Evaluation of Mronj Knowledge in Senior Dental and Medical Students

Evaluation of Mronj Knowledge in Senior Dental and Medical Students | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Evaluation of Mronj Knowledge in Senior Dental and Medical Students Tuba Develi, Merve Gaye Akgök, Madina Wardak This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5073401/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a complication that occurs in patients receiving antiresorptive or antiangiogenic medical therapy. Treatment of MRONJ requires meticulous treatment planning and protocols. The aim of this study is to evaluate and compare the knowledge level of senior dentistry and medicine students about MRONJ. Materials and Methods: A cross-sectional study was conducted on a total of 154 senior dentistry and medical faculty students. Data were collected using a structured electronic survey consisting of six sections. Data were entered and analyzed using SPSS version 23, and a P-value <0.05 was considered significant. Results: More than half of the sample (66.7%) had knowledge about antiresorptive and antiangiogenic drugs; 76.4% of those who had knowledge had heard about it during their university education. The underlying diseases that antiresorptive and antiangiogenic drugs target were unknown to the majority. Almost half of the sample (45.2%) could not identify any antiresorptive or anti-angiogenic drugs, and 62.5% of senior students of the Faculty of Medicine and 15.9% of senior students of Dentistry did not know that these drugs could cause jaw necrosis. Conclusion: Although the level of knowledge about MRONJ was higher among dental students for all departments in the survey, it was quite insufficient for both medical and dental students. Clinical Relevance: Enhancing knowledge of dentistry students and medicine students about MRONJ will be an important step in reducing and even preventing this public health problem, which is quite common in society. MRONJ bisphosphonates antiresorptive therapy antiangiogenic therapy INTRODUCTION Bisphosphonate-related osteonecrosis (BRONJ) was first described by Marx et al. in 2003 [ 1 ]. In 2009, the American Association of Oral and Maxillofacial Surgeons (AAOMS) defined BRONJ as exposed bone in the oral cavity for more than eight weeks in patients using bisphosphonates without a history of radiation therapy. Later in 2014, the AAOMS changed the term to medication-related osteonecrosis of the jaw (MRONJ) to include the significant number of cases of osteonecrosis associated with other antiresorptive and antiangiogenic therapies [ 2 , 3 , 4 ]. MRONJ include bisphosphonates (BP), denosumab, and antiangiogenics [ 5 ]. BPs bind to hydroxyapatites, inhibit bone remodeling, and have a very long half-life [ 6 ]. Denosumab is an inhibitor of nuclear factor kappa B ligand (RANKL). It inhibits osteoblast differentiation and function. Its half-life is shorter compared to BP. BPs and denosumabs are used to prevent bone metastasis in osteoporosis and cancer treatment [ 7 ]. Antiangiogenics are generally used to prevent new vessel formation in cases of malignancy. Examples include sunitib, sorafenib, bevacizumab [ 8 ]. MRONJ manifests itself as exposed and lifeless bone in the maxillofacial structures following the use of intravenous or oral antiresorptive drugs [ 9 , 10 , 11 ]. Although more than 20 years have passed since MRONJ was first reported, the pathophysiology and pathology of MRONJ are still not fully clarified. Definitive treatment strategies for MRONJ have not been developed. There are three main hypotheses explaining the pathophysiology of MRONJ [ 3 , 6 ]. The first hypothesis and the most accepted one is that it suppresses the turnover of bone by inhibiting osteoclastic activity and apoptosis [ 6 ]. The second hypothesis is that it disrupts the integrity of the oral mucosa through a direct toxic effect on epithelial cells and macrophages, leading to infection and subsequent bone necrosis. According to the last hypothesis, excessive bone resorption due to bacterial infection leads to osteonecrosis of the jaw [ 12 ]. The main risk factors for the development of MRONJ include those directly related to the drug, treatment indications, duration, dosage, and route of administration [ 13 ]. Other risk factors include dentoalveolar operations, anatomical factors, periapical pathologies, periodontal diseases, smoking, patients with comorbidities such as anemia and diabetes, and those receiving concurrent corticosteroid and chemotherapy treatment. Patients at risk of MRONJ are classified into different risk categories. BP, which is generally used for benign bone diseases that are not related to cancer, such as osteoporosis, osteopenia, Paget's disease, osteogenesis imperfecta, is considered low risk [ 2 ]. Patients in this risk category are usually prescribed oral or intravenous BP medications [ 14 , 15 ]. The risk of developing MRONJ is low in patients who take oral antiresorptives for less than four years in cases unrelated to cancer and who do not have other clinical risk factors [ 2 ]. However, patients undergoing cancer treatment, especially conditions such as multiple myeloma and bone metastases, are at high risk [ 2 , 14 , 16 ]. There is evidence showing that providing predental treatment and oral hygiene motivation before starting treatment provides the best results in patients at risk of developing MRONJ [ 2 , 3 ]. Therefore, a multidisciplinary treatment approach should be adopted, including medical doctors and dentists. There are very few studies evaluating the knowledge level of dental students and dentists about MRONJ [ 17 , 18 , 19 ]. The number of studies measuring the knowledge level of medical students is relatively few [ 25 ]. Comparison and evaluation of MRONJ knowledge levels of dentistry and medicine students have not been conducted before in the literature. Identifying, addressing and comparing knowledge gaps may contribute to the prevention of potential complications in patients at risk of MRONJ and may enable the development of educational programs. The aim of this study is to evaluate the knowledge levels of dentistry and medicine students about medication-related osteonecrosis of the jaw bones. The hypothesis of this study is that there is no difference in the level of knowledge between senior dentistry students and senior medicine students. MATERIAL AND METHOD This survey was conducted to evaluate and compare the knowledge of senior dentistry students and senior medicine students at Istanbul Medipol University regarding MRONJ. This study was approved by the institutional ethics committee of Istanbul Medipol University and was conducted in accordance with the ethical standards defined in the Declaration of Helsinki (1120 no.). The survey included 157 participants, including Istanbul Medipol University senior dentistry and medicine students. Three participants were excluded from the study because they answered the questions incompletely. Group 1 (senior dentistry students 82), Group 2 (senior medicine students 72). All participation in the study was voluntary and a written informed consent was obtained from the participants before completing the questionnaire. Participants were selected using a nonprobability purposive sampling technique and the data was collected using a validated self-administered structured questionnaire. Approval to use the questionnaire was obtained from a published article [ 17 ]. The survey was later modified [ 3 ]. The modified survey has been updated for our own research. Table 1 The modified survey 1 Age? A) 19–20 B) 21–22 C) 23–24 D) 25 or above 2 Gender? A) Male B) Female 3 In what year did you enroll in university? A) 2016 B) 2017 C) 2018 D) 2019 4 Select the faculty you studied at. A )Faculty of Dentistry B) Faculty of Medicine 5 Have you encountered any antiresorptive drugs such as bisphosphonates during your education? A) Yes B) No 6 Have you encountered any antiangiogenic drugs such as bisphosphonates during your education? A) Yes B) No 7 Where have you heard about antiresorptive drugs? A) Never heard of it B) University C) Mass media D) Scientific journals E) Other 8 Where did you hear about antiangiogenic drugs? A) Never heard of it B) University C) Mass media D) Scientific journals E) Other 9 Do you think it is important to ask whether patients are using antiresorptive/antiangiogenic medications? A) Yes B) No 10 In which diseases are antiresorptive drugs used? (more than one option can be selected) A) Bone metastasis B) Osteomyelitis C) Multiple Myeloma D) Malignant Hypercalcemia E) Osteopetrosis F) Osteopenia G) Chondroblastoma H) Osteogenesis Imperfecta I) Paget 11 In which diseases are antiangiogenic drugs used? (more than one option can be selected) A) Elastofibroma B) Metastatic Colorectal Cancer C) Leiomyoma D) Renal Cell Carcinoma E) Pancreatic Neuroendocrine Tumors F) Multiple Myeloma G) Granular Cell Tumor 12 Please select the antiresorptive drugs you know. A) I do not know any antiresorptive drugs B) Alendronate (Fosamax) C) Risedronate (Antonel) D) Ibandronate (Boniva) E) Neridronate (Nerixia) F) Pamidronate (Aredia) G) Zolendronate (Zometa) H) Tiludronate (Skelid) I) Denosumab (Prolia) 13 Please select the antiangiogenic drugs you know. (more than one option can be selected A) I do not know any antiangiogenic drugs. B) Sunitinib (Sutent) C) Sorafenib (Nexavar) D) Bevacizumab (Avastin) E) Sirolimus (Rapamune) 14 Did you know that antiresorptive/antiangiogenic medications can cause osteonecrosis of the jaw? A) Yes B) No 15 Which of the following are risk factors for osteonecrosis of the jaw? (more than one option can be selected) A) Cigarette B) Antibiotic treatment C) Alcohol D) Hypertension E)Treatment duration F) Hyperlipidemia G) Steroid treatment H) Amount of medicine i) Micro trauma 16 Do you think patients should be checked by dentists before starting IV bisphosphonate therapy? A) Yest B) No 17 Can invasive dental treatments be safely performed on patients during intravenous bisphosphonate drug therapy? A) Yes B) No C) I do not know 18 Can invasive dental treatments be safely applied to patients who have used oral bisphosphonates for less than 4 years and have no risk factors? A) Yes B) No C) I do not know 19 Oral bifosfonatları 4 yıldan az kullanan ve risk faktörlerine sahip hastalarda invaziv diş tedavileri güvenle uygulanabilir mi? A) Yes B) No C) I do not know 20 Can invasive dental treatments be performed safely in patients who have used oral bisphosphonates for less than 4 years and have risk factors? A) Yes B) No C) I do not know 21 Have you ever treated patients with osteonecrosis of the jaw who were receiving antiresorptive therapy? A) Yes B) No 22 Have you ever treated patients with osteonecrosis of the jaw who were not receiving antiresorptive therapy? A) Yes B) No 23 Have you ever treated patients without osteonecrosis of the jaw who were receiving antiresorptive therapy? A) Yes B) No Table 1 shows that the survey is divided into six sections. The first section contains items regarding general demographic data (age, gender, university). The second section has six items related to prior information received about antiresorptive and antiangiogenic medication and the participant’s perception of the importance of the information. Section three has five items evaluating the participant’s knowledge about the therapeutic uses of antiresorptive and antiangiogenic medication. The fourth section includes three items assessing the participant’s knowledge about osteonecrosis of the jaw and the risk. The fifth section has four items related to knowledge about the dental management of patients taking BP therapy. The last section, with three items, explores the frequency of encountering patients with osteonecrosis of the jaw with or without BPs in their clinics. RESULT Our hypothesis was rejected. Of the 157 participants who participated in the study, 3 participants were excluded from the study because they did not complete the questions. Of the 154 participants, 53% were senior dentistry students and 47% were senior medicine students. 65.9% of the dentistry students were female and 34.1% were male, and 55.6% of the medicine students were female while 44.4% were male. Table 2 shows the details of the survey responses regarding receiving prior information and perception of the importance of information. It was determined that the source of information about antiresorptive and antiangiogenic drugs was largely universities in both groups. 96.3% of the Faculty of Dentistry students and 72.2% of the Faculty of Medicine students stated that it is important to ask questions about the patient’s use of antiresorptive/antiangiogenic drugs during the examination. There is a statistically significant difference between the 2 groups. Table 2 General Knowledge of Antiresorptive/Antiangiogenic Medications Faculty P Medicine Dentistry Where did you hear about antiresorptive drugs? N % n % 0,209 I have never heard of it 17 23,60% 9 11,00% University 51 70,80% 69 84,10% Social Media 1 1,40% 0 0,00% Scientific journals 1 1,40% 2 2,40% Other 2 2,80% 2 2,40% Where did you hear about antiangiogenic drugs? N % n % 0,098 I have never heard of it 16 22,20% 8 9,80% University 48 66,70% 69 84,10% Social Media 1 1,40% 0 0,00% Scientific journals 4 5,60% 4 4,90% Other 3 4,20% 1 1,20% Do you think it is important to ask whether patients are using antiresorptive/antiangiogenic medications? N % n % 0,000* Yes 52 72,20% 79 96,30% No 20 27,80% 3 3,70% Table 3 shows questions and answers about antiresorptive and antiangiogenic drugs. When the relationship between the two groups and the diseases in which antiresorptive drugs are used; There is a statistically significant difference between the groups with bone metastasis, osteomyelitis, multiple myeloma, Paget's and not knowing the answer. When looking at the indications for the use of antiresorptive drugs for bone metastasis, osteomyelitis, multiple myeloma, and Paget's disease, there is a significant difference between the knowledge level of the two groups. The level of knowledge about these disorders is high among dentistry students. Considering the indications of antiangiogenic drugs, there is a significant difference between the groups for elastofibroma and pancreatic neuroendocrine tumors. When it comes to elastofibroma, dentistry students are more dominant, while medical students are more dominant for pancreatic neuroendocrine tumors. When the relationship between known antiresorptive drugs and the groups is examined; A significant difference was found between the groups in terms of knowledge of the drugs Zolendronate (Zometa), Tiludronate (Skelid) and Denosumab (Prolia). It is seen that the knowledge level of dentistry students is higher for these 3 drugs, but it is still insufficient. When the relationship between known antiangiogenic drugs and the groups is examined; Known status of bevacizumab (Avastin) and groups, there is a significant relationship between. It appears that the knowledge level of medical students is better regarding this drug. There is a significant difference between the groups in terms of knowing that antiresorptive/antiangiogenic drugs can cause osteonecrosis of the jaw. Although the knowledge level of dentistry students is higher, there is still a need to increase their knowledge level for public health. Table 3 Knowledge of Therapeutic Uses of Antiresorptive / Antiangiogenic Medication Faculty P Medicine Dentistry What diseases are targeted by antiresorptive therapy? ? n % N % Bone metastases 16 22,20% 42 51,20% 0,000* Osteomyelitis 12 16,70% 42 51,20% 0,000* Multiple myeloma 23 31,90% 40 48,80% 0,025* Hypercalcemia of malignancy 21 29,20% 27 32,90% 0,372 Osteopetrosiss 21 29,20% 30 36,60% 0,211 Osteopenia 28 38,90% 22 26,80% 0,078 Chondroblastoma 6 8,30% 6 7,30% 0,524 Osteogenesis imperfecta 13 18,10% 20 24,40% 0,224 Paget's disease of bone 14 19,40% 35 42,70% 0,002* I do not know 28 38,90% 13 15,90% 0,001* What diseases are targeted by anti-angiogenic therapy?? n % N % 0,015* Elastofibromas 3 4,20% 13 15,90% 0,549 Metastatic colorectal cancer 17 23,60% 19 23,20% 0,07 Leiomyomas 5 6,90% 13 15,90% 0,081 Renal cell cancer 21 29,20% 15 18,30% 0,008* Neuroendocrine tumor of the pancreas 22 30,60% 11 13,40% 0,382 Multiple myeloma 16 22,20% 21 25,60% 0,431 Granular cell tumors 14 19,40% 14 17,10% 0,409 I do not know 39 54,20% 47 57,30% 0,41 Mark the name of the antiresorptive drugs you are familiar with : n % N % 0,222 I do not know of any antiresorptive drug 25 34,70% 31 37,80% 0,124 Alendronate (Fosamax) 18 25,00% 16 19,50% 0,373 Risedronate (Actonel) 9 12,50% 15 18,30% 0,054 Ibandronate (Boniva) 12 16,70% 21 25,60% 0,001* Neridronate (Nerixia) 11 15,30% 10 12,20% 0,014* Pamidronate (Aredia) 13 18,10% 25 30,50% 0,007* Zolendronate (Zometa) 20 27,80% 45 54,90% 0,035 Tiludronate (Skelid) 7 9,70% 20 24,40% 0,211 Denosumab (Prolia) 12 16,70% 29 35,40% 0,177 Mark the name of the anti-angiogenic drugs you are familiar with : n % N % 0,294 I do not know of any anti-angiogenic drugs 37 51,40% 55 67,10% 0.000* Sunitib (Sutent) 16 22,20% 13 15,90% Sorafenib (Nexavar)) 28 38,90% 25 30,50% 0.000* Bevacizumab (Avastin) 24 33,30% 10 12,20% Sirolimus (Rapamune) 9 12,50% 7 8,50% Do you know that anti-resorptive/antiangiogenic medications can lead to osteonecrosis of the jaw? n % N % YES 27 37,50% 69 84,10% NO 62,50% 13 15,90% 0.000* Table 4 shows risk factors related to osteonecrosis of the jaw. When the relationship between the stated risk factors for jaw osteonecrosis and the faculties is examined; Smoking, alcohol, treatment duration, steroid treatment, amount of medication, microtrauma and not knowing the answer have a significant relationship with the groups. Table 4 Knowledge of Risk Factors Related to Osteonecrosis of the Jaw Faculty P Medicine Dentistry Which of the following are the risk factors related to osteonecrosis of the jaw? n % n % Tobacco 43 59,70% 62 75,60% 0,026* Antibiotic therapy 12 16,70% 16 19,50% 0,404 Alcohol 27 37,50% 48 58,50% 0,007* Arterial hypertension 12 16,70% 17 20,70% 0,332 Length of therapy 28 38,90% 55 67,10% 0,000* Hyperlipidemia 12 16,70% 19 23,20% 0,211 Steroid therapy 29 40,30% 47 57,30% 0,025* Total amount of drug administered 25 34,70% 63 76,80% 0,000* Micro-trauma 20 27,80% 41 50,00% 0,004* I do not know 22 30,60% 4 4,90% 0,000* Table 5 shows questions and answers about dental treatment in patients receiving BP treatment. There is a statistically significant difference between patient’s opinion that they should be checked by dentists before starting BP treatment. It seems that medicine faculty students have less awareness. There is a significant difference between the groups in the answers given to questions about whether invasive dental treatments can be safely applied to patients who are or will be treated with intravenous and oral BP medication. While the knowledge level of medical students should be increased, the knowledge level of dental students with better knowledge should also be increased. Table 5 Knowledge of Dental Management in Patients Undergoing Bisphosphonate Therapy Faculty P Medicine Dewntistry Do you think patients should be checked by the dentist before starting an IV bisphosphonates treatment? n % n % Yes 54 78,30% 80 97,60% 0,000* No 15 21,70% 2 2,40% I do not know 0 0,00% 0 0,00% Can invasive dental treatments be performed safely to patients during an intravenous bisphosphonate drug therapy? n % n % Yes 3 4,20% 13 15,90% 0,000* No 16 22,20% 62 75,60% I do not know 53 73,60% 7 8,50% Can invasive dental treatments be performed safely to patients using oral bisphosphonates for < 4 years without risk factors? n % n % Yes 14 19,40% 70 85,40% 0,000* No 5 6,90% 6 7,30% I do not know 53 73,60% 6 7,30% Can invasive dental treatments be performed safely to patients using oral bisphosphonates for < 4 years with risk factors? n % n % Yes 5 6,90% 20 24,40% 0,000* No 11 15,30% 51 62,20% I do not know 56 77,80% 11 13,40% Can invasive dental treatments be performed safely to patients using oral bisphosphonates for > 4 years? n % n % Yes 4 5,60% 10 12,20% 0,000* No 14 19,40% 65 79,30% I do not know 54 75,00% 7 8,50% Table 6 includes the survey results examining the relationship between the presence of jaw osteonecrosis and antiresorptive drug use and treatment. Table 6 Knowledge of jaw osteonecrosis and antiresorptive drug use and treatment Faculty P Medicine Dentistry Have you treated patients with osteonecrosis of the jaw and are on antiresorptive therapy? n % n % Yes 1 1,40% 7 8,50% 0,047* No 71 98,60% 75 91,50% Have you treated patients with osteonecrosis of the jaw and are NOT on antiresorptive therapy? Yes 52 2,80% 14 17,10% 0,003* No 70 97,20% 68 82,90% Have you treated patients WITHOUT osteonecrosis of the jaw and are on anti-resorptive therapy? Yes 2 2,80% 12 14,60% 0,009* No 70 97,20% 70 85,40% DISCUSSION MRONJ is a serious drug side effect in patients receiving long-term antiresorptive or antiangiogenic drug therapy and usually affects the bones of the jaw. Having sufficient knowledge about MRONJ is of great importance to improve treatment results, prevent this problem and reduce complications [ 2 ]. It has been observed that 99.7% of dentists do not have sufficient knowledge about diagnosing and managing MRONJ [ 20 ]. Another study showed that 60% of the participants had a good level of knowledge about MRONJ. While 50% of the participants hesitated to treat patients using BP, 63% stated that they could refer patients using BP [ 21 ]. In a study comparing the knowledge levels of dentists and dental students, it was found that 62% of dentists and 58% of dental students had insufficient knowledge of MRONJ [ 18 ]. According to the study measuring the knowledge level of dentists and dental students, 50% of the students and 68% of the dentists have up-to-date information about MRONJ. Most correctly identified the relevant risk factors. 13% of the students and 33% of the dentists knew how to treat osteonecrosis when it occurred [ 19 ]. Another study in the literature showed that 99% of the participants knew BPs and that sixth-semester students had better knowledge than fourth-semester students [ 17 ]. On the contrary, another study showed that knowledge about the side effects of antiresorptive drugs decreased as the years of professional practice increased [ 22 ]. Another study showed that oral maxillofacial surgeons had more knowledge than general dentists [ 23 ]. According to a study conducted in Saudi Arabia in 2020, 60% of the participants were found to have poor BP knowledge [ 24 ]. According to a study conducted on medical students, almost all of the students stated that comprehensive dental screening was necessary and essential before starting BP use. 16% of the students answered correctly about the drugs that cause MRONJ [ 25 ] . In our study, senior dentistry students had 84.1% knowledge about MRONJ, while medical students had 37.5% knowledge. There is a significant statistical difference between faculties. However, although studies investigating the level of knowledge about MRONJ among dental students are limited, there is no study comparing the level of knowledge of dental students and medical students about MRONJ. Generally, existing studies in the literature have focused on BPs. At this point, it is important to conduct a comprehensive study to evaluate the knowledge level of dental and medical students about MRONJ, improve their education, and enable them to manage these potential complications more effectively. Such a study could fill knowledge gaps in this field by identifying deficiencies in the diagnosis and treatment of MRONJ and contribute to the creation of a more effective training program for future dentists and medical practitioners. According to the research results, the level of knowledge about antiresorptive drugs shows a significant difference between the two faculties. However, interestingly, a lack of knowledge about antiresorptive drugs was detected in both faculties. This highlights the need for more comprehensive teaching and learning in both faculties, given the importance of this group of drugs. Having deeper knowledge on issues such as the effects, side effects and indications for use of antiresorptive drugs can increase the professional competencies of medical and dental students. In this context, updating training programs and adopting an interdisciplinary approach that emphasizes the role of antiresorptive drugs in clinical practice may better equip future healthcare professionals on this important issue. These efforts will be an important step in terms of drug safety and best management of patients. The knowledge level of medical students that these drugs can cause osteonecrosis was determined as 33%. This low level of knowledge shows that the potential risks and side effects of this drug group are not well known by students. One of the most important results is that the rate of thinking that a dentist should be consulted before starting BP treatment is 20% among medicine students. This approach is considered a preventive treatment to prevent the occurrence of MRONJ in advance, saving time and resources in this process for both the patient and the treatment cost. Therefore, the adoption of this preventive approach by medical school students should be considered a critical step in minimizing the risks associated with MRONJ. It has been observed that dentistry students generally have good knowledge of drug relations in areas such as bone metastasis, osteomyelitis, multiple myeloma, and Paget's, but they have deficiencies in subjects they encounter less frequently, such as neuroendocrine tumors. On the other hand, it has been observed that medical students have better knowledge about some antiangiogenic drugs. Since it is not expected to provide specific and in-depth knowledge in this field other than the questions discussed here, it is not considered as important as the previous questions. As a result, it is necessary to increase the awareness of MRONJ among faculty of medicine students and take preventive measures such as directing patients to the dentist, especially before starting this medication, performing oral and dental examination of the patients by the dentist, and protecting and intervening in their health. In particular, it is important to remember that MRONJ is the gold standard in prevention to avoid this troublesome and protracted complication. The need to strengthen information and education programs for students by increasing awareness in this field and emphasizing these preventive strategies comes to the fore. Addressing this deficiency may help future healthcare professionals guide their patients more effectively and minimize such complications. Although the general level of knowledge about MRONJ was higher among dental students for all departments in the survey, it was quite inadequate for both medical and dental students. This lack of information may result in necessary treatments not being implemented, delayed or affected. However, a greater concern is that as clinicians they will likely not be aware of the risk when treating MRONJ patients. These findings ultimately highlight the need for continuing education to improve patient care. These issues should be given more attention in the education of physician candidates. Declarations COMPLIANCE WITH ETHICAL STANDARDS Conflict of Interest: The authors have no conflicts of interest to declare. Funding: The authors declare that no funds, grants, or other support were received during the preparation of this manuscript. Ethical Approval: Not Applicable. 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Cochrane Database of Systematic Reviews , (7). https://doi.org/10.1002/14651858.CD012432.pub3 Conte, P., & Guarneri, V. (2004). Safety of intravenous and oral bisphosphonates and compliance with dosing regimens. The oncologist , 9 (S4), 28-37. https://doi.org/10.1634/theoncologist.9-90004-28 Jeffcoat, M. K. (2006). Safety of oral bisphosphonates: controlled studies on alveolar bone. International Journal of Oral & Maxillofacial Implants , 21 (3). Rosella, D., Papi, P., Giardino, R., Cicalini, E., Piccoli, L., & Pompa, G. (2016). Medication-related osteonecrosis of the jaw: Clinical and practical guidelines. Journal of International Society of Preventive and Community Dentistry , 6 (2), 97-104. https://doi.org/10.4103/2231-0762.178742 Rosella, D., Papi, P., Pompa, G., Capogreco, M., De Angelis, F., & Di Carlo, S. (2017). Dental students' knowledge of medication-related osteonecrosis of the jaw. European journal of dentistry , 11 (04), 461-468. https://doi.org/10.4103/ejd.ejd_27_17 de Lima, P. B., Brasil, V. L. M., de Castro, J. F. L., de Moraes Ramos-Perez, F. M., Alves, F. A., dos Anjos Pontual, M. L., & da Cruz Perez, D. E. (2015). Knowledge and attitudes of Brazilian dental students and dentists regarding bisphosphonate-related osteonecrosis of the jaw. Supportive care in cancer , 23 , 3421-3426. https://doi.org/10.1007/s00520-015-2689-6 López‐Jornet, P., Camacho‐Alonso, F., Molina‐Miñano, F., & Gomez‐Garcia, F. (2010). Bisphosphonate‐associated osteonecrosis of the jaw. Knowledge and attitudes of dentists and dental students: a preliminary study. Journal of evaluation in clinical practice , 16 (5), 878-882. https://doi.org/10.1111/j.1365-2753.2009.01203.x Vinitzky-Brener, I., Ibáñez-Mancera, N. G., Aguilar-Rojas, A. M., & Álvarez-Jardón, A. P. (2017). Knowledge of bisphosphonate-related osteonecrosis of the Jaws among Mexican dentists. Medicina oral, patologia oral y cirugia bucal , 22 (1), e84. https://doi.org/10.4317/medoral.21433 Alhussain, A., Peel, S., Dempster, L., Clokie, C., & Azarpazhooh, A. (2015). Knowledge, practices, and opinions of Ontario dentists when treating patients receiving bisphosphonates. Journal of Oral and Maxillofacial Surgery , 73 (6), 1095-1105. https://doi.org/10.1016/j.joms.2014.12.040 Escobedo, M., García-Consuegra, L., Junquera, S., Olay, S., Ascani, G., & Junquera, L. (2018). Medication-related osteonecrosis of the jaw: A survey of knowledge, attitudes, and practices among dentists in the principality of Asturias (Spain). Journal of stomatology, oral and maxillofacial surgery , 119 (5), 395-400. https://doi.org/10.1016/j.jormas.2018.04.008 Al-Samman, A. A., & Al-Ani, R. S. (2019). Across-sectional survey on medication-related osteonecrosis of the jaws' knowledge and awareness in a sample of dental society. Journal of Cranio-Maxillofacial Surgery , 47 (6), 926-931. https://doi.org/10.1016/j.jcms.2019.02.006 Alqhtani, N. R., Almalki, A. K., Zuhair, F. A., Alenazi, A. A., Nabhan, A. B., & Alqahtani, M. (2020). Knowledge, attitude, and management of general dentist toward medication-related osteonecrosis of the jaws. Journal of Pharmacy and Bioallied Sciences , 12 (Suppl 1), S151-S154. https://doi.org/10.4103/jpbs.JPBS_47_20 Franchi, S., Brucoli, M., Boffano, P. A. O. L. O., Dosio, C., & Benech, A. (2020). Medical students’ knowledge of medication related osteonecrosis of the jaw. Journal of stomatology, oral and maxillofacial surgery , 121 (4), 344-346. https://doi.org/10.1016/j.jormas.2019.10.005 Additional Declarations No competing interests reported. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5073401","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":367151667,"identity":"c2ef1ca5-b44a-4929-b2b0-5c921fee86b6","order_by":0,"name":"Tuba Develi","email":"","orcid":"","institution":"Istanbul Medipol University","correspondingAuthor":false,"prefix":"","firstName":"Tuba","middleName":"","lastName":"Develi","suffix":""},{"id":367151668,"identity":"03da42a2-f576-42f8-b5af-97fce9936ccf","order_by":1,"name":"Merve Gaye Akgök","email":"data:image/png;base64,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","orcid":"","institution":"Istanbul Medipol University","correspondingAuthor":true,"prefix":"","firstName":"Merve","middleName":"Gaye","lastName":"Akgök","suffix":""},{"id":367151669,"identity":"8b98427d-0c32-40be-8ced-08f608aab81b","order_by":2,"name":"Madina Wardak","email":"","orcid":"","institution":"Istanbul Medipol University","correspondingAuthor":false,"prefix":"","firstName":"Madina","middleName":"","lastName":"Wardak","suffix":""}],"badges":[],"createdAt":"2024-09-11 20:18:43","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5073401/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5073401/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":67170070,"identity":"1c616936-499c-428c-8966-aab157b88369","added_by":"auto","created_at":"2024-10-22 03:14:12","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1157704,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5073401/v1/3da15b9e-7c13-434d-b833-a554809c5454.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"\u003cp\u003eEvaluation of Mronj Knowledge in Senior Dental and Medical Students\u003c/p\u003e","fulltext":[{"header":"INTRODUCTION","content":"\u003cp\u003eBisphosphonate-related osteonecrosis (BRONJ) was first described by Marx et al. in 2003 [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. In 2009, the American Association of Oral and Maxillofacial Surgeons (AAOMS) defined BRONJ as exposed bone in the oral cavity for more than eight weeks in patients using bisphosphonates without a history of radiation therapy. Later in 2014, the AAOMS changed the term to medication-related osteonecrosis of the jaw (MRONJ) to include the significant number of cases of osteonecrosis associated with other antiresorptive and antiangiogenic therapies [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eMRONJ include bisphosphonates (BP), denosumab, and antiangiogenics [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. BPs bind to hydroxyapatites, inhibit bone remodeling, and have a very long half-life [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. Denosumab is an inhibitor of nuclear factor kappa B ligand (RANKL). It inhibits osteoblast differentiation and function. Its half-life is shorter compared to BP. BPs and denosumabs are used to prevent bone metastasis in osteoporosis and cancer treatment [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. Antiangiogenics are generally used to prevent new vessel formation in cases of malignancy. Examples include sunitib, sorafenib, bevacizumab [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eMRONJ manifests itself as exposed and lifeless bone in the maxillofacial structures following the use of intravenous or oral antiresorptive drugs [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e, \u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. Although more than 20 years have passed since MRONJ was first reported, the pathophysiology and pathology of MRONJ are still not fully clarified. Definitive treatment strategies for MRONJ have not been developed. There are three main hypotheses explaining the pathophysiology of MRONJ [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. The first hypothesis and the most accepted one is that it suppresses the turnover of bone by inhibiting osteoclastic activity and apoptosis [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. The second hypothesis is that it disrupts the integrity of the oral mucosa through a direct toxic effect on epithelial cells and macrophages, leading to infection and subsequent bone necrosis. According to the last hypothesis, excessive bone resorption due to bacterial infection leads to osteonecrosis of the jaw [\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe main risk factors for the development of MRONJ include those directly related to the drug, treatment indications, duration, dosage, and route of administration [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e]. Other risk factors include dentoalveolar operations, anatomical factors, periapical pathologies, periodontal diseases, smoking, patients with comorbidities such as anemia and diabetes, and those receiving concurrent corticosteroid and chemotherapy treatment. Patients at risk of MRONJ are classified into different risk categories. BP, which is generally used for benign bone diseases that are not related to cancer, such as osteoporosis, osteopenia, Paget's disease, osteogenesis imperfecta, is considered low risk [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. Patients in this risk category are usually prescribed oral or intravenous BP medications [\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]. The risk of developing MRONJ is low in patients who take oral antiresorptives for less than four years in cases unrelated to cancer and who do not have other clinical risk factors [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. However, patients undergoing cancer treatment, especially conditions such as multiple myeloma and bone metastases, are at high risk [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThere is evidence showing that providing predental treatment and oral hygiene motivation before starting treatment provides the best results in patients at risk of developing MRONJ [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]. Therefore, a multidisciplinary treatment approach should be adopted, including medical doctors and dentists.\u003c/p\u003e \u003cp\u003eThere are very few studies evaluating the knowledge level of dental students and dentists about MRONJ [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e, \u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e, \u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]. The number of studies measuring the knowledge level of medical students is relatively few [\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eComparison and evaluation of MRONJ knowledge levels of dentistry and medicine students have not been conducted before in the literature. Identifying, addressing and comparing knowledge gaps may contribute to the prevention of potential complications in patients at risk of MRONJ and may enable the development of educational programs. The aim of this study is to evaluate the knowledge levels of dentistry and medicine students about medication-related osteonecrosis of the jaw bones. The hypothesis of this study is that there is no difference in the level of knowledge between senior dentistry students and senior medicine students.\u003c/p\u003e"},{"header":"MATERIAL AND METHOD","content":"\u003cp\u003eThis survey was conducted to evaluate and compare the knowledge of senior dentistry students and senior medicine students at Istanbul Medipol University regarding MRONJ. This study was approved by the institutional ethics committee of Istanbul Medipol University and was conducted in accordance with the ethical standards defined in the Declaration of Helsinki (1120 no.). The survey included 157 participants, including Istanbul Medipol University senior dentistry and medicine students. Three participants were excluded from the study because they answered the questions incompletely. Group 1 (senior dentistry students 82), Group 2 (senior medicine students 72). All participation in the study was voluntary and a written informed consent was obtained from the participants before completing the questionnaire. Participants were selected using a nonprobability purposive sampling technique and the data was collected using a validated self-administered structured questionnaire. Approval to use the questionnaire was obtained from a published article [\u003cspan class=\"CitationRef\"\u003e17\u003c/span\u003e]. The survey was later modified [\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e]. The modified survey has been updated for our own research.\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003ctable id=\"Tab1\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eThe modified survey\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eAge?\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) 19\u0026ndash;20\u003c/p\u003e\n \u003cp\u003eB) 21\u0026ndash;22\u003c/p\u003e\n \u003cp\u003eC) 23\u0026ndash;24\u003c/p\u003e\n \u003cp\u003eD) 25 or above\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eGender?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Male\u003c/p\u003e\n \u003cp\u003eB) Female\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eIn what year did you enroll in university?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) 2016\u003c/p\u003e\n \u003cp\u003eB) 2017\u003c/p\u003e\n \u003cp\u003eC) 2018\u003c/p\u003e\n \u003cp\u003eD) 2019\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSelect the faculty you studied at.\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA )Faculty of Dentistry\u003c/p\u003e\n \u003cp\u003eB) Faculty of Medicine\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHave you encountered any antiresorptive drugs such as bisphosphonates during your education?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yes\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHave you encountered any antiangiogenic drugs such as bisphosphonates during your education?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yes\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eWhere have \u0026nbsp;you heard about antiresorptive drugs?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Never heard of it\u003c/p\u003e\n \u003cp\u003eB) \u0026nbsp;University\u003c/p\u003e\n \u003cp\u003eC) Mass media\u003c/p\u003e\n \u003cp\u003eD) Scientific journals\u003c/p\u003e\n \u003cp\u003eE) Other\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eWhere did you hear about antiangiogenic drugs?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Never heard of it\u003c/p\u003e\n \u003cp\u003eB) University\u003c/p\u003e\n \u003cp\u003eC) Mass media\u003c/p\u003e\n \u003cp\u003eD) Scientific journals\u003c/p\u003e\n \u003cp\u003eE) Other\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eDo you think it is important to ask whether patients are using antiresorptive/antiangiogenic medications?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yes\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eIn which diseases are antiresorptive drugs used? (more than one option can be selected)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Bone metastasis\u003c/p\u003e\n \u003cp\u003eB) Osteomyelitis\u003c/p\u003e\n \u003cp\u003eC) Multiple Myeloma\u003c/p\u003e\n \u003cp\u003eD) Malignant Hypercalcemia\u003c/p\u003e\n \u003cp\u003eE) Osteopetrosis\u003c/p\u003e\n \u003cp\u003eF) Osteopenia\u003c/p\u003e\n \u003cp\u003eG) Chondroblastoma\u003c/p\u003e\n \u003cp\u003eH) Osteogenesis Imperfecta\u003c/p\u003e\n \u003cp\u003eI) Paget\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eIn which diseases are antiangiogenic drugs used? (more than one option can be selected)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Elastofibroma\u003c/p\u003e\n \u003cp\u003eB) Metastatic Colorectal Cancer\u003c/p\u003e\n \u003cp\u003eC) Leiomyoma\u003c/p\u003e\n \u003cp\u003eD) Renal Cell Carcinoma\u003c/p\u003e\n \u003cp\u003eE) Pancreatic Neuroendocrine Tumors\u003c/p\u003e\n \u003cp\u003eF) Multiple Myeloma\u003c/p\u003e\n \u003cp\u003eG) Granular Cell Tumor\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003ePlease select the antiresorptive drugs you know.\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) I do not know any antiresorptive drugs\u003c/p\u003e\n \u003cp\u003eB) Alendronate (Fosamax)\u003c/p\u003e\n \u003cp\u003eC) Risedronate (Antonel)\u003c/p\u003e\n \u003cp\u003eD) Ibandronate (Boniva)\u003c/p\u003e\n \u003cp\u003eE) Neridronate (Nerixia)\u003c/p\u003e\n \u003cp\u003eF) Pamidronate (Aredia)\u003c/p\u003e\n \u003cp\u003eG) Zolendronate (Zometa)\u003c/p\u003e\n \u003cp\u003eH) Tiludronate (Skelid)\u003c/p\u003e\n \u003cp\u003eI) Denosumab (Prolia)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003ePlease select \u0026nbsp;the antiangiogenic drugs you know. (more than one option can be selected\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) I do not know any antiangiogenic drugs.\u003c/p\u003e\n \u003cp\u003eB) Sunitinib (Sutent)\u003c/p\u003e\n \u003cp\u003eC) Sorafenib (Nexavar)\u003c/p\u003e\n \u003cp\u003eD) Bevacizumab (Avastin)\u003c/p\u003e\n \u003cp\u003eE) Sirolimus (Rapamune)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eDid you know that antiresorptive/antiangiogenic medications can cause osteonecrosis of the jaw?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yes\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eWhich of the following are risk factors for osteonecrosis of the jaw? (more than one option can be selected)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Cigarette\u003c/p\u003e\n \u003cp\u003eB) Antibiotic treatment\u003c/p\u003e\n \u003cp\u003eC) Alcohol\u003c/p\u003e\n \u003cp\u003eD) Hypertension\u003c/p\u003e\n \u003cp\u003eE)Treatment duration\u003c/p\u003e\n \u003cp\u003eF) Hyperlipidemia\u003c/p\u003e\n \u003cp\u003eG) Steroid treatment\u003c/p\u003e\n \u003cp\u003eH) Amount of medicine\u003c/p\u003e\n \u003cp\u003ei) Micro trauma\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eDo you think patients should be checked by dentists before starting IV bisphosphonate therapy?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yest\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eCan invasive dental treatments be safely performed on patients during intravenous bisphosphonate drug therapy?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yes\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003cp\u003eC) I do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eCan invasive dental treatments be safely applied to patients who have used oral bisphosphonates for less than 4 years and have no risk factors?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yes\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003cp\u003eC) I do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOral bifosfonatları 4 yıldan az kullanan \u0026nbsp;ve risk fakt\u0026ouml;rlerine sahip hastalarda invaziv diş tedavileri g\u0026uuml;venle uygulanabilir mi?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yes\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003cp\u003eC) I do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eCan invasive dental treatments be performed safely in patients who have used oral bisphosphonates for less than 4 years and have risk factors?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yes\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003cp\u003eC) I do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHave you ever treated patients with osteonecrosis of the jaw who were receiving antiresorptive therapy?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yes\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHave you ever treated patients with osteonecrosis of the jaw who were not receiving antiresorptive therapy?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yes\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHave you ever treated patients without osteonecrosis of the jaw who were receiving antiresorptive therapy?\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eA) Yes\u003c/p\u003e\n \u003cp\u003eB) No\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003eTable \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e shows that the survey is divided into six sections. The first section contains items regarding general demographic data (age, gender, university). The second section has six items related to prior information received about antiresorptive and antiangiogenic medication and the participant\u0026rsquo;s perception of the importance of the information. Section three has five items evaluating the participant\u0026rsquo;s knowledge about the therapeutic uses of antiresorptive and antiangiogenic medication. The fourth section includes three items assessing the participant\u0026rsquo;s knowledge about osteonecrosis of the jaw and the risk. The fifth section has four items related to knowledge about the dental management of patients taking BP therapy. The last section, with three items, explores the frequency of encountering patients with osteonecrosis of the jaw with or without BPs in their clinics.\u003c/p\u003e"},{"header":"RESULT","content":"\u003cp\u003eOur hypothesis was rejected. Of the 157 participants who participated in the study, 3 participants were excluded from the study because they did not complete the questions. Of the 154 participants, 53% were senior dentistry students and 47% were senior medicine students. 65.9% of the dentistry students were female and 34.1% were male, and 55.6% of the medicine students were female while 44.4% were male.\u003c/p\u003e\n\u003cp\u003eTable \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e shows the details of the survey responses regarding receiving prior information and perception of the importance of information. It was determined that the source of information about antiresorptive and antiangiogenic drugs was largely universities in both groups. 96.3% of the Faculty of Dentistry students and 72.2% of the Faculty of Medicine students stated that it is important to ask questions about the patient\u0026rsquo;s use of antiresorptive/antiangiogenic drugs during the examination. There is a statistically significant difference between the 2 groups.\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003ctable id=\"Tab2\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eGeneral Knowledge of Antiresorptive/Antiangiogenic Medications\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"4\"\u003e\n \u003cp\u003eFaculty\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eP\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"2\"\u003e\n \u003cp\u003eMedicine\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colspan=\"2\"\u003e\n \u003cp\u003eDentistry\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eWhere did you hear about antiresorptive drugs?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eN\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,209\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI have never heard of it\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e11,00%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eUniversity\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e70,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e84,10%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSocial Media\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,00%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eScientific journals\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOther\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eWhere did you hear about antiangiogenic drugs?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eN\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,098\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI have never heard of it\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e9,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eUniversity\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e66,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e84,10%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSocial Media\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,00%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eScientific journals\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOther\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eDo you think it is important to ask whether patients are using antiresorptive/antiangiogenic medications?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eN\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e72,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e96,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e27,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003eTable \u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e shows questions and answers about antiresorptive and antiangiogenic drugs. When the relationship between the two groups and the diseases in which antiresorptive drugs are used; There is a statistically significant difference between the groups with bone metastasis, osteomyelitis, multiple myeloma, Paget\u0026apos;s and not knowing the answer. When looking at the indications for the use of antiresorptive drugs for bone metastasis, osteomyelitis, multiple myeloma, and Paget\u0026apos;s disease, there is a significant difference between the knowledge level of the two groups. The level of knowledge about these disorders is high among dentistry students.\u003c/p\u003e\n\u003cp\u003eConsidering the indications of antiangiogenic drugs, there is a significant difference between the groups for elastofibroma and pancreatic neuroendocrine tumors. When it comes to elastofibroma, dentistry students are more dominant, while medical students are more dominant for pancreatic neuroendocrine tumors. When the relationship between known antiresorptive drugs and the groups is examined; A significant difference was found between the groups in terms of knowledge of the drugs Zolendronate (Zometa), Tiludronate (Skelid) and Denosumab (Prolia). It is seen that the knowledge level of dentistry students is higher for these 3 drugs, but it is still insufficient. When the relationship between known antiangiogenic drugs and the groups is examined; Known status of bevacizumab (Avastin) and groups, there is a significant relationship between. It appears that the knowledge level of medical students is better regarding this drug. There is a significant difference between the groups in terms of knowing that antiresorptive/antiangiogenic drugs can cause osteonecrosis of the jaw. Although the knowledge level of dentistry students is higher, there is still a need to increase their knowledge level for public health.\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003ctable id=\"Tab3\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eKnowledge of Therapeutic Uses of Antiresorptive / Antiangiogenic Medication\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"4\"\u003e\n \u003cp\u003eFaculty\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eP\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"2\"\u003e\n \u003cp\u003eMedicine\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colspan=\"2\"\u003e\n \u003cp\u003eDentistry\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eWhat diseases are targeted by antiresorptive therapy?\u0026nbsp;?\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eN\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eBone metastases\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e51,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOsteomyelitis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e51,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eMultiple myeloma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e31,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e48,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,025*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHypercalcemia of malignancy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e29,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e32,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,372\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOsteopetrosiss\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e29,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e36,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,211\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOsteopenia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e38,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e26,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,078\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eChondroblastoma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,524\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOsteogenesis imperfecta\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e18,10%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e24,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,224\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003ePaget\u0026apos;s disease of bone\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e42,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,002*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e38,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,001*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eWhat diseases are targeted by anti-angiogenic therapy??\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003en\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e0,015*\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eElastofibromas\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,549\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eMetastatic colorectal cancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,07\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eLeiomyomas\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,081\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eRenal cell cancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e29,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e18,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,008*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNeuroendocrine tumor of the pancreas\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,382\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eMultiple myeloma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,431\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eGranular cell tumors\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e17,10%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,409\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e54,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e57,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,41\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eMark the name of the antiresorptive drugs you are familiar with\u003c/strong\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003en\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e0,222\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI do not know of any antiresorptive drug\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e34,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e37,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,124\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eAlendronate (Fosamax)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25,00%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,373\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eRisedronate (Actonel)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e18,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,054\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eIbandronate (Boniva)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,001*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNeridronate (Nerixia)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,014*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003ePamidronate (Aredia)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e18,10%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,007*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eZolendronate (Zometa)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e27,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e54,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,035\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eTiludronate (Skelid)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e9,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e24,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,211\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eDenosumab (Prolia)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e35,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,177\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eMark the name of the anti-angiogenic drugs you are familiar with\u003c/strong\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003en\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e0,294\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI do not know of any anti-angiogenic drugs\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e51,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e67,10%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSunitib (Sutent)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSorafenib (Nexavar))\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e38,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eBevacizumab (Avastin)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e33,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSirolimus (Rapamune)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eDo you know that anti-resorptive/antiangiogenic medications\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003ecan lead to osteonecrosis of the jaw?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003en\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYES\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e37,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e84,10%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e62,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.000*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003eTable \u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003e shows risk factors related to osteonecrosis of the jaw. When the relationship between the stated risk factors for jaw osteonecrosis and the faculties is examined; Smoking, alcohol, treatment duration, steroid treatment, amount of medication, microtrauma and not knowing the answer have a significant relationship with the groups.\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003ctable id=\"Tab4\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 4\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eKnowledge of Risk Factors Related to Osteonecrosis of the Jaw\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"4\"\u003e\n \u003cp\u003eFaculty\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eP\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"2\"\u003e\n \u003cp\u003eMedicine\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colspan=\"2\"\u003e\n \u003cp\u003eDentistry\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eWhich of the following are the risk factors related to osteonecrosis of the jaw?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eTobacco\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e59,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e75,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,026*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eAntibiotic therapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,404\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eAlcohol\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e37,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e58,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,007*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eArterial hypertension\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,332\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eLength of therapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e38,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e67,10%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHyperlipidemia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,211\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSteroid therapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e40,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e57,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,025*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eTotal amount of drug administered\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e34,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e76,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eMicro-trauma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e27,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e50,00%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,004*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003eTable \u003cspan class=\"InternalRef\"\u003e5\u003c/span\u003e shows questions and answers about dental treatment in patients receiving BP treatment.\u003c/p\u003e\n\u003cp\u003eThere is a statistically significant difference between patient\u0026rsquo;s opinion that they should be checked by dentists before starting BP treatment. It seems that medicine faculty students have less awareness. There is a significant difference between the groups in the answers given to questions about whether invasive dental treatments can be safely applied to patients who are or will be treated with intravenous and oral BP medication. While the knowledge level of medical students should be increased, the knowledge level of dental students with better knowledge should also be increased.\u0026nbsp;\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003ctable id=\"Tab5\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 5\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eKnowledge of Dental Management in Patients Undergoing Bisphosphonate Therapy\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"4\"\u003e\n \u003cp\u003eFaculty\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eP\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"2\"\u003e\n \u003cp\u003eMedicine\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colspan=\"2\"\u003e\n \u003cp\u003eDewntistry\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eDo you think patients should be checked by the dentist before starting an IV bisphosphonates treatment?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e78,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e97,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e21,70%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,00%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,00%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eCan invasive dental treatments be performed safely to patients during an intravenous bisphosphonate drug therapy?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e75,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e73,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eCan invasive dental treatments be performed safely to patients using oral bisphosphonates for \u0026lt;\u0026thinsp;4\u0026nbsp;years without risk factors?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e85,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e73,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eCan invasive dental treatments be performed safely to patients using oral bisphosphonates for \u0026lt;\u0026thinsp;4\u0026nbsp;years with risk factors?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e24,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e62,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e77,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eCan invasive dental treatments be performed safely to patients using oral bisphosphonates for \u0026gt;\u0026thinsp;4\u0026nbsp;years?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,000*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e79,30%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eI do not know\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e75,00%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003cdiv align=\"left\" class=\"colspec\"\u003e\u003cbr\u003eTable \u003cspan class=\"InternalRef\"\u003e6\u003c/span\u003e includes the survey results examining the relationship between the presence of jaw osteonecrosis and antiresorptive drug use and treatment.\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003ctable id=\"Tab7\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 6\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eKnowledge of jaw osteonecrosis and antiresorptive drug use and treatment\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"4\"\u003e\n \u003cp\u003eFaculty\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eP\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\" colspan=\"2\"\u003e\n \u003cp\u003eMedicine\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" colspan=\"2\"\u003e\n \u003cp\u003eDentistry\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eHave you treated patients with osteonecrosis of the jaw and are on antiresorptive therapy?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003en\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,047*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e71\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e98,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e91,50%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eHave you treated patients with osteonecrosis of the jaw and are NOT on antiresorptive therapy?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e17,10%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,003*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e97,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e82,90%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eHave you treated patients WITHOUT osteonecrosis of the jaw and are on anti-resorptive therapy?\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2,80%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e14,60%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0,009*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e97,20%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e85,40%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e"},{"header":"DISCUSSION","content":"\u003cp\u003eMRONJ is a serious drug side effect in patients receiving long-term antiresorptive or antiangiogenic drug therapy and usually affects the bones of the jaw. Having sufficient knowledge about MRONJ is of great importance to improve treatment results, prevent this problem and reduce complications [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. It has been observed that 99.7% of dentists do not have sufficient knowledge about diagnosing and managing MRONJ [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. Another study showed that 60% of the participants had a good level of knowledge about MRONJ. While 50% of the participants hesitated to treat patients using BP, 63% stated that they could refer patients using BP [\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e]. In a study comparing the knowledge levels of dentists and dental students, it was found that 62% of dentists and 58% of dental students had insufficient knowledge of MRONJ [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]. According to the study measuring the knowledge level of dentists and dental students, 50% of the students and 68% of the dentists have up-to-date information about MRONJ. Most correctly identified the relevant risk factors. 13% of the students and 33% of the dentists knew how to treat osteonecrosis when it occurred [\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]. Another study in the literature showed that 99% of the participants knew BPs and that sixth-semester students had better knowledge than fourth-semester students [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]. On the contrary, another study showed that knowledge about the side effects of antiresorptive drugs decreased as the years of professional practice increased [\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. Another study showed that oral maxillofacial surgeons had more knowledge than general dentists [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e]. According to a study conducted in Saudi Arabia in 2020, 60% of the participants were found to have poor BP knowledge [\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e]. According to a study conducted on medical students, almost all of the students stated that comprehensive dental screening was necessary and essential before starting BP use. 16% of the students answered correctly about the drugs that cause MRONJ [\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]\u003c/p\u003e \u003cp\u003e. In our study, senior dentistry students had 84.1% knowledge about MRONJ, while medical students had 37.5% knowledge. There is a significant statistical difference between faculties.\u003c/p\u003e \u003cp\u003eHowever, although studies investigating the level of knowledge about MRONJ among dental students are limited, there is no study comparing the level of knowledge of dental students and medical students about MRONJ. Generally, existing studies in the literature have focused on BPs. At this point, it is important to conduct a comprehensive study to evaluate the knowledge level of dental and medical students about MRONJ, improve their education, and enable them to manage these potential complications more effectively. Such a study could fill knowledge gaps in this field by identifying deficiencies in the diagnosis and treatment of MRONJ and contribute to the creation of a more effective training program for future dentists and medical practitioners. According to the research results, the level of knowledge about antiresorptive drugs shows a significant difference between the two faculties. However, interestingly, a lack of knowledge about antiresorptive drugs was detected in both faculties. This highlights the need for more comprehensive teaching and learning in both faculties, given the importance of this group of drugs.\u003c/p\u003e \u003cp\u003eHaving deeper knowledge on issues such as the effects, side effects and indications for use of antiresorptive drugs can increase the professional competencies of medical and dental students. In this context, updating training programs and adopting an interdisciplinary approach that emphasizes the role of antiresorptive drugs in clinical practice may better equip future healthcare professionals on this important issue. These efforts will be an important step in terms of drug safety and best management of patients. The knowledge level of medical students that these drugs can cause osteonecrosis was determined as 33%. This low level of knowledge shows that the potential risks and side effects of this drug group are not well known by students.\u003c/p\u003e \u003cp\u003eOne of the most important results is that the rate of thinking that a dentist should be consulted before starting BP treatment is 20% among medicine students. This approach is considered a preventive treatment to prevent the occurrence of MRONJ in advance, saving time and resources in this process for both the patient and the treatment cost. Therefore, the adoption of this preventive approach by medical school students should be considered a critical step in minimizing the risks associated with MRONJ.\u003c/p\u003e \u003cp\u003eIt has been observed that dentistry students generally have good knowledge of drug relations in areas such as bone metastasis, osteomyelitis, multiple myeloma, and Paget's, but they have deficiencies in subjects they encounter less frequently, such as neuroendocrine tumors. On the other hand, it has been observed that medical students have better knowledge about some antiangiogenic drugs. Since it is not expected to provide specific and in-depth knowledge in this field other than the questions discussed here, it is not considered as important as the previous questions.\u003c/p\u003e \u003cp\u003eAs a result, it is necessary to increase the awareness of MRONJ among faculty of medicine students and take preventive measures such as directing patients to the dentist, especially before starting this medication, performing oral and dental examination of the patients by the dentist, and protecting and intervening in their health. In particular, it is important to remember that MRONJ is the gold standard in prevention to avoid this troublesome and protracted complication. The need to strengthen information and education programs for students by increasing awareness in this field and emphasizing these preventive strategies comes to the fore. Addressing this deficiency may help future healthcare professionals guide their patients more effectively and minimize such complications.\u003c/p\u003e \u003cp\u003eAlthough the general level of knowledge about MRONJ was higher among dental students for all departments in the survey, it was quite inadequate for both medical and dental students.\u003c/p\u003e \u003cp\u003eThis lack of information may result in necessary treatments not being implemented, delayed or affected.\u003c/p\u003e \u003cp\u003eHowever, a greater concern is that as clinicians they will likely not be aware of the risk when treating MRONJ patients. These findings ultimately highlight the need for continuing education to improve patient care. These issues should be given more attention in the education of physician candidates.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003e\u003cu\u003eCOMPLIANCE WITH ETHICAL STANDARDS\u003c/u\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflict of Interest:\u0026nbsp;\u003c/strong\u003eThe authors have no\u0026nbsp;\u003cem\u003econflicts of interest\u003c/em\u003e to declare.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding:\u0026nbsp;\u003c/strong\u003eThe authors declare that no funds, grants, or other support were received during the preparation of this manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthical Approval:\u0026nbsp;\u003c/strong\u003eNot Applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eInformed Consent:\u0026nbsp;\u003c/strong\u003eWritten informed consent was obtained from each participant, ensuring that they were fully informed of the study's details and voluntarily agreed to participate.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n \u003cli\u003eMarx, R. E., Sawatari, Y., Fortin, M., \u0026amp; Broumand, V. (2005). Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. \u003cem\u003eJournal of oral and maxillofacial surgery\u003c/em\u003e, \u003cem\u003e63\u003c/em\u003e(11), 1567-1575. https://doi.org/10.1016/j.joms.2005.07.010\u003c/li\u003e\n \u003cli\u003eRuggiero, S. L., Dodson, T. B., Aghaloo, T., Carlson, E. R., Ward, B. B., \u0026amp; Kademani, D. (2022). American Association of Oral and Maxillofacial Surgeons\u0026rsquo; position paper on medication-related osteonecrosis of the jaws\u0026mdash;2022 update. \u003cem\u003eJournal of oral and maxillofacial surgery\u003c/em\u003e, \u003cem\u003e80\u003c/em\u003e(5), 920-943. https://doi.org/10.1016/j.joms.2022.02.008\u003c/li\u003e\n \u003cli\u003eAlmousa, M. A., Alharbi, G. K., Alqahtani, A. S., Chachar, Y., Alkadi, L., \u0026amp; Aboalela, A. (2021). 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Update MRONJ and perspectives of its treatment. \u003cem\u003eJournal of Stomatology, Oral and Maxillofacial Surgery\u003c/em\u003e, \u003cem\u003e118\u003c/em\u003e(4), 232-235. https://doi.org/10.1016/j.jormas.2017.06.012\u003c/li\u003e\n \u003cli\u003eK\u0026ouml;v\u0026eacute;r, Z., B\u0026aacute;n, \u0026Aacute;., Gajd\u0026aacute;cs, M., Polg\u0026aacute;r, B., \u0026amp; Urb\u0026aacute;n, E. (2023). Role of Actinomyces spp. and related organisms in the development of medication-related osteonecrosis of the jaw (MRONJ): Clinical evidence based on a case series. \u003cem\u003eEuropean Journal of Microbiology and Immunology\u003c/em\u003e, \u003cem\u003e13\u003c/em\u003e(4), 125-134. https://doi.org/10.1556/1886.2023.00041\u003c/li\u003e\n \u003cli\u003eAcharya, S., Patil, V., Ravindranath, V., Kudva, A., \u0026amp; Nikhil, K. (2022). 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(2024). Medication-related osteonecrosis of the jaw: a retrospective single center study of recurrence-related factors after surgical treatment. \u003cem\u003eClinical Oral Investigations\u003c/em\u003e, \u003cem\u003e28\u003c/em\u003e(10), 1-12. https://doi.org/10.1007/s00784-024-05911-z\u003c/li\u003e\n \u003cli\u003eMigliorati, C. A., Casiglia, J., Epstein, J., Jacobsen, P. L., Siegel, M. A., \u0026amp; Woo, S. B. (2005). Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper. \u003cem\u003eThe Journal of the American Dental Association\u003c/em\u003e, \u003cem\u003e136\u003c/em\u003e(12), 1658-1668. https://doi.org/10.14219/jada.archive.2005.0108\u003c/li\u003e\n \u003cli\u003eWat, W. Z. M. (2016). Current controversies on the pathogenesis of medication-related osteonecrosis of the jaw. \u003cem\u003eDentistry journal\u003c/em\u003e, \u003cem\u003e4\u003c/em\u003e(4), 38. https://doi.org/10.3390/dj4040038\u003c/li\u003e\n \u003cli\u003eBeth-Tasdogan, N. H., Mayer, B., Hussein, H., Zolk, O., \u0026amp; Peter, J. U. (2022). Interventions for managing medication‐related osteonecrosis of the jaw. \u003cem\u003eCochrane Database of Systematic Reviews\u003c/em\u003e, (7). https://doi.org/10.1002/14651858.CD012432.pub3\u003c/li\u003e\n \u003cli\u003eConte, P., \u0026amp; Guarneri, V. (2004). Safety of intravenous and oral bisphosphonates and compliance with dosing regimens. \u003cem\u003eThe oncologist\u003c/em\u003e, \u003cem\u003e9\u003c/em\u003e(S4), 28-37. https://doi.org/10.1634/theoncologist.9-90004-28\u003c/li\u003e\n \u003cli\u003eJeffcoat, M. K. (2006). Safety of oral bisphosphonates: controlled studies on alveolar bone. \u003cem\u003eInternational Journal of Oral \u0026amp; Maxillofacial Implants\u003c/em\u003e, \u003cem\u003e21\u003c/em\u003e(3).\u003c/li\u003e\n \u003cli\u003eRosella, D., Papi, P., Giardino, R., Cicalini, E., Piccoli, L., \u0026amp; Pompa, G. (2016). Medication-related osteonecrosis of the jaw: Clinical and practical guidelines. \u003cem\u003eJournal of International Society of Preventive and Community Dentistry\u003c/em\u003e, \u003cem\u003e6\u003c/em\u003e(2), 97-104. https://doi.org/10.4103/2231-0762.178742\u003c/li\u003e\n \u003cli\u003eRosella, D., Papi, P., Pompa, G., Capogreco, M., De Angelis, F., \u0026amp; Di Carlo, S. (2017). Dental students\u0026apos; knowledge of medication-related osteonecrosis of the jaw. \u003cem\u003eEuropean journal of dentistry\u003c/em\u003e, \u003cem\u003e11\u003c/em\u003e(04), 461-468. https://doi.org/10.4103/ejd.ejd_27_17\u003c/li\u003e\n \u003cli\u003ede Lima, P. B., Brasil, V. L. M., de Castro, J. F. L., de Moraes Ramos-Perez, F. M., Alves, F. A., dos Anjos Pontual, M. L., \u0026amp; da Cruz Perez, D. E. (2015). Knowledge and attitudes of Brazilian dental students and dentists regarding bisphosphonate-related osteonecrosis of the jaw. \u003cem\u003eSupportive care in cancer\u003c/em\u003e, \u003cem\u003e23\u003c/em\u003e, 3421-3426. https://doi.org/10.1007/s00520-015-2689-6\u003c/li\u003e\n \u003cli\u003eL\u0026oacute;pez‐Jornet, P., Camacho‐Alonso, F., Molina‐Mi\u0026ntilde;ano, F., \u0026amp; Gomez‐Garcia, F. (2010). Bisphosphonate‐associated osteonecrosis of the jaw. Knowledge and attitudes of dentists and dental students: a preliminary study. \u003cem\u003eJournal of evaluation in clinical practice\u003c/em\u003e, \u003cem\u003e16\u003c/em\u003e(5), 878-882. https://doi.org/10.1111/j.1365-2753.2009.01203.x\u003c/li\u003e\n \u003cli\u003eVinitzky-Brener, I., Ib\u0026aacute;\u0026ntilde;ez-Mancera, N. G., Aguilar-Rojas, A. M., \u0026amp; \u0026Aacute;lvarez-Jard\u0026oacute;n, A. P. (2017). Knowledge of bisphosphonate-related osteonecrosis of the Jaws among Mexican dentists. \u003cem\u003eMedicina oral, patologia oral y cirugia bucal\u003c/em\u003e, \u003cem\u003e22\u003c/em\u003e(1), e84. https://doi.org/10.4317/medoral.21433\u003c/li\u003e\n \u003cli\u003eAlhussain, A., Peel, S., Dempster, L., Clokie, C., \u0026amp; Azarpazhooh, A. (2015). Knowledge, practices, and opinions of Ontario dentists when treating patients receiving bisphosphonates. \u003cem\u003eJournal of Oral and Maxillofacial Surgery\u003c/em\u003e, \u003cem\u003e73\u003c/em\u003e(6), 1095-1105. https://doi.org/10.1016/j.joms.2014.12.040\u003c/li\u003e\n \u003cli\u003eEscobedo, M., Garc\u0026iacute;a-Consuegra, L., Junquera, S., Olay, S., Ascani, G., \u0026amp; Junquera, L. (2018). Medication-related osteonecrosis of the jaw: A survey of knowledge, attitudes, and practices among dentists in the principality of Asturias (Spain). \u003cem\u003eJournal of stomatology, oral and maxillofacial surgery\u003c/em\u003e, \u003cem\u003e119\u003c/em\u003e(5), 395-400. https://doi.org/10.1016/j.jormas.2018.04.008\u003c/li\u003e\n \u003cli\u003eAl-Samman, A. A., \u0026amp; Al-Ani, R. S. (2019). Across-sectional survey on medication-related osteonecrosis of the jaws\u0026apos; knowledge and awareness in a sample of dental society. \u003cem\u003eJournal of Cranio-Maxillofacial Surgery\u003c/em\u003e, \u003cem\u003e47\u003c/em\u003e(6), 926-931. https://doi.org/10.1016/j.jcms.2019.02.006\u003c/li\u003e\n \u003cli\u003eAlqhtani, N. R., Almalki, A. K., Zuhair, F. A., Alenazi, A. A., Nabhan, A. B., \u0026amp; Alqahtani, M. (2020). Knowledge, attitude, and management of general dentist toward medication-related osteonecrosis of the jaws. \u003cem\u003eJournal of Pharmacy and Bioallied Sciences\u003c/em\u003e, \u003cem\u003e12\u003c/em\u003e(Suppl 1), S151-S154. https://doi.org/10.4103/jpbs.JPBS_47_20\u003c/li\u003e\n \u003cli\u003eFranchi, S., Brucoli, M., Boffano, P. A. O. L. O., Dosio, C., \u0026amp; Benech, A. (2020). Medical students\u0026rsquo; knowledge of medication related osteonecrosis of the jaw. \u003cem\u003eJournal of stomatology, oral and maxillofacial surgery\u003c/em\u003e, \u003cem\u003e121\u003c/em\u003e(4), 344-346. https://doi.org/10.1016/j.jormas.2019.10.005\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"MRONJ, bisphosphonates, antiresorptive therapy, antiangiogenic therapy","lastPublishedDoi":"10.21203/rs.3.rs-5073401/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5073401/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eObjectives: \u003c/strong\u003eMedication-related osteonecrosis of the jaw (MRONJ) is a complication that occurs in patients receiving antiresorptive or antiangiogenic medical therapy. Treatment of MRONJ requires meticulous treatment planning and protocols. The aim of this study is to evaluate and compare the knowledge level of senior dentistry and medicine students about MRONJ.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaterials and Methods: \u003c/strong\u003eA cross-sectional study was conducted on a total of 154 senior dentistry and medical faculty students. Data were collected using a structured electronic survey consisting of six sections. Data were entered and analyzed using SPSS version 23, and a P-value \u0026lt;0.05 was considered significant.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eMore than half of the sample (66.7%) had knowledge about antiresorptive and antiangiogenic drugs; 76.4% of those who had knowledge had heard about it during their university education. The underlying diseases that antiresorptive and antiangiogenic drugs target were unknown to the majority. Almost half of the sample (45.2%) could not identify any antiresorptive or anti-angiogenic drugs, and 62.5% of senior students of the Faculty of Medicine and 15.9% of senior students of Dentistry did not know that these drugs could cause jaw necrosis.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eAlthough the level of knowledge about MRONJ was higher among dental students for all departments in the survey, it was quite insufficient for both medical and dental students.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical Relevance: \u003c/strong\u003eEnhancing knowledge of dentistry students and medicine students about MRONJ will be an important step in reducing and even preventing this public health problem, which is quite common in society.\u003c/p\u003e","manuscriptTitle":"Evaluation of Mronj Knowledge in Senior Dental and Medical Students","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-10-22 03:06:04","doi":"10.21203/rs.3.rs-5073401/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"5b52fec7-0950-4d4e-ba0b-8114777d6554","owner":[],"postedDate":"October 22nd, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-10-22T03:06:04+00:00","versionOfRecord":[],"versionCreatedAt":"2024-10-22 03:06:04","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-5073401","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5073401","identity":"rs-5073401","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}