosamine [94] and it seems some chitinases are able to remove these residues from mucin [27]. Salmon mucin is also rich in galactose residues and from the genome data most of the salmon isolates were found to possess the Leloir galactose metabolism pathway based on the PANNZER-based annotations. Interestingly, salmon isolate groups could synthesise multiple types of polysaccharide that may be involved in colonisation (syp, VPS and cellulose, Table 3), but it is unknown how they co-contribute during colonisation. Aliivibrio genetic diversity may also impact other biological aspects of colonisation, such as quorum sensing regulation. The types of AHL synthetases differed between the coloniser genetic groups and can even differ within the same group, for example the A32 group strains have either LuxI or AinS family AHL synthetases. Aliivibrio strains are known to produce an array of chemical messengers [70] due to possessing multiple AHL synthetases (Table 3) and also the LuxS system. In terms of the gut ecosystem Aliivibrio strains may be able to respond to the signals from other strains allowing rapid responses in gene regulation simultaneously maximising fitness and competitiveness during both colonization [95]. Potentially linked to signal transduction are potentially pathogen-like functions where some colonists exploit host cells. Virulence gene occurrence amongst Aliivibrio species is sporadic and less conserved than other traits examined (Table 3). The occurrence of CDT-gene positive strains in some salmon isolates is intriguing, but raises many questions. Are the genes expressed in vivo ? Do they have a functional role that does not involve harming the host – for example aiding persistence in the salmon gut or are they merely unstable genes derived from recent horizontal gene transfer events? The distribution of CDT is presently unknown in marine bacteria but is likely extremely rare. The fact the genes are identical between two different Aliivibrio genetic groups suggests lateral gene transfer involved the same source and occurred in a similar time frame. The genomic region the cdtABC operon was found to be rich with pseudogenes, mainly remnant transposase genes. This suggests the transfer of genes could have been within a mobile element that is now decayed. Conclusions. Since specific Vibrionaceae occur in high abundance in the GI tracts of Atlantic salmon (farmed in Tasmania) they can be construed as being non-pathogenic to the fish. The farm surveys and controlled tank experiments done here revealed a restricted range of species, mostly novel, are robust colonisers of Atlantic salmon and could be a focus for future studies related to Atlantic salmon gut function and health. The most common Aliivibrio strain groups lacked any obvious virulence factors, which is good news but at the same time other relatively abundant species were found to have specific virulence genes. Understanding the significance of such genes in relation to Atlantic salmon health and productivity as well as the biology of gut colonisation is a logical next step. Combining temporal sampling with the genome biology of colonising isolates proved very useful in defining the dynamics of colonising bacteria and also defined traits that may be relevant to salmon health and welfare. The results, however, provide no clear leads for the cause of faecal casts in salmon. This is hampered by the fact many aspects of Atlantic salmon gut function relevant to microbiome interaction-influence require basic investigation. Nevertheless, the findings revealed interesting and complex traits amongst different Aliivibrio spp. genetic groups that likely contribute to their success in colonisation of salmon and presumably other marine fauna. Overall, the findings fundamentally help clarify approaches needed in order to study microbiomes of farmed fish, for example feed analysis alongside typical samples helped clarify the components of the microbiome possible source and significance to a degree. Analysis of surrounding water could also be useful in the same capacity Methods Sea pen sampling For sea pen derived fish, data in this study included several different surveys performed between 2010 and 2018. Four of these surveys have been previously published and where the purpose of the research was to understand the effect of diet, faecal consistency and short term sampling [16, 20, 24], while further data were obtained from another study which compared microbiome of salmon to farm-associated Australian fur seals ( Arctocephalus pusillus doriferus ) [96] (Table 1). In each studied cohort, smolt had been put to sea over winter (June to August). Samples were collected between 4 to 56 weeks after smolt transfer digesta samples were obtained by faecal stripping as previously described [16, 20, 24]. In the case of samples obtained from Reid et al. [16] fish were also euthanised and dissected to obtain both gut mucosa and digesta samples. Feed samples were collected from automatic feeders by transferring directly to sterile zip lock bags. All samples were kept frozen at -80 °C until processed. Animal ethics permits and data deposition accession codes are provided in Table 1. Temperature-based experiments Temperature-based experiments were run in three successive years (2016 to 2018) where Atlantic salmon were reared under elevated temperature conditions. Experiments were performed at the Experimental Aquaculture Facility of the University of Tasmania, Taroona, Hobart which is a multi-tank RAS system which utilises 1 mm filtered seawater from the Derwent Estuary at a daily 10% exchange rate Water quality is maintained using a combination of protein skimmers and a series of treatment steps including <40 mm drum filtration, ammonia removal via nitrification-based biofilters, and UV light irradiation. For this series of experiments operating conditions used were similar to that described by Foddai et al. [97]. Smolt, adapted to seawater in the hatchery were transferred to a 13000 l seawater tank and fed until they reached an average weight of ~1.5 kg. Fish were then evenly distributed between twelve 7000 l tanks in a common RAS system with a stocking density of 50-100 fish per tank and photoperiod set at 12:12 (light:dark hours). The tanks were maintained at 15°C for 25-28 d. Tank temperatures were then increased at 0.1°C per day over 7 weeks to reach on average 18.5-19.0°C and maintained at this temperature for at least 10 weeks or until fish ceased feeding. Tank temperatures were then reduced to 15-16°C for 2 to 4 weeks. Fish were stripped of faeces at the end of each phase, with samples collected into sterile 15 ml Falcon tubes. Tubes were snap frozen and then stored in liquid nitrogen until transported to the laboratory where they were transferred to -80°C storage. Fish were fed commercial diets continually throughout. DNA extraction of samples and sequencing. DNA was obtained from faecal and feed samples (0.25 g frozen weight) using QIAamp Fast DNA Stool Mini Kits (Cat. No. 51604, Qiagen) following the manufacturer’s protocol. Resultant DNA concentration and purity were estimated using a Nanodrop 888 instrument (ThermoFisher). Sequencing was performed at the Ramaciotti Centre for Genomics, University of NSW, Sydney, Australia using the Illumina MiSeq platform as previously described [16, 20, 24, 96]. 16S rRNA genes were amplified using V1/27F (5’-AGA GTT TGA TYM TGG CTC AG-3’; [98]) and V3/519R (5’-GWA TTA CCG CGG CKG CTG-3’ [99]) primers for all samples from this study as noted in Table S1. Sequence processing and classification The Illumina pipeline used automatically trimmed adaptors from the 3’ prime end of sequences. Paired end reads were joined in Seed 2 [100] using FastqJoin 1.1.2. The joined files were then quality filtered in SEED2 (using Mothur 1.34.4) without pre-clustering, yielding reads with mean median quality scores of ≥35 (range 35 to 39). This resulted in loss of on average 20% of joined reads. FASTA files of the filtered reads were generated and then processed by VSEARCH [101] to remove putative chimeric sequences and to create a list of reads clustered at 1% dissimilarity. The output cluster FASTA files from different surveys were then combined into a single FASTA file in SEED2 and the process of clustering and chimera removal was repeated to create a single non-redundant OTU dataset covering all the samples. The OTU list was then classified using megaBLAST v. 2.2.26+ against the Silva 138.1 non redundant 16S rRNA gene database [102] in SEED2. Further taxonomic detail was obtained by utilising 16S rRNA gene variants from genome sequence data obtained in this study, focusing on the V1-V3 region. The V1-V3 region of isolate genome-derived 16S rRNA genes (detected by BARRNAP, see below) after being clustered at a 1% resolution were added to the Silva 138.1 database prior to the final classification steps. The classified non-redundant salmon-derived reads were then converted to a custom database in SEED2 using makeBLSTdb v. 2.2.26+ and then used to classify reads in individual samples (again at 1% dissimilarity) resulting in an OTU table. Supplementary datafiles 1 and 2 includes the OTU tables, proportions and other information for each farm survey and the EAF tank trials for which the classification are collapsed to the genus level and grouped at the order level. A more granular dataset is available for members of family Vibrionaceae at the individual OTU level (Supplementary datafile 1). Co-occurrence network analysis The goal was to determine the structure of the overall salmon farm data and determine influence of feed and water DNA. In order to create a co-occurrence network the taxonomic data used to from nodes is described at the order level, except specifically for the genera Aliivibrio , Vibrio , Photobacterium and Mycoplasma due to these taxa making up relatively large proportion of the reads. Feed-derived plant chloroplasts and mitochondria 16S rRNA gene reads were pooled to form separate data nodes. By pooling specimens from individual fish from each collection time (as specified in Table 1) the variance and high sparsity in OTU profiles between individual fish was homogenized. Pearson product moment correlations were generated in SPSS v. 29 (IBM) between pooled data, all marine surveys but not the tank trial data for each taxonomic group Correlations were imported into Gephi 0.10.1 ( https://gephi.org/ ; [31]) to visualise the relations with size of nodes (n = 32) representing overall relative abundance across all reads and the thickness and colour of edges (n = 259) based on the strength (≥0.4) and nature of the correlations. Enumeration, isolation and 16S rRNA gene analysis of salmon gut bacteria Enumeration of bacteria from Atlantic salmon digest utilised marine agar (MA - 0.5% w/v Bacto-peptone, 0.2% w/v yeast extract, 3.5% w/v seawater salts, 1.5% w/v agar) and Thiosulfate Citrate Bile Sucrose agar (TCBS, Oxoid). Samples for total viable count (TVC) data is from unpublished data from surveys performed in 2010/2011, 2011/2012 and 2014/2015 (Table 1) since these covered a wide range of times and used exactly the same protocol as described here. This protocol involved fixed wet weight amounts of TVC faecal samples (typically 0.2 to 1.0 g) being suspended and serially diluted in 3% (w/v) sterile seawater salt solutions, spread onto the surface of MA and TCBS and then incubated at 25°C for up to 7 d. Counts were calculated as colony forming units (CFU) per g of faeces (wet weight). For various salmon samples (mainly obtained between 2015/2016 to 2017/2018) bacterial isolates were obtained onto TCBS or MA. For MA the medium used contained either no antibiotics or was supplemented with either 10 or 100 mg/ml of oxytetracyline, trimethoprim or tylosin (Sigma-Aldrich). Individual colonies were picked from MA and TCBS plates and purified on MA. Pure cultures were cryopreserved in marine broth that included 30% (v/v) glycerol at -80°C or at 4°C on thick MA plates wrapped in petrifilm. DNA was extracted from each strain using the Ultraclean Microbial DNA Extraction kit (Qiagen). 16S rRNA sequence gene analysis was based on 10 pmol/ml 27F and 1492R (GGT TAC CTT GTT ACG ACT T; [98]) primers using MyTaq PCR reagent (Bioline) and using 1 ml (20-50 ng) of template DNA. Thermocycler (Peltier PTC200, MJ Research) conditions used were 95°C 1 min (1 cycle); 95°C – 30 s, 50°C – 30 s, 72°C – 30 s (34 cycles); 72°C – 10 min (1 cycle); 10°C soak. PCR products were purified and then sequenced using BigDye chemistry using an AB3730xl sequencer instrument (Applied BioSytems). Sequence data were aligned and end regions trimmed to remove poorly resolved base calls. Along with reference sequences, phylogenetic trees were generated using the BioNJ algorithm in NGphylogeny.fr [103] and visualised with Interactive Tree of Life [104]. Growth analyses and biofilm formation ability The ability to grow at a range of temperatures and salinity levels was assessed using agar and broth cultures. For broth cultures isolates tested were diluted to 10 4 to 10 5 CFU/ml in liquid media arrayed into L-shaped 15 ml test tubes trays containing either marine broth for temperature assessment (2°C to 40°C) or marine broth in which sea salts were replaced by different concentrations of NaCl (0 to 10% NaCl). Bile salt tolerance was assessed similarly with marine broth supplemented with bile salts no. 3 (0 to 5%, Oxoid). Optical density readings were taken regularly using a Spectronic 200 (ThermoScientific). A custom-built aluminium block temperature gradient incubator (Terratec, Kingston, Tasmania) was used to assess biokinetic responses as previously described [105]. The ability of isolates to form biofilms were assessed using the crystal violet assay in 96 well polystyrene trays and on acid-washed glass surfaces as previously described [106, 107]. The motility of cultures (incubated in marine broth for 40 to 72 h at 20°C) was tested under phase contrast microscopy using wet mounts. Chitinolytic activity was assessed using 1% w/v colloidal chitin in MA poured as thin layer on a MA base. The appearance of clear zones around colonies was indicative of chitinolytic activity. Genome assembly and annotation Genome sequence data were obtained using either the Illumina HiSeq or the NovaSeq 6000 platforms in which 200 or 250 bp pair end sequences were generated. Fastq files were uploaded onto the Galaxy Australia cloud server and assemblies generated using Unicycler v. 0.050 and samtools v. 1.15.1 [108]. Genomes were then annotated using the PANNZER2 server [109]. Non-coding RNA genes were detected using BARRNAP v. 0.9 (To rsten Seemann, https://github.com/tseemann/barrnap) as implemented in Galaxy. Genome-based taxonomy Genomes were compared using ortho-ANI [32] and GGDC 3.0 model 2 [33] to discern putative species level groups assuming 95% and 70% demarcate approximate boundaries for species, respectively. Similarity values from both approaches were used to create dendrograms in Primer 7 (Primer-E, Auckland, New Zealand) using the complete linkage method. The 16S rRNA genes directly amplified from isolates and those annotated in genomes were compared including determination of variants from the genome data using BARRNAP v. 0.9. Estimates of copy number were obtained using RasperGade16S [110] in R Studio. The V1 to V3 regions of sequences from isolates and available genomes of other Aliivibrio species, as defined by Klementsen and colleagues [34], were collated and added to Silva 138.1 and the custom created 16S rRNA databases as described above. Compositional and differential abundance analysis For comparison of relative abundances bacteria taxa enriched in digesta and mucosal samples in different parts of the gastrointestinal tract of Atlantic salmon [16] and from the tank trials the read abundances of individual OTUs were transformed to centred log ratios (CLR) [111]. This allowed pairwise assessment of OTUs that are enriched either in gut section digesta or mucosa samples collected in summer and in winter. A major challenge for this analysis was the high number of zero values. To deal with this low abundance taxa were excluded and pseudocount of 1 was then applied as a conservative approach. Since the samples to be compared were paired, with each dataset comparison possessing 27 paired samples per OTU, the Wilcoxon signed rank test was used. Assessment of the data indicated that as the OTU occurrence declined asymmetry tended to increase since the pseudocount generated small negative numbers. The Mann Whitney U test was thus also performed to help eliminate false positives. Nevertheless, meaningful changes occurring in OTU abundances as indicated by the average of differences between paired CLR (DCLR) were large. False discovery rate (FDR) testing of the Wilcoxon (CLR) p-values, using the method of Benjamini and Hochberg [112], indicated OTUs with nominal significance (<p=0.05) was achieved with paired DCLR values of ≥0.4/≤-0.3, corresponding to large effect sizes ( r ≥ 0.5) [113]. DCLR values for abundant OTUs with FDR adjust p -values <0.05 were arrayed into a heat map in order to show broader patterns of abundance changes through gut sections. The overall paired dataset results and OTU DCLR values across the paired datasets was hierarchically clustered using complete linkage and assuming an un-centred correlation. Colonisation and virulence based features annotated from genome data Genes associated with host colonisation associated phenotypes, including adherence, biofilm formation, quorum sensing, interbacterial competition and host-directed virulence were surveyed in Aliivibrio as well as Vibrio scophthalmi genomes. This survey was based on mechanistic studies of gene and protein function performed to date in mostly A. fischeri and V. cholerae , coupled to data gleaned from the online databases KEGG [114] and VFDB [115]. The presence of target proteins for this survey was assessed using protein comparisons using BLAST-P in NCBI with confirmation sequences matched on the basis of similarity (>40%), length (>90%) and conserved domain structure. NCBI database contains 5 available assembled V. scophthalmi genome sequences which were used these analyses. Abbreviations AHL: acylated homoserine lactone ANI: average nucleotide identity BLAST: Basic Local Alignment Search Tool CFU: colony forming units CLR: centred log ratio DCLR: centred log ratio difference (between paired samples) CDT: cytolethal distending toxin GGDC: genome-to-genome distance calculator KEGG: Kyoto Encyclopedia of Genes and Genomes LPMO: lytic polysaccharide monooxygenase MA: marine agar MSHA: mannose-sensitive hemagglutinin (pili/fimbriae) OTU(s): operational taxonomic unit(s) PANZZER: Protein Annotation with z-Score RAS: recirculation aquaculture systems T1SS, T2SS, T6SS: type (I, II or VI) secretion system TCBS: thiosulfate citrate bile sucrose agar VFDB: Virulence Factor Database VPS: Vibrio polysaccharide (of V. cholerae ) Declarations Availability of data and materials The raw 16S rRNA gene sequence data and metadata files are deposited at the NCBI SRA database under the BioProject codes listed in Table 1. 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Benjamini Y, Hochberg Y. Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J Royal Stat Soc B 1995; 57:289-300. Fritz CO, Morris PE, Richler JJ. Effect size estimates: current use, calculations, and interpretation. J Exp Psychol Gen. 2012 Feb;141(1):2-18. doi: 10.1037/a0024338. Kanehisa M, Goto S. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 2000; 28:27–30. https://doi.org/10.1093/nar/28.1.27. Liu B, Zheng D, Zhou S, Chen L, Yang J. VFDB 2022: a general classification scheme for bacterial virulence factors. Nucleic Acids Res. 2022;50:D912-D917. https://doi.org/10.1093/nar/gkab1107. Tables Table 1. Experimental datasets utilized in the study including design, data sources and related information. Exper-iment-type Location of sampling 16S rRNA gene primers used Sequencing method Time period samples collected (timepoint number) Number of samples per time point Fish weigh range (kg) Reads per sample: average (range) Reference NCBI sequence read accession code Animal ethics approval no. Farm-based Meads Creek, Port Esperance (1) V3-V5 Pyroseq-uencing Aug 2010 – Apr 2011 (5) 20, 49, 50, 50, 50 0.4-4.1 3900 (654-21356) 24 PRJNA1021267 DPIPWE 30/2009-10 Farm-based Robert’s Point lease, D’Entre- casteaux Channel (2) V3-V5 Pyroseq-uencing Jul 2011 – Aug 2012 (9) 6, 12, 12, 11, 12, 11, 10, 12, 12 0.5-1.8 3994 (489-13691) 20 PRJNA1021267 UTAS A0012001 Farm-based North West Bay (3) V3-V5 Illumina MiSeq Nov 2013 – Jun 2014 (3) 9, 8, 11 Not available 146271 (22193-404791) This study PRJNA1021367 UTAS A0013971 Farm-based Red Cliffs, D’Entrecasteaux Channel (4) V1-V3 Illumina MiSeq Mar 2014 – Jun 2014 (3) 64, 49, 76 1.2-2.2 221637 (6932-627716) 96 PRJNA979964 UTAS A0013971 Farm-based North West Bay (3) V1-V3 Illumina MiSeq Jan 2015 – Apr 2015 (3) 22, 29, 18 Not available 55446 (1240-118582) This study PRJNA1021684 UTAS A0013971 Farm-based Soldier’s Point, D’Entre-casteaux Channel(5) V3-V5 Illumina MiSeq Dec 2015 – May 2016 (4) 16, 30, 21, 11 Not available Not available 31740 (1254-81741) This study PRJNA1021687 UTAS A0015452 Farm-based Red Cliffs, Shep-pards leases, D’Entre-casteaux Channel(4, 6) V1-V3 Illumina MiSeq Jan 2018, Jul 2018 (2) a 182, 196 2.1-2.3 13820 (602-51163) 16 PRJNA1025921, PRJNA1026149 UTAS A0016307 A0016588, A0017010 Farm-based feed pellets V1-V3 Illumina MiSeq Jan 2018 – Jul 2018 40 13727 (6999-31697) This study PRJNA1025868 Not applicable Tank-based EAF, Taroona V1-V3 Illumina MiSeq Apr to Sep 2016: 15°C (initial), 19°C (10 weeks), 15°C (4 weeks) (3) 9, 59,26 ≥1.5 13102 (1276-26560) This study PRJNA1023021 UTAS A0015452 Tank-based EAF, Taroona V1-V3 Illumina MiSeq Apr to Sep 2017: 15°C (initial), 19°C (10 weeks), 15°C (4 weeks) (3) 10, 36, 36 ≥1.5 1038087 (35938-318200) This study PRJNA1023026 UTAS A0015452 Tank-based EAF, Taroona V1-V3 Illumina MiSeq Apr to Sep 2019: 15°C (initial), 19°C (10 weeks), 15°C (4 weeks) (3) 23, 57, 11 ≥1.5 111731 (4091-416609) This study PRJNA1023294 UTAS A0015452 a Samples were collected from fore-gut, mid-gut, and hind-gut digesta and mucosa as well as by faecal stripping in the 24 h period after fish fed (Reid et al. 2023). Table 2. Phenotypic data for Aliivibrio genetic sub-groups isolated from farmed Atlantic salmon Phenotype: A2 group A9 group A32 group a S4TY1 group S2MY1 group Growth temperature range (°C) a 8-30 (25) 8-30 (25) <8-30 (25) 4-30 (25) 4-30 (25) Salinity range for growth (sea salts % w/v) b 1.0-5.0 (2.5) 1.0-5.0 (3.0) 1.0-5.0 (2.5-3.0) 1.0-5.0 (2.5) 1.0-5.0 (2.5) pH range for growth c 5.0-9.0 (6.5-8.3) 5.0-9.0 (6.5-8.3) 5.0-9.0 (6.5-8.6) 5.0-9.0 (6.5-8.6) 5.0-9.0 (6.5-8.6) Maximum toleration of bile salts (% w/v) d 2.5 2.0-2.5 3.0 1.0-2.0 2.0-2.5 Bioluminescence - - varies - - Biofilm formation on polystyrene/glass e ++/++ -/++ varies (- to ++)/++ +++/+ to ++ -/++ Chitinolytic, carbohydrate fermentation + + + + + a Detectable growth (A600 (≥0.2 A 600 ) occurring within 48 h incubation. The approximate optimal temperature for growth is shown in parentheses, doubling time ranged from 4.2 to 6.0 h at this temperature. Strains S2TY2 and S3TY1 grew at 4°C but A32 did not. b No growth occurs in the presence of ≤0.5% or ≥7.0% (w/v) sea salts; optimal salinity for growth is shown in parentheses. c Values in parentheses denotes luxuriant growth occurs within the indicated pH range. d Oxoid ox bile salts no. 3 LP0056 - 50% w/v cholate; 50% w/v deoxycholate. The value shown is the solution concentration that allows detectable growth (≥0.2 A 600 nm). e The degree of biofilm formation is based on the crystal violet assay absorbance (A 550 nm) values for growth developed after 24 h of incubation at 25°C (+++ ≥ 0.6, ++ 0.3-0.6, + 0.1-0.3, - <0.1). Strain A32 did not form biofilms on polystyrene and is non-bioluminescent. Table 3. Host colonization relevant protein content in Allivibrio species and Vibrio scophthalmi based on genome annotations and protein similarity analysis. Coloured values represent the percent of strains containing the indicated protein homolog having >40% similarity and >80% of length to the reference protein. Proteins Protein function Broad function (host) A. salmon-icida A. logei A. sifiae A. fischeri A. finister- ensis A2 group A9 group A32/ S2TY2 group S4MY1 group S2MY1 group A. wod- anis A. “vili” A. “figg- ae” V. scoph- thalmi No. of genomes: 2 4 2 72 1 3 6 3 6 2 1 3 1 5 GpbA (LPMO10A) GlcNAc-binding protein adherence 100 100 100 100 100 100 100 100 100 100 100 100 100 100 LPMO10B Chitin monooxygenase 100 100 100 100 100 100 100 100 100 100 0 100 100 100 OmpU Outer membrane protein U 100 100 100 100 100 100 100 100 100 100 100 100 100 100 IlpA (MetQ) Immunogenic lipoprotein A 100 100 100 100 100 100 100 100 100 100 100 100 100 100 MAM7 (PqiB) Multivalent adhesion factor 100 100 100 100 100 100 100 100 100 100 100 100 100 100 PilABCD Chitin-regulated pilus 0 100 100 94.4 100 100 100 100 100 100 100 100 100 100 MSHA gene cluster MSH-type pilus 100 100 100 100 100 100 100 100 100 100 100 100 100 100 CsgABDEFG Curli fibres 100 100 100 100 0 100 100 67 100 0 0 100 100 0 TadABCDEFG (Flp) Tight adherence pilus 100 100 100 100 0 0 0 100 100 0 0 0 0 80 Tcp gene cluster Toxin co-regulated pilus 0 0 0 2.8 0 0 0 0 0 0 0 0 0 0 AfcA Accessory colonization factors host colonization 100 75 100 100 100 100 100 100 100 100 0 100 100 100 AfcB 0 0 0 0 0 0 0 0 0 0 0 0 0 0 AfcC 0 0 0 5.5 0 0 0 0 0 0 0 0 0 0 AfcD/SslE 0 0 0 11 0 0 0 0 0 100 0 0 0 0 NanA operon Neu5AC degradation 100 100 100 97.2 0 100 0 0 0 0 0 0 100 100 StcE/TagA/HapA Mucinases (putative) 0 100 100 24.3 100 100 100 100 100 100 100 100 100 100 NanH Sialidase 0 0 0 0 0 0 0 0 0 0 0 0 0 0 KatA Class II peroxidase 100 100 100 100 100 100 100 100 100 100 100 100 100 100 EroS glucosaminoglycan lyase “aphrodisiac” other? 0 0 50 100 0 100 0 0 0 0 0 0 100 0 LuxA Lux system bioluminescence 100 100 100 100 100 0 0 67 0 0 0 0 100 0 LuxI homologs AHL synthesis quorum sensing 100 100 100 84.7 100 0 0 67 100 0 0 0 100 0 other homologs AHL synthesis 100 75 100 100 0 100 100 100 100 100 100 100 100 0 CqsA homologs Chemical messenger synthesis 0 0 0 0 0 0 0 0 0 0 0 0 0 20 Eps/Gps gene cluster T2SS EPS system biofilm formation 100 100 100 100 100 100 100 100 100 100 100 100 100 100 Syp gene cluster Syp polysaccharide 100 100 100 100 0 100 100 100 100 100 100 100 100 100 BscABC Bacterial cellulose synthesis 50 100 100 100 0 100 100 100 100 100 0 0 0 100 Vps gene cluster Vps polysaccharide 0 0 0 0 0 100 100 100 100 0 0 0 0 0 RbmABD, RbmC/Bap1 Rugosity/biofilm structure regulation 0 0 0 0 0 100 100 100 100 0 0 0 0 0 LapV/LapI T1SS adhesins 100 100 100 100 0 100 100 100 100 100 0 100 100 100 LapBCEDG Biofilm modulation system 100 100 100 100 100 100 100 100 100 100 100 100 100 100 BdlA Biofilm dispersal 0 0 0 2.8 0 100 0 0 0 0 100 0 0 0 HapR/LitR Biofilm repressor 100 100 100 100 100 100 100 100 100 100 100 100 100 100 VpsR Biofilm positive regulator 100 100 100 100 100 100 100 100 100 100 100 100 100 100 VpsT Biofilm positive regulator 100 100 100 100 0 100 100 0 100 0 0 100 100 100 HbtRC (TcpPH) Habitat transition regulator 0 75 100 80.6 0 0 100 100 100 100 0 0 0 0 T6SS T6SS VAS system/effectors cell competition 100 100 100 100 0 100 100 100 100 0 100 100 0 100 CNF-1 Cytotoxic necrotizing factor 1 toxins/virulence 100 100 100 2.8 0 0 0 0 0 0 0 0 0 0 Hap/Vva Vibriolysin 0 100 100 0 0 0 0 0 0 0 100 0 0 0 RtxABCD RTX toxin 0 100 0 0 0 0 0 0 0 0 0 0 0 0 Tdh/Trh Thermostable direct hemolysin 0 0 50 1.4 0 0 0 0 0 0 0 0 100 0 Tlh Thermolabile hemolysin 0 0 0 0 0 0 0 0 0 0 100 0 0 0 CdtABC Cytolethal distending toxin 0 0 0 0 0 0 0 0 100 50 0 0 0 0 Ace Accessory cholera enterotoxin 0 0 0 2.8 0 0 0 0 0 0 0 0 0 0 Zot/Zot-like Zonula occludens toxin/homologs 0 0 0 11 0 0 0 0 0 0 0 0 100 40 VCC/VvhA-like Leukocidin family pore-forming toxin 0 0 100 29.1 0 0 0 0 0 0 0 0 0 20 Footnote for Table 3. Of the 74 A. fischeri genomes 3 represent the type strain (ATCC7744 = DSM507 = JCM 18803) and are considered as one strain for the analysis. AfcB and AfcD homologs are present in most strains but only have 35-40% similarity with homologs from V. cholerae . PilA and PilC homologs are absent in some A. fischeri and A. salmonicida strains. The tad operon may be present in two separate alleles but three alleles is rare. MSHA genes mshE , mshP and/or mshQ may have diverged homologs in some strains. The tcp gene cluster occurs in the very similar A. fischeri ES114 and VCW2E2 genomes, but both lack tcpR . Some strains possess two or three StcE/Tag-like homologs. GAG (glycosaminoglycan) lyases of the PL8 family are present in A. logei IS159 and all three A. “vili” strains (1S128, 1S165, 1S175) though these proteins share only 38-40% homology with the GAG lyase EroS of A. fischeri ES114. The Vps cluster gene vpsC is not present in any strain while additional genes in the cluster are found in some strains e.g. strain A32. Many strains have a Zot domain-containing protein except ES114 and VCWE2E, which have adjacent Zot and Ace homologs. Additional Declarations No competing interests reported. Supplementary Files TableS1Metastudyofgutmicrobiomesalmon.xlsx Supplementarydatafile1.xlsx Supplementarydatafile2.xlsx Aliivibriopapersupplementaryfigures030524.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4361310","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":300392795,"identity":"67f2195b-a702-456f-a8c5-597dec1b4b66","order_by":0,"name":"Kate Hall","email":"","orcid":"","institution":"University of Tasmania","correspondingAuthor":false,"prefix":"","firstName":"Kate","middleName":"","lastName":"Hall","suffix":""},{"id":300392796,"identity":"ecbcdc38-a8e9-4931-bff2-5c644ca5fa30","order_by":1,"name":"Chantelle E Reid","email":"","orcid":"","institution":"University of Tasmania","correspondingAuthor":false,"prefix":"","firstName":"Chantelle","middleName":"E","lastName":"Reid","suffix":""},{"id":300392797,"identity":"4e1533b7-df4a-4f32-a1e0-5616068342ab","order_by":2,"name":"Qi Zhi Tan","email":"","orcid":"","institution":"University of Tasmania","correspondingAuthor":false,"prefix":"","firstName":"Qi","middleName":"Zhi","lastName":"Tan","suffix":""},{"id":300392798,"identity":"a5b60100-c2f9-4555-951e-b59bbe32caaf","order_by":3,"name":"Richard S Taylor","email":"","orcid":"","institution":"CSIRO","correspondingAuthor":false,"prefix":"","firstName":"Richard","middleName":"S","lastName":"Taylor","suffix":""},{"id":300392799,"identity":"eb9865f3-492d-4152-bf89-0614ab12be7f","order_by":4,"name":"Andrew Bissett","email":"","orcid":"","institution":"CSIRO","correspondingAuthor":false,"prefix":"","firstName":"Andrew","middleName":"","lastName":"Bissett","suffix":""},{"id":300392800,"identity":"37e3a2e6-c656-4ea6-a682-2f9a8e5b168e","order_by":5,"name":"Nicole Ruff","email":"","orcid":"","institution":"Skretting Australia Pty Ltd","correspondingAuthor":false,"prefix":"","firstName":"Nicole","middleName":"","lastName":"Ruff","suffix":""},{"id":300392801,"identity":"ff00f305-f0aa-431b-bfc6-a1b367125541","order_by":6,"name":"Barbara F Nowak","email":"","orcid":"","institution":"University of Tasmania","correspondingAuthor":false,"prefix":"","firstName":"Barbara","middleName":"F","lastName":"Nowak","suffix":""},{"id":300392802,"identity":"b84c86b3-38f4-4df0-8d0b-b77787f3e57c","order_by":7,"name":"John P. Bowman","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA7UlEQVRIiWNgGAWjYBACxgYeEAFhP4AKGhCthdmAIYEILQwMCC1sEkRpYW7vPfaAcYdN4tr2s8eqeX/Y2TOwN2+TYKg5jNthPefSDRjPpCVuO5OXdpsnITmxgedYmQTDMTxaZuSYSTC2Hc7ddiDHDKiFOYFBAijCwEaMlvNvzIp5EurtGeTfALX8I0bLjRwzZp6Ew4wNEjxgETx+OWMmkXgmrX7bjTfGknPSjie28aQVWyT2pePUYtjeYybxcYeNsdn5HMMPb2yq7fnZD2+88eGbNW4tDUAiAVmEjQFdBA3I45EbBaNgFIyCUQABAG53UTsqkL7hAAAAAElFTkSuQmCC","orcid":"","institution":"University of Tasmania","correspondingAuthor":true,"prefix":"","firstName":"John","middleName":"P.","lastName":"Bowman","suffix":""}],"badges":[],"createdAt":"2024-05-03 00:39:06","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4361310/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4361310/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":56176688,"identity":"8040858d-4614-4a51-88e4-4b4dcf8094d0","added_by":"auto","created_at":"2024-05-09 13:12:49","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":49131,"visible":true,"origin":"","legend":"\u003cp\u003eThe proportional representation of taxa from farmed Atlantic salmon fish gut samples collected over several surveys in Tasmania (Table 1). More details are also shown in Supplementary datafile 1.\u003c/p\u003e","description":"","filename":"Figure1.png","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/5e6ecff38ab210e1edd93eb7.png"},{"id":56174962,"identity":"f81646e3-1901-43cc-aad0-1b38da4c5444","added_by":"auto","created_at":"2024-05-09 12:48:45","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":108149,"visible":true,"origin":"","legend":"\u003cp\u003eThe upper 4 graphs show the change in abundance of \u003cem\u003eAliivibrio\u003c/em\u003e, \u003cem\u003eVibrio\u003c/em\u003e, \u003cem\u003ePhotobacterium\u003c/em\u003e and “Cand. Mycoplasma salmoninae” following Atlantic salmon smolt insertion in marine cages. Abundances are shown as CLR values. The results are shown in comparison to the annual average seawater temperature found for the six farm regions (Supplementary Fig. S1) from which fish were sampled. The shaded section indicates the optimal range for Atlantic salmon growth rates (13-16°C) relative to the seawater averages. The bottom left hand graph shows the TVC of bacteria in Atlantic salmon stripped faecal samples collected at different times (see Methods section). The TVC data is the average of counts on marine and TCBS agars, incubated aerobically at 25°C. The bottom right-hand graph shows the estimated maximum optical densities and growth rates (transformed to square root) of \u003cem\u003eAliivibrio\u003c/em\u003e salmon isolates from the A2, A9 and A32 groups in relation to incubation temperature.\u003c/p\u003e","description":"","filename":"Figure2.png","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/6db277db5b2ec92226f860e3.png"},{"id":56175806,"identity":"3890b42b-91d9-424e-8a61-c840ef3f8fb7","added_by":"auto","created_at":"2024-05-09 12:56:48","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":698787,"visible":true,"origin":"","legend":"\u003cp\u003eCo-occurrence network comparing groups of taxa from Atlantic salmon digesta collected over several surveys in Tasmania (Table 1) by Pearson product correlation. The nodes indicate taxonomic groups at the order level except for specific taxa (Aliivibrio, Vibrio, Photobacterium and Mycoplasma) and for certain families. The colour of the edges reflects whether the correlations are positive (green) or negative (red). The thickness of the edge indicates correlation strength with no edge shown having a correlation below 0.4. It should be noted according to the Genome Taxonomy Database (GTDB) the order Micrococcales is now a subset of the order Actinomycetales within phylum Actinomycetota. In addition, Alteromonadales is now a subset of the order Enterobacterales, which also includes families Vibrionaceae, Enterobacteriaceae, Pasteurellaceae, and Aeromonadaceae.\u003c/p\u003e","description":"","filename":"Figure3.png","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/df64ff684e37623314568bb5.png"},{"id":56176218,"identity":"c41ed0b9-b265-48dc-aa7a-cd427dd19887","added_by":"auto","created_at":"2024-05-09 13:04:46","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":176246,"visible":true,"origin":"","legend":"\u003cp\u003eUnweighted mean pair group tree relating ANI values for \u003cem\u003eAliivibrio\u003c/em\u003e and \u003cem\u003ePhotobacterium\u003c/em\u003e strains isolated from Atlantic salmon gut samples. Labelled groups are based on the 95% ANI demarcation indicated by the dashed vertical line. \u003cem\u003eA. finisterrensis\u003c/em\u003eand S4MTY1 groups are close to the 95% boundary. A complementary cluster analysis using the GGDC model 2 approach, an in silico version of DNA:DNA hybridization is shown in Supplementary Figure S2.\u003c/p\u003e","description":"","filename":"Figure4.png","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/08baf784c581b56487301c43.png"},{"id":56174967,"identity":"862dd8a9-af48-476b-b545-7d34513de144","added_by":"auto","created_at":"2024-05-09 12:48:46","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":446296,"visible":true,"origin":"","legend":"\u003cp\u003eA BioNJ clustered tree comparing the 16S rRNA gene V1-V3 region between the genomes of Aliivibrio species. In the tree the position of OTUs are indicated that were detected in the overall survey dataset. This includes 16S rRNA variants of different strain groups/species. The alignments of these variants for different species and strain groups are shown in Supplementary Figure S3. The identification of the OTUs of the \u003cem\u003eA. logei/A. sifiae/A. wodanis\u003c/em\u003e strain group are only indicative, based on the top match during read classification. As indicated by Klemetsen and colleagues [ ] multi-locus sequence typing or genome to genome comparisons (such as ANI, GGDC) are needed to clearly resolve species of \u003cem\u003eAliivibrio\u003c/em\u003e.\u003c/p\u003e","description":"","filename":"Figure5.png","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/94d301500432324ae6ea0e1a.png"},{"id":56175805,"identity":"1cad3ba8-7c5f-4bdd-81d0-0a926ff862cb","added_by":"auto","created_at":"2024-05-09 12:56:47","extension":"png","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":253473,"visible":true,"origin":"","legend":"\u003cp\u003eHeat map showing distribution of taxa across gut section digesta and mucosa (FG, foregut; MG, midgut; HG, hindgut) for Atlantic salmon collected in the summer and winter of 2018 in Tasmania based on data obtained in the study of Reid et al. [16]. The sampling immediately followed feeding and was done over a 24 h period The differences between abundances in these sections is indicated by the averaged differences in CLR values (DCLR) from paired samples (n=27 for each comparison). The OTUs included show significant (DCLR) based on FDR adjusted significance testing and those showing large DCLR for at least one of the 8 dataset comparisons. Four OTU groups are defined via hierarchical clustering (using uncentered correlations). Colonists demonstrate increases in abundance in the mucosa when midgut and hindgut samples are compared to foregut mucosa. Digesta associated OTUs are those mainly showing an increase in abundance in the hindgut digesta compared to foregut digesta but do not accumulate in the mucosa. Seawater associated taxa also show this trend but mainly only for samples collected in summer. Summer acquired digesta had a waterier consistency than winter samples as indicated in Reid et al. [16]. Diet-associated taxa show decreasing abundance for both digesta and mucosa relative to the foregut suggesting these taxa could be mainly feed-derived DNA.\u003c/p\u003e","description":"","filename":"Figure6.png","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/5ec5a6e5446bace9111e2ee3.png"},{"id":56176221,"identity":"4cf71243-1c87-41d9-8855-0e21d3929273","added_by":"auto","created_at":"2024-05-09 13:04:48","extension":"png","order_by":7,"title":"Figure 7","display":"","copyAsset":false,"role":"figure","size":5713,"visible":true,"origin":"","legend":"\u003cp\u003eBox plot graph showing the CLR normalised abundances of taxa from Atlantic salmon reared in seawater containing tanks. The sequence data was derived from stripped faeces from the fish at three different times. This involved smolt being fed at 15°C until they reached roughly 1.5 kg. The initial samples were then collected from randomly chosen fish. The tank water temperature was slowly raised until it reach 19°C and fish were fed for approximately 10 weeks or until they showed signs of reduced voluntary feeding at which point thermal phase samples were collected. The water temperature was then reduced back to 15°C and after 4 weeks the final sample set was obtained, reflecting a “recovery” phase.\u003c/p\u003e","description":"","filename":"PlaceholderimageCopy3.png","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/01df0226d9a11d01b55b917a.png"},{"id":56444224,"identity":"686c1c6c-5be6-4c84-8e3e-23a65e8786f0","added_by":"auto","created_at":"2024-05-14 09:10:11","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":3001698,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/abffa436-7d7c-4abd-8386-e1461566a6e3.pdf"},{"id":56176692,"identity":"431f95f2-517d-4cf3-8b66-1cd40b4d7f46","added_by":"auto","created_at":"2024-05-09 13:12:55","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":24187,"visible":true,"origin":"","legend":"","description":"","filename":"TableS1Metastudyofgutmicrobiomesalmon.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/b9a93c0b04bde9b385484fe4.xlsx"},{"id":56174970,"identity":"cd0ff703-0be4-449b-97bf-b20c5b38a281","added_by":"auto","created_at":"2024-05-09 12:48:47","extension":"xlsx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":584822,"visible":true,"origin":"","legend":"","description":"","filename":"Supplementarydatafile1.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/32c87aacd8957e6848a72a40.xlsx"},{"id":56174963,"identity":"f93b9d32-325a-4988-8e92-429615c96d9d","added_by":"auto","created_at":"2024-05-09 12:48:46","extension":"xlsx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":145551,"visible":true,"origin":"","legend":"","description":"","filename":"Supplementarydatafile2.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/b9b23967233980edeb8d4f83.xlsx"},{"id":56175801,"identity":"a20cfed4-1d55-4f29-b62f-42105e2d64d2","added_by":"auto","created_at":"2024-05-09 12:56:46","extension":"pdf","order_by":3,"title":"","display":"","copyAsset":false,"role":"supplement","size":592237,"visible":true,"origin":"","legend":"","description":"","filename":"Aliivibriopapersupplementaryfigures030524.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4361310/v1/6979b529f68cd5fe44547f0d.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Active colonisers of the gastrointestinal tract of Atlantic salmon farmed in a warm water region","fulltext":[{"header":"Background","content":"\u003cp\u003eAquaculture, in particular finfish aquaculture, has greatly expanded in the last three decades to overtake wild caught fish for human consumption on a volume production basis [1] This trend is fuelled by the limited capacity of capture fisheries to feed global population growth and increasing per capita consumption, with aquaculture offering an efficient source of protein due to a high feed efficiency and the development of improved production technologies [2,3]. Some farmed species, such as Atlantic salmon (\u003cem\u003eSalmo salar\u003c/em\u003e) and Pacific salmon (\u003cem\u003eOncorhynchus tshawytscha\u003c/em\u003e), are mainly sold in premium markets. The expansion of aquaculture and volatility of prices in recent years [4] has lead farming practices to try to achieve improved production efficiencies, especially in relation to feed sustainability [5-7]. To preserve product quality, improve social acceptability and feed ingredient production, improvements that guarantee farm performance, feed efficiency, and animal welfare is an ongoing effort by the salmon industry. There has been a rapid shift in freshwater hatchery production towards recirculation aquaculture systems (RAS) that have enabled larger smolt (the salmon life stage adapting to seawater) to be stocked to sea [8], thus shortening the marine production phase. Development of land based RAS as an alternative to sea pens for production of harvest sized fish faces several technical and economic challenges [9]. At the same time off-shore farming has been contemplated where aquaculture can be coupled to renewable energy generation [10]. Part of the reason for the latter trend is to reduce coastal environmental impacts and improve the scale of efficiency of aquaculture production. Increasing sea surface temperatures nevertheless present a future challenge to aquaculturists, in particular to the Atlantic salmon industry; with temperature optima for adult fish of between 13 to 16\u0026deg;C [11, 12].\u003c/p\u003e\n\u003cp\u003eIn Tasmania (Australia), the Atlantic salmon industry relies on sea cage farming. The industry operates at the high end of the temperature scale owing to summer sea surface temperatures being on average 16-18\u0026deg;C [13]. For example, a 117-day \u0026ldquo;heat wave\u0026rdquo; during the summer of 2015/16, where surface (5 m depth) temperatures of the Tamar River Estuary averaged above 18\u0026deg;C (maximum 22.9\u0026deg;C) had significant effects on farmed salmon health and downstream marketability [14]. The main sign of thermal stress to Atlantic salmon and other salmonid species is lethargic behaviour and reduced or no voluntary feeding, resulting in substantial size and condition variation within cohorts. Lack of feeding may also lead to inconsistent flesh colour due to uneven deposition of dietary astaxanthin into white muscle [15]. Thermal stress and inappetence could be partly due to impacts on renal, liver and osmoregulatory functions and has also been associated with a steep increase in the excretion of pale yellow sloughed intestinal mucosal layer referred to as \u0026ldquo;pseudofaeces\u0026rdquo; or faecal casts [16]. These issues are managed in farms with other summer seasonal phenomena, in particular amoebic gill disease, which requires reiterative freshwater bathing [17].\u003c/p\u003e\n\u003cp\u003eGut microbiome studies on Atlantic salmon and other farmed fish species, including the full production cycle and related to ecological, health, farm performance and diet-related questions, have greatly increased in recent years. Several recent salmon-specific studies are summarised in Supplementary Table S1 summarising gut microbiome composition of Atlantic and Chinook salmon in a range of scenarios. Fish have a gut microbiome that reflects their environment [18], however in farmed fish It is necessary to first decipher microbiome data to determine what bacterial taxa actually make up the active microbiome rather than bacteria simply transiting through via water or detected as remnant DNA associated with feed [19]. Smolt, when transferred to sea pens, are physiologically adapted to the marine environment via smoltification, however their gut microbiota dynamically changes over time [20-22]. As fish grow in sea pens the microbiome changes have been related to fish age and/or weight gain [23]. Diet by comparison typically represents a more subtle influence on the community composition [24]. Bacteria in the gut that are autochthonous would typically be highly predominant, associated with the mucosal layer and/or the digesta to different degrees. A major autochthonous species present in wild Atlantic salmon is \u0026ldquo;Candidatus Mycoplasma salmoninae salar\u0026rdquo; [25]. In sea farmed salmon this species and other members of the Mycoplasmatales can be readily detected [16, 20, 21, 23, 24]. Recent evidence confirms this species is co-diversified within wild Atlantic salmon populations. Other core taxa attributed to salmon usually include \u003cem\u003eLactobacillaceae\u003c/em\u003e [22] in smolt in hatcheries, which could be feed ingredient associated, while \u003cem\u003ePhotobacterium\u003c/em\u003e is typically the most abundant member of the \u003cem\u003eVibrionaceae\u003c/em\u003e in salmon from cold waters, consistent with its psychrophilic adaptations. In temperate conditions (sea surface temperature 10-20\u0026deg;C) surveys have shown that the gut bacteria changes from a predominance of lactic acid bacteria to \u003cem\u003eVibrionaceae\u003c/em\u003e (\u003cem\u003eAliivibrio\u003c/em\u003e and \u003cem\u003eVibrio\u003c/em\u003e) after fish experience their first summer, with \u003cem\u003eVibrionaceae\u0026nbsp;\u003c/em\u003eremaining predominant thereafter [20]. Atlantic salmon fed diets where energy content and protein/lipid ratios and fish meal contents were contrasted had only transient impacts on gut community structure, in the end \u003cem\u003eVibrionaceae\u003c/em\u003e and other core taxa always predominated suggesting particular taxa have traits enabling stable colonisation of the gut of sea cage reared salmon GI tract [24]. High abundances of taxa such as \u003cem\u003eAliivibrio\u003c/em\u003e are suspected to be more predominant in fish expressing casts and faeces with a watery composition [13, 22], though the connection to dysbiosis [26] is yet to be shown conclusively. \u003cem\u003eAliivibrio\u003c/em\u003e are of particular interest due to their potential to cause disease [27, 28] but also as beneficial bacteria [29, 30]. Significant knowledge of host interactions obtained for the model species \u003cem\u003eAliivibrio fischeri\u003c/em\u003e provides a foundation for functional comparison of different \u003cem\u003eAliivibrio\u003c/em\u003e species. \u003cem\u003ePhotobacterium\u003c/em\u003e and \u003cem\u003eVibrio\u003c/em\u003e are also of interest for similar reasons, due to the abundance of these genera in maricultured salmon and known pathogenic traits amongst some strains.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eLittle is yet known about salmon-associated \u003cem\u003eVibrionaceae\u003c/em\u003e, however due to their predominance in farmed salmon and the anecdotal links with fish health there is a need to understand the underlying biology with farmed salmon, particularly in warmer regions. This includes understanding capabilities related to persistent colonisation, growth \u003cem\u003ein vivo\u0026nbsp;\u003c/em\u003eand response to sea surface temperature. In this study we examined the colonisation of Atlantic salmon reared in marine pens, located in the D\u0026rsquo;Entrecasteaux Channel region of Tasmania, utilising data collected between 2010 to 2018 (Table 1). To enhance this we isolated strains from salmon digesta samples and sequenced their genomes. This data was used to track 16S rRNA gene amplicon operational taxonomic units (OTUs) and to also assess differential abundance throughout the gut of marine farmed Atlantic salmon in winter and in summer using data from the feeding study of Reid et al. [16]. To assess the effect of water temperature the hind gut distributions of \u003cem\u003eVibrionaceae\u003c/em\u003e were determined in Atlantic salmon reared in seawater tanks. The tank water temperature was raised into a temperature range that eventually induced reduced voluntary feeding to determine which species predominated during thermal stress. We finally examined the genome biology of representative strains of abundant species to link the gut ecology with traits linked to host colonisation and also discover any traits that have potential links to dysbiosis or disease.\u0026nbsp;\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003e\u003cem\u003eAliivibrio\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003eand other Vibrionaceae predominate annually in sea cage Atlantic salmon\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eGut microbiome taxonomic profiles (supplementary datafile 1) of Atlantic salmon surveyed from different farms between 2010-2018 in D\u0026rsquo;Entrecasteaux Channel region (supplementary data Fig. S1 shows locations) are shown in Figure 1. The profiles are arranged temporally from the point when smolt are placed in sea pens. On an individual fish level the presence of Vibrionaceae exhibits a high level of variability, however a clear pattern of increase can be visually observed (Figure 1). When abundances are normalised to CLR values instead, which helps deal with the influence of sampling depth, Vibrionaceae taxa have sigmoidal growth-like responses (Figure 2). From a low starting abundance at the point of smolt input in winter there is an increase in abundance in the spring to mid-summer period (September to December) after which point populations plateau. \u003cem\u003eAliivibrio\u003c/em\u003e CLR values, where \u003cem\u003eAliivibrio\u003c/em\u003e OTUs have been amalgamated, had the most definable sigmoidal response with average CLR values reaching a maximal level in the late summer or early autumn, about 6 to 9 months after smolt transfer (Figure 2). The findings are supported by bacterial TVC data, measured between smolt transfer and the first summer period for some of the survey years. TVC was determined on marine agar as a non-specific medium given the digesta content is saline (~20-25 psu) and also utilised TCBS as a selective medium for members of family Vibrionaceae. The TVC data indicates that measurable populations reach a maximum level (8 to 9 log CFU/g sample wet weight) within 7 months after smolt transfer (Figure 2). The similarity observed between marine and TCBS count data indicates most of the TVC data come from bile salts-tolerant marine bacteria, expected to mostly belong to family \u003cem\u003eVibrionaceae\u003c/em\u003e. For the 2018 survey period 40 feed pellet samples were analysed for microbiota profiles since it was expected that the feeds contain substantial levels of bacterial DNA from the ingredients [19], which in turn originate from both plant and animal sources. The feed profile is shown in summary in Figure 1 and in detail in Supplementary datafile 1. Salmon-associated \u003cem\u003eAliivibrio\u003c/em\u003e and \u003cem\u003eMycoplasma\u003c/em\u003e OTUs were either absent or present at only low levels (\u0026lt;0.03% of total reads) in the feed samples investigated. The levels of \u003cem\u003eVibrio\u003c/em\u003e and \u003cem\u003ePhotobacterium\u003c/em\u003e in the feed were comparatively higher (0.17% and 0.70% of reads, respectively ) and 16 out of 62 OTUs of these genera could be found that occur in both digesta and feed (supplementary datafile 1) but not in laboratory blank and extraction kit elution buffer control samples. The detections of the same OTUs in digesta and feed samples possibly arises from cross contamination within the farms but it seems more logical that many if not most OTUs arise from trace DNA from feed ingredients, especially for OTUs occurring at relatively high proportions, such as Lactobacillales OTUs, which represented 46% of total reads in the feed samples. The results confirm \u003cem\u003eAliivibrio\u003c/em\u003e and some other Vibrionaceae are predominant microbiota in Atlantic salmon gut samples year-on-year and exhibit a growth-like increase in population through the summer into the autumn. Feeds do not seem to be a significant source of \u003cem\u003eAliivibrio\u003c/em\u003e or \u003cem\u003eMycoplasma\u003c/em\u003e but could be a source for some other Vibrionaceae.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTaxa found in feeds, water and which may be fish colonists\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo further understand the associative patterns of the microbial community, co-occurrence network analysis was utilised. The network was visualised using Gephi [31]. Specifically this was done to observe if any taxa have an association with feed-only OTUs or to seawater derived OTUs than with the Atlantic salmon GI tract digesta and mucosa. Feed only OTUs consist of 16S rRNA genes from chloroplasts and mitochondria of the feed plant sourced ingredients, i.e. wheat, lupins, \u003cem\u003ePisum sativa\u003c/em\u003e meals while seawater OTUs include oligotrophic bacteria adapted to growth under low nutrient conditions or are obligately phototrophic, for example taxa of orders \u0026ldquo;Candidatus Pelagibacterales\u0026rdquo; and Synechococcales. The results (Figure 3) show that the occurrence of \u003cem\u003eAliivibrio\u003c/em\u003e, \u003cem\u003ePhotobacterium\u003c/em\u003e, \u003cem\u003eVibrio\u003c/em\u003e and also \u003cem\u003eMycoplasma\u003c/em\u003e did not correlate or were only weakly negatively correlated (\u003cem\u003er\u003c/em\u003e \u0026lt; 0.20) with most other taxa detected. By comparison, the majority of the microbiota were positively correlated with each other and with feed chloroplast and mitochondria derived sequences. This relationship was strongest (\u003cem\u003er\u003c/em\u003e 0.61-0.80) for anaerobic taxa including Lactobacillales, Bacteroidales, Clostridiales, and Fusobacteriales. Furthermore, seawater oligotrophic and phototrophic taxa were most positively correlated with each other but also were associated positively with chloroplast and mitochondrial-derived sequences and the other linked feed associated taxa. Since the samples had high water content, especially in summer [16], this could be a reason why seawater specialists are readily detected and show broadly similar distribution patterns to each other. The results also indicated that feed and water seem to contribute to a large proportion of the bacterial diversity. Based on the network analysis taxa that are not associated with seawater or feeds, including \u003cem\u003eAliivibrio\u003c/em\u003e, \u003cem\u003eVibrio\u003c/em\u003e, \u003cem\u003ePhotobacterium\u003c/em\u003e and \u003cem\u003eMycoplasma\u003c/em\u003e, represent only a small portion of the total diversity.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenome sequencing of Vibrionaceae species of the Atlantic salmon gut reveals novel diversity.\u0026nbsp;\u003c/strong\u003eShort read amplicon sequencing has limits in resolving taxonomic details in microbial assemblages. We attempted to overcome this by isolating and sequencing the genomes of bacteria from Atlantic salmon digesta samples. Doing this has the advantage of confirming isolate distributions in comparison to the sequence data since it allows determination of all 16S rRNA gene variants on genomes, which was investigated in the next experimental section. The isolates obtained included five genetic groups of \u003cem\u003eAliivibrio\u003c/em\u003e designated A2, A9, A32, S2MY1 and S4TY1 strain groups. The relationship of these strains to relatives \u0026nbsp;was determined using OrthoANI [32] (Figure 4) and by use of GGDC 3.0 model 2 [33], which simulates DNA:DNA hybridization in silico (Figure S2). Groups A2, A9 and A32 may represent groups within a single species and are most closely related to the \u003cem\u003eA. finisterrensis\u003c/em\u003e type strain (LMG 23689\u003csup\u003eT\u003c/sup\u003e) which was isolated from the manila clam (\u003cem\u003eLajonkairia lajonkairii\u003c/em\u003e, also called \u003cem\u003eRuditapes phillipinarum\u003c/em\u003e). Though there is a possible common species \u0026nbsp;relationship of the salmon strains with \u003cem\u003eA. finisterrensis\u003c/em\u003e with genome-level comparisons are at the species boundary (ANI 95%, in silico DNA:DNA hybridization 58-65%). The S4TY1 group is further separated from \u003cem\u003eA. finisterrensis\u003c/em\u003e (94% ANI, 55% DNA:DNA hybridization), while S2MY1 is a definitely a distinct species with ANI at 80-87% with other \u003cem\u003eAliivibrio\u003c/em\u003e species. Of the salmon \u003cem\u003ePhotobacterium\u0026nbsp;\u003c/em\u003estrains, these were found to belong to \u003cem\u003ePhotobacterium piscicola\u003c/em\u003e, \u003cem\u003eP. toruni\u003c/em\u003e and an apparently novel species represented by strain S4TG1. Strain S4TG1 had ANI at 92% and 87% to \u003cem\u003eP. piscicola\u003c/em\u003e and \u003cem\u003eP. toruni\u003c/em\u003e type strains, respectively. \u003cem\u003eVibrio\u003c/em\u003e isolates obtained were all closely related \u003cem\u003eto V. scophthalmi\u003c/em\u003e.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eAliivibrio\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;coloniser species can be tracked using their 16S rRNA gene variants from genome data.\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTwo of three distinct 16S rRNA gene variants that occur amongst salmon \u003cem\u003eAliivibrio\u0026nbsp;\u003c/em\u003eoccur in the V1-V3 region. These two variants have a nucleotide similarity of only 96% and thus resolve as distinct OTUs in the analysis. The second variant (V1-V3 region \u0026ndash; 506 bp length) has a distinct 15 bp insert at position 200/201 (\u003cem\u003eE. coli\u003c/em\u003e numbering). This is shown contrasted to variant 1 (V1-V3 region \u0026ndash; 491 bp length) in Supplementary Figure S3. The third distinct variant is located in the hypervariable palindrome of the V9 region. OTUs of \u003cem\u003eAliivibrio\u003c/em\u003e from salmon samples along with genome derived V1-V3 regions were clustered into a phylogenetic tree. The ability to resolve OTUs was determined based on the relation with type strain sequences or representative sequences for placeholder names [34] (Figure 5). Both 16S rRNA sequence variants were found to occur in all of the \u003cem\u003eAliivibrio\u003c/em\u003e salmon isolates after inspection of raw genome sequence data. Based on this analysis the second variant represents 1 copy within the full set of 10-12 copies present in one of the strain\u0026rsquo;s two chromosomes. Proportionally, the second variant read detection was less than expected. Its occurrence versus the common variant theoretically should be a ratio of approximately 1:10-12. Read data, however indicated it was 20-60 (average 44)-fold less abundant than the more common variant. This disparity between the expected ratio could be potentially due to biases in the forward/reverse read joining process or the sequence clustering process. The V1-V3 region \u003cem\u003eAliivibrio\u003c/em\u003e variants were used for tracking \u003cem\u003eAliivibrio\u003c/em\u003e OTUs in digesta and other samples so they could be linked to the isolates. The same approach was performed for available \u003cem\u003ePhotobacterium\u003c/em\u003e and \u003cem\u003eVibrio\u003c/em\u003e colonisers that had genomic data available (data not shown). Examining the survey data and comparing reads to the 16S rRNA gene sequences of isolates we determined all of the \u003cem\u003eAliivibrio\u003c/em\u003e diversity and a portion of the \u003cem\u003ePhotobacterium\u003c/em\u003e diversity could be accounted for amongst the main colonising taxa, however based on the data, several genetic groups of \u003cem\u003ePhotobacterium\u0026nbsp;\u003c/em\u003elikely remain to be isolated since we could not link isolate genome-derived 16S rRNA genes sequence variants to several \u003cem\u003ePhotobacterium\u003c/em\u003e OTUs. Data for \u003cem\u003eVibrio\u003c/em\u003e colonisers remains virtually incomplete being hampered by lacking isolate genomes as a reference point.\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eBy tracking OTUs we could determine the main species compositions of \u003cem\u003eAliivibrio\u003c/em\u003e in Atlantic salmon farmed in south east Tasmania in significantly more detail (Figure 5), though there are notable limitations. In this respect, groups A2, A9 and A32 along with \u003cem\u003eA. finisterrensis\u003c/em\u003e LMG 23689 (the type strain) cannot be separated, however S2MY1, S4TY1 and \u003cem\u003eA. fischeri\u003c/em\u003e formed distinct clusters. \u003cem\u003eA. fischeri\u003c/em\u003e occurred at low abundance in the samples, but OTUs were retrieved for strains in both of the \u003cem\u003eA. fischeri\u003c/em\u003e clusters evident from the 16S rRNA gene data (Figure 5). The remaining \u003cem\u003eAliivibrio\u003c/em\u003e species and species placeholders cluster into a single large clade that includes lower abundance taxa also detected in the salmon surveys (Figure 5). Due to the lack of resolution reliable identification of these latter species is not possible with the data available.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDistribution of bacteria in GI tract of post-smolt to adult Atlantic salmon farmed in Tasmania.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eRaw sequence data was utilised from the study of Reid et al. [16], previously focused on the effect of feeding and relation of digesta consistency on Atlantic salmon gut community profiles. The data was here used to assess the specific distributions of microbiota through the Atlantic salmon GI tract, comparing paired fore-, mid- and hindgut (also referred to as the distal gut) mucosa and digesta samples collected in summer and winter. The results are shown in a heat map (Figure 6) that is based on the average of CLR differences (DCLR) between 27 pairs of samples. In essence, the\u0026nbsp;DCLR calculation was used to compare the abundances of OTUs in either the mid-gut or hind-gut samples to the fore-gut samples from the same source fish rather than comparing samples as groups. By requiring non-parametric effect size (\u003cem\u003er\u0026nbsp;\u003c/em\u003e\u0026gt;0.5) and\u0026nbsp;DCLR (\u0026gt;0.4 or \u0026lt;-0.3) to be large avoided false positives emerging form the paired data being slightly asymmetrical. Taxa shown in the heat map had\u0026nbsp;DCLR that passed this criteria and had significant W-values (p\u0026lt;0.05, FDR) for at least one of the dataset comparisons. Furthermore, the OTUs that fulfilled significance were present in at least 20-25% of total samples. Based on the results the contrast between summer and winter samples was distinctive based on hierarchical clustering, which used uncentered correlations, of the overall dataset comparisons. In addition clustering indicated 4 groups of OTUs were formed. The first group included both 16S rRNA gene variants of \u003cem\u003eAliivibrio finisterrensis\u003c/em\u003e and S2MY1 strains, \u003cem\u003eAliivibrio\u003c/em\u003e S4TY1 group, \u0026ldquo;Cand. Mycoplasma salmoninae\u0026rdquo;, and a \u003cem\u003eVibrio\u003c/em\u003e OTU related to \u003cem\u003eV. scophthalmi\u003c/em\u003e. These species are likely colonist species since they show positive\u0026nbsp;DCLR for mid- and hind-gut mucosa samples and we can show these OTUs occur at high abundance (Figures 1 and 2, Supplementary data file 1). The data points to these species being active in attachment and growth within the salmon gut. A second group of OTUs, the most abundant being of the genera \u003cem\u003ePelomonas\u003c/em\u003e and \u003cem\u003eCutibacterium\u003c/em\u003e, show positive\u0026nbsp;DCLR values for digesta samples collected during winter and to a lesser extent summer. In addition, seawater taxa show a similar response but increases in the midgut and hindgut are restricted to the summer. All of these taxa show reduced or unchanged\u0026nbsp;DCLR for mucosa. This suggests these taxa potentially grow in the digesta or the difference relates to the water content of the digesta [16], especially in the case of the seawater taxa. The final group showed reduced\u0026nbsp;DCLR values for both digesta and mucosa and mainly included Lactobacillales, Clostridia, Tissierellia, Bacteroidales, Enterobacteriaceae and Fusobacteriales. Based on the network analysis the correlations between these taxa and feed-derived plant chloroplasts is particularly strong (correlations of 0.6-0.8), thus the bacterial DNA almost certainly derives from the feed. The observations again suggest relatively few taxa actively colonise the mucosal layer in Atlantic salmon. Secondly, what we think as feed derived taxa exhibit a dilution trend when progressing through the GI tract, a response previously predicted for bacterial DNA sourced from feed [19]. It is likely many taxa grow or persist within the digesta that remain viable but no data is available to enable estimates of what these species are and what viable numbers actually occur. Only the most abundant taxa can be observed to have a recognisable growth trend i.e. higher abundances in the hind gut relative to the fore gut and this appears most clear in winter samples when gut residence times are longer [35].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarm water temperatures promote colonisation of \u003cem\u003eVibrionaceae\u003c/em\u003e.\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTank trials were performed in three successive years (trial 1, 2 and 3) to determine whether exposure to elevated temperatures affects Atlantic salmon GI tract microbiota in a predictable manner. More than 90% of digesta samples from 1.5 kg salmon kept at 15\u0026deg;C had faecal consistency scores between 1 to 3 (solid to watery consistency, no faecal casts) in the scheme described by Zarkasi et al. [24]. The microbial composition of these initial samples (15\u0026deg;C) show that most specimens possess \u003cem\u003eVibrionaceae\u0026nbsp;\u003c/em\u003eand a high feed DNA background as indicated by the relatively high abundance of feed chloroplast-derived 16S rRNA genes (median CLR 1.2 to 1.8, Figure 7). \u003cem\u003eVibrio\u0026nbsp;\u003c/em\u003ewas much more predominant in trials 1 and 2 (median CLR 0.3 to 1.0) at the initial stage than \u003cem\u003eAliivibrio\u003c/em\u003e or \u003cem\u003ePhotobacterium\u003c/em\u003e (CLR \u0026lt;-1.0) (Figure 7). Most digesta samples (65-87%)at the end of the elevated temperature (19\u0026deg;C) phase contained faecal casts with consistency scores being mostly 3, 3.5 (faecal casts plus digesta) or 4 (only faecal casts; [24]). The feed derived background remained relatively stable or declined slightly, based on the chloroplast-derived CLR values (median 0.5 to 1.1). This is also suggested by the CLR values for taxa positively correlated in the sea cage community co-occurrence network (Fig. 2). It is assumed that not all detected reads of these groups purely arise from the feed but could be also received from the tank environment, which was not assessed. The microbial compositions after the warm water phase differed each time and Vibrionaceae populations were less diverse compared to those observed in fish from sea pens. In trials 1 and 2 \u003cem\u003eVibrio\u003c/em\u003e increased in predominance (median CLRs 2.4, 3.1). In trial 2 \u003cem\u003eAliivibrio\u003c/em\u003e exhibited a distinct abundance increase (median CLR \u0026lt;-2.0 to -0.6), while in trial 3 \u003cem\u003eAliivibrio\u003c/em\u003e was the only predominant taxon (median CLR 2.9). The warm water phase was followed by a 4 week \u0026ldquo;recovery\u0026rdquo; phase at 15\u0026deg;C. In samples collected after this phase the proportion of faecal cast samples was between 40-60% for the three trials. Vibrionaceae CLR abundance levels did not increase further, except for \u003cem\u003eAliivibrio\u003c/em\u003e in trial 2 with median CLR -0.6 becoming 1.7, equivalent to 1% of reads increasing to up to 30% of reads. Species-level analysis (as explained above) was also conducted and two OTUs most similar to \u003cem\u003eVibrio scophthlami\u003c/em\u003e made up virtually all Vibrionaceae reads in trial1 1 (99.8% of Vibrionaceae reads; 69.6% of total reads), while the \u003cem\u003eA. finisterrensis\u0026nbsp;\u003c/em\u003egroup (including A2, A9 and A32 groups) made up almost all reads in trial 3 (99.2% of Vibrionaceae reads; 84.1% of total reads). In trial 2 most \u003cem\u003eAliivibrio\u003c/em\u003e reads were closely related to \u003cem\u003eAliivibrio sifiae\u003c/em\u003e or other species in its clade (12.8% of total reads) (Figure 5) or belonged to \u003cem\u003eV. scophthalmi\u003c/em\u003e or a close relative (76.3% of total reads).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eAliivibrio\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;attributes that enable colonisation of the Atlantic salmon gut.\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eOverall, \u003cem\u003eAliivibrio\u003c/em\u003e represented about half of the sequence reads obtained from Atlantic salmon isolates when all the farm cage survey data was combined. \u003cem\u003eAliivibrio\u003c/em\u003e has also been observed in many other surveys of Atlantic salmon, as well as Chinook salmon (\u003cem\u003eOncorhynchus tshawytscha\u003c/em\u003e) [23], as summarised in Supplementary Data Table S1, though the species identification is absent due to the16S rRNA primers being utilised having low resolution. These data prompted an analysis on basic growth and phenotypic properties (Table 2) of the Atlantic salmon strains as well as colonisation traits based on genome annotations. The salmon isolates have several features in common: Gram-negative cell wall; mesophilic growth range (8 to 30\u0026deg;C) with an optimum at 20-25\u0026deg;C; halophilic, optimal growth is with 2-3% NaCl or sea salts; bile salt tolerance (tolerates 1-3% ox bile salts); chitinolytic; and facultatively anaerobic being able to ferment D-glucose. The strains are likely able to respire anaerobically using various alternative electron acceptors based on genome data, including at least nitrate, trimethylamine N-oxide, and fumarate. The strains are able to form biofilms on glass or polystyrene to different degrees, with only the S4TY1 and A2 group strains able to form significant biofilm on polystyrene within 2-3 d (Table 2), and most of the strains are non-bioluminescent except for two strains of the A32 group. One of the key results is that the specific growth rate is relatively slow below 10\u0026deg;C (\u0026le;0.6 d\u003csup\u003e-1\u003c/sup\u003e, Fig. 2). This suggests that \u003cem\u003ein vivo\u003c/em\u003e \u003cem\u003eAliivibrio\u003c/em\u003e in spring and summer when water temperatures are on average 15\u0026deg;C growth rates exceed 1.0 d\u003csup\u003e-1\u003c/sup\u003e while in winter water temperatures (~10-11\u0026deg;C in south east Tasmania) and salmon core body temperature are still well within the biokinetic growth range. The tank experimental results suggest that warm water condition result in relatively rapid colonisation albeit this reflects a situation where fewer species become dominant.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenome annotation data provides indications of colonisation mechanisms.\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn regard to assessment of traits that enable colonisation if the Atlantic salmon gut the focus was placed only on \u003cem\u003eAliivibrio\u003c/em\u003e as well as \u003cem\u003eVibrio scophthalmi\u003c/em\u003e (Table 3) since these taxa show strong colonisation capabilities based on the tank experiments. Most if not all \u003cem\u003eAliivibrio\u003c/em\u003e possess an array of traits that are likely the basis for adherence and virulence in animal hosts and thus the analysis here relies heavily on what has been previously shown for \u003cem\u003eA. fischeri\u0026nbsp;\u003c/em\u003e[36-38], \u003cem\u003eA. salmonicida\u0026nbsp;\u003c/em\u003e[27] and various \u003cem\u003eVibrio\u003c/em\u003e spp., in particular \u003cem\u003eV. cholerae\u003c/em\u003e [39]. A near universal trait for Vibrionaceae is motility, which is needed for initial adherence in the gut as well as spreading throughout [40] [Homma et al. 2022 ]. The salmon associated bacterial strains examined were all motile and based on the genome data this only is driven by polar flagella. Homologs of flagellin genes forming lateral flagella (Laf proteins), which could aid spread in viscous fluids, in or on the host [40] were not found in any \u003cem\u003eAliivibrio\u003c/em\u003e genome. Vibrionaceae also produce pili and a range of other specific proteins to enable stable adherence to host gut cells and mucosa. Lytic chitin monooxygenase proteins LPM010A and LPM010B [27, 41], chitin-regulated pili [42], an MSHA-type pili [43], were found in all \u003cem\u003eAliivibrio\u0026nbsp;\u003c/em\u003estrains and seem to be mechanistic elements for adherence and establishing populations in fish and squid host GI tracts (Table 3). Most salmon isolates also possess genes for curli fibre synthesis (\u003cem\u003ecsg\u003c/em\u003e operon) [44] while 1 or 2 alleles for the tight adherence pili (Tad operon) [45] were present in specific strain groups (A32, S4TY1 groups). Toxin co-regulated pilus genes (\u003cem\u003etcp\u003c/em\u003e operon) [46] were only found in a minority of \u003cem\u003eA. fischeri\u003c/em\u003e strains. Potentially other proteins could be involved as well for adherence as found for \u003cem\u003eV. cholerae\u003c/em\u003e and that are broadly conserved in Vibrionaceae e.g., IlpA/MetQ, OmpU, MAM7/PqiB [47-50]. A homolog of outer membrane accessory colonization factor gene \u003cem\u003eafcA,\u003c/em\u003e which influences spreading in the host [51, 52], is universally present. Homologs of the other accessory colonization genes (\u003cem\u003e\u003cu\u003eafcB\u003c/u\u003e\u003c/em\u003e, \u003cem\u003eafcC\u003c/em\u003e, \u003cem\u003eafcD\u003c/em\u003e), putatively linked to mucin chemotaxis and degradation [53] are not evident in most \u003cem\u003eAliivibrio\u003c/em\u003e strains, but occur as diverged (35-40% identity) homologs. Most of the salmon isolates possess a number of putative mucinases, including YghJ/SslE/AfcD [54, 55] and/or StcE/TagA [56] family lipoprotein metallopeptidases. Adding to a probable capability of colonising and degrading mucin and other proteins making up the gut epithelial layer are putative chondroitinase -like enzymes (polysaccharide lyase family 8). These glycosaminoglycan degradative enzymes are co-located with genes coding enzymes for D-glucuronate, N-acetyl-D-glucosamine and N-acetyl-D-galactosamine degradation in several \u003cem\u003eAliivibrio\u003c/em\u003e species. Chondroitinase activity (\u003cem\u003eeroS\u003c/em\u003e gene) by \u003cem\u003eA. fischeri\u003c/em\u003e has been shown to induce sexual reproduction in a choanaflagellate [56, 57], but the role in colonisation is unclear. The \u003cem\u003eeroS\u003c/em\u003e gene and associated metabolic pathway genes are strain group specific being absent in most of the salmon isolates, except the A2 group. The potential ability to utilize N-acetylneuraminate and other carbohydrates liberated from mucins (N-acetyl-D-glucosamine, D-galactose, L-fucose) is also present in many \u003cem\u003eAliivibrio\u003c/em\u003e species (e.g. the \u003cem\u003e\u003cu\u003enanA\u003c/u\u003e\u003c/em\u003e\u003cu\u003e\u0026nbsp;\u003c/u\u003eoperon [58]). Amongst the salmon isolates the \u003cem\u003enanA\u003c/em\u003e operon is found in the A2 group strains. All genomes surveyed have a \u003cem\u003ekatA\u003c/em\u003e homolog shown to be needed by \u003cem\u003eA. fischeri\u003c/em\u003e for dealing with host-driven peroxide defences [59].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eInferred biofilm formation mechanisms of salmon \u003cem\u003eAliivibrio\u003c/em\u003e include conserved and species-dependent features.\u0026nbsp;\u003c/strong\u003eBiofilm formation and compatibility with the host is likely key for bacteria to establish stable populations in fish. Bacteria not native to the host, such as commercial probiotic strains, may only colonise transiently and less efficiently due to inability to form a stable biofilm [60].\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eAs mentioned above model species, especially \u003cem\u003eA. fischeri\u003c/em\u003e was used as an exemplar based on research on biofilm formation in squid hosts [61]. From this the salmon strains have genes that code proteins required for biofilm establishment, build-up and dispersal as found in \u003cem\u003eA. fischeri\u0026nbsp;\u003c/em\u003efor colonisation of squid hosts [62]. Fundamentally the mechanisms enables population to expand in vivo since the colonising bacteria needs to spread spatially on mucosal surfaces. As found in \u003cem\u003eA. fischeri\u003c/em\u003e and \u003cem\u003eAliivibrio\u003c/em\u003e in general, the salmon isolates have a type I secretion system (T1SS) which delivers the adhesin LapV and proteins of the Lap adhesin delivery system (operon \u003cem\u003elapBCEDG\u003c/em\u003e [62]). In addition the salmon isolates also possess a conserved T2SS for exopolysaccharide (EPS) delivery. EPS in the salmon isolates like that of \u003cem\u003eA. fischeri\u003c/em\u003e includes the syp polysaccharide, coded by the \u003cem\u003esyp\u003c/em\u003e gene cluster which includes defined regulators (e.g. \u003cem\u003evspR\u003c/em\u003e) [63]. Similarly, conserved regulators are present for biofilm matrix formation, such as the quorum sensing/competence repressor HapR/LitR [64,65]. These genes are prevalent in most \u003cem\u003eAliivibrio\u003c/em\u003e species and homologs also occur in \u003cem\u003eV. scophthalmi\u003c/em\u003e suggesting a degree of conservation of the fundamental biofilm formation mechanism. The gene locus of the syp polysaccharide was found to be syntenic in the salmon strains as well as most other \u003cem\u003eAliivibrio\u003c/em\u003e species (data not shown). Beyond conserved traits, several genes were noted to be specific to species or sub-species strain groups (Table 3). These traits likely contribute to colonization in several ways. These could determine host specificity, an area that remains largely unresearched. For example, cellulose synthesis genes (\u003cem\u003ebsc\u003c/em\u003e operon, [66]) are present in genomes of 75% of \u003cem\u003eAliivibrio\u003c/em\u003e genetic groups while homologs for the VPS polysaccharide locus of \u003cem\u003eV. cholerae\u003c/em\u003e [67] were found only in the genomes of salmon colonising \u003cem\u003eAliivibrio\u003c/em\u003e. The VPS polysaccharide contributes to a viscous polysaccharide that enables \u003cem\u003eV. cholerae\u003c/em\u003e and other \u003cem\u003eVibrio\u003c/em\u003e spp. colonisation of a range of ecosystems and hosts [61]. Some genes in this locus are different in the salmon isolates compared to \u003cem\u003eV. cholerae\u003c/em\u003e and the synteny is not fully preserved suggesting the polysaccharide formed conceivably could have different chemical properties. Furthermore, the same strains possess adjacent genes that may regulate colony rugosity and biofilm thickness and structure as found for \u003cem\u003eV. cholerae\u003c/em\u003e (\u003cem\u003erbmABD\u003c/em\u003e, \u003cem\u003erbmC/bap1\u003c/em\u003e) [68]. Many of the indicated systems are regulated by quorum sensing systems controlled by synthesis of different acylated homoserine lactones (AHLs) and autoinducer-2 (LuxS system) [69]. The salmon strains, all possess LuxS and possess genes for two AinS, LasI or LuxI family AHL synthetases [70] (Table 3). This suggests the salmon isolates (and most other \u003cem\u003eAliivibrio\u003c/em\u003e) likely can form an array of quorum sensing-related chemical messengers.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMost salmon associated \u003cem\u003eAliivibrio\u003c/em\u003e species completely lack virulence genes but some possess cytolethal distending toxin genes.\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eVirulence gene distribution was of considerable interest, in particular to discover genes that might be linked to faecal cast production. The survey conducted examined genes flagged generically as virulence factors but also cross-referenced this with proteins known to directly cause cytotoxicity of some form. This includes T6SS systems that have been suggested to sometimes be involved in host virulence as well as interbacterial competition [71]. In this respect, all of the salmon strains possess a T6SS system, except the S2MY1 group, and also possess multiple associated effectors (i.e., \u003cem\u003ehcp\u003c/em\u003e, \u003cem\u003evgrG\u003c/em\u003e) [72, 73]. Strains A9 and A21 possess both \u003cem\u003ehcp\u003c/em\u003e and S-type pyocin-like [74] homologs on a contig that is likely a large plasmid. T6SS is prevalent amongst most other \u003cem\u003eAliivibrio\u003c/em\u003e species. It is so far unknown if T6SS has any effect on hosts directly, however the T6SS in \u003cem\u003eA. fischeri\u003c/em\u003e is used to effectively to become predominant in squid hosts [75]. By comparison toxin genes are sporadically distributed across \u003cem\u003eAliivibrio\u003c/em\u003e. For example, a minority of \u003cem\u003eA. fischeri\u003c/em\u003e strains possess genes for CNF-1, Tdh, Ace, VCC/VvhA-like leucocidin and/or Zot/Zot-like proteins found in various pathogenic \u003cem\u003eVibrio\u003c/em\u003e [52]. Surprisingly, \u003cem\u003ecdtABC\u003c/em\u003e genes coding the subunits for CTD [76] occur in one S2MY1 group strain (S2MY1, but not S3MY1) and all six of the S4TY1 group strains. The gene nucleotide and the amino acid sequences for the three Cdt subunits\u003cem\u003e\u0026nbsp;\u003c/em\u003ewere surprisingly found to be identical between the isolates but are more distantly related to homologs from \u003cem\u003eE. coli\u003c/em\u003e and \u003cem\u003eSalmonella\u003c/em\u003e (~50-55% amino acid homology) and are also distinct from homologs found to occur in a single\u003cem\u003e\u0026nbsp;V. cholerae\u003c/em\u003e isolate 633012 (supplementary data Fig. S5). The genes occur in a region of chromosome II where extensive transposase/integrase gene decay has occurred. The most populous salmon groups (A2, A9 and A32) completely lack any known genes linked to a known cytotoxic function.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eDNA present in feeds, which can confound analysis of fish gut microbiomes, was specifically studied by Karlsen and colleagues [19]. We observed a predominance of Lactobacillales classified reads in feeds, which could derive from feed ingredients but also might be due to deliberate probiotic addition that aids growth of juvenile salmon in hatcheries [77, 78]. The decline in abundance of bacteria that occurs from the fore-gut to the hind-gut as shown with the\u0026nbsp;DCLR data (Figure 6) could be due to Vibrionaceae, \u003cem\u003eMycoplasma\u003c/em\u003e and other bacterial populations increasing across the same sections. We cannot exclude the possibility many bacteria could be transiently colonising and growing to lesser extent in the digesta as well as in the mucosa. A group of bacteria were found to show increased abundance in the digesta in the hind-gut relative to the fore gut digesta during winter while seawater specialist taxa do the same in summer. There is a distinct possibility the abundance increase could be due to water concentration effects. Since intestinal residence time is longer at lower temperatures [35] there is more time for water absorption within the gut especially in the foregut area (pyloric caeca). The \u0026ldquo;drinking\u0026rdquo; rate is increased in salmon adapted to seawater and during active feeding and is used for the purposes of osmoregulation [79] maintaining a level of salinity in the gut lumen. This occurrence has been suggested a reason that presumably seawater dwelling Vibrionaceae are able to colonise the gut [80]. In addition, this process affects digesta water content with summer fish having more water content in their digesta than those examined during the winter [16] potentially due to the residence time difference [35]. The seawater specialists observed are common in Tasmanian waters during summer but less common in winter when ammonia-oxidizing and rhodopsin-containing heterotrophic archaea are more predominant [81]. Since most sea-going wild salmon and those that have returned to rivers also possess considerable levels of \u003cem\u003eVibrionaceae\u003c/em\u003e (Supplementary data Table S1, [82]), colonisation by Vibrionaceae is clearly a natural process and certainly not a peculiarity of aquaculture systems. An interesting observation made here is that \u003cem\u003eAliivibrio\u003c/em\u003e, \u003cem\u003eMycoplasma\u003c/em\u003e and probably also \u003cem\u003eVibrio scophthalmi\u003c/em\u003e-related strains are the only taxa able to colonise the mucosa, at least for the data utilised here. This specificity likely requires a chemotactic element not simply a random process of water transfer. Also interesting is the fact that few if any of the taxa \u0026nbsp;that show an increase in the hindgut digesta during winter (\u0026ldquo;digesta associated\u0026rdquo; in Figure 6) are marine specialists or even halophilic. Of the 14 taxa of this set shown in Figure 6 only \u003cem\u003ePseudoalteromonas\u003c/em\u003e is mostly found only in marine environments and requires salt for growth. The other taxa are not specifically associated with marine ecosystems and might be considered ubiquitous. The most abundant of these taxa were OTUs closely related to the species \u003cem\u003eCutibacterium acnes\u003c/em\u003e and \u003cem\u003ePelomonas saccharophila\u003c/em\u003e. The first species is a major member of the skin microbiome and found associated with a range of fish species, potentially as a pathogen [83] while \u003cem\u003eP. saccharophila\u003c/em\u003e and its relatives are common in the gut of fish and other vertebrates from freshwater to brackish ecosystems (e.g. 23, 84]. More research is needed to determine where the \u0026ldquo;digesta-associated\u0026rdquo; bacteria actually come from. The taxa are likely able to survive in smolt that have undergone smoltification as well as marine transfer due to being able to grow at the environmental temperatures (10-20\u0026deg;C), halotolerant and able to tolerate basic host defences, such as bile secretions. The digesta associated taxa do not seem to derive from the feed but do show an association with feed, possibly because they are largely restricted to the digesta. In regards, to mucosal colonising taxa this study indicates there are other important deciding factors, one of the clearest being that the taxa involved have traits that allow them to actively colonise and thrive in the salmon GI tract, not merely persist. The data presented here also suggests that faunal GI tracts are their preferred habitat. The species that colonise are not random in nature and can be defined and studied.\u003c/p\u003e\n\u003cp\u003eA large proportion of abundant Lactobacillales OTUs originated in the feed, as did many other typically gut-associated anaerobic taxa. Most if not all of these probably arise from trace DNA in the feed ingredients due to the dilution trend they demonstrate between gut sections. Trace bacterial DNA levels in feeds is very poorly researched and most analysis veers towards the presence of harmful bacteria [85]. Because feeds are sourced from raw ingredients from many supply chains, especially with the push towards improved industry sustainability it would be expected that the bacterial DNA present will vary considerably and also lead to a high level of background diversity. Of the \u0026gt;3500 OTUs detected in the samples [16] as much as 90% could be just from diet DNA with the vast majority only occurring at very low abundances. As feed is extruded and steam cooked (~120\u0026deg;C, 20 min) when made into pellets most feed bacterial DNA is likely from remnant cells though various thermoduric spore-formers may remain viable, e.g. \u003cem\u003eGeobacillus\u003c/em\u003e, \u003cem\u003eUreibacillus\u003c/em\u003e [22]. DNA could also be contributed to bacteria covering the surface of feed when it is stored, though the low water activity would be restrictive to growth.\u003c/p\u003e\n\u003cp\u003eOur focus on the V1-V3 region of 16S rRNA genes supported by addition of gene variants from isolate genome sequences helped to improve pinpointing colonising taxa and defining their diversity. This approach was successful for \u003cem\u003eAliivibrio\u003c/em\u003e but much more work is needed to examine other possible colonists , besides \u003cem\u003eMycoplasma\u003c/em\u003e [25]. Full length 16S rRNA gene sequences is required for such analysis, in particular for \u003cem\u003eA. sifiae\u003c/em\u003e, \u003cem\u003eA.logei\u003c/em\u003e, \u003cem\u003eA. salmonicida\u003c/em\u003e and related species with placeholder designations [34]. Taxonomically unresolved \u003cem\u003eAliivibrio\u003c/em\u003e spp., along with \u003cem\u003eA. fischeri\u003c/em\u003e, were readily detected in most salmon samples of this study. Thus the data suggests \u003cem\u003eAliivibrio\u003c/em\u003e as a whole is adapted to be able to colonise Atlantic salmon and presumably other fish. The array of taxa found in this study could be peculiar to Tasmanian waters, different species likely are \u0026nbsp;important colonists in salmon in other regions of the world.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eAs the data analysed here included summer and winter sampling and there was also concern of longer term implications of ocean warming since temperature seems a key factor when considering fish host colonisation. In colder waters, typical for northern hemisphere salmon farming regions, the species of Vibrionaceae detected will most likely differ from those observed here. Based on summer and winter data the salmon Vibrionaceae taxa observed in this study seem to prefer comparatively warmer conditions, but persist in the Tasmanian winter, which is relatively warm (10 \u0026ndash; 12\u0026deg;C) compared to sub-Arctic salmon farming regions. This is suggested by the slow build-up of populations and the peak level of biomass being mostly maintained after the first summer (as shown in Fig. 2, and also discussed in [20]). Some \u003cem\u003eAliivibrio\u003c/em\u003e and \u003cem\u003ePhotobacterium\u003c/em\u003e taxa seem to have higher relative abundances in winter than summer (Fig. S4). By comparison most if not all \u003cem\u003eVibrio\u003c/em\u003e spp. preferred summer conditions (Fig S4) based on the abundance trends. The neutral response between summer and winter by the abundant \u003cem\u003eAliivibrio\u003c/em\u003e colonisers is possibly due to these taxa being well-established in the gut mucosal layer. The persistence in the gut may also be aided by external temperatures still being growth permissive even though growth rates are relatively slow. In salmon production areas, such as Norway, taxa adapted to the lower temperatures (psychrotolerant or psychrophilic species) of sub-polar waters could be more predominant. We hypothesise that which species end up being most common is also driven by the ability to successfully compete, for example using T6SS systems. T6SS and associated effector proteins (Hcp, VgrG, MIX family) were found in most \u003cem\u003eAliivibrio\u0026nbsp;\u003c/em\u003egenomes (Table 3) and are suspected to shape the intestinal microbiomes of fish [85]. \u003cem\u003eAliivibrio\u003c/em\u003e seems widespread in wild and marine farmed salmonids due to being a good competitor. For example, in chinook salmon grown in marine farms in New Zealand, which has similar water temperatures as Tasmania, \u003cem\u003eAliivibrio\u003c/em\u003e was abundant in stripped faecal samples [23]. However, \u003cem\u003ePhotobacterium piscicola\u003c/em\u003e was also highly abundant and even present in fish reared in alpine canals and in hatcheries [23], suggesting a combination of colonising bacterial and host features could be influential in what species occur.\u003c/p\u003e\n\u003cp\u003eWe have hypothesised previously\u003cem\u003e\u0026nbsp;Aliivibrio\u003c/em\u003e colonisers are a possible cause of the production of faecal casts in fish sampled during summer [16]. Faecal cast production in finfish has been attributed to disease or stress [86-90]. The expected higher growth rates and biomass of \u003cem\u003eAliivibrio\u003c/em\u003e and \u003cem\u003eVibrio\u003c/em\u003e spp. in summer may increase the risk of dysbiosis or disease, but this relies on the species having some capacity to affect the host negatively. At this point in time the causal relationships remain completely unclear. The tank trials were intended to create a situation in which fish were thermally stressed and it was found that the thermally stressed experimental fish had high faecal cast production, at least equal or higher than what was found for sea pen fish in summer [16, 24]. The experiments could demonstrate certain \u003cem\u003eVibrionaceae\u003c/em\u003e respond strongly to warm water conditions alongside the high incidence in faecal cast production. However, different species predominated in each of the three trials performed. Thus at this stage no conclusion can be made so far on whether Vibrionaceae are specifically responsible for inducing faecal cast production or it is instead a more general response. A cell biology-based approach is needed to unravel these phenomena. A survey of the genomes of the salmon isolates and other \u003cem\u003eAliivibrio\u003c/em\u003e species provides an indication of the range of possible colonisation-relevant mechanisms and traits that these bacteria possess. However, the data does not provide a \u0026ldquo;smoking gun\u0026rdquo; for dysbiosis or other forms of deleterious host interactions as we simply know too little at this stage. The results indicated \u003cem\u003eAliivibrio\u003c/em\u003e possess various colonisation-relevant genes as a whole but there are also group or species specific genes. This suggests that coloniser genetic groups seem to have particular features that could result in colonisation specificity and preferences. Many features are also shared with \u003cem\u003eVibrio scophthalmi\u003c/em\u003e, a very successful coloniser of fish that is sometimes an opportunistic pathogen [91]. The differences that could be highlighted may affect adherence, mucin/mucosal interactions, signal transduction, and biofilm structure within different hosts thus determining specificity, success rate and persistence. The mechanisms of colonisation are presently obscure but the data is suggestive of some proteins that could be further researched in this respect. For example, putative mucinases were detected in the salmon colonisers. The \u003cem\u003eVibrio cholerae\u003c/em\u003e HapA mucinase facilitates penetration and detachment into the mucosal layer and also may release substrate sugars and amino acids [92]. Few of the Atlantic salmon isolates seem to be able to degrade neuraminate, a major glycocomponent of intestinal mucins of Atlantic salmon [93]. Mucinase activity by coloniser strains could instead mainly allow persistence in the mucosal layer [92]. However, the coloniser community combined mucinase secretion activity could liberate a range of glycopeptides, amino acids, and sugar residues that can be used as nutrients by the microbiome as a whole. In this respect all coloniser strains could grow on chitin and possessed chitinolytic enzymes (e.g., LPMO10A, LPMO10B, Table 3) shown to be important in mucosal layer adherence and required for virulence in some strains [27, 41]. Gut mucins of Atlantic salmon typically contain N-acetyl-D-glucosamine [94] and it seems some chitinases are able to remove these residues from mucin [27]. Salmon mucin is also rich in galactose residues and from the genome data most of the salmon isolates were found to possess the Leloir galactose metabolism pathway based on the PANNZER-based annotations. Interestingly, salmon isolate groups could synthesise multiple types of polysaccharide that may be involved in colonisation (syp, VPS and cellulose, Table 3), but it is unknown how they co-contribute during colonisation. \u003cem\u003eAliivibrio\u003c/em\u003e genetic diversity may also impact other biological aspects of colonisation, such as quorum sensing regulation. The types of AHL synthetases differed between the coloniser genetic groups and can even differ within the same group, for example the A32 group strains have either LuxI or AinS family AHL synthetases. \u003cem\u003eAliivibrio\u003c/em\u003e strains are known to produce an array of chemical messengers [70] due to possessing multiple AHL synthetases (Table 3) and also the LuxS system. In terms of the gut ecosystem \u003cem\u003eAliivibrio\u0026nbsp;\u003c/em\u003estrains may be able to respond to the signals from other strains allowing rapid responses in \u0026nbsp;gene regulation simultaneously maximising fitness and competitiveness during both colonization [95]. Potentially linked to signal transduction are potentially pathogen-like functions where some colonists exploit host cells. Virulence gene occurrence amongst \u003cem\u003eAliivibrio\u003c/em\u003e species is sporadic and less conserved than other traits examined (Table 3). The occurrence of CDT-gene positive strains in some salmon isolates is intriguing, but raises many questions. Are the genes expressed \u003cem\u003ein vivo\u003c/em\u003e? Do they have a functional role that does not involve harming the host \u0026ndash; for example aiding persistence in the salmon gut or are they merely unstable genes derived from recent horizontal gene transfer events? The distribution of CDT is presently unknown in marine bacteria but is likely extremely rare. The fact the genes are identical between two different \u003cem\u003eAliivibrio\u003c/em\u003e genetic groups suggests lateral gene transfer involved the same source and occurred in a similar time frame. The genomic region the \u003cem\u003ecdtABC\u003c/em\u003e operon was found to be rich with pseudogenes, mainly remnant transposase genes. This suggests the transfer of genes could have been within a mobile element that is now decayed.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions.\u003c/strong\u003e Since specific Vibrionaceae occur in high abundance in the GI tracts of Atlantic salmon (farmed in Tasmania) they can be construed as being non-pathogenic to the fish. The farm surveys and controlled tank experiments done here revealed a restricted range of species, mostly novel, are robust colonisers of Atlantic salmon and could be a focus for future studies related to Atlantic salmon gut function and health. The most common \u003cem\u003eAliivibrio\u003c/em\u003e strain groups lacked any obvious virulence factors, which is good news but at the same time other relatively abundant species were found to have specific virulence genes. Understanding the significance of such genes in relation to Atlantic salmon health and productivity as well as the biology of gut colonisation is a logical next step. Combining temporal sampling with the genome biology of colonising isolates proved very useful in defining the dynamics of colonising bacteria and also defined traits that may be relevant to salmon health and welfare. The results, however, provide no clear leads for the cause of faecal casts in salmon. This is hampered by the fact many aspects of Atlantic salmon gut function relevant to microbiome interaction-influence require basic investigation. Nevertheless, the findings revealed interesting and complex traits amongst different \u003cem\u003eAliivibrio\u0026nbsp;\u003c/em\u003espp. genetic groups that likely contribute to their success in colonisation of salmon and presumably other marine fauna. Overall, the findings fundamentally help clarify approaches needed in order to study microbiomes of farmed fish, for example feed analysis alongside typical samples helped clarify the components of the microbiome possible source and significance to a degree. Analysis of surrounding water could also be useful in the same capacity\u0026nbsp;\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eSea pen sampling\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFor sea pen derived fish, data in this study included several different surveys performed between 2010 and 2018. Four of these surveys have been previously published and where the purpose of the research was to understand the effect of diet, faecal consistency and short term sampling [16, 20, 24], while further data were obtained from another study which compared microbiome of salmon to farm-associated Australian fur seals (\u003cem\u003eArctocephalus pusillus doriferus\u003c/em\u003e) [96] (Table 1). In each studied cohort, smolt had been put to sea over winter (June to August). Samples were collected between 4 to 56 weeks after smolt transfer digesta samples were obtained by faecal stripping as previously described [16, 20, 24]. In the case of samples obtained from Reid et al. [16] fish were also euthanised and dissected to obtain both gut mucosa and digesta samples. Feed samples were collected from automatic feeders by transferring directly to sterile zip lock bags. All samples were kept frozen at -80 \u0026deg;C until processed. Animal ethics permits and data deposition accession codes are provided in Table 1.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTemperature-based experiments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTemperature-based experiments were run in three successive years (2016 to 2018) where Atlantic salmon were reared under elevated temperature conditions. Experiments were performed at the Experimental Aquaculture Facility of the University of Tasmania, Taroona, Hobart which is a multi-tank RAS system which utilises 1\u0026nbsp;mm filtered seawater from the Derwent Estuary at a daily 10% exchange rate Water quality is maintained using a combination of protein skimmers and a series of treatment steps including \u0026lt;40\u0026nbsp;mm drum filtration, ammonia removal via nitrification-based biofilters, and UV light irradiation. For this series of experiments operating conditions used were similar to that described by Foddai et al. [97]. Smolt, adapted to seawater in the hatchery were transferred to a 13000 l seawater tank and fed until they reached an average weight of ~1.5 kg. Fish were then evenly distributed between twelve 7000 l tanks in a common RAS system with a stocking density of 50-100 fish per tank and photoperiod set at 12:12 (light:dark hours). The tanks were maintained at 15\u0026deg;C for 25-28 d. Tank temperatures were then increased at 0.1\u0026deg;C per day over 7 weeks to reach on average 18.5-19.0\u0026deg;C and maintained at this temperature for at least 10 weeks or until fish ceased feeding. Tank temperatures were then reduced to 15-16\u0026deg;C for 2 to 4 weeks. Fish were stripped of faeces at the end of each phase, with samples collected into sterile 15 ml Falcon tubes. Tubes were snap frozen and then stored in liquid nitrogen until transported to the laboratory where they were transferred to -80\u0026deg;C storage. Fish were fed commercial diets continually throughout.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDNA extraction of samples and sequencing.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDNA was obtained from faecal and feed samples (0.25 g frozen weight) using QIAamp Fast DNA Stool Mini Kits (Cat. No. 51604, Qiagen) following the manufacturer\u0026rsquo;s protocol. Resultant DNA concentration and purity were estimated using a Nanodrop 888 instrument (ThermoFisher). Sequencing was performed at the Ramaciotti Centre for Genomics, University of NSW, Sydney, Australia using the Illumina MiSeq platform as previously described [16, 20, 24, 96]. 16S rRNA genes were amplified using V1/27F (5\u0026rsquo;-AGA GTT TGA TYM TGG CTC AG-3\u0026rsquo;; [98]) and V3/519R (5\u0026rsquo;-GWA TTA CCG CGG CKG CTG-3\u0026rsquo; [99]) primers for all samples from this study as noted in Table S1.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSequence processing and classification\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe Illumina pipeline used automatically trimmed adaptors from the 3\u0026rsquo; prime end of sequences. Paired end reads were joined in Seed 2 [100] using FastqJoin 1.1.2. The joined files were then quality filtered in SEED2 (using Mothur 1.34.4) without pre-clustering, yielding reads with mean median quality scores of \u0026ge;35 (range 35 to 39). This resulted in loss of on average 20% of joined reads. FASTA files of the filtered reads were generated and then processed by VSEARCH [101] to remove putative chimeric sequences and to create a list of reads clustered at 1% dissimilarity. The output cluster FASTA files from different surveys were then combined into a single FASTA file in SEED2 and the process of clustering and chimera removal was repeated to create a single non-redundant OTU dataset covering all the samples. The OTU list was then classified using megaBLAST v. 2.2.26+ against the Silva 138.1 non redundant 16S rRNA gene database [102] in SEED2. Further taxonomic detail was obtained by utilising 16S rRNA gene variants from genome sequence data obtained in this study, focusing on the V1-V3 region. The V1-V3 region of isolate genome-derived 16S rRNA genes (detected by BARRNAP, see below) after being clustered at a 1% resolution were added to the Silva 138.1 database prior to the final classification steps. The classified non-redundant salmon-derived reads were then converted to a custom database in SEED2 using makeBLSTdb v. 2.2.26+ and then used to classify reads in individual samples (again at 1% dissimilarity) resulting in an OTU table. Supplementary datafiles 1 and 2 includes the OTU tables, proportions and other information for each farm survey and the EAF tank trials for which the classification are collapsed to the genus level and grouped at the order level. A more granular dataset is available for members of family Vibrionaceae at the individual OTU level (Supplementary datafile 1).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCo-occurrence network analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe goal was to determine the structure of the overall salmon farm data and determine influence of feed and water DNA. In order to create a co-occurrence network the taxonomic data used to from nodes is described at the order level, except specifically for the genera \u003cem\u003eAliivibrio\u003c/em\u003e, \u003cem\u003eVibrio\u003c/em\u003e, \u003cem\u003ePhotobacterium\u003c/em\u003e and \u003cem\u003eMycoplasma\u0026nbsp;\u003c/em\u003edue to these taxa making up relatively large proportion of the reads. Feed-derived plant chloroplasts and mitochondria 16S rRNA gene reads were pooled to form separate data nodes. By pooling specimens from individual fish from each collection time (as specified in Table 1) the variance and high sparsity in OTU profiles between individual fish was homogenized. Pearson product moment correlations were generated in SPSS v. 29 (IBM) between pooled data, all marine surveys but not the tank trial data for each taxonomic group Correlations were imported into Gephi 0.10.1 (\u003ca href=\"https://gephi.org/\"\u003ehttps://gephi.org/\u003c/a\u003e; [31]) to visualise the relations with size of nodes (n = 32) representing overall relative abundance across all reads and the thickness and colour of edges (n = 259) based on the strength (\u0026ge;0.4) and nature of the correlations.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnumeration, isolation and 16S rRNA gene analysis of salmon gut bacteria\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eEnumeration of bacteria from Atlantic salmon digest utilised marine agar (MA - 0.5% w/v Bacto-peptone, 0.2% w/v yeast extract, 3.5% w/v seawater salts, 1.5% w/v agar) and Thiosulfate Citrate Bile Sucrose agar (TCBS, Oxoid). Samples for total viable count (TVC) data is from unpublished data from surveys performed in 2010/2011, 2011/2012 and 2014/2015 (Table 1) since these covered a wide range of times and used exactly the same protocol as described here. This protocol involved fixed wet weight amounts of TVC faecal samples (typically 0.2 to 1.0 g) being suspended and serially diluted in 3% (w/v) sterile seawater salt solutions, spread onto the surface of MA and TCBS and then incubated at 25\u0026deg;C for up to 7 d. Counts were calculated as colony forming units (CFU) per g of faeces (wet weight). For various salmon samples (mainly obtained between 2015/2016 to 2017/2018) bacterial isolates were obtained onto TCBS or MA. For MA the medium used contained either no antibiotics or was supplemented with either 10 or 100\u0026nbsp;mg/ml of oxytetracyline, trimethoprim or tylosin (Sigma-Aldrich). Individual colonies were picked from MA and TCBS plates and purified on MA. Pure cultures were cryopreserved in marine broth that included 30% (v/v) glycerol at -80\u0026deg;C or at 4\u0026deg;C on thick MA plates wrapped in petrifilm. DNA was extracted from each strain using the Ultraclean Microbial DNA Extraction kit (Qiagen). 16S rRNA sequence gene analysis was based on 10 pmol/ml 27F and 1492R (GGT TAC CTT GTT ACG ACT T; [98]) primers using MyTaq PCR reagent (Bioline) and using 1\u0026nbsp;ml (20-50 ng) of template DNA. Thermocycler (Peltier PTC200, MJ Research) conditions used were 95\u0026deg;C 1 min (1 cycle); 95\u0026deg;C \u0026ndash; 30 s, 50\u0026deg;C \u0026ndash; 30 s, 72\u0026deg;C \u0026ndash; 30 s (34 cycles); 72\u0026deg;C \u0026ndash; 10 min (1 cycle); 10\u0026deg;C soak. PCR products were purified and then sequenced using BigDye chemistry using an AB3730xl sequencer instrument (Applied BioSytems). Sequence data were aligned and end regions trimmed to remove poorly resolved base calls. Along with reference sequences, phylogenetic trees were generated using the BioNJ algorithm in NGphylogeny.fr [103] and visualised with Interactive Tree of Life [104].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eGrowth analyses and biofilm formation ability\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe ability to grow at a range of temperatures and salinity levels was assessed using agar and broth cultures. For broth cultures isolates tested were diluted to 10\u003csup\u003e4\u0026nbsp;\u003c/sup\u003eto 10\u003csup\u003e5\u0026nbsp;\u003c/sup\u003eCFU/ml in liquid media arrayed into L-shaped 15 ml test tubes trays containing either marine broth for temperature assessment (2\u0026deg;C to 40\u0026deg;C) or marine broth in which sea salts were replaced by different concentrations of NaCl (0 to 10% NaCl). Bile salt tolerance was assessed similarly with marine broth supplemented with bile salts no. 3 (0 to 5%, Oxoid). Optical density readings were taken regularly using a Spectronic 200 (ThermoScientific). A custom-built aluminium block temperature gradient incubator (Terratec, Kingston, Tasmania) was used to assess biokinetic responses as previously described [105]. The ability of isolates to form biofilms were assessed using the crystal violet assay in 96 well polystyrene trays and on acid-washed glass surfaces as previously described [106, 107]. The motility of cultures (incubated in marine broth for 40 to 72 h at 20\u0026deg;C) was tested under phase contrast microscopy using wet mounts. Chitinolytic activity was assessed using 1% w/v colloidal chitin in MA poured as thin layer on a MA base. The appearance of clear zones around colonies was indicative of chitinolytic activity.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenome assembly and annotation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eGenome sequence data were obtained using either the Illumina HiSeq or the NovaSeq 6000 platforms in which 200 or 250 bp pair end sequences were generated. Fastq files were uploaded onto the Galaxy Australia cloud server and assemblies generated using Unicycler v. 0.050 and samtools v. 1.15.1 [108]. Genomes were then annotated using the PANNZER2 server [109]. Non-coding RNA genes were detected using BARRNAP v. 0.9 (To\u003ca href=\"file:///C%3A/Users/john/AppData/Roaming/Microsoft/Word/rsten%20Seemann,\"\u003ersten Seemann,\u003c/a\u003e https://github.com/tseemann/barrnap) as implemented in Galaxy.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenome-based taxonomy\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eGenomes were compared using ortho-ANI [32] and GGDC 3.0 model 2 [33] to discern putative species level groups assuming 95% and 70% demarcate approximate boundaries for species, respectively. Similarity values from both approaches were used to create dendrograms in Primer 7 (Primer-E, Auckland, New Zealand) using the complete linkage method. The 16S rRNA genes directly amplified from isolates and those annotated in genomes were compared including determination of variants from the genome data using BARRNAP v. 0.9. Estimates of copy number were obtained using RasperGade16S [110] in R Studio. The V1 to V3 regions of sequences from isolates and available genomes of other \u003cem\u003eAliivibrio\u003c/em\u003e species, as defined by Klementsen and colleagues [34], were collated and added to Silva 138.1 and the custom created 16S rRNA databases as described above.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompositional and differential abundance analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFor comparison of relative abundances bacteria taxa enriched in digesta and mucosal samples in different parts of the gastrointestinal tract of Atlantic salmon [16] and from the tank trials the read abundances of individual OTUs were transformed to centred log ratios (CLR) [111]. This allowed pairwise assessment of OTUs that are enriched either in gut section digesta or mucosa samples collected in summer and in winter. A major challenge for this analysis was the high number of zero values. To deal with this low abundance taxa were excluded and pseudocount of 1 was then applied as a conservative approach. Since the samples to be compared were paired, with each dataset comparison possessing 27 paired samples per OTU, the Wilcoxon signed rank test was used. Assessment of the data indicated that as the OTU occurrence declined asymmetry tended to increase since the pseudocount generated small negative numbers. The Mann Whitney U test was thus also performed to help eliminate false positives. Nevertheless, meaningful changes occurring in OTU abundances as indicated by the average of differences between paired CLR (DCLR) were large. False discovery rate (FDR) testing of the Wilcoxon (CLR) p-values, using the method of Benjamini and Hochberg [112], indicated OTUs with nominal significance (\u0026lt;p=0.05) was achieved with paired\u0026nbsp;DCLR values of \u0026ge;0.4/\u0026le;-0.3, corresponding to large effect sizes (\u003cem\u003er\u0026nbsp;\u003c/em\u003e\u0026ge; 0.5) [113].\u0026nbsp;DCLR values for abundant OTUs with FDR adjust \u003cem\u003ep\u003c/em\u003e-values \u0026lt;0.05 were arrayed into a heat map in order to show broader patterns of abundance changes through gut sections. The overall paired dataset results and OTU\u0026nbsp;DCLR values across the paired datasets was hierarchically clustered using complete linkage and assuming an un-centred correlation.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eColonisation and virulence based features annotated from genome data\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eGenes associated with host colonisation associated phenotypes, including adherence, biofilm formation, quorum sensing, interbacterial competition and host-directed virulence were surveyed in \u003cem\u003eAliivibrio\u003c/em\u003e as well as \u003cem\u003eVibrio scophthalmi\u003c/em\u003e genomes. This survey was based on mechanistic studies of gene and protein function performed to date in mostly \u003cem\u003eA. fischeri\u003c/em\u003e and \u003cem\u003eV. cholerae\u003c/em\u003e, coupled to data gleaned from the online databases KEGG [114] and VFDB [115]. The presence of target proteins for this survey was assessed using protein comparisons using BLAST-P in NCBI with confirmation sequences matched on the basis of similarity (\u0026gt;40%), length (\u0026gt;90%) and conserved domain structure. NCBI database contains 5 available assembled \u003cem\u003eV. scophthalmi\u0026nbsp;\u003c/em\u003egenome sequences which were used these analyses.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eAHL: acylated homoserine lactone\u003c/p\u003e\n\u003cp\u003eANI: average nucleotide identity\u003c/p\u003e\n\u003cp\u003eBLAST: Basic Local Alignment Search Tool\u003c/p\u003e\n\u003cp\u003eCFU: colony forming units\u003c/p\u003e\n\u003cp\u003eCLR: centred log ratio\u003c/p\u003e\n\u003cp\u003eDCLR: centred log ratio difference (between paired samples)\u003c/p\u003e\n\u003cp\u003eCDT: cytolethal distending toxin\u003c/p\u003e\n\u003cp\u003eGGDC: genome-to-genome distance calculator\u003c/p\u003e\n\u003cp\u003eKEGG: Kyoto Encyclopedia of Genes and Genomes\u003c/p\u003e\n\u003cp\u003eLPMO: lytic polysaccharide monooxygenase\u003c/p\u003e\n\u003cp\u003eMA: marine agar\u003c/p\u003e\n\u003cp\u003eMSHA: mannose-sensitive hemagglutinin (pili/fimbriae)\u003c/p\u003e\n\u003cp\u003eOTU(s): operational taxonomic unit(s)\u003c/p\u003e\n\u003cp\u003ePANZZER: Protein Annotation with z-Score\u003c/p\u003e\n\u003cp\u003eRAS: recirculation aquaculture systems\u003c/p\u003e\n\u003cp\u003eT1SS, T2SS, T6SS: type (I, II or VI) secretion system\u003c/p\u003e\n\u003cp\u003eTCBS: thiosulfate citrate bile sucrose agar\u003c/p\u003e\n\u003cp\u003eVFDB: Virulence Factor Database\u003c/p\u003e\n\u003cp\u003eVPS: Vibrio polysaccharide (of \u003cem\u003eV. cholerae\u003c/em\u003e)\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe raw 16S rRNA gene sequence data and metadata files are deposited at the NCBI SRA database under the BioProject codes listed in Table 1. \u003cem\u003eAliivibrio\u003c/em\u003e and \u003cem\u003ePhotobacterium\u003c/em\u003e genome sequence data are deposited in the NCBI database under WGS project codes WBVP00000000 (\u003cem\u003eA. finsterrensis\u003c/em\u003e LMG 23689), SEZJ00000000 to SEZQ00000000 (\u003cem\u003eAliivibrio\u003c/em\u003e strains A32,A46, A37, A26, A21, A15, A9, A33, A4, A2), JARACN00000000 to JARACX00000000 (\u003cem\u003eAliivibrio\u003c/em\u003e strains S2MY1, S3MY1, S4MY1, S4TY1, A6, S2TY2, S3TY1, S4MY2, S4MY3, S4MY4, S4TY2), and JAYXUB00000000-JAYXUK00000000 (\u003cem\u003ePhotobacterium piscicola\u0026nbsp;\u003c/em\u003estrains S1MW1, S2TG4, S4MY1, S5TY1; \u003cem\u003eP. toruni\u0026nbsp;\u003c/em\u003estrains S2MW2, S3MW1; S4TG1).\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eOECD-FAO Agricultural Outlook, 6 July 2023. 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Nucleic Acids Res. 2022;50:D912-D917. https://doi.org/10.1093/nar/gkab1107.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003e\u003cstrong\u003eTable 1.\u003c/strong\u003e Experimental datasets utilized in the study including design, data sources and related information.\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1096\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eExper-iment-type\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eLocation of sampling\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e16S rRNA gene primers used\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eSequencing method\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eTime period samples collected (timepoint number)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eNumber of samples per time point\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eFish weigh range (kg)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eReads per sample: average (range)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eReference\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eNCBI sequence read accession code\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eAnimal ethics approval no.\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eFarm-based\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eMeads Creek, Port Esperance (1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eV3-V5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePyroseq-uencing\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eAug 2010 \u0026ndash; Apr 2011 (5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e20, 49, 50, 50, 50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e0.4-4.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e3900 (654-21356)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePRJNA1021267\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eDPIPWE 30/2009-10\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eFarm-based\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eRobert\u0026rsquo;s Point lease, D\u0026rsquo;Entre- casteaux Channel (2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eV3-V5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePyroseq-uencing\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eJul 2011 \u0026ndash; Aug 2012 (9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e6, 12, 12, 11, 12, 11, 10, 12, 12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e0.5-1.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e3994 (489-13691)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePRJNA1021267\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eUTAS A0012001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eFarm-based\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eNorth West Bay (3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eV3-V5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eIllumina MiSeq\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eNov 2013 \u0026ndash; Jun 2014 (3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e9, 8, 11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eNot available\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e146271 (22193-404791)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eThis study\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePRJNA1021367\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eUTAS A0013971\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eFarm-based\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eRed Cliffs, D\u0026rsquo;Entrecasteaux Channel (4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eV1-V3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eIllumina MiSeq\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eMar 2014 \u0026ndash; Jun 2014 (3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e64, 49, 76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e1.2-2.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e221637 (6932-627716)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePRJNA979964\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eUTAS A0013971\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eFarm-based\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eNorth West Bay (3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eV1-V3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eIllumina MiSeq\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eJan 2015 \u0026ndash; Apr 2015 (3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e22, 29, 18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eNot available\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e55446 (1240-118582)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eThis study\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePRJNA1021684\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eUTAS A0013971\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eFarm-based\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eSoldier\u0026rsquo;s Point, D\u0026rsquo;Entre-casteaux Channel(5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eV3-V5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eIllumina MiSeq\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eDec 2015 \u0026ndash; May 2016 (4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e16, 30, 21, 11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eNot available Not available\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e31740 (1254-81741)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eThis study\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePRJNA1021687\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eUTAS A0015452\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eFarm-based\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eRed Cliffs, Shep-pards leases, D\u0026rsquo;Entre-casteaux Channel(4, 6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eV1-V3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eIllumina MiSeq\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eJan 2018, Jul 2018 (2)\u003csup\u003ea\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e182, 196\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e2.1-2.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e13820 (602-51163)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePRJNA1025921,\u003c/p\u003e\n \u003cp\u003ePRJNA1026149\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eUTAS A0016307 A0016588, A0017010\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eFarm-based\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003efeed pellets\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eV1-V3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eIllumina MiSeq\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eJan 2018 \u0026ndash; Jul 2018\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e13727 (6999-31697)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eThis study\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePRJNA1025868\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eNot applicable\u003c/p\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eTank-based\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eEAF, Taroona\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eV1-V3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eIllumina MiSeq\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eApr to Sep 2016: 15\u0026deg;C (initial), 19\u0026deg;C (10 weeks), 15\u0026deg;C (4 weeks) (3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e9, 59,26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026ge;1.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e13102 (1276-26560)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eThis study\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePRJNA1023021\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eUTAS A0015452\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eTank-based\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eEAF, Taroona\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eV1-V3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eIllumina MiSeq\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eApr to Sep 2017: 15\u0026deg;C (initial), 19\u0026deg;C (10 weeks), 15\u0026deg;C (4 weeks) (3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e10, 36, 36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026ge;1.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e1038087 (35938-318200)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eThis study\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePRJNA1023026\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eUTAS A0015452\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eTank-based\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eEAF, Taroona\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eV1-V3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eIllumina MiSeq\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eApr to Sep 2019: 15\u0026deg;C (initial), 19\u0026deg;C (10 weeks), 15\u0026deg;C (4 weeks) (3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e23, 57, 11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026ge;1.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003e111731 (4091-416609)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eThis study\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003ePRJNA1023294\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.090909090909092%\" valign=\"top\"\u003e\n \u003cp\u003eUTAS A0015452\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003csup\u003ea\u003c/sup\u003eSamples were collected from fore-gut, mid-gut, and hind-gut digesta and mucosa as well as by faecal stripping in the 24 h period after fish fed (Reid et al. 2023).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2.\u003c/strong\u003e Phenotypic data for \u003cem\u003eAliivibrio\u003c/em\u003e genetic sub-groups isolated from farmed Atlantic salmon\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"841\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.466030989272944%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003ePhenotype:\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eA2 group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eA9 group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.66030989272944%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eA32 group\u003csup\u003ea\u003c/sup\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eS4TY1 group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eS2MY1 group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.466030989272944%\" valign=\"top\"\u003e\n \u003cp\u003eGrowth temperature range (\u0026deg;C)\u003csup\u003ea\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e8-30 (25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e8-30 (25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.66030989272944%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026lt;8-30 (25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e4-30 (25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e4-30 (25)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.466030989272944%\" valign=\"top\"\u003e\n \u003cp\u003eSalinity range for growth (sea salts % w/v)\u003csup\u003eb\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e1.0-5.0 (2.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e1.0-5.0 (3.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.66030989272944%\" valign=\"top\"\u003e\n \u003cp\u003e1.0-5.0 (2.5-3.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e1.0-5.0 (2.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e1.0-5.0 (2.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.466030989272944%\" valign=\"top\"\u003e\n \u003cp\u003epH range for growth\u003csup\u003ec\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e5.0-9.0 (6.5-8.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e5.0-9.0 (6.5-8.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.66030989272944%\" valign=\"top\"\u003e\n \u003cp\u003e5.0-9.0 (6.5-8.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e5.0-9.0 (6.5-8.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e5.0-9.0 (6.5-8.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.466030989272944%\" valign=\"top\"\u003e\n \u003cp\u003eMaximum toleration of bile salts (% w/v)\u003csup\u003ed\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e2.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e2.0-2.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.66030989272944%\" valign=\"top\"\u003e\n \u003cp\u003e3.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e1.0-2.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e2.0-2.5\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.466030989272944%\" valign=\"top\"\u003e\n \u003cp\u003eBioluminescence\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.66030989272944%\" valign=\"top\"\u003e\n \u003cp\u003evaries\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.466030989272944%\" valign=\"top\"\u003e\n \u003cp\u003eBiofilm formation on polystyrene/glass\u003csup\u003ee\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e++/++\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e-/++\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.66030989272944%\" valign=\"top\"\u003e\n \u003cp\u003evaries (- to ++)/++\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e+++/+ to ++\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e-/++\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.466030989272944%\" valign=\"top\"\u003e\n \u003cp\u003eChitinolytic, carbohydrate fermentation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e+\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e+\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.66030989272944%\" valign=\"top\"\u003e\n \u003cp\u003e+\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e+\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.468414779499405%\" valign=\"top\"\u003e\n \u003cp\u003e+\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003csup\u003ea\u003c/sup\u003eDetectable growth (A600 (\u0026ge;0.2 A\u003csub\u003e600\u003c/sub\u003e) occurring within 48 h incubation. The approximate optimal temperature for growth is shown in parentheses, doubling time ranged from 4.2 to 6.0 h at this temperature. Strains S2TY2 and S3TY1 grew at 4\u0026deg;C but A32 did not.\u003c/p\u003e\n\u003cp\u003e\u003csup\u003eb\u003c/sup\u003eNo growth occurs in the presence of \u0026le;0.5% or \u0026nbsp; \u0026ge;7.0% (w/v) sea salts; optimal salinity for growth is shown in parentheses.\u003c/p\u003e\n\u003cp\u003e\u003csup\u003ec\u003c/sup\u003eValues in parentheses denotes luxuriant growth occurs within the indicated pH range.\u003c/p\u003e\n\u003cp\u003e\u003csup\u003ed\u003c/sup\u003eOxoid ox bile salts no. 3 LP0056 - 50% w/v cholate; 50% w/v deoxycholate. The value shown is the solution concentration that allows detectable growth (\u0026ge;0.2 A\u003csub\u003e600\u0026nbsp;\u003c/sub\u003enm).\u003c/p\u003e\n\u003cp\u003e\u003csup\u003ee\u003c/sup\u003eThe degree of biofilm formation is based on the crystal violet assay absorbance (A\u003csub\u003e550\u003c/sub\u003e nm) values for growth developed after 24 h of incubation at 25\u0026deg;C (+++ \u0026ge; 0.6, ++ 0.3-0.6, + 0.1-0.3, - \u0026lt;0.1). Strain A32 did not form biofilms on polystyrene and is non-bioluminescent.\u003c/p\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:8.0pt;font-size:11.0pt;line-height:200%;'\u003e\u003cstrong\u003eTable 3.\u003c/strong\u003e Host colonization relevant protein content in \u003cem\u003eAllivibrio\u003c/em\u003e species and \u003cem\u003eVibrio\u003c/em\u003e \u003cem\u003escophthalmi\u003c/em\u003e based on genome annotations and protein similarity analysis. Coloured values represent the percent of strains containing the indicated protein homolog having \u0026gt;40% similarity and \u0026gt;80% of length to the reference protein.\u003c/p\u003e\n\u003ctable style=\"border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border: 1pt solid windowtext;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003eProteins\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003eProtein function\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.6pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003eBroad function (host)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003eA.\u003c/em\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003esalmon-icida\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003eA.\u003c/em\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003elogei\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003eA.\u003c/em\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003esifiae\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003eA.\u003c/em\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003efischeri\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003eA.\u003c/em\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003efinister-\u003c/em\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003eensis\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003eA2\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003egroup\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003eA9\u003c/p\u003e\n \u003cp 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solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003eS4MY1 group\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003eS2MY1 group\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003eA. wod-\u003c/em\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003eanis\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003eA.\u003c/em\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003e\u0026ldquo;vili\u0026rdquo;\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 43.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003eA.\u003c/em\u003e\u003c/p\u003e\n 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style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003eV.\u003c/em\u003e\u003c/p\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cem\u003escoph- thalmi\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n 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0in 5.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eGpbA (LPMO10A)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eGlcNAc-binding protein\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"10\" style=\"width: 65.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eadherence\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eLPMO10B\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eChitin monooxygenase\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eOmpU\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eOuter membrane protein U\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eIlpA (MetQ)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eImmunogenic lipoprotein A\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eMAM7 (PqiB)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eMultivalent adhesion factor\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003ePilABCD\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eChitin-regulated pilus\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e94.4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eMSHA gene cluster\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eMSH-type pilus\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eCsgABDEFG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eCurli fibres\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e67\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eTadABCDEFG (Flp)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eTight adherence pilus\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e80\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eTcp gene cluster\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eToxin co-regulated pilus\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e2.8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.05pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eAfcA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"4\" style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eAccessory colonization factors\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"8\" style=\"width: 65.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003ehost colonization\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e75\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eAfcB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eAfcC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e5.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eAfcD/SslE\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e11\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eNanA operon\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eNeu5AC degradation\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e97.2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eStcE/TagA/HapA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eMucinases (putative)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e24.3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eNanH\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eSialidase\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eKatA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eClass II peroxidase\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eEroS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eglucosaminoglycan lyase\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003e\u0026ldquo;aphrodisiac\u0026rdquo; other?\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e50\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eLuxA\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eLux system\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003ebioluminescence\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e67\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eLuxI homologs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eAHL synthesis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width: 65.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003equorum sensing\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e84.7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e67\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eother homologs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eAHL synthesis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e75\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eCqsA homologs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eChemical messenger synthesis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eEps/Gps gene cluster\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eT2SS EPS system\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"12\" style=\"width: 65.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003ebiofilm formation\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eSyp gene cluster\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eSyp polysaccharide\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eBscABC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eBacterial cellulose synthesis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e50\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eVps gene cluster\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eVps polysaccharide\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border: none;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border: none;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eRbmABD, RbmC/Bap1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eRugosity/biofilm structure regulation\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 23.55pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eLapV/LapI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eT1SS adhesins\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eLapBCEDG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eBiofilm modulation system\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n 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255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eBdlA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eBiofilm dispersal\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e2.8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eHapR/LitR\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eBiofilm repressor\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eVpsR\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eBiofilm positive regulator\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eVpsT\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eBiofilm positive regulator\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eHbtRC (TcpPH)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eHabitat transition regulator\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e75\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e80.6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 11.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eT6SS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eT6SS VAS system/effectors\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003ecell competition\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eCNF-1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eCytotoxic necrotizing factor 1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"9\" style=\"width: 65.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003etoxins/virulence\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e2.8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eHap/Vva\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eVibriolysin\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eRtxABCD\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eRTX toxin\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n 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style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eTdh/Trh\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eThermostable direct hemolysin\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e50\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e1.4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eTlh\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eThermolabile hemolysin\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eCdtABC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eCytolethal distending toxin\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n 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102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e50\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eAce\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eAccessory cholera enterotoxin\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e2.8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eZot/Zot-like\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eZonula occludens toxin/homologs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e11\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 9.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.9pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;\"\u003eVCC/VvhA-like\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 106.1pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:normal;'\u003e\u003cspan style=\"font-size:11px;\"\u003eLeukocidin family pore-forming toxin\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.4pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 204, 255);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e29.1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45.25pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.2pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.35pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(255, 255, 102);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;background: rgb(153, 255, 153);padding: 0in 5.4pt;height: 24.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;text-align:center;line-height:normal;'\u003e\u003cspan style=\"font-size:12px;color:black;\"\u003e20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:8.0pt;font-size:11.0pt;line-height:200%;'\u003e\u003cspan style=\"font-size:12px;line-height:200%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-right:0in;margin-left:0in;font-size:16px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-bottom:0in;font-size:11.0pt;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style=\"color:black;\"\u003eFootnote for Table 3.\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"color:black;\"\u003e\u0026nbsp;Of the 74 \u003cem\u003eA. fischeri\u003c/em\u003e genomes 3 represent the type strain (ATCC7744 = DSM507 = JCM 18803) and are considered as one strain for the analysis. AfcB and AfcD homologs are present in most strains but only have 35-40% similarity with homologs from \u003cem\u003eV. cholerae\u003c/em\u003e. PilA and PilC homologs are absent in some \u003cem\u003eA. fischeri\u003c/em\u003e and \u003cem\u003eA. salmonicida\u003c/em\u003e strains. The \u003cem\u003etad\u003c/em\u003e operon may be present in two separate alleles but three alleles is rare. MSHA genes \u003cem\u003emshE\u003c/em\u003e, \u003cem\u003emshP\u003c/em\u003e and/or \u003cem\u003emshQ\u003c/em\u003e may have diverged homologs in some strains. The \u003cem\u003etcp\u003c/em\u003e gene cluster occurs in the very similar \u003cem\u003eA. fischeri\u003c/em\u003e ES114 and VCW2E2 genomes, but both lack \u003cem\u003etcpR\u003c/em\u003e. Some strains possess two or three StcE/Tag-like homologs. GAG (glycosaminoglycan) lyases of the PL8 family are present in \u003cem\u003eA. logei\u003c/em\u003e IS159 and all three \u003cem\u003eA. \u0026ldquo;vili\u0026rdquo;\u003c/em\u003e strains (1S128, 1S165, 1S175) though these proteins share only 38-40% homology with the GAG lyase EroS of \u003cem\u003eA. fischeri\u003c/em\u003e ES114. The Vps cluster gene \u003cem\u003evpsC\u003c/em\u003e is not present in any strain while additional genes in the cluster are found in some strains e.g. strain A32. Many strains have a Zot domain-containing protein except ES114 and VCWE2E, which have adjacent Zot and Ace homologs.\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Atlantic salmon, microbiome, Aliivibrio, Mycoplasma, colonisation","lastPublishedDoi":"10.21203/rs.3.rs-4361310/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4361310/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground. \u003c/strong\u003eAtlantic salmon (\u003cem\u003eSalmo salar\u003c/em\u003e) farmed in seawater in Tasmania (\u003cem\u003elutruwita\u003c/em\u003e) can experience temper-atures close to their thermotolerance limit during summer and \u003cem\u003eVibrionaceae\u003c/em\u003e are a major component of their gut microbiome. This study focuses on understanding the microbiome of the Atlantic salmon gastrointestinal tract via the taxonomy, population dynamics, and traits of the main colonists.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults. \u003c/strong\u003eMultiyear survey\u003cem\u003e \u003c/em\u003eand co-occurrence network analyses confirmed novel members of \u003cem\u003eAliivibrio\u003c/em\u003e reliably colonise the gut microbiome in Atlantic salmon farmed in marine pens in Tasmania when the confounding influences of DNA and bacteria from feed and water was considered. \u003cem\u003eAliivibrio \u003c/em\u003eand \u003cem\u003eMycoplasma\u003c/em\u003e were the main taxa found to colonise the gut mucosal layers. Warm water temperature(19°C) experiments performed in seawater tanks indicated \u003cem\u003eAliivibrio \u003c/em\u003eand \u003cem\u003eVibrio \u003c/em\u003erapidly become predominant in the digesta of Atlantic salmon that had reduced feeding and high faecal cast production while \u003cem\u003eMycoplasma\u003c/em\u003e were found to be mostly absent.\u003cstrong\u003e \u003c/strong\u003eSalmon-associated \u003cem\u003eAliivibrio\u003c/em\u003e isolates were found to share many genes required for host colonisation with that of the faunal mutualist \u003cem\u003eAliivibrio fischeri\u003c/em\u003e. Though most salmon digesta isolates seem to lack obvious virulence factors, strains of two abundant novel colonising \u003cem\u003eAliivibrio\u003c/em\u003estrain groups possessed the genes for cytolethal distending toxin (CDT).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions. \u003c/strong\u003eMultiyear surveys confirm Atlantic salmon farmed in the relatively warm conditions of Tasmania are persistently colonised by the same, largely novel, \u003cem\u003eAliivibrio\u003c/em\u003e species and a restricted range of other \u003cem\u003eVibrionaceae\u003c/em\u003e. Some of these species were found to be particularly adept at colonising salmon in warm water conditions. Though some \u003cem\u003eAliivibrio\u003c/em\u003e coloniser strains possessed CDT-genes it is yet unknown whether CDT-gene-positive \u003cem\u003eAliivibrio\u003c/em\u003e negatively impact Atlantic salmon . Since the strains studies possess a range of different colonization enabling mechanisms, interactions between \u003cem\u003eVibrionaceae\u003c/em\u003e in the gut of Atlantic salmon could be important for overall fish health, especially when they are exposed to stressful conditions, such as elevated sea surface temperatures.\u003c/p\u003e","manuscriptTitle":"Active colonisers of the gastrointestinal tract of Atlantic salmon farmed in a warm water region","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-05-09 12:48:24","doi":"10.21203/rs.3.rs-4361310/v1","editorialEvents":[{"type":"communityComments","content":1}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"f0de8615-e758-4afb-bb2b-c24b6fc6f6e9","owner":[],"postedDate":"May 9th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-05-16T04:06:51+00:00","versionOfRecord":[],"versionCreatedAt":"2024-05-09 12:48:24","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4361310","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4361310","identity":"rs-4361310","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}