USE OF THIO-OXINDOLE DERIVATIVES IN TREATMENT OF HORMONE-RELATED CONDITIONS

The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula (I), or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula (I) and wherein R1-R5 and Q1 are defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.